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Associations of urinary 5-methyl-2'-deoxycytidine and 5-hydroxymethyl-2'-deoxycytidine with phthalate exposure and semen quality in 562 Chinese adult men
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
Reproductive Medical Center, Nanjing Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China.
Örebro University, School of Science and Technology. (Man-Technology-Environment Research Centre (MTM))ORCID iD: 0000-0001-6800-5658
Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, PR China.
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2016 (English)In: Environment International, ISSN 0160-4120, E-ISSN 1873-6750, Vol. 94, p. 583-590Article in journal (Refereed) Published
Abstract [en]

5-methyl-2'-deoxycytidine (5mdC) and 5-hydroxymethyl-2'-deoxycytidine (5hmdC), products of DNA methylation and hydroxymethylation processes, have been detected previously in human urine, but their associations with environmental chemicals or healthy outcomes are unclear. The present investigation explored the associations between urinary 5mdC and 5hmdC with phthalate exposure and semen quality. We assessed semen parameters including sperm concentration, motility, and morphology, before measuring urinary 5mdC, 5hmdC and 13 phthalate metabolites among 562 subfertile men from Nanjing, China. Urinary 5mdC and 5hmdC were positively associated with the levels of low molecular weight phthalate metabolites (Low-MWP), high molecular weight phthalate metabolites (High-MWP), and the sum of all phthalate metabolites (ΣPAEs), respectively. Urinary 5mdC was associated with below-reference sperm concentration (odds ratios for increasing quartiles=1.0, 2.2, 3.0, 2.0; p for trend =0.02), sperm motility (1.0, 1.1, 1.9, 1.3; p for trend =0.05), and sperm morphology (1.0, 1.4, 2.3, 1.5; p for trend =0.05). Sperm concentration was associated with the highest quartile of urinary 5hmdC [odds ratio=1.9 (95% CI: 1.1, 3.6)]. Our findings showed significant associations between urinary 5mdC and 5hmdC with phthalate metabolites and semen parameters, which suggested urinary 5mdC and 5hmdC may be promising biomarkers in future epidemiological studies.

Place, publisher, year, edition, pages
Oxford, United Kingdom: Elsevier, 2016. Vol. 94, p. 583-590
Keywords [en]
DNA methylation, hydroxymethylation, 5mdC, 5hmdC, phthalate metabolites, semen quality
National Category
Analytical Chemistry Environmental Sciences
Identifiers
URN: urn:nbn:se:oru:diva-51070DOI: 10.1016/j.envint.2016.06.020ISI: 000382339000065PubMedID: 27346742Scopus ID: 2-s2.0-84977504391OAI: oai:DiVA.org:oru-51070DiVA, id: diva2:943974
Note

Funding Agencies:

National Basic Research Program of China (973) 2013CB945204

Chinese Academy Of Sciences XDB14040202

National Natural Science Foundation of China 21477127

Available from: 2016-06-28 Created: 2016-06-28 Last updated: 2018-09-14Bibliographically approved

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Yeung, Leo W. Y.

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