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Fucoidan-Mimetic Glycopolymers as Tools for Studying Molecular and Cellular Responses in Human Blood Platelets
Division of Organic Chemistry, Department of Physics, Biology and Chemistry (IFM), Linköping University, Linköping , Sweden.
Örebro University, School of Medical Sciences. (Cardiovascular Research Centre)
Örebro University, School of Medical Sciences. (Cardiovascular Research Centre)ORCID iD: 0000-0003-2519-203X
Division of Cell Biology, Department of Clinical and Experimental Medicine (IKE), Linköping University, Linköping, Sweden.
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2017 (English)In: Macromolecular Bioscience, ISSN 1616-5187, E-ISSN 1616-5195, Vol. 17, no 2, UNSP 1600257Article in journal (Refereed) Published
Abstract [en]

The marine sulfated polysaccharide fucoidan displays superior ability to induce platelet aggregation compared to other sulfated polysaccharides. As such, it is an attractive tool for studying molecular and cellular responses in activated platelets. The heterogeneous structure, however, poses a problem in such applications. This study describes the synthesis of sulfated α-l-fucoside-pendant poly(methacryl amides) with homogeneous structures. By using both thiol-mediated chain transfer and reversible addition-fragmentation chain transfer polymerization techniques, glycopolymers with different chain lengths are obtained. These glycopolymers show platelet aggregation response and surface changes similar to those of fucoidan, and cause platelet activation through intracellular signaling as shown by extensive protein tyrosine phosphorylation. As the platelet activating properties of the glycopolymers strongly mimic those of fucoidan, this study concludes these fucoidan-mimetic glycopolymers are unique tools for studying molecular and cellular responses in human blood platelets.

Place, publisher, year, edition, pages
Weinheim, Germany: Wiley-VCH Verlagsgesellschaft, 2017. Vol. 17, no 2, UNSP 1600257
Keyword [en]
biological applications of polymers; biomimetic; radical polymerization; reversible addition fragmentation chain transfer; structure-property relations
National Category
Medical Biotechnology (with a focus on Cell Biology (including Stem Cell Biology), Molecular Biology, Microbiology, Biochemistry or Biopharmacy)
Identifiers
URN: urn:nbn:se:oru:diva-52179DOI: 10.1002/mabi.201600257ISI: 000394592600012PubMedID: 27616165ScopusID: 2-s2.0-84987653303OAI: oai:DiVA.org:oru-52179DiVA: diva2:972620
Note

Funding Agency:

AFA Insurance, VR Treatments of the Future grant

Available from: 2016-09-21 Created: 2016-09-14 Last updated: 2017-04-10Bibliographically approved

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Kardeby, CarolineFälker, KnutGrenegård, Magnus
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