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HPV-DNA, vascular space invasion, and their impact on the clinical outcome in early-stage cervical carcinomas
Department of Gynecological Oncology, Örebro University Hospital, Örebro, Sweden.
Department of Gynecological Oncology, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0002-5063-631X
Department of Pathology, Örebro University Hospital, Örebro, Sweden.
Department of Pathology, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0001-6881-237X
2014 (English)In: International Journal of Gynecological Cancer, ISSN 1048-891X, E-ISSN 1525-1438, Vol. 14, no 5, 896-902 p.Article in journal (Refereed) Published
Abstract [en]

The present study was designed to analyze the relationship of human papillomavirus (HPV)-DNA, microvessel density, and their impact on clinical outcome in early cervical carcinoma. HPV-DNA was evaluated in 171 cases of cervical carcinoma treated from 1965 to 1990. In 110 cases, the analyses could be performed. A polymerase chain reaction technique was used on paraffin-embedded specimens obtained before the start of therapy. HPV-DNA of any type was detected in 78% (86/110) of all evaluable tumors. HPV16 was the predominant type and was detected in 56% (62/110), HPV18 in 8% (9/110), and HPV35 in 21% (23/110). Patients with tumors containing HPV16 or HPV18 were significantly (P = 0.011) younger than patients with tumors not containing either of these two subtypes. Vascular space invasion and lymph node metastases were observed more frequently in tumors expressing HPV16 and HPV18 (P = 0.002, P = 0.047) than in tumors negative for these HPV strains. Tumors containing HPV16 and HPV18 were significantly (P = 0.012) larger and more frequently (P = 0.005) associated with higher FIGO stages. The cancer-specific survival rate was lower for patients with HPV16- and HPV18-positive tumors, but the difference was not statistically significant. The microvessel density was a non-significant prognostic factor. The overall 5-year survival rate of the complete series was 91%. It was concluded that HPV-DNA was a prognostic factor in early-stage cervical cancer and was associated with the age of the patient, vascular space invasion, lymph node metastases, tumor size, and FIGO stage.

Place, publisher, year, edition, pages
Malden, USA: Blackwell Publishing, 2014. Vol. 14, no 5, 896-902 p.
Keyword [en]
Cervical cancer, HPV, prognostic factors, vascular space invasion
National Category
Cancer and Oncology Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:oru:diva-49506DOI: 10.1111/j.1048-891X.2004.014527.xISI: 000223822000024PubMedID: 15361201Scopus ID: 2-s2.0-4544356428OAI: oai:DiVA.org:oru-49506DiVA: diva2:914910
Available from: 2016-03-27 Created: 2016-03-25 Last updated: 2017-10-17Bibliographically approved

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Sorbe, BengtKarlsson, Mats G.
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