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Multi-component assessment of chronic obstructive pulmonary disease: an evaluation of the ADO and DOSE indices and the global obstructive lung disease categories in international primary care data sets
Clinical Trials and Population Studies, Plymouth University Peninsula Schools of Medicine and Dentistry ITTC Building (N14), Plymouth Science Park, Plymouth, UK.
Centre of Academic Primary Care, University of Aberdeen, Aberdeen, UK.
Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, The Netherlands.
Medical Statistics Team, Applied Health Sciences, University of Aberdeen, Aberdeen, UK.
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2016 (English)In: NPD Bulletin, ISSN 1892-8110, E-ISSN 2055-1010, Vol. 26, 16010Article in journal (Refereed) Published
Abstract [en]

Suitable tools for assessing the severity of chronic obstructive pulmonary disease (COPD) include multi-component indices and the global initiative for chronic obstructive lung disease (GOLD) categories. The aim of this study was to evaluate the dyspnoea, obstruction, smoking, exacerbation (DOSE) and the age, dyspnoea, obstruction (ADO) indices and GOLD categories as measures of current health status and future outcomes in COPD patients. This was an observational cohort study comprising 5,114 primary care COPD patients across three databases from UK, Sweden and Holland. The associations of DOSE and ADO indices with (i) health status using the Clinical COPD Questionnaire (CCQ) and St George's Respiratory Questionnaire (SGRQ) and COPD Assessment test (CAT) and with (ii) current and future exacerbations, admissions and mortality were assessed in GOLD categories and DOSE and ADO indices. DOSE and ADO indices were significant predictors of future exacerbations: incident rate ratio was 1.52 (95% confidence intervals 1.46-1.57) for DOSE, 1.16 (1.12-1.20) for ADO index and 1.50 (1.33-1.68) and 1.23 (1.10-1.39), respectively, for hospitalisations. Negative binomial regression showed that the DOSE index was a better predictor of future admissions than were its component items. The hazard ratios for mortality were generally higher for ADO index groups than for DOSE index groups. The GOLD categories produced widely differing assessments for future exacerbation risk or for hospitalisation depending on the methods used to calculate them. None of the assessment systems were excellent at predicting future risk in COPD; the DOSE index appears better than the ADO index for predicting many outcomes, but not mortality. The GOLD categories predict future risk inconsistently. The DOSE index and the GOLD categories using exacerbation frequency may be used to identify those at high risk for exacerbations and admissions.

Place, publisher, year, edition, pages
London, United Kingdom: Nature Publishing Group, 2016. Vol. 26, 16010
National Category
Respiratory Medicine and Allergy
Research subject
Pulmonary Medicine
Identifiers
URN: urn:nbn:se:oru:diva-49813DOI: 10.1038/npjpcrm.2016.10ISI: 000375122000002PubMedID: 27053297Scopus ID: 2-s2.0-84963620455OAI: oai:DiVA.org:oru-49813DiVA: diva2:919238
Note

Funding Agencies:

International Primary Care Respiratory Group (IPCRG)

Novartis AG, Basel, Switzerland

REG

PICASSO for COPD

Available from: 2016-04-13 Created: 2016-04-12 Last updated: 2016-05-31Bibliographically approved

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