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Salivary duct carcinoma: a highly aggressive salivary gland tumour with overexpression of c-erbB-2
Department of Pathology, Örebro Medical Center Hospital, Örebro, Sweden .
Department of Pathology, Örebro Medical Center Hospital, Örebro, Sweden.ORCID iD: 0000-0001-6881-237X
Department of Otorhinolaryngology, Örebro Medical Center Hospital, Örebro, Sweden.
1994 (English)In: Journal of Pathology, ISSN 0022-3417, E-ISSN 1096-9896, Vol. 172, no 1, 35-44 p.Article in journal (Refereed) Published
Abstract [en]

The clinicopathological and immunocytochemical features of nine cases of salivary duct carcinoma are described. This relatively rare tumour, which only recently has been widely recognized as a separate entity, is highly malignant and caused the death in eight of the patients. The tumour cells are arranged in cribriform and solid growth patterns, where the solid tumour nests frequently have comedo necrosis, and a fibrous, often sclerotic, stroma is present. The infiltrating desmoplasmic component and the diffuse invasive growth into adjacent adipose parotid tissue have similarities to ductal breast carcinoma. Immunocytochemical investigation of salivary duct carcinoma showed constant overexpression of c-erbB-2 as detected by membrane accentuation, and high proliferative activity as detected by nuclear positivity for MIB 1 (Ki-67). Changes in the expression of p53 and retinoblastoma gene product do not constitute a constant event in salivary duct carcinoma. A few of the tumours showed scattered cells with distinct nuclear positivity for both progesterone and oestrogen receptors. We emphasize that this highly malignant salivary gland tumour has a characteristic morphology, may not be as rare as previously considered, and that prompt and aggressive therapy is needed.

Place, publisher, year, edition, pages
West Sussex, United Kingdom: John Wiley & Sons, 1994. Vol. 172, no 1, 35-44 p.
Keyword [en]
Adenocarcinoma, c-erbB-2, oncogenes, p53, Ki-67, steroid receptors, salivary gland neoplasms, salivary duct carcinoma
National Category
Cancer and Oncology Clinical Laboratory Medicine Otorhinolaryngology
Research subject
Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-49533DOI: 10.1002/path.1711720108ISI: A1994MV11900007PubMedID: 7931825Scopus ID: 2-s2.0-0028330812OAI: oai:DiVA.org:oru-49533DiVA: diva2:914788
Available from: 2016-03-25 Created: 2016-03-25 Last updated: 2016-04-04Bibliographically approved

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