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Involvement of Antibiotic Efflux Machinery in Glutathione-Mediated Decreased Ciprofloxacin Activity in Escherichia coli
Molecular Biology Division, Bhabha Atomic Research Centre, Mumbai, India; The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden .
Bio-Organic Division, Bhabha Atomic Research Centre, Mumbai, India.
The Life Science Center, School of Science and Technology, Örebro University, Örebro, Sweden.
Örebro University, School of Science and Technology. The Life Science Center.ORCID iD: 0000-0001-7957-0310
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2016 (English)In: Antimicrobial Agents and Chemotherapy, ISSN 0066-4804, E-ISSN 1098-6596, Vol. 60, no 7, p. 4369-4374Article in journal (Refereed) Published
Abstract [en]

We have analyzed the contribution of different efflux components to glutathione-mediated abrogation of ciprofloxacin's activity in Escherichia coli and the underlying potential mechanism(s) behind this phenomenon. The results indicated that glutathione increased the total active efflux, thereby partially contributing to glutathione-mediated neutralization of ciprofloxacin's antibacterial action in E. coli However, the role of glutathione-mediated increased efflux becomes evident in the absence of a functional TolC-AcrAB efflux pump.

Place, publisher, year, edition, pages
Washington, USA: American Society for Microbiology , 2016. Vol. 60, no 7, p. 4369-4374
National Category
Microbiology Pharmacology and Toxicology
Research subject
Microbiology
Identifiers
URN: urn:nbn:se:oru:diva-51136DOI: 10.1128/AAC.00414-16ISI: 000378094400063PubMedID: 27139480Scopus ID: 2-s2.0-84977123217OAI: oai:DiVA.org:oru-51136DiVA, id: diva2:945503
Funder
Knowledge Foundation
Note

Funding Agency:

Internal departmental funds of the Department of Atomic Energy (DAE), Government of India

Available from: 2016-07-01 Created: 2016-07-01 Last updated: 2018-07-16Bibliographically approved

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Jass, Jana

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