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Relation between HPV-DNA and expression of p53, bcl-2, p21WAF-1, MIB-1, HER-2/neu and DNA ploidy in early cervical carcinoma: correlation with clinical outcome
Department of Gynecological Oncology, Örebro University Hospital, Örebro, Sweden.
Department of Gynecological Oncology, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0002-5063-631X
Department of Pathology, Örebro University Hospital, Örebro, Sweden.
Department of Pathology, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0001-6881-237X
2004 (English)In: Oncology Reports, ISSN 1021-335X, E-ISSN 1791-2431, Vol. 12, no 1, p. 169-176Article in journal (Refereed) Published
Abstract [en]

The purpose of the present study was to analyze the relation between the expression of p53, bcl-2, p21WAF1, MIB-1, HER-2/neu, DNA ploidy and HPV16 or 18 infections with clinical parameters. HPV-DNA was evaluated in 171 early cervical carcinomas treated from 1965 to 1990 and detected by PCR (polymerase chain reaction) on paraffin specimens obtained before therapy was started. HPV-DNA of any type was detected in 78% (86/110) of all tumors, HPV16 was the predominant type and was seen in 56% (62/110), HPV18 in 8% (9/110) and HPV35 in 21% (23/110). Patients with HPV16 or 18 were significantly (P=0.011) younger than patients with tumors not containing these two HPV subtypes. Lymph node metastases were seen more frequently (P=0.047) in tumors expressing HPV16 or 18. Tumor size was associated with the HPV-type. The frequency of DNA aneuploidy was lower in high-risk HPV tumors than in tumors with other HPV subtypes (P=0.014). MIB-1 expression was highly significantly (P=0.00007) associated with presence of HPV16 or 18. The cancer-specific survival rate was lower for patients with HPV16 and 18 positive tumors, but the difference was not statistically significant. The overall 5-year survival rate of the complete series was 91%. In conclusion, the HPV DNA subtype was a prognostic factor in early stage cervical cancer and it was associated with age, positive lymph nodes, tumor size, DNA ploidy and the proliferation marker MIB-1.

Place, publisher, year, edition, pages
Athens, Greece: Spandidos Publications , 2004. Vol. 12, no 1, p. 169-176
Keywords [en]
Cervical cancer, human papillomavirus, DNA ploidy, p53, bcl-2; p21(WAF1), MIB-1, HER-2/neu, prognostic factors
National Category
Cancer and Oncology Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:oru:diva-49507DOI: 10.3892/or.12.1.169ISI: 000222169100029PubMedID: 15201979Scopus ID: 2-s2.0-21044447167OAI: oai:DiVA.org:oru-49507DiVA, id: diva2:914912
Available from: 2016-03-27 Created: 2016-03-25 Last updated: 2017-11-30Bibliographically approved

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Sorbe, BengtKarlsson, Mats G.

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