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Nationwide population-based cohort study of psychiatric disorders in individuals with Ehlers-Danlos syndrome or hypermobility syndrome and their siblings
Karolinska Institutet, Department Medical Epidemiology and Biostatistics, Stockholm, Sweden.
Karolinska Institutet, Department Medical Epidemiology and Biostatistics, Stockholm, Sweden.
Karolinska Institutet, Department Medical Epidemiology and Biostatistics, Stockholm, Sweden.
Karolinska Institutet, Department Medical Epidemiology and Biostatistics, Stockholm, Sweden; Karolinska University Hospital, Astrid Lindgren Children's Hospital, Stockholm, Sweden.
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2016 (English)In: BMC Psychiatry, ISSN 1471-244X, E-ISSN 1471-244X, Vol. 16, 207Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

Background: To assess the risk of psychiatric disorders in Ehlers-Danlos syndrome (EDS) and hypermobility syndrome.

Methods: Nationwide population-based matched cohort study. EDS, hypermobility syndrome and psychiatric disorders were identified through Swedish national registries. Individuals with EDS (n = 1,771) were matched with comparison individuals (n = 17,710). Further, siblings to individuals with EDS who did not have an EDS diagnosis themselves were compared with matched comparison siblings. Using conditional logistic regression, risk of autism spectrum disorder (ASD), bipolar disorder, attention deficit hyperactivity disorder (ADHD), depression, attempted suicide, suicide and schizophrenia were estimated. The same analyses were conducted in individuals with hypermobility syndrome (n = 10,019) and their siblings.

Results: EDS was associated with ASD: risk ratio (RR) 7.4, 95 % confidence interval (95 % CI) 5.2-10.7; bipolar disorder: RR 2.7, CI 1.5-4.7; ADHD: RR 5.6, CI 4.2-7.4; depression: RR 3.4, 95 % CI 2.9-4.1; and attempted suicide: RR 2.1, 95 % CI 1.7-2.7, but not with suicide or schizophrenia. EDS siblings were at increased risk of ADHD: RR 2.1, 95 % CI 1.4-3.3; depression: RR 1.5, 95 % CI 1.1-1.8; and suicide attempt: RR 1.8, 95 % CI 1.4-2.3. Similar results were observed for individuals with hypermobility syndrome and their siblings.

Conclusions: Individuals with EDS and hypermobility syndrome are at increased risks of being diagnosed with psychiatric disorders. These risk increases may have a genetic and/or early environmental background as suggested by evidence showing that siblings to patients have elevated risks of certain psychiatric disorders.

Place, publisher, year, edition, pages
London, United Kingdom: BioMed Central, 2016. Vol. 16, 207
Keyword [en]
Cohort study, Ehlers-Danlos syndrome, Hypermobility syndrome, Epidemiology, Psychiatric disorders
National Category
Psychiatry
Research subject
Psychiatry
Identifiers
URN: urn:nbn:se:oru:diva-51459DOI: 10.1186/s12888-016-0922-6ISI: 000379224900003PubMedID: 27377649Scopus ID: 2-s2.0-84976902550OAI: oai:DiVA.org:oru-51459DiVA: diva2:950294
Funder
Swedish Society of MedicineSwedish Research Council
Note

Funding Agencies:

Swedish Celiac Society

Swedish Initiative for Research on Microdata in the Social and Medical Sciences (SIMSAM) framework 340-2013-5867

Available from: 2016-07-29 Created: 2016-07-29 Last updated: 2016-08-03Bibliographically approved

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CiteExportLink to record
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