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Special AT-rich sequence binding protein 1 expression correlates with response to preoperative radiotherapy and clinical outcome in rectal cancer
Department of Gastrointestinal Surgery; West China Hospital; Sichuan University; Chengdu, China; Department of Oncology and Department of Clinical and Experimental Medicine; Linköping University; Linköping, Sweden.
Department of Oncology and Department of Clinical and Experimental Medicine; Linköping University; Linköping, Sweden.
Cancer Center and State Key Laboratory of Biotherapy; West China Hospital; Sichuan University; Chengdu, China.
Örebro University, School of Medicine, Örebro University, Sweden.
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2015 (English)In: Cancer Biology & Therapy, ISSN 1538-4047, E-ISSN 1555-8576, Vol. 16, no 12, 1738-1745 p.Article in journal (Refereed) Published
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Text
Abstract [en]

Our recent study showed the important role of special AT-rich sequence binding protein 1 (SATB1) in the progression of human rectal cancer. However, the value of SATB1 in response to radiotherapy (RT) for rectal cancer hasn't been reported so far. Here, SATB1 was determined using immunohistochemistry in normal mucosa, biopsy, primary cancer, and lymph node metastasis from 132 rectal cancer patients: 66 with and 66 without preoperative RT before surgery. The effect of SATB1 knockdown on radiosensitivity was assessed by proliferation-based assay and clonogenic assay. The results showed that SATB1 increased from normal mucosa to primary cancer, whereas it decreased from primary cancer to metastasis in non-RT patients. SATB1 decreased in primary cancers after RT. In RT patients, positive SATB1 was independently associated with decreased response to preoperative RT, early time to metastasis, and worse survival. SATB1 negatively correlated with ataxia telangiectasia mutated (ATM) and pRb2/p130, and positively with Ki-67 and Survivin in RT patients, and their potential interaction through different canonical pathways was identified in network ideogram. Taken together, our findings disclose for the first time that radiation decreases SATB1 expression and sensitizes cancer cells to confer clinical benefit of patients, suggesting that SATB1 is predictive of response to preoperative RT and clinical outcome in rectal cancer.

Place, publisher, year, edition, pages
Taylor & Francis, 2015. Vol. 16, no 12, 1738-1745 p.
Keyword [en]
colorectal cancer, Ingenuity Pathway Analysis, preoperative radiotherapy, prognosis, SATB1
National Category
Cancer and Oncology
Research subject
Oncology
Identifiers
URN: urn:nbn:se:oru:diva-48946DOI: 10.1080/15384047.2015.1095408ISI: 000369916100007PubMedID: 26528635Scopus ID: 2-s2.0-84954570421OAI: oai:DiVA.org:oru-48946DiVA: diva2:909041
Funder
Swedish Cancer SocietySwedish Research Council
Note

Funding Agency:

Health Research Council in the South-East of Sweden

Available from: 2016-03-04 Created: 2016-03-04 Last updated: 2016-03-04Bibliographically approved

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