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Effect of Gastric Bypass on Bone Mineral Density, Parathyroid Hormone and Vitamin D: 5 Years Follow-up
Lindesberg Hospital, Örebro, Sweden.
Lindesberg Hospital, Örebro, Sweden.
Lindesberg Hospital, Örebro, Sweden.
Lindesberg Hospital, Örebro, Sweden.
2016 (English)In: Obesity Surgery, ISSN 0960-8923, E-ISSN 1708-0428, Vol. 26, no 5, p. 1141-1145Article in journal (Refereed) Published
Abstract [en]

Background: The aim of the present study was to see if there are longitudinal changes in bone mineral density (BMD), vitamin D or parathyroid hormone (PTH) in females 5 years after Laparoscopic Roux-en-Y Gastric Bypass (LRYGB).

Methods: Thirty-two women with mean age 41.6 ± 9.3 years and mean body mass index (BMI) 44.5 ± 4.6 kg/m(2) were included. Preoperatively, 2 and 5 years postoperatively, BMD, weight, height, S-calcium, S-albumin, S-creatinine, S-25(OH)-vitamin D and fP-PTH were measured.

Results: The mean decrease in BMI between baseline and 5 years after surgery was 29.4 %. BMD of the spine and femur measured as z- and t-scores, showed a linear, statistically significant declining trend over the years. The fall in BMD of the spine and femoral neck between baseline and 5 years after surgery was 19 and 25 %, respectively. The mean fP-PTH showed a significant increase over the study period (20.2 μg/L increase, 95 % CI:-31.99 to -8.41). S-calcium, both free and corrected for albumin, showed a decrease between baseline and 5 years after surgery. Eight patients developed osteopenia and one osteoporosis after a 5-year follow-up.

Conclusion: LRYGB is an efficient method for sustained long-term body weight loss. There is, however, a concomitant decrease in BMD and S-calcium, and an increase in fP-PTH.

Place, publisher, year, edition, pages
New York, USA: Springer, 2016. Vol. 26, no 5, p. 1141-1145
Keywords [en]
Bone mineral density, gastric bypass, BMI, parathyroid hormone, obesity, vitamin D
National Category
Endocrinology and Diabetes
Identifiers
URN: urn:nbn:se:oru:diva-49206DOI: 10.1007/s11695-016-2114-3ISI: 000374400900037PubMedID: 26926187Scopus ID: 2-s2.0-84959431689OAI: oai:DiVA.org:oru-49206DiVA, id: diva2:910988
Available from: 2016-03-10 Created: 2016-03-10 Last updated: 2018-03-09Bibliographically approved

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Raoof, MustafaRask, Eva

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