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Broad and complex antifungal activity among environmental isolates of lactic acid bacteria
Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Department of Microbiology, Swedish University of Agricultural Sciences, Uppsala, Sweden.
Department of Chemistry, Swedish University of Agricultural Sciences, Uppsala, Sweden.
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2003 (English)In: FEMS Microbiology Letters, ISSN 0378-1097, E-ISSN 1574-6968, Vol. 219, no 1, 129-135 p.Article in journal (Refereed) Published
Abstract [en]

More than 1200 isolates of lactic acid bacteria isolated from different environments were screened for antifungal activity in a dual-culture agar plate assay. Approximately 10% of the isolates showed inhibitory activity and 4% showed strong activity against the indicator mould Aspergillus fumigatus. The antifungal spectra for 37 isolates with strong activity and five isolates with low or no activity were determined. Several of the strains showed strong inhibitory activity against the moulds A. fumigatus, Aspergillus nidulans, Penicillium commune and Fusarium sporotrichioides, and also against the yeast Rhodotorula mucilaginosa. Penicillium roqueforti and the yeasts Pichia anomala and Kluyveromyces marxianus were not inhibited. Several isolates showed reduced antifungal activity after storage and handling. The majority of the fungal inhibitory isolates were identified by 16S rDNA sequencing as Lactobacillus coryniformis. Lactobacillus plantarum and Pediococcus pentosaceus were also frequently identified among the active isolates. The degree of fungal inhibition was not only related to production of lactic or acetic acid. In addition, antifungal cyclic dipeptides were identified after HPLC separation and several other active fractions were found suggesting a highly complex nature of the antifungal activity.

Place, publisher, year, edition, pages
Elsevier, 2003. Vol. 219, no 1, 129-135 p.
Keyword [en]
phenyllactic acid, 16S rRNA, antifungal activity, lactic acid bacterium, cyclic dipeptide, Lactobacillus coryniformis
National Category
Microbiology
Identifiers
URN: urn:nbn:se:oru:diva-52357DOI: 10.1016/S0378-1097(02)01207-7ISI: 000181306900020PubMedID: 12594034ScopusID: 2-s2.0-0037436139OAI: oai:DiVA.org:oru-52357DiVA: diva2:972067
Available from: 2016-09-20 Created: 2016-09-19 Last updated: 2016-09-20Bibliographically approved

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