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Pineal Gland Volume Assessed by MRI and Its Correlation with 6-Sulfatoxymelatonin Levels among Older Men
Icelandic Cancer Society, Reykjavik, Iceland; Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.
Icelandic Heart Association, Kopavogur, Iceland.
Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland; Icelandic Heart Association, Kopavogur, Iceland.
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2016 (English)In: Journal of Biological Rhythms, ISSN 0748-7304, E-ISSN 1552-4531, Vol. 31, no 5, 461-469 p.Article in journal (Refereed) Published
Abstract [en]

The pineal gland produces the hormone melatonin, and its volume may influence melatonin levels. We describe an innovative method for estimating pineal volume in humans and present the association of pineal parenchyma volume with levels of the primary melatonin metabolite, 6-sulfatoxymelatonin. We selected a random sample of 122 older Icelandic men nested within the AGES-Reykjavik cohort and measured their total pineal volume, their parenchyma volume, and the extent of calcification and cysts. For volume estimations we used manual segmentation of magnetic resonance images in the axial plane with simultaneous side-by-side view of the sagittal and coronal plane. We used multivariable adjusted linear regression models to estimate the association of pineal parenchyma volume and baseline characteristics, including 6-sulfatoxymelatonin levels. We used logistic regression to test for differences in first morning urinary 6-sulfatoxymelatonin levels among men with or without cystic or calcified glands. The pineal glands varied in volume, shape, and composition. Cysts were present in 59% of the glands and calcifications in 21%. The mean total pineal volume measured 207 mm(3) (range 65-536 mm(3)) and parenchyma volume 178 mm(3) (range 65-503 mm(3)). In multivariable-adjusted models, pineal parenchyma volume was positively correlated with 6-sulfatoxymelatonin levels (β = 0.52, p < 0.001). Levels of 6-sulfatoxymelatonin did not differ significantly by presence of cysts or calcification. By using an innovative method for pineal assessment, we found pineal parenchyma volume to be positively correlated with 6-sulfatoxymelatonin levels, in line with other recent studies.

Place, publisher, year, edition, pages
Thousand Oaks, USA: Sage Publications, 2016. Vol. 31, no 5, 461-469 p.
Keyword [en]
MRI, circadian, melatonin, pineal, sleep
National Category
Physiology
Research subject
Physiology
Identifiers
URN: urn:nbn:se:oru:diva-51525DOI: 10.1177/0748730416656948ISI: 000383436700004PubMedID: 27449477Scopus ID: 2-s2.0-84988353102OAI: oai:DiVA.org:oru-51525DiVA: diva2:951039
Note

Funding Agencies:

RANNIS (the Icelandic Research Fund)

National Institutes on Aging Intramural Research Program N01-AG-12100

Hjartavernd (the Icelandic Heart Association)

Althingi (the Icelandic Parliament)

Harvard Catalyst Award

National Cancer Institute at the National Institutes of Health Training Grant NIH T32 CA09001

Prostate Cancer Foundation

Available from: 2016-08-05 Created: 2016-08-02 Last updated: 2017-10-17Bibliographically approved

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