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Are humans exposed to increasing amounts of unidentified organofluorine?
Department of Chemistry, University of Toronto, Toronto ON, Canada.ORCID iD: 0000-0001-6800-5658
Department of Chemistry, University of Toronto, Toronto ON, Canada.
2016 (English)In: Environmental Chemistry, ISSN 1448-2517, E-ISSN 1449-8979, Vol. 13, no 1, p. 102-110Article in journal (Refereed) Published
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Abstract [en]

Samples of human plasma (n=122) from two German cities (collected in 1982-2009, excluding 1994) and whole blood (n=47) from seven Chinese cities (collected in 2004) were analysed for 52 polyfluoroalkyl/perfluoroalkyl substances (PFASs) using LC-MS/MS. Quantifiable PFASs included some newly identified and commercially available chemicals PFPAs, PFPiAs, FTSAs, PAPs and di-SAmPAP, metabolites of fluorotelomer-based products (FTCAs/FTUCAs), PFCAs, PFSAs, FASAs and FOSAAs. The blood samples were also analysed for extractable organofluorine (EOF) using total organofluorine combustion ion chromatography (TOF-CIC). Seven more PFASs (C7 and C10 PFSAs, FOSAA, MeFOSAA, EtFOSAA, C13 PFCA and 8 : 2 FTSA) were detected in the Chinese samples than had been previously reported. For the German samples, PFHpS, FOSA, MeFOSA, EtFOSA, FTSAs (6 : 2, 8 : 2), PFPAs (C6, C8) and PFPiAs (C6/C6, C6/C8, C8/C8) were additional chemicals identified that were not measured in the earlier studies. Those newly identified and commercially available PFASs were either at trace levels (pg mL-1) or not detected. A mass balance of fluorine between quantifiable PFAS and EOF in the Chinese samples indicated quantifiable PFASs accounted for 31-86% of EOF. For the German samples, the quantifiable PFAS accounted for 52-100% and 57-100% of EOF in Münster and Halle samples respectively. After the year 2000, an increasing amount and proportion of unidentified organofluorine were observed in Munster samples. The increasing trend of unidentified organofluorine in plasma samples suggested humans are being exposed to new and unidentified fluorinated products.

Place, publisher, year, edition, pages
CSIRO Publishing, 2016. Vol. 13, no 1, p. 102-110
National Category
Analytical Chemistry Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-49961DOI: 10.1071/EN15041ISI: 000367596000013Scopus ID: 2-s2.0-84953849208OAI: oai:DiVA.org:oru-49961DiVA, id: diva2:924190
Note

Funding Agency:

Canada Foundation for Innovation

Available from: 2016-04-28 Created: 2016-04-28 Last updated: 2018-07-10Bibliographically approved

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Yeung, Leo W. Y.

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