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LACC1 polymorphisms in inflammatory bowel disease and juvenile idiopathic arthritis
Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
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2016 (English)In: Genes and Immunity, ISSN 1466-4879, E-ISSN 1476-5470, Vol. 17, no 4, 261-264 p.Article in journal (Refereed) Published
Abstract [en]

The function of the Laccase domain-containing 1 (LACC1) gene is unknown, but genetic variation at this locus has been reported to consistently affect the risk of Crohn's disease (CD) and leprosy. Recently, a LACC1 missense mutation was found in patients suffering from monogenic forms of CD, but also systemic juvenile idiopathic arthritis. We tested the hypothesis that LACC1 single nucleotide polymorphisms (SNPs), in addition to CD, are associated with juvenile idiopathic arthritis (JIA, non-systemic), and another major form of inflammatory bowel disease, ulcerative colitis (UC). We selected 11 LACC1 tagging SNPs, and tested their effect on disease risk in 3855 Swedish individuals from three case-control cohorts of CD, UC and JIA. We detected false discovery rate corrected significant associations with individual markers in all three cohorts, thereby expanding previous results for CD also to UC and JIA. LACC1's link to several inflammatory diseases suggests a key role in the human immune system and justifies further characterization of its function(s).

Place, publisher, year, edition, pages
Nature Publishing Group, 2016. Vol. 17, no 4, 261-264 p.
National Category
Medical Genetics Immunology in the medical area
Research subject
Genetics; Immunology
Identifiers
URN: urn:nbn:se:oru:diva-49947DOI: 10.1038/gene.2016.17ISI: 000377451500008PubMedID: 27098602Scopus ID: 2-s2.0-84964389702OAI: oai:DiVA.org:oru-49947DiVA: diva2:923343
Funder
Swedish Research Council
Note

Funding Agencies:

Stockholm County regional grant (ALF) 20120637

Juvenile Arthritis Bio Bank Astrid Lindgren's Children Hospital (JABBA)

Berth von Kantzow's foundation

Available from: 2016-04-26 Created: 2016-04-26 Last updated: 2016-07-26Bibliographically approved

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CiteExportLink to record
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