The expression of EGFR family ligands in breast carcinomasShow others and affiliations
2002 (English)In: International Journal of Surgical Pathology, ISSN 1066-8969, E-ISSN 1940-2465, Vol. 10, no 2, p. 91-99Article in journal (Refereed) Published
Abstract [en]
Expression of EGF, HB-EGF, TGF-alpha, HRG-alpha, HRG-beta1, and HRG-beta3 in 100 frozen breast carcinoma materials was immunohistochemically studied. Among these tumors, 67% were positive for EGF, 53% for HB-EGF, 57% for TGF-alpha, 60% for HRG-alpha, 53% for HRG-beta1, and 63% for HRG-beta3 in the neoplastic epithelial cells. No significant associations between expression of the growth factors and clinicopathological features like tumor size, histologic grade, node status, ploidy, ER status, and c-erbB-4 expression were observed, with the exceptions that significant relations were present between EGF expression and tumor size (p = 0.01) and between HRG-beta3 expression and node status (p = 0.02). The expressions of these growth factors showed no association with cancer-specific survival by the Kaplan Meier analysis.
Place, publisher, year, edition, pages
Thousand Oaks, USA: Sage Publications, 2002. Vol. 10, no 2, p. 91-99
National Category
Cancer and Oncology Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:oru:diva-49514DOI: 10.1177/106689690201000202ISI: 000176324200002PubMedID: 12075402Scopus ID: 2-s2.0-0036081784OAI: oai:DiVA.org:oru-49514DiVA, id: diva2:914898
2016-03-272016-03-252017-11-30Bibliographically approved