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Nasal memory T lymphocytes capable of producing IL-4 in the allergic reaction
Department of Pathology, Örebro Medical Center Hospital, Örebro, Sweden.
Department of Pathology, Örebro Medical Center Hospital, Örebro, Sweden.ORCID iD: 0000-0001-6881-237X
1992 (English)In: Allergy. European Journal of Allergy and Clinical Immunology, ISSN 0105-4538, E-ISSN 1398-9995, Vol. 47, no 4 Pt 1, p. 334-336Article in journal (Refereed) Published
Abstract [en]

This paper reports the presence of memory T cells in the nasal mucosa of allergic patients. The demonstration of CD4+/CD29+ (CD4+/CD45RO+) T lymphocytes, which are capable of interleukin-4 production, can indicate a complementary cell-mediated regulatory mechanism for mast cell proliferation and IgE synthesis in human nasal allergy. No substantial IgE production can be obtained in the absence of IL-4. Therefore, the existence of IL-4 producing cells on site in the nasal mucosa of allergic subjects probably implies a complementary interaction between cytokines and different immunocompetent nasal cells in the regulation of B cells and IgE synthesis.

Place, publisher, year, edition, pages
West Sussex, United Kingdom: Wiley-Blackwell, 1992. Vol. 47, no 4 Pt 1, p. 334-336
Keywords [en]
nasal allergy, memory T cells, interleukin-4, cytokines
National Category
Respiratory Medicine and Allergy Clinical Laboratory Medicine
Research subject
Biomedicine
Identifiers
URN: urn:nbn:se:oru:diva-49534DOI: 10.1111/j.1398-9995.1992.tb02065.xISI: A1992JM68400015PubMedID: 1443456Scopus ID: 2-s2.0-0026656171OAI: oai:DiVA.org:oru-49534DiVA, id: diva2:914790
Available from: 2016-03-25 Created: 2016-03-25 Last updated: 2017-11-30Bibliographically approved

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Karlsson, Mats G.

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