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PCB126 and PFPAs (FS-780) Combined Effect on Zebrafish Embryos
Örebro University, School of Science and Technology, Örebro University, Sweden.
2015 (English)Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
Abstract [en]

Chemicals are present all around us, in our environment, our food and our bodies. Causing most concern are the persistent organic pollutants, the POPs. Both polychlorinated biphenyls (PCBs) and perfluoroalkyl phosphonic acids (PFPAs) are considered to be POPs. PCBs negative effects are well known, e.g. they are embryotoxic. About PFPAs biological fate not much is known, but they seem to be spreading in the environment. In the environment chemicals are present as a mixture with diverse effects, usually referred to as cocktail effect. However chemicals toxicity assessment is usually based on single compound testing. The aim of the present study is to examine the toxicity of PFPAs (FS-780), PCB126 and the binary mixture towards zebrafish (Danio rerio) embryos. Fish Embryo acute Toxicity test (FET) with zebrafish is used, lethal and sub-lethal effects are observed over 96hpf. The results show that PFPAs have an enhancing effect on PCB126. The effects observed was abnormal heartbeat, abnormal blood circulation, edema and deformation of the tail.

Place, publisher, year, edition, pages
2015.
Keyword [en]
Zebrafish, PCB126 PFPA, mixture, toxicology
National Category
Environmental Sciences
Identifiers
URN: urn:nbn:se:oru:diva-45600OAI: oai:DiVA.org:oru-45600DiVA: diva2:921882
Subject / course
Environmental Science
Supervisors
Examiners
Available from: 2016-04-21 Created: 2015-08-19 Last updated: 2016-04-21Bibliographically approved

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