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Verrucine F, a quinazoline from Penicillium verrucosum
Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Department of Microbiology, Swedish University of Agricultural Sciences (SLU), Uppsala, Sweden.
Department of Chemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.
2008 (English)In: Journal of natural products (Print), ISSN 0163-3864, E-ISSN 1520-6025, Vol. 71, no 8, p. 1455-1457Article in journal (Refereed) Published
Abstract [en]

Verrucine F (3), a quinazoline similar to verrucines A (1) and B (2), contains one anthranilic acid residue, one L-glutamine residue, and one alpha,beta-unsaturated phenylalanine residue, as determined by NMR, MS, and chemical methods. Compounds I and 3, but not 2, were produced by Penicillium verrucosum J255 and eight additional P. verrucosum strains. Verrucines were typically more concentrated in the inner (older) parts of the colony, and 3 peaked 4-8 days after 1, but at 10-fold lower concentrations (similar to 200 mu g/g). Verrucine F (3) formed spontaneously from 1 in buffered water solutions. probably by oxidation at C-1 followed by water elimination.

Place, publisher, year, edition, pages
Washington, USA: American Chemical Society , 2008. Vol. 71, no 8, p. 1455-1457
National Category
Pharmacology and Toxicology
Identifiers
URN: urn:nbn:se:oru:diva-52283DOI: 10.1021/np800105eISI: 000258637900024PubMedID: 18578540Scopus ID: 2-s2.0-51849128236OAI: oai:DiVA.org:oru-52283DiVA, id: diva2:971406
Note

Funding Agency:

Foundation for Strategic Environmental Research (MISTRA)

Available from: 2016-09-16 Created: 2016-09-16 Last updated: 2018-01-10Bibliographically approved

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