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Adiponectin: An Endothelium-Derived Vasoprotective Factor?
Ctr Clin Pharmacol, Adipokines & Metab Res Grp, University College London (UCL), London, England.
Ctr Cardiovasc Biol & Med, Div Med, University College London (UCL), London, England.
Department of Cardiothoracic and Vascular Surgery, Örebro University Hospital, Örebro, Sweden.
Örebro University, School of Health Sciences. Department of Cardiothoracic and Vascular Surgery, Örebro University Hospital, Örebro, Sweden.ORCID iD: 0000-0001-5585-1783
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2016 (English)In: Current Vascular Pharmacology, ISSN 1570-1611, E-ISSN 1875-6212, Vol. 14, no 2, p. 168-174Article in journal (Refereed) Published
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Text
Abstract [en]

Adipose tissue (AT) is now widely accepted as a key secretary organ, as well as an energy storage depot. It secretes a series of cytokines, hormones and bioactive molecules: adipokines. Adiponectin is an abundant systemic adipokine that uniquely is reduced in obesity and increases on weight loss, is anti-inflammatory, promotes insulin sensitivity and affords cardiometabolic protection. It was considered a true adipokine, in that it is exclusively generated by the adipocytes of the adipose tissue. However, recent evidence points to it being secreted by a range of other organs. This review summarizes the non-adipose sources of adiponectin especially that derived from the endothelium, its vasoprotective role and intracellular signalling pathways. Endothelium derived adiponectin may potentially be a new target for clinical intervention in cardiovascular disease.

Place, publisher, year, edition, pages
Bentham Science Publishers , 2016. Vol. 14, no 2, p. 168-174
Keywords [en]
Adiponectin, coronary artery bypass grafting, endothelium, perivascular adipose tissue
National Category
Pharmacology and Toxicology Cardiac and Cardiovascular Systems
Research subject
Cardiology
Identifiers
URN: urn:nbn:se:oru:diva-50064DOI: 10.2174/1570161114666151202210128ISI: 000373712200006PubMedID: 26638793OAI: oai:DiVA.org:oru-50064DiVA, id: diva2:925434
Available from: 2016-05-02 Created: 2016-05-02 Last updated: 2018-07-10Bibliographically approved

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