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Associations between the FKBP5 haplotype, exposure to violence and anxiety in females
Department of Neuroscience, Uppsala University, Uppsala, Sweden; Department of Women’s and Children’s Health, Pediatric Neuropsychiatry Unit, Center for Neurodevelopmental Disorders at Karolinska Institutet (KIND),Karolinska Institutet, Stockholm, Sweden.
Department of Neuroscience, Uppsala University, Uppsala, Sweden.
Centre for Clinical Research, Västmanland County Hospital Västerås, Uppsala University, Västerås, Sweden.
Centre for Clinical Research, Västmanland County Hospital Västerås, Uppsala University, Västerås, Sweden.
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2016 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 72, 196-204 p.Article in journal (Refereed) Published
Abstract [en]

The gene that encodes the FK506-binding protein 5 (FKBP5) is regarded as a candidate for investigating how negative life events interact with a genetic predisposition to stress-related disorders, such as depression and anxiety. Given the role of FKBP5 as an important regulator of stress responses, we aimed to investigate if single-nucleotide polymorphisms (SNPs) in FKBP5-in the presence/absence of exposure to violence-are associated with symptoms of depression and anxiety. Data from two community-based samples of adolescents (n=1705) and young adults (n=1800) regarding ratings on depression, anxiety, exposure to violence and FKBP5 genotype were collected. A risk haplogenotype including the minor alleles of seven common SNPs in the FKBP5 (rs3800373, rs9296158, rs7748266, rs1360780, rs9394309, rs9470080 and rs4713916) conferred higher ratings on anxiety among females, but not males, in the presence of violence. Exposure to violence and female sex were associated with higher ratings on both depression and anxiety, with the exception of ratings on depression among young adults, on which sex had no effect. Ratings on depression were not associated with the haplogenotype. These findings may correspond to differences in the regulation of the HPA axis and with the higher vulnerability to anxiety in females.

Place, publisher, year, edition, pages
Oxford, United Kingdom: Elsevier, 2016. Vol. 72, 196-204 p.
Keyword [en]
FKBP5, anxiety, depression, exposure to violence, sex differences
National Category
Psychiatry Neurology
Research subject
Psychiatry; Neurology
Identifiers
URN: urn:nbn:se:oru:diva-51478DOI: 10.1016/j.psyneuen.2016.07.206ISI: 000382594600026PubMedID: 27448712Scopus ID: 2-s2.0-84979255267OAI: oai:DiVA.org:oru-51478DiVA: diva2:951117
Funder
The Swedish Brain FoundationSwedish National Board of Health and Welfare
Note

Funding Agencies:

Uppsala University Hospital Research Fund (ALF)

Uppsala and Örebro Regional Research Council

Fredrik and Ingrid Thurings Foundation

County Council of Västmanland

König-Söderströmska Foundation SLS-559921

Svenska Spel Research Council

Åke Wiberg's Foundation

Swedish Council for Working Life and Social Research 2011-0627  2015-00897

Available from: 2016-08-05 Created: 2016-08-02 Last updated: 2017-10-17Bibliographically approved

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