oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Upregulation of nucleoporin 88 is associated with nodal metastasis and poor differentiation in oral squamous cell carcinoma
Örebro University, School of Medical Sciences.
Department of Pathology, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Stomatology, The Third Hospital of Hebei Medical University, Shijiazhuang, China.
Department of Pathology, The First Hospital of Hebei Medical University, Shijiazhuang, China.
Show others and affiliations
2016 (English)In: International Journal of Clinical and Experimental Medicine, ISSN 1940-5901, E-ISSN 1940-5901, Vol. 9, no 5, 8399-8404 p.Article in journal (Refereed) Published
Abstract [en]

Nucleoporin 88 (Nup 88) is a component of the nuclear pore complexes (NPCs) that mediates nucleocytoplasmic trafficking of macromolecules, Nup 88 has been reported to be up-regulated in a wide variety of malignancies. Studies show that overexpression of this antigen is associated with the development, agressiveness, differentiation and prognosis in some tumours. Since no study has been carried out in the relationship between the Nup 88 expression and clinicopathological features in the patients with oral squamous cell carcinoma (OSCC), this study aimed to determine Nup 88 expression in OSCC and its clinicopathological significance. Nup 88 expression was examined by immunohistochemistry in 20 normal oral mucosa specimens and 83 OSCC tissues. The frequency of positive Nup 88 expression was gradually increased from normal oral mucosa (10%) to primary OSCC (40%, P=0.012). The Nup 88 positive rate in OSCC patient with nodal metastasis was significantly higher than those without nodal metastasis (64% vs. 21%, P=0.000085). The frequency of positive Nup 88 expression was significantly different between worse and better differentiation (80 vs. 27%, P=0.000024). Nup 88 expression was not related to the patients' gender, age, location and tumour size (P>0.05). In conclusion, Nup 88 may play an important role in tumorigenesis in oral squamous cell carcinoma. Upregulation of Nup 88 is associated with nodal metastasis and poor differentiation in oral squamous cell carcinoma.

Place, publisher, year, edition, pages
e-Century Publishing , 2016. Vol. 9, no 5, 8399-8404 p.
Keyword [en]
Nup 88, metastasis, differentiation, immunohistochemistry, oral squamous cell carcinoma
National Category
Cancer and Oncology
Identifiers
URN: urn:nbn:se:oru:diva-52159ISI: 000379956500090Scopus ID: 2-s2.0-84971382096OAI: oai:DiVA.org:oru-52159DiVA: diva2:970691
Note

Funding Agency:

Health department of Hebei Province, China 20120098

Available from: 2016-09-14 Created: 2016-09-14 Last updated: 2017-10-17Bibliographically approved

Open Access in DiVA

No full text

Other links

ScopusArticle

Search in DiVA

By author/editor
Zhang, Hong
By organisation
School of Medical Sciences
In the same journal
International Journal of Clinical and Experimental Medicine
Cancer and Oncology

Search outside of DiVA

GoogleGoogle Scholar

Total: 7 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf