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Brief Report: alterations in cerebral blood flow as assessed by PET/CT in adults with autism spectrum disorder with normal IQ
Department of Nuclear Medicine, Karolinska University, Stockholm, Sweden; Institute of Cognitive Sciences and Technologies, CNR, Rome, Italy.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Department of Nuclear Medicine, Karolinska University, Stockholm, Sweden.
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2012 (English)In: Journal of autism and developmental disorders, ISSN 0162-3257, E-ISSN 1573-3432, Vol. 42, no 2, 313-318 p.Article in journal (Refereed) Published
Abstract [en]

Specific biological markers for autism spectrum disorder (ASD) have not yet been established. Functional studies have shown abnormalities in the anatomo-functional connectivity of the limbic-striatal "social" brain. This study aimed to investigate regional cerebral blood flow (rCBF) at rest. Thirteen patients with ASD of normal intelligence and ten IQ-, sex- and age-matched healthy controls (HC) underwent PET/CT using [1-(11)C]butanol, a perfusion tracer. As compared to HC, ASD showed significant CBF increases in the right parahippocampal, posterior cingulate, primary visual and temporal cortex, putamen, caudatus, substantia nigra and cerebellum. No statistically significant correlation between CBF and IQ was found. The limbic, posterior associative and cerebellar cortices showed increased blood flow in ASD, confirming previous findings about the neurobiology of ASD.

Place, publisher, year, edition, pages
New York, USA: Springer, 2012. Vol. 42, no 2, 313-318 p.
Keyword [en]
High functioning autism, PET/CT, [1- 11C]butanol, Cerebral blood flow
National Category
Medical and Health Sciences Psychiatry Neurology
Identifiers
URN: urn:nbn:se:oru:diva-50152DOI: 10.1007/s10803-011-1240-yISI: 000299526100017PubMedID: 21487836Scopus ID: 2-s2.0-84858862959OAI: oai:DiVA.org:oru-50152DiVA: diva2:925926
Available from: 2016-05-03 Created: 2016-05-03 Last updated: 2017-10-17Bibliographically approved

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CiteExportLink to record
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