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Biochemical Responses and Accumulation Properties of Long-Chain Perfluorinated Compounds (PFOS/PFDA/PFOA) in Juvenile Chickens (Gallus gallus)
Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki, Japan; Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong; National Institute of Advanced Industrial Science and Technology, Onogawa 16-1, Tsukuba, Japan.ORCID iD: 0000-0001-6800-5658
Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki, Japan; Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong.
Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki, Japan; Department of Biology and Chemistry, City University of Hong Kong, Kowloon, Hong Kong.
Safety Research Team, National Institute of Animal Health, Kannondai 3-1-5, Tsukuba, Ibaraki, Japan.
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2009 (English)In: Archives of Environmental Contamination and Toxicology, ISSN 0090-4341, E-ISSN 1432-0703, Vol. 57, no 2, 377-386 p.Article in journal (Refereed) Published
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Abstract [en]

One-day-old male chickens were exposed via oral gavage to mixtures of perfluorooctane sulfonate (PFOS), perfluorooctanoate (PFOA), and perfluorodecanoate (PFDA) at either a low dose (0.1 mg/kg body weight [b.w.]) or a high dose (1.0 mg/kg b.w.), or a saline/ethanol vehicle control, three times a week for 3 weeks. After 3 weeks of exposure, half of the chicks were sacrificed and the other half were allowed to depurate for a further 3 weeks. No dose-dependent statistically significant differences in body/organ weights were observed among treatment and control groups after 3 weeks of exposure or after three 3 of depuration. Neither 15 histological nor 14 measured plasma biochemical parameters were significantly different in chicks from the exposed groups and vehicle controls. PFOS, PFDA, and PFOA concentrations in blood/liver/kidney samples were measured throughout the exposure and depuration periods at different time intervals. PFOS and PFDA accumulated at much higher concentrations than PFOA during the experimental periods. Interestingly, PFOS and PFDA accumulation patterns in the blood were similar during the exposure and depuration periods. The half-lives for each PFC at the 0.1 and 1.0 mg/kg doses were, respectively, approximately 15 and 17 days for PFOS, 11 and 16 days for PFDA, and 3.9 and 3.9 days for PFOA. PFDA accumulation in organs was greater than or similar to that of PFOS: the liver was the main target during exposure and the blood was the main reservoir during depuration. These results indicate that exposure to a 1.0-mg mixture of PFOS/PFDA/PFOA/kg b.w. has no adverse effect on juvenile chickens.

Place, publisher, year, edition, pages
Springer, 2009. Vol. 57, no 2, 377-386 p.
National Category
Environmental Sciences
Research subject
Enviromental Science
Identifiers
URN: urn:nbn:se:oru:diva-49986DOI: 10.1007/s00244-008-9278-3ISI: 000267329800019PubMedID: 19130113Scopus ID: 2-s2.0-67651171280OAI: oai:DiVA.org:oru-49986DiVA: diva2:950419
Note

Funding Agencies:

Global Environment Conservation Research Fund

City University of Hong Kong 7002293

Available from: 2016-07-29 Created: 2016-04-28 Last updated: 2016-08-05Bibliographically approved

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