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Plasma 1-carbon metabolites and academic achievement in 15-yr-old adolescents
Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden.
Örebro University, School of Health Sciences.ORCID iD: 0000-0003-1067-8627
Department of Biosciences and Nutrition, Karolinska Institute, Stockholm, Sweden.
Department of Clinical Chemistry and Laboratory Medicine, Saarland University Hospital, Homburg/Saar, Germany.
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2016 (English)In: The FASEB Journal, ISSN 0892-6638, E-ISSN 1530-6860, Vol. 30, no 4, 1683-1688 p.Article in journal (Refereed) Published
Abstract [en]

Academic achievement in adolescents is correlated with 1-carbon metabolism (1-CM), as folate intake is positively related and total plasma homocysteine (tHcy) negatively related to academic success. Because another 1-CM nutrient, choline is essential for fetal neurocognitive development, we hypothesized that choline and betaine could also be positively related to academic achievement in adolescents. In a sample of 15-yr-old children (n = 324), we measured plasma concentrations of homocysteine, choline, and betaine and genotyped them for 2 polymorphisms with effects on 1-CM, methylenetetrahydrofolate reductase (MTHFR) 677C>T, rs1801133, and phosphatidylethanolamine N-methyltransferase (PEMT), rs12325817 (G>C). The sum of school grades in 17 major subjects was used as an outcome measure for academic achievement. Lifestyle and family socioeconomic status (SES) data were obtained from questionnaires. Plasma choline was significantly and positively associated with academic achievement independent of SES factors (paternal education and income, maternal education and income, smoking, school) and of folate intake (P = 0.009, R-2 = 0.285). With the addition of the PEMT rs12325817 polymorphism, the association value was only marginally changed. Plasma betaine concentration, tHcy, and the MTHFR 677C>T polymorphism did not affect academic achievement in any tested model involving choline. Dietary intake of choline is marginal in many adolescents and may be a public health concern.

Place, publisher, year, edition, pages
Bethesda, USA: Federation of American Societies for Experimental Biology , 2016. Vol. 30, no 4, 1683-1688 p.
Keyword [en]
Betaine, choline, folate, school grades
National Category
Pediatrics Cell and Molecular Biology
Research subject
Biochemistry; Molecular Cellbiology
Identifiers
URN: urn:nbn:se:oru:diva-49650DOI: 10.1096/fj.15-281097ISI: 000372629100028PubMedID: 26728177OAI: oai:DiVA.org:oru-49650DiVA: diva2:919171
Funder
Swedish Heart Lung Foundation
Note

Funding Agencies:

U.S. National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases DK56350

Örebro Lans Landsting, Nyckelfonden, Örebro

Umeå University

Stockholm County Council

Available from: 2016-04-13 Created: 2016-04-05 Last updated: 2016-04-26Bibliographically approved

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