Verrucine F, a quinazoline from Penicillium verrucosum
2008 (English)In: Journal of natural products (Print), ISSN 0163-3864, E-ISSN 1520-6025, Vol. 71, no 8, 1455-1457 p.Article in journal (Refereed) Published
Verrucine F (3), a quinazoline similar to verrucines A (1) and B (2), contains one anthranilic acid residue, one L-glutamine residue, and one alpha,beta-unsaturated phenylalanine residue, as determined by NMR, MS, and chemical methods. Compounds I and 3, but not 2, were produced by Penicillium verrucosum J255 and eight additional P. verrucosum strains. Verrucines were typically more concentrated in the inner (older) parts of the colony, and 3 peaked 4-8 days after 1, but at 10-fold lower concentrations (similar to 200 mu g/g). Verrucine F (3) formed spontaneously from 1 in buffered water solutions. probably by oxidation at C-1 followed by water elimination.
Place, publisher, year, edition, pages
Washington, USA: American Chemical Society , 2008. Vol. 71, no 8, 1455-1457 p.
Pharmacology and Toxicology
IdentifiersURN: urn:nbn:se:oru:diva-52283DOI: 10.1021/np800105eISI: 000258637900024PubMedID: 18578540ScopusID: 2-s2.0-51849128236OAI: oai:DiVA.org:oru-52283DiVA: diva2:971406
Foundation for Strategic Environmental Research (MISTRA)2016-09-162016-09-162016-09-16Bibliographically approved