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No association between immunohistochemical expression of p53, c-erbB-2, Ki-67, estrogen and progesterone receptors in female papillary thyroid cancer and ionizing radiation
Department of Pathology, Örebro Medical Center, Örebro, Sweden.ORCID iD: 0000-0001-6881-237X
Department of Oncology, Örebro Medical Center, Örebro, Sweden.
Stockholms Sjukhem, Stockholm, Sweden.
1997 (English)In: Cancer Letters, ISSN 0304-3835, E-ISSN 1872-7980, Vol. 120, no 2, 173-177 p.Article in journal (Refereed) Published
Abstract [en]

An association has previously been reported between exposure to medical diagnostic ionizing radiation and papillary thyroid cancer in women. To further evaluate potential mechanisms in carcinogenesis, the expression of p53, c-erbB-2, as well as Ki-67, estrogen and progesterone receptors were analyzed by immunohistochemistry in 19 women exposed to X-rays and for comparison in nine women without such reported exposure. They all had papillary thyroid cancer. No difference was found between these groups. The results of this study showed that p53, c-erbB-2, Ki-67, estrogen and progesterone receptors are not involved in papillary thyroid cancer associated with exposure to medical diagnostic ionizing radiation.

Place, publisher, year, edition, pages
Clare, Ireland: Elsevier, 1997. Vol. 120, no 2, 173-177 p.
Keyword [en]
p53, c-erbB-2, Ki-67, estrogen receptors, progesterone receptors, papillary thyroid cancer, ionizing radiation
National Category
Cancer and Oncology Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:oru:diva-49523DOI: 10.1016/S0304-3835(97)00307-8ISI: A1997YH95200007PubMedID: 9461034Scopus ID: 2-s2.0-0030693873OAI: oai:DiVA.org:oru-49523DiVA: diva2:914804
Available from: 2016-03-25 Created: 2016-03-25 Last updated: 2017-10-17Bibliographically approved

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