oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Risk of symptomatic venous thromboembolism following emergency appendicectomy in adults
Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Nottingham Digestive Diseases Biomedical Research Unit, Queens Medical Centre Campus, University of Nottingham Nottingham, UK; Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden.
Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK .
Thrombosis and Haemophilia Centre Guy's and St Thomas' NHS Foundation Trust, London, UK.
Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK.
Show others and affiliations
2016 (English)In: British Journal of Surgery, ISSN 0007-1323, E-ISSN 1365-2168, Vol. 103, no 4, 443-450 p.Article in journal (Refereed) Published
Abstract [en]

Background: Appendicectomy is the commonest intra-abdominal emergency surgical procedure, and little is known regarding the magnitude and timing of the risk of venous thromboembolism (VTE) after surgery. This study aimed to determine absolute and relative rates of symptomatic VTE following emergency appendicectomy.

Methods: A cohort study was undertaken using linked primary (Clinical Practice Research Datalink) and secondary (Hospital Episode Statistics) care data of patients who had undergone emergency appendicectomy from 2001 to 2011. Crude rates and adjusted incidence rate ratios (IRRs) for VTE were calculated using Poisson regression, compared with baseline risk in the year before appendicectomy.

Results: A total of 13 441 patients were identified, of whom 56 (0·4 per cent) had a VTE in the first year after surgery. The absolute rate of VTE was highest during the in-hospital period, with a rate of 91·29 per 1000 person-years, which was greatest in those with a length of stay of 7 days or more (267·12 per 1000 person-years). This risk remained high after discharge, with a 19·1- and 6·6-fold increased risk of VTE in the first and second months respectively after discharge, compared with the year before appendicectomy (adjusted IRR: month 1, 19·09 (95 per cent c.i. 9·56 to 38·12); month 2, 6·56 (2·62 to 16·44)).

Conclusion: The risk of symptomatic VTE following appendicectomy is relatively high during the in-hospital admission and remains increased after discharge. Trials of extended thromboprophylaxis are warranted in patients at particularly high risk.

Place, publisher, year, edition, pages
West, Sussex, United Kingdom: John Wiley & Sons, 2016. Vol. 103, no 4, 443-450 p.
National Category
Cardiac and Cardiovascular Systems
Identifiers
URN: urn:nbn:se:oru:diva-49209DOI: 10.1002/bjs.10091PubMedID: 26818405OAI: oai:DiVA.org:oru-49209DiVA: diva2:910944
Available from: 2016-03-10 Created: 2016-03-10 Last updated: 2016-03-10Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMed

Search in DiVA

By author/editor
Ludvigsson, Jonas F.
In the same journal
British Journal of Surgery
Cardiac and Cardiovascular Systems

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 205 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • harvard1
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf