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Frequency and typing of Propionibacterium acnes in prostate tissue obtained from men with and without prostate cancer
Örebro University, School of Medical Sciences. Department of Urology, Örebro University Hospital, Örebro, Sweden; A Member of the Transdisciplinary Prostate Cancer Partnership (TopCaP), Örebro, Sweden.
Department of Laboratory Medicine, Clinical Microbiology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA; Channing Division of Network Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, USA; A Member of the Transdisciplinary Prostate Cancer Partnership (TopCaP), Örebro, Sweden.
Örebro University, School of Health Sciences. Department of Laboratory Medicine, Clinical Microbiology.
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2016 (English)In: Infectious Agents and Cancer, ISSN 1750-9378, E-ISSN 1750-9378, Vol. 11, 26Article in journal (Refereed) Published
Abstract [en]

Background: Prostate cancer is the most common cancer among men in Western countries but the exact pathogenic mechanism of the disease is still largely unknown. An infectious etiology and infection-induced inflammation has been suggested to play a role in prostate carcinogenesis and Propionibacterium acnes has been reported as the most prevalent microorganism in prostatic tissue. We investigated the frequency and types of P. acnes isolated from prostate tissue samples from men with prostate cancer and from control patients without the disease.

Methods: We included 100 cases and 50 controls in this study. Cases were men diagnosed with prostate cancer undergoing radical prostatectomy and controls were men undergoing surgery for bladder cancer without any histological findings of prostate cancer. Six biopsies taken from each patient's prostate gland at the time of surgery were used for cultivation and further characterization of P. acnes.

Results: The results revealed that P. acnes was more common in men with prostate carcinoma than in controls, with the bacteria cultured in 60 % of the cases vs. 26 % of the controls (p = 0.001). In multivariable analyses, men with P. acnes had a 4-fold increase in odds of a prostate cancer diagnosis after adjustment for age, calendar year of surgery and smoking status (OR: 4.46; 95 % CI: 1.93-11.26). To further support the biologic plausibility for a P. acnes infection as a contributing factor in prostate cancer development, we subsequently conducted cell-based experiments. P. acnes- isolates were co-cultured with the prostate cell line PNT1A. An increased cell proliferation and cytokine/chemokine secretion in infected cells was observed.

Conclusion: The present study provides further evidence for a role of P. acnes in prostate cancer development.

Place, publisher, year, edition, pages
London, United Kingdom: BioMed Central, 2016. Vol. 11, 26
Keyword [en]
Prostate cancer, propionibacterium acnes, infection, inflammation
National Category
Cancer and Oncology Urology and Nephrology
Research subject
Oncology; Immunology
Identifiers
URN: urn:nbn:se:oru:diva-50868DOI: 10.1186/s13027-016-0074-9ISI: 000377521800001PubMedID: 27284286Scopus ID: 2-s2.0-84975266712OAI: oai:DiVA.org:oru-50868DiVA: diva2:937584
Note

The erratum to this article has been published in Infectious Agents and Cancer 2016 11:36.

Funding Agencies:

Örebro County Council Research Committee

Foundation for Medical Research at Örebro University Hospital, Sweden

Available from: 2016-06-15 Created: 2016-06-15 Last updated: 2017-10-17Bibliographically approved

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