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  • 1.
    Abbas, Monika
    Örebro University, School of Health and Medical Sciences.
    Bedömning av variabler vid postocklusiv reaktiv hyperemi (PORH)-test med Laser Doppler Flowmetry teknik2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 2.
    Abdallah Athumani, Ngenya
    Örebro University, School of Health Sciences.
    Characterization of tick-born encephalitis and West Nile virus non-structural 5 protein interactions with host factors involved in immune evasion and cellular apoptosis.2016Independent thesis Advanced level (degree of Master (Two Years)), 20 credits / 30 HE creditsStudent thesis
  • 3.
    Akhras, Michael S.
    et al.
    Stanford Genome Technol Ctr, Stanford Univ, Palo Alto CA, USA.
    Pettersson, Erik
    Stanford Genome Technol Ctr, Stanford Univ, Palo Alto CA, USA.
    Diamond, Lisa
    Stanford Genome Technol Ctr, Stanford Univ, Palo Alto CA, USA.
    Unemo, Magnus
    Örebro University Hospital.
    Okamoto, Jennifer
    Dept Bioengn, Stanford Univ, Stanford CA, USA.; Howard Hughes Med Inst, Stanford Univ, Stanford CA, USA.
    Davis, Ronald W.
    Stanford Genome Technol Ctr, Stanford Univ, Palo Alto CA , USA.
    Pourmand, Nader
    Dept Biomol Engn, University of California, Santa Cruz CA, USA.
    The Sequencing Bead Array (SBA), a Next-Generation Digital Suspension Array2013In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 8, no 10, article id UNSP e76696Article in journal (Refereed)
    Abstract [en]

    Here we describe the novel Sequencing Bead Array (SBA), a complete assay for molecular diagnostics and typing applications. SBA is a digital suspension array using Next-Generation Sequencing (NGS), to replace conventional optical readout platforms. The technology allows for reducing the number of instruments required in a laboratory setting, where the same NGS instrument could be employed from whole-genome and targeted sequencing to SBA broad-range biomarker detection and genotyping. As proof-of-concept, a model assay was designed that could distinguish ten Human Papillomavirus (HPV) genotypes associated with cervical cancer progression. SBA was used to genotype 20 cervical tumor samples and, when compared with amplicon pyrosequencing, was able to detect two additional co-infections due to increased sensitivity. We also introduce in-house software Sphix, enabling easy accessibility and interpretation of results. The technology offers a multi-parallel, rapid, robust, and scalable system that is readily adaptable for a multitude of microarray diagnostic and typing applications, e. g. genetic signatures, single nucleotide polymorphisms (SNPs), structural variations, and immunoassays. SBA has the potential to dramatically change the way we perform probe-based applications, and allow for a smooth transition towards the technology offered by genomic sequencing.

  • 4.
    Al Hwamdeh, Yaseen
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Urinary Stone Diagnosis Non: Contrast Computed Tomography versus Intravenous Urography2015Independent thesis Advanced level (degree of Master (One Year)), 10 credits / 15 HE creditsStudent thesis
  • 5.
    Altun, O.
    et al.
    Division of Clinical Microbiology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.
    Athlin, Simon
    Örebro University, School of Medical Sciences. Department of Infectious Diseases, Örebro University, Örebro, Sweden.
    Almuhayawi, M.
    Division of Clinical Microbiology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden; Department of Microbiology, Faculty of Medicine, King Abdul-Aziz University, Jeddah, Saudi Arabia.
    Strålin, K.
    Department of Infectious Diseases, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.
    Özenci, V.
    Division of Clinical Microbiology, Karolinska University Hospital Huddinge, Karolinska Institutet, Stockholm, Sweden.
    Rapid identification of Streptococcus pneumoniae in blood cultures by using the ImmuLex, Slidex and Wellcogen latex agglutination tests and the BinaxNOW antigen test2016In: European Journal of Clinical Microbiology and Infectious Diseases, ISSN 0934-9723, E-ISSN 1435-4373, Vol. 35, no 4, p. 579-585Article in journal (Refereed)
    Abstract [en]

