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Bcl-2 immunoreactivity in salivary gland neoplasms is unrelated to the expression of mRNA for natural killer cell stimulatory cytokines interleukin (IL)-2 and IL-12
Department of Pathology II, University Hospital, Linköping, Sweden.
Department of Pathology, Medical Center Hospital, Örebro, Sweden.ORCID iD: 0000-0001-6881-237X
Department of Pathology, Medical Center Hospital, Örebro, Sweden.
Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Milan, Italy.
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1996 (English)In: Virchows Archiv, ISSN 0945-6317, E-ISSN 1432-2307, Vol. 429, no 2-3, 149-158 p.Article in journal (Refereed) Published
Abstract [en]

Certain cytokines are involved in the generation of natural killer (NK) cells and participate in the regulation of the proto-oncogene bcl-2. We aimed to study the mRNA expression of interleukin (IL)-2, IL-4 and IL-5, the composition of the tumour infiltrating lymphocytes (TIL), and the expression of bcl-2 in 14 benign and malignant human parotid tumours. T IL were predominantly composed of T lymphocytes and NK cells. We found evidence for the homing of T cells, and for generation of NK cells in the vicinity of the tumours. mRNA for IL-2 and IL-12, were identified but IL-4 mRNA was not found. The cytokine profiles and the composition of TIL of the two tumour categories were indistinguishable, suggesting that these host-response variables do not explain the differences in biological behaviour of these particular tumours. The results support a shift towards Th 1 (T helper 1) cells and interferon-gamma production, and that IL-12 also in vivo may play an important role in the regulatory interaction between innate resistance and adaptive immunity in tumour diseases. Most infiltrating lymphocytes showed strong expression of bcl-2; an interesting observation with regard to lymphocytic apoptosis in neoplastic diseases. The immunoreactivity for the bcl-2 protein varied considerably between and within tumours, and almost all benign tumours showed strong bcl-2 positively whereas several of the malignant tumours showed weak or absent staining. The variable expression of bcl-2 protein suggests a different susceptibility of tumour cells to apoptosis. The results also indicate that bcl-2 cannot pla a major role as protective agent in the specific apoptotic pathway induced by NK cells.

Place, publisher, year, edition, pages
New York, USA: Springer, 1996. Vol. 429, no 2-3, 149-158 p.
Keyword [en]
Salivary gland neoplasms, cytokines, bcl-2, apoptosis, NK cells
National Category
Cancer and Oncology Clinical Laboratory Medicine
Identifiers
URN: urn:nbn:se:oru:diva-49542DOI: 10.1007/BF00192437ISI: A1996VQ04300010PubMedID: 8917716Scopus ID: 2-s2.0-0029910973OAI: oai:DiVA.org:oru-49542DiVA: diva2:914920
Available from: 2016-03-27 Created: 2016-03-27 Last updated: 2017-10-17Bibliographically approved

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