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Activated T cells in the nasal mucosa of patients with grass-pollen allergy. A pilot study
Örebro Medical Center, Örebro, Sweden.
Örebro Medical Center, Örebro, Sweden.ORCID iD: 0000-0001-6881-237X
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1992 (English)In: Rhinology, ISSN 0300-0729, E-ISSN 1996-8604, Vol. 30, no 1, 57-63 p.Article in journal (Refereed) Published
Abstract [en]

Six patients with grass-pollen allergy were provoked with water-soluble grass pollen until a pronounced allergic reaction occurred. This was performed outside the grass-pollen season, and the allergen was administered on the edge of the inferior turbinate. Biopsies were taken both before provocation and during the reaction, 15-30 minutes after provocation. The nasal population of immunohistochemically positive cells for HLA-DR, CD1, interleukin-2-receptor, IgE, CD4 and CD8 were studied. There was a marked increase of IL2-R-positive cells (activated T lymphocytes) in the nasal mucosa after provocation, whilst the other cell populations approximately remained unchanged (apart from a certain increase of IgE). The increase of activated T lymphocytes may imply that certain subsets of T cells play a role in the allergic response, and that the role of helper T cells very likely is much more complex than the regulation of mast cells and eosinophils. The concomitant presence of Langerhans' cells (CD1-positive) and activated T lymphocytes may indicate a possible association on site between an antigen-presenting cell and both effector as well as memory cells in allergic reactions.

Place, publisher, year, edition, pages
Amsterdam, Netherlands: International Rhinologic Society , 1992. Vol. 30, no 1, 57-63 p.
National Category
Clinical Laboratory Medicine Respiratory Medicine and Allergy
Research subject
Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-49535PubMedID: 1579813Scopus ID: 2-s2.0-0026580669OAI: oai:DiVA.org:oru-49535DiVA: diva2:914785
Available from: 2016-03-25 Created: 2016-03-25 Last updated: 2017-10-17Bibliographically approved

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Karlsson, Mats G.Davidsson, Åke
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