    Rapid identification of Streptococcus pneumoniae in blood culture (BC) bottles is important for early directed antimicrobial therapy in pneumococcal bacteraemia. We evaluated a new latex agglutination (LA) test on BC bottles, the ImmuLex™ S. pneumoniae Omni (Statens Serum Institut, Denmark), and compared the performance with the Slidex® pneumo-Kit (bioMérieux, France) and the Wellcogen™ S. pneumoniae (Remel, UK) LA tests, as well as the BinaxNOW® S. pneumoniae (Alere, USA) antigen test. The four tests were directly applied on 358 positive BC bottles with Gram-positive cocci in pairs or chains and on 15 negative bottles. Valid test results were recorded in all cases for ImmuLex and BinaxNOW and in 88.5 % (330/373) and 94.1 % (351/373) of cases for Slidex and Wellcogen, respectively. Based on bottles positive for S. pneumoniae by conventional methods, the sensitivity of ImmuLex was 99.6 %, similar to the other tests (range, 99.6-100 %). Based on bottles positive for non-pneumococcal pathogens, the specificity of ImmuLex was 82.6 %, in comparison to 97.6 % for Slidex (p < 0.01) and 85.4 % for Wellcogen (p = ns). The BinaxNOW test had a lower specificity (64.1 %) than any LA test (p < 0.01). On BC bottles positive for α-haemolytic streptococci, ImmuLex was positive in 12/67 (17.9 %) cases, Slidex in 2/59 (3.4 %) cases, Wellcogen in 11/64 (17.2 %) cases and BinaxNOW in 25/67 (37.3 %) cases. In conclusion, the ImmuLex test provides a valid and sensitive technique for the rapid detection of S. pneumoniae in BC bottles, similar to the other compared methods. However, the specificity was sub-optimal, since the test may cross-react with other Gram-positive bacteria.

  • 6.
    Alwandawy, Heba
    Örebro University, School of Health Sciences.
    Evaluation of Direct-on-Target Microdroplet Growth Assay as a tool for rapid antibiotic susceptibility testing using MALDI- TOF MS2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 7.
    Andersson, Anna-Maria
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Interaction between the periodontal pathogen Porphyromonas gingivalis and human fibroblasts - effects on cell viability and cytokine production2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
    Abstract [en]

    The oral bacterium Porphyromonas gingivalis is one of the key-pathogens causing the inflammatory disease periodontitis, as well as being associated with the progression of atherosclerosis. The bacterium has different virulence factors that induce an inflammation, including production of cytokines and chemokines, which has a role in both diseases. The proteases, called gingipains, are one important group of virulence factors that for example degrade host proteins, causing tissue damage. The aim of this study is to investigate whether viable P. gingivalis affects fibroblasts’ viability and modulate the associated immuno-regulatory mechanisms. The fibroblasts were therefore stimulated with the bacteria and the viability and interleukin (IL)-8 production were measured. The morphology was also studied using microscopy. We found that P. gingivalis adheres to fibroblasts, which survives and proliferate even at high concentrations of bacteria over time. In addition viable bacteria induce a production of IL-8, however the chemokine is probably degraded by the gingipains at high concentrations of bacteria. In conclusion, P. gingivalis adheres to fibroblasts, stimulate fibroblast proliferation, and trigger the release of IL-8, which is then decreased, possibly due to the catalytic activity of the gingipains.  

  • 8.
    Andersson, Carina
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Utvärdering av Hepatit C Virus RNA Test med automatiserad provberedning2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 9.
    Andersson, Christoffer R.
    et al.
    Department of Neurology, Örebro University Hospital, Örebro, Sweden.
    Bergquist, Jonas
    Department of Chemistry (BMC), Analytical Chemistry and Neurochemistry, Uppsala University, Uppsala, Sweden.
    Theodorsson, Elvar
    Departments of Clinical Chemistry and Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Ström, Jakob O.
    Örebro University, School of Medical Sciences. Department of Neurology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Clinical Chemistry and Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Comparisons between commercial salivary testosterone enzyme-linked immunosorbent assay kits2017In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 77, no 8, p. 582-586Article in journal (Refereed)
    Abstract [en]

    INTRODUCTION: Measuring testosterone concentrations is of interest both in clinical situations and for research, the latter expanding rapidly during recent years. An increased demand for convenient methods has prompted a number of companies to develop enzyme-linked immunosorbent assay (ELISA) kits to measure testosterone concentrations in saliva. However, the inter-comparability of kits from different manufacturers have yet to be determined.

    AIM OF STUDY: The aim of this study was to compare commercially available ELISA kits from four different manufacturers (Salimetrics, IBL, DRG and Demeditec).

    METHODS: Saliva was collected from 50 participants (25 men and 25 women). Each sample was analysed by the four ELISA kits.

    RESULTS: The correlations between the ELISA kits from Demeditec, DRG and Salimetrics were moderate to high with r-values > .77; however, proportional errors between the methods calls for caution. The ELISA kit from IBL malfunctioned and no results from this kit was obtained.

    CONCLUSIONS: Results from studies using the ELISA kits from Demeditec, DRG and Salimetrics are generally comparable; however, translation using the formulae presented in the current study could increase the accuracy of these comparisons.

