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Renal cell carcinoma recurrences and metastases in primary non-metastatic patients: a population-based study
Department of Urology, Skåne University Hospital, Malmö, Sweden.
Section of Urology, Department of Molecular Medicine and Surgery, Karolinska Institute, Solna, Stockholm, Sweden.
Örebro University, School of Medical Sciences. Department of Urology.
Department of Oncology, Karolinska University Hospital, Solna, Stockholm, Sweden.
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2016 (English)In: World journal of urology, ISSN 0724-4983, E-ISSN 1433-8726, Vol. 34, no 8, 1081-1086 p.Article in journal (Refereed) Published
Abstract [en]

Purpose: To present the occurrence of metastases and local recurrences in primary non-metastatic patients with renal cell carcinoma (RCC) in a contemporary Swedish population-based cohort.

Methods: Between 2005 and 2009, a total of 4527 patients were included in the prospective National Swedish Kidney Cancer Register accounting for nearly all RCC patients in Sweden. Among M0 patients, 472 (13 %) had no follow-up data registered within 5-year follow-up time and were excluded from the analysis.

Results: In total, 939 (21 %) had distant metastases at presentation with a decrease from 23 to 18 % during the inclusion period. Of 3107 patients with follow-up data and with M0 disease, 623 (20 %) were diagnosed with a tumor recurrence during 5-year follow-up. Mean time to recurrence was 24 months (SD ± 20 months). Among these, 570 patients (92 %) were at primary diagnosis treated with radical nephrectomy, 23 patients (3.7 %) with partial nephrectomy and 12 patients (1.9 %) with minimally invasive treatments. The most frequent sites of metastases were lung (54 %), lymph nodes (22 %) and bone (20 %). The treatment of recurrence was in 50 % systemic treatments, while metastasectomy was performed in 17 % of the patients, out of which 68 % were with a curative intention.

Conclusions: In this population-based study, 21 % of the patients had metastatic disease at presentation, with a decreasing trend over the study period. During 5-year follow-up, 20 % of the primary non-metastatic patients had recurrent disease. Of the patients with recurrence, half were given systemic oncological treatment and 17 % underwent metastasectomy.

Place, publisher, year, edition, pages
New York, USA: Springer, 2016. Vol. 34, no 8, 1081-1086 p.
Keyword [en]
Renal cell carcinoma, metastases, recurrent disease, local recurrence, surgery, nephrectomy, partial nephrectomy, minimal invasive therapy
National Category
Cancer and Oncology Urology and Nephrology
Identifiers
URN: urn:nbn:se:oru:diva-48084DOI: 10.1007/s00345-016-1773-yISI: 000381101100006PubMedID: 26847337Scopus ID: 2-s2.0-84957538219OAI: oai:DiVA.org:oru-48084DiVA: diva2:904654
Note

Funding Agencies:

Umeå University

Lions Cancer Research Foundation in Umeå

Research Foundation at the Urology Department of Sahlgrenska University Hospital

Foundation of Anna-Lisa and Bror Björnsson

Available from: 2016-02-19 Created: 2016-02-07 Last updated: 2017-10-17Bibliographically approved

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