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Circulating levels of perfluoroalkyl substances and biomarkers of liver function in a large population based sample of elderly men and women from Sweden
Occupational and Environmental Medicine, Uppsala University, Uppsala, Sweden.
Örebro University, School of Science and Technology. Department of Medicine, Uppsala University, Uppsala, Sweden. (MTM)ORCID iD: 0000-0001-5752-4196
Department of Clinical Chemistry, Uppsala University, Uppsala, Sweden.
Örebro University, School of Science and Technology. (MTM)ORCID iD: 0000-0001-6217-8857
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2015 (English)In: Toxicology Letters, ISSN 0378-4274, E-ISSN 1879-3169, Vol. 238, no 2, p. S91-S91Article in journal, Meeting abstract (Other academic) Published
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Abstract [en]

Objective: Since perfluoroalkyl substances (PFAS), also called perfluorinated compounds (PFCs), have been shown to accumulate in the liver in experimental studies, we investigated the relationships between PFAS and biomarkers of liver function in the general population.

Methods: 1016 subjects aged 70 years were investigated in the Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study. Eight PFAS were detected in almost all participants era by liquid chromatograph/tandem mass spectrometry. Several biomarkers of liver function were measured in parallel.

Results: Bilirubin levels were significantly related to several of the PFAS, like perfluoroheptanoic acid (PFHpA), perfluorooctanoicacid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA). Of those, PFHpA, PFOA, PFDA, and PFNA were also related to Alanine Aminotransferase (ALT) levels. PFNA and PFUnDA were inversely related to alkaline phosphatases, while only PFHpA levels were significantly related to gamma-glutamyl transferase (GGT) levels. All associations were adjusted for life-style factors, like smoking, education, exercise habits, energy and alcohol intake.

Conclusion: Circulating level of PFAS were related to biomarkers of liver function in this population-based sample, suggesting that PFAS could have a negative effect on liver function also in humans.

Place, publisher, year, edition, pages
Elsevier, 2015. Vol. 238, no 2, p. S91-S91
National Category
Pharmacology and Toxicology
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URN: urn:nbn:se:oru:diva-49619DOI: 10.1016/j.toxlet.2015.08.304ISI: 000370693801141OAI: oai:DiVA.org:oru-49619DiVA, id: diva2:916662
Conference
51st Congress of the European-Societies-of-Toxicology (EUROTOX), Portuguese Soc Pharmacol, Sect Toxicol, Porto, Portugal, September 13-16, 2015
Available from: 2016-04-04 Created: 2016-04-04 Last updated: 2018-07-03Bibliographically approved

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Salihovic, Samiravan Bavel, Bert

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