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Part I. A Temporal Study of PFCAs and Their Precursors in Human Plasma from Two German Cities 1982-2009
Department of Chemistry, University of Toronto, Toronto, Canada.ORCID iD: 0000-0001-6800-5658
Department of Chemistry, University of Toronto, Toronto, Canada.
Umweltbundesamt, Dessau-Roßlau, Germany.
Department of Chemistry, University of Toronto, Toronto, Canada.
2013 (English)In: Environmental Science and Technology, ISSN 0013-936X, E-ISSN 1520-5851, Vol. 47, no 8, 3865-3874 p.Article in journal (Refereed) Published
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Abstract [en]

A total of 420 human plasma samples from two cities (Halle and Münster, Germany), collected between 1982 and 2009, were analyzed for a suite of PFCAs (C6−C12) and selected PFCA precursors (4:2-, 4:2/6:2-, 6:2-, 6:2/8:2-, 8:2-, 8:2/10:2-, and 10:2-diPAPs). PFCAs (C7−C11 and C13) were detected in over 80% of the samples (<0.005−39.4 ng/mL), while C12 PFCA was detected in fewer than 10% of the samples. In a range of 10−46% of the samples, 4:2-, 4:2/6:2-, 6:2, and 8:2-diPAPs were identified at concentrations of <0.0002−0.687 ng/mL; fewer than 10% of the samples had detectable 10:2-diPAP. Temporal trends (2000−2009) showed increasing concentrations of PFNA, PFDA, and PFUnDA, whereas PFOA concentrations were decreasing. Calculated population halving time for PFOA varied between 8.2−14.5 years, which contrasts to the generally accepted value of 3.8 years. This suggests an ongoing or additional exposure to PFOA or one of its precursor compounds. DiPAPs, known to metabolize rapidly to PFCAs, were detected in a significant number of samples and at concentrations that have not declined significantly over the past half-decade. The evidence suggests they have contributed to the continued presence of the longer chain PFCAs and perhaps contribute to the slow decline of PFOA.

Place, publisher, year, edition, pages
Washington, USA: American Chemical Society (ACS), 2013. Vol. 47, no 8, 3865-3874 p.
National Category
Environmental Sciences
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URN: urn:nbn:se:oru:diva-49969DOI: 10.1021/es303716kISI: 000317813400042PubMedID: 23484973Scopus ID: 2-s2.0-84876229520OAI: oai:DiVA.org:oru-49969DiVA: diva2:950434
Note

Funding Agency:

Canada Foundation for Innovation 

Available from: 2016-07-29 Created: 2016-04-28 Last updated: 2017-10-17Bibliographically approved

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