  • 10.
    Andersson, Elin
    Örebro University, School of Health Sciences.
    PREANALYTISK HÅLLBARHETSSTUDIE: IN VITRO BILDNING AV FOSFATIDYLETANOL IBLODET2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 11.
    Andersson, Linda
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Simultaneous detection of multiple Betalactamases with MALDI-TOF2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 12.
    Antila, Kari
    et al.
    VTT Technical Research Centre of Finland, Tampere, Finland.
    Lötjönen, Jyrki
    VTT Technical Research Centre of Finland, Tampere, Finland.
    Thurfjell, Lennart
    GE Healthcare, Stockholm, Sweden.
    Laine, Jarmo
    Nexstim Ltd, Helsinki, Finland.
    Massimini, Marcello
    University of Milan, Milan, Italy.
    Rueckert, Daniel
    Imperial College London, London, United Kingdom.
    Zubarev, Roman A.
    Karolinska Institutet, Stockholm, Sweden.
    Oresic, Matej
    Örebro University, School of Medical Sciences. VTT Technical Research Centre of Finland, Tampere, Finland.
    van Gils, Mark
    VTT Technical Research Centre of Finland, Tampere, Finland.
    Mattila, Jussi
    VTT Technical Research Centre of Finland, Tampere, Finland.
    Hviid Simonsen, Anja
    Rigshospitalet, Copenhagen, Denmark.
    Waldemar, Gunhild
    Rigshospitalet, Copenhagen, Denmark.
    Soininen, Hilkka
    University of Eastern Finland, Kuopio, Finland.
    The PredictAD project: development of novel biomarkers and analysis software for early diagnosis of the Alzheimer's disease2013In: Interface Focus, ISSN 2042-8898, E-ISSN 2042-8901, Vol. 3, no 2, article id 20120072Article in journal (Refereed)
    Abstract [en]

    Alzheimer's disease (AD) is the most common cause of dementia affecting 36 million people worldwide. As the demographic transition in the developed countries progresses towards older population, the worsening ratio of workers per retirees and the growing number of patients with age-related illnesses such as AD will challenge the current healthcare systems and national economies. For these reasons AD has been identified as a health priority, and various methods for diagnosis and many candidates for therapies are under intense research. Even though there is currently no cure for AD, its effects can be managed. Today the significance of early and precise diagnosis of AD is emphasized in order to minimize its irreversible effects on the nervous system. When new drugs and therapies enter the market it is also vital to effectively identify the right candidates to benefit from these. The main objective of the PredictAD project was to find and integrate efficient biomarkers from heterogeneous patient data to make early diagnosis and to monitor the progress of AD in a more efficient, reliable and objective manner. The project focused on discovering biomarkers from biomolecular data, electrophysiological measurements of the brain and structural, functional and molecular brain images. We also designed and built a statistical model and a framework for exploiting these biomarkers with other available patient history and background data. We were able to discover several potential novel biomarker candidates and implement the framework in software. The results are currently used in several research projects, licensed to commercial use and being tested for clinical use in several trials.

  • 13.
    Aronsson, Ulrika
    Örebro University, School of Health Sciences.
    Metodutvärdering och mervärde av Treponema pallidum IgM analys vid diagnostik av syfilis2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 14.
    Asaei, Ava
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Effekten av interleukin-6, interleukin-17 och kombinationen av dessa på inflammatoriskt svar i humana endotelceller2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 15.
    Awdalla, Mohamed
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Homology Models of Human Retinoic Acid Hydroxylase CYP26A1 and CYP26B1: Molecular Dynamics Refinement and Evaluation of Statins Docking2012Independent thesis Advanced level (degree of Master (Two Years)), 30 credits / 45 HE creditsStudent thesis
  • 16.
    Azrakhshi, Shler
    Örebro University, School of Health Sciences.
    Jämförelse mellan ACUSON SC2000 och General Electric Vivid E9 med pulsad vävnadsdoppler2016Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 17.
    Blaad, Emilia
    Örebro University, School of Health Sciences.
    Tolkning av neurografisvar vid frågeställningen karpaltunnelsyndrom – en jämförelse mellan erfaren och oerfaren tolkare2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 18.
    Boerman, Susanna
    Örebro University, School of Health Sciences.
    Histokemisk och immunhistokemisk detektion av brosktillväxt i en tre-dimensionell odling av hyalint brosk2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 19.
    Bohman, Malin
    Örebro University, School of Health Sciences.
    Kvantitativ analys av DNA-metylering i biomarkörgener för cervixcancer2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 20.
    Boman, Michaela
    Örebro University, School of Health Sciences.
    En jämförelsestudie av två andningstekniker vid dynamisk spirometri2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 21.
    Breimer, Lars H.
    et al.
    Fac Med & Hlth, Dept Lab Med, Örebro University Hospital, Örebