oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Effects of fifteen PBDE metabolites, DE71, DE79 and TBBPA on steroidogenesis in the H295R cell line
Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong; State Key Laboratory of Organic Geochemistry, Guangzhou Research Center of Mass Spectrometry, Guangzhou Institute of Geochemistry, Guangzhou, China; Graduate School, the Chinese Academy of Sciences, Beijing, China.
Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong.
Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong.
Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong.ORCID iD: 0000-0001-6800-5658
Show others and affiliations
2008 (English)In: Chemosphere, ISSN 0045-6535, E-ISSN 1879-1298, Vol. 71, no 10, 1888-1894 p.Article in journal (Refereed) Published
Resource type
Text
Abstract [en]

Polybrominated diphenyl ethers (PBDEs) and tetrabromobisphenol A (TBBPA) are brominated flame retardants that are produced in large quantities and are commonly used in construction materials, textiles, and as polymers in electronic equipment. Environmental and human levels of PBDEs have been increasing in the past 30 years, but the toxicity of PBDEs is not fully understood. Studies on their effects are relatively limited, and show that PBDEs are neurotoxins and potential endocrine disrupters. Hydroxylated (OH{single bond}) and methoxylated (MeO{single bond}) PBDEs have also been reported in the adipose tissue, blood and milk of wild animals and humans. In the present study, 15 PBDE metabolites, two BDE mixtures (DE71 and DE79), and TBBPA were studied individually to determine their effects on ten steroidogenic genes, aromatase activity, and concentrations of two steroid hormones (testosterone and 17β-estradiol) in the H295R human adrenocortical carcinoma cell line. Exposure to 0.05 μM 2′-OH-BDE-68 significantly induced the expression of CYP11A, CYP11B2, CYP17, CYP21, 3βHSD2, 17βHSD1, and 17βHSD4, and the expression of StAR was induced by 6-OH-BDE-90 at the three exposure concentrations. Exposure to DE71 and DE79 resulted in dose-dependent trend towards induction, but these effects were not significant. Exposure to 0.5 μM 2-OH-BDE-123 and 2-MeO-BDE-123 resulted in significantly greater aromatase activity. However, none of the compounds affected sex hormone production at the concentrations tested. Generally, OH-BDEs had a much stronger ability to affect steroidogenic gene expression than MeO-BDEs.

Place, publisher, year, edition, pages
Elsevier, 2008. Vol. 71, no 10, 1888-1894 p.
Keyword [en]
H295R cells; PBDEs; Steroidogenesis; TBBPA
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-50002DOI: 10.1016/j.chemosphere.2008.01.032ISI: 000256257000013PubMedID: 18313098Scopus ID: 2-s2.0-42249092646OAI: oai:DiVA.org:oru-50002DiVA: diva2:950400
Available from: 2016-07-29 Created: 2016-04-28 Last updated: 2017-10-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Yeung, Leo W. Y.Lam, Paul K. S.
In the same journal
Chemosphere
Environmental Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 156 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf