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Physical and verbal aggressive behavior and COMT genotype: Sensitivity to the environment
Örebro University, School of Law, Psychology and Social Work, Örebro University, Sweden. Department of Psychology, University of Southern California, Los Angeles, California.ORCID iD: 0000-0001-8768-6954
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
Department of Neuroscience, Uppsala University, BMC, Uppsala, Sweden.
Örebro University, School of Law, Psychology and Social Work, Örebro University, Sweden.ORCID iD: 0000-0002-8163-6558
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2016 (English)In: American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, ISSN 1552-4841, E-ISSN 1552-485X, Vol. 171, no 5, 708-718 p.Article in journal (Refereed) Published
Abstract [en]

Catechol-O-methyltransferase (COMT) genotype has been implicated as a vulnerability factor for several psychiatric diseases as well as aggressive behavior, either directly, or in interaction with an adverse environment. The present study aimed at investigating the susceptibility properties of COMT genotype to adverse and favorable environment in relation to physical and verbal aggressive behavior. The COMT Val158Met polymorphism was genotyped in a Swedish population-based cohort including 1,783 individuals, ages 20-24 years (47% males). A significant three-way interaction was found, after correction for multiple testing, between COMT genotype, exposure to violence, and parent-child relationship in association with physical but not verbal aggressive behavior. Homozygous for the Val allele reported lower levels of physical aggressive behavior when they were exposed to violence and at the same time experienced a positive parent-child relationship compared to Met carriers. Thus, susceptibility properties of COMT genotype were observed in relation to physical aggressive behavior supporting the hypothesis that COMT genotypes are modifying the sensitivity to environment that confers either risk or protection for aggressive behavior. As these are novel findings, they warrant further investigation and replication in independent samples.

Place, publisher, year, edition, pages
Hoboken, USA: John Wiley & Sons, 2016. Vol. 171, no 5, 708-718 p.
Keyword [en]
COMT, aggression, physical, verbal, environmental
National Category
Psychiatry Genetics
Research subject
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-51141DOI: 10.1002/ajmg.b.32430ISI: 000382873900010PubMedID: 26888414Scopus ID: 2-s2.0-84973904197OAI: oai:DiVA.org:oru-51141DiVA: diva2:945364
Funder
Swedish National Board of Health and WelfareThe Swedish Brain Foundation, PS2013-0052
Note

Funding Agency:

Swedish Council for Working Life and Social Research FAS: 2011-0627

Available from: 2016-07-01 Created: 2016-07-01 Last updated: 2016-10-24Bibliographically approved

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Tuvblad, CatherineAndershed, HenrikAndershed, Anna-Karin
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CiteExportLink to record
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