oru.sePublikationer
Change search
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Electroactive biomimetic collagen-silver nanowire composite scaffolds
Division of Molecular Physics, Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping, Sweden .
Division of Chemical and Optical Sensor Systems, Department of Physics, Chemistry and Biology (IFM), Linköping University, Linköping, Sweden.
Örebro University, School of Medical Sciences. Cardiovascular Research Centre.
Department of Medical Physics and Biomedical Engineering, University College London, Malet Place Engineering Building, London, UK .
Show others and affiliations
2016 (English)In: Nanoscale, ISSN 2040-3364, E-ISSN 2040-3372, Vol. 8, no 29, 14146-14155 p.Article in journal (Refereed) Published
Abstract [en]

Electroactive biomaterials are widely explored as bioelectrodes and as scaffolds for neural and cardiac regeneration. Most electrodes and conductive scaffolds for tissue regeneration are based on synthetic materials that have limited biocompatibility and often display large discrepancies in mechanical properties with the surrounding tissue causing problems during tissue integration and regeneration. This work shows the development of a biomimetic nanocomposite material prepared from self-assembled collagen fibrils and silver nanowires (AgNW). Despite consisting of mostly type I collagen fibrils, the homogeneously embedded AgNWs provide these materials with a charge storage capacity of about 2.3 mC cm(-2) and a charge injection capacity of 0.3 mC cm(-2), which is on par with bioelectrodes used in the clinic. The mechanical properties of the materials are similar to soft tissues with a dynamic elastic modulus within the lower kPa range. The nanocomposites also support proliferation of embryonic cardiomyocytes while inhibiting the growth of both Gram-negative Escherichia coli and Gram-positive Staphylococcus epidermidis. The developed collagen/AgNW composites thus represent a highly attractive bioelectrode and scaffold material for a wide range of biomedical applications.

Place, publisher, year, edition, pages
Cambridge: Royal Society of Chemistry, 2016. Vol. 8, no 29, 14146-14155 p.
National Category
Chemical Sciences
Identifiers
URN: urn:nbn:se:oru:diva-52701DOI: 10.1039/c6nr02027eISI: 000381815000038PubMedID: 27385421Scopus ID: 2-s2.0-84979626544OAI: oai:DiVA.org:oru-52701DiVA: diva2:999653
Funder
Swedish Foundation for Strategic Research
Note

Funding Agency:

Linköping University

Available from: 2016-09-30 Created: 2016-09-30 Last updated: 2017-10-17Bibliographically approved

Open Access in DiVA

No full text

Other links

Publisher's full textPubMedScopus

Search in DiVA

By author/editor
Khalaf, HazemBengtsson, TorbjornAili, Daniel
By organisation
School of Medical Sciences
In the same journal
Nanoscale
Chemical Sciences

Search outside of DiVA

GoogleGoogle Scholar

Altmetric score

Total: 160 hits
CiteExportLink to record
Permanent link

Direct link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf