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The expression of EGFR family ligands in breast carcinomas
Departments of Pathology, The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Oslo, Norway.
Departments of Pathology, The Norwegian Radium Hospital and Institute for Cancer Research, University of Oslo, Oslo, Norway.
Department of Pathology, Örebro Medical Center Hospital, Örebro, Sweden.ORCID iD: 0000-0001-6881-237X
Department of Oncology, Örebro Medical Center Hospital, Örebro, Sweden.
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2002 (English)In: International Journal of Surgical Pathology, ISSN 1066-8969, E-ISSN 1940-2465, Vol. 10, no 2, p. 91-99Article in journal (Refereed) Published
Abstract [en]

Expression of EGF, HB-EGF, TGF-alpha, HRG-alpha, HRG-beta1, and HRG-beta3 in 100 frozen breast carcinoma materials was immunohistochemically studied. Among these tumors, 67% were positive for EGF, 53% for HB-EGF, 57% for TGF-alpha, 60% for HRG-alpha, 53% for HRG-beta1, and 63% for HRG-beta3 in the neoplastic epithelial cells. No significant associations between expression of the growth factors and clinicopathological features like tumor size, histologic grade, node status, ploidy, ER status, and c-erbB-4 expression were observed, with the exceptions that significant relations were present between EGF expression and tumor size (p = 0.01) and between HRG-beta3 expression and node status (p = 0.02). The expressions of these growth factors showed no association with cancer-specific survival by the Kaplan Meier analysis.

Place, publisher, year, edition, pages
Thousand Oaks, USA: Sage Publications, 2002. Vol. 10, no 2, p. 91-99
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Cancer and Oncology Clinical Laboratory Medicine
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URN: urn:nbn:se:oru:diva-49514DOI: 10.1177/106689690201000202ISI: 000176324200002PubMedID: 12075402Scopus ID: 2-s2.0-0036081784OAI: oai:DiVA.org:oru-49514DiVA, id: diva2:914898
Available from: 2016-03-27 Created: 2016-03-25 Last updated: 2017-11-30Bibliographically approved

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Karlsson, Mats G

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