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Analysis of Novel and Legacy Brominated Flame Retardants Including Their Derivates by Atmospheric Pressure Chemical Ionization Using Gas Chromatography Coupled to Triple Quadrupole Mass Spectrometry
Örebro University, School of Science and Technology, Örebro University, Sweden.ORCID iD: 0000-0002-8553-8824
Örebro University, School of Science and Technology, Örebro University, Sweden. RECETOX Masaryk University, Brno, Czech Republic.ORCID iD: 0000-0003-1733-8334
Örebro University, School of Science and Technology, Örebro University, Sweden.ORCID iD: 0000-0002-6330-789X
(English)Manuscript (preprint) (Other academic)
National Category
Other Chemistry Topics
Research subject
Chemistry
Identifiers
URN: urn:nbn:se:oru:diva-52072OAI: oai:DiVA.org:oru-52072DiVA: diva2:967599
Available from: 2016-09-09 Created: 2016-09-09 Last updated: 2016-09-09Bibliographically approved
In thesis
1. Gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry methods for the determination of environmental contaminants
Open this publication in new window or tab >>Gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry methods for the determination of environmental contaminants
2016 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

The recent developments and improvements of instrumental methods for the analyses of the environmental contaminants, especially the persistent organic pollutants (POPs), have made it possible to detect and quantify these at very low concentrations in environmental and biotic matrices.

The main objective of this thesis is to demonstrate the capability of the atmospheric pressure chemical ionization technique (APCI), using gas chromatography coupled to tandem mass spectrometry for the determination of a wide range of environmental contaminants, including the POPs regulated by Stockholm Convention, such as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), but also the derivates of PBDEs and novel brominated flame retardants (NBFRs).

The APCI was operated in charge transfer condition, preferably producing molecular ions. Multiple reaction monitoring (MRM) experiments were optimized by adjusting cone voltage, collision energy and dwell time. Optimization of source parameters, such as gas flows and temperatures was also performed. Low concentration standards were analyzed, achieving a visible chromatographic peak for 2 fg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) demonstrating the excellent sensitivity of the system. Adequate linearity and repeatability were observed for all the studied compounds. The performance of APCI methods was validated against the conventional methods using gas chromatography coupled to high resolution mass spectrometry for chlorinated compounds in a wide range of matrices including environmental, air, human and food matrices.

The GC-APCI-MS/MS method was successfully applied to a set of 75 human serum samples to study the circulating levels of POPs in epidemiologic studies. Moreover the method was utilized to establish temporal trends of POPs in osprey eggs samples collected during the past five decades.

Place, publisher, year, edition, pages
Örebro: Örebro university, 2016. 83 p.
Series
Örebro Studies in Chemistry, ISSN 1651-4270 ; 17
Keyword
PCDD/Fs, PCBs, OCPs, PBDEs, NBFRs, APCI, MS/MS, HRMS, human serum, osprey egg
National Category
Chemical Sciences Other Chemistry Topics
Research subject
Chemistry
Identifiers
urn:nbn:se:oru:diva-51727 (URN)978-91-7668-157-4 (ISBN)
Public defence
2016-09-30, Örebro universitet, Musikhögskolan, Hörsalen, Fakultetsgatan 1, Örebro, 10:15 (English)
Opponent
Supervisors
Available from: 2016-08-22 Created: 2016-08-22 Last updated: 2016-12-14Bibliographically approved

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