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Inhibitory effects of foscarnet on herpesvirus multiplication in cell culture
Department of Antiviral Research, Research and Development Laboratories, Astra Läkemedel AB, Södertälje, Sweden.
Department of Antiviral Research, Research and Development Laboratories, Astra Läkemedel AB, Södertälje, Sweden.
1981 (English)In: Archives of Virology, ISSN 0304-8608, E-ISSN 1432-8798, Vol. 68, no 3-4, p. 203-209Article in journal (Refereed) Published
Abstract [en]

The effect of phosphonoformate (INN; foscarnet sodium) on Herpes Simplex Virus type 1 replication in cell-culture has been studied. At 55 μm, foscarnet reduced the yield by 50 per cent which correlated well with a 50 per cent reduction of plaque formation at 60 μm. Foscarnet had to be added before 8 hours post infection to inhibit virus production. The inhibition of herpesvirus plaque formation by the presence of foscarnet for 24 hours was not reversed by the removal of the drug. The inhibition of virus replication by foscarnet could, in contrast to the inhibition by acycloguanosine, not be reversed by addition of deoxynucleosides.

Place, publisher, year, edition, pages
Vienna, Austria: Springer, 1981. Vol. 68, no 3-4, p. 203-209
National Category
Microbiology in the medical area
Identifiers
URN: urn:nbn:se:oru:diva-52195DOI: 10.1007/BF01314573ISI: A1981LZ07200006PubMedID: 6268019Scopus ID: 2-s2.0-0019826520OAI: oai:DiVA.org:oru-52195DiVA, id: diva2:970946
Available from: 2016-09-15 Created: 2016-09-15 Last updated: 2018-01-10Bibliographically approved

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