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Postoperative inspiratory muscle training in addition to breathing exercises and early mobilization improves oxygenation in high-risk patients after lung cancer surgery: a randomized controlled trial
Örebro University, School of Health Sciences. Department of Physiotherapy and Occupational Therapy, Aalborg University Hospital, Aalborg, Denmark.ORCID iD: 0000-0001-7085-6507
Department of Cardiothoracic Surgery, Aalborg University, Aalborg, Denmark; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
KU Leuven Faculty of Kinesiology and Rehabilitation Sciences, Leuven, Belgium; Respiratory Rehabilitation and Respiratory Division, University Hospital Leuven, Leuven, Belgium.
Faculty of Medicine and Health, Surgery, Örebro University, Örebro, Sweden.
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2016 (English)In: European Journal of Cardio-Thoracic Surgery, ISSN 1010-7940, E-ISSN 1873-734X, Vol. 49, no 5, 1483-1491 p.Article in journal (Refereed) Published
Abstract [en]

Objectives: The aim was to investigate whether 2 weeks of inspiratory muscle training (IMT) could preserve respiratory muscle strength in high-risk patients referred for pulmonary resection on the suspicion of or confirmed lung cancer. Secondarily, we investigated the effect of the intervention on the incidence of postoperative pulmonary complications.

Methods: The study was a single-centre, parallel-group, randomized trial with assessor blinding and intention-to-treat analysis. The intervention group (IG, n = 34) underwent 2 weeks of postoperative IMT twice daily with 2 × 30 breaths on a target intensity of 30% of maximal inspiratory pressure, in addition to standard postoperative physiotherapy. Standard physiotherapy in the control group (CG, n = 34) consisted of breathing exercises, coughing techniques and early mobilization. We measured respiratory muscle strength (maximal inspiratory/expiratory pressure, MIP/MEP), functional performance (6-min walk test), spirometry and peripheral oxygen saturation (SpO2), assessed the day before surgery and again 3-5 days and 2 weeks postoperatively. Postoperative pulmonary complications were evaluated 2 weeks after surgery.

Results: The mean age was 70 ± 8 years and 57.5% were males. Thoracotomy was performed in 48.5% (n = 33) of cases. No effect of the intervention was found regarding MIP, MEP, lung volumes or functional performance at any time point. The overall incidence of pneumonia was 13% (n = 9), with no significant difference between groups [IG 6% (n = 2), CG 21% (n = 7), P = 0.14]. An improved SpO2 was found in the IG on the third and fourth postoperative days (Day 3: IG 93.8 ± 3.4 vs CG 91.9 ± 4.1%, P = 0.058; Day 4: IG 93.5 ± 3.5 vs CG 91 ± 3.9%, P = 0.02). We found no association between surgical procedure (thoracotomy versus thoracoscopy) and respiratory muscle strength, which was recovered in both groups 2 weeks after surgery.

Conclusions: Two weeks of additional postoperative IMT, compared with standard physiotherapy alone, did not preserve respiratory muscle strength but improved oxygenation in high-risk patients after lung cancer surgery. Respiratory muscle strength recovered in both groups 2 weeks after surgery.

CLINICAL TRIALSGOV ID: NCT01793155.

Place, publisher, year, edition, pages
Oxford University Press, 2016. Vol. 49, no 5, 1483-1491 p.
Keyword [en]
Inspiratory muscle training, lung cancer, surgery, pulmonary complications • Postoperative • Physiotherapy
National Category
Cardiac and Cardiovascular Systems Respiratory Medicine and Allergy Surgery
Research subject
Cardiology; Pulmonary Medicine; Surgery
Identifiers
URN: urn:nbn:se:oru:diva-50098DOI: 10.1093/ejcts/ezv359ISI: 000378501300040PubMedID: 26489835Scopus ID: 2-s2.0-84965109623OAI: oai:DiVA.org:oru-50098DiVA: diva2:925765
Note

Funding Agencies:

Danish Cancer Society R72-A4690

Danish Lung Foundation

Danish Physiotherapists Association

Örebro University

Tomrermester Jorgen Holm og Hustru Elise f. Hansens Mindelegat

Aalborg University Hospital

Available from: 2016-05-03 Created: 2016-05-03 Last updated: 2017-10-17Bibliographically approved

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CiteExportLink to record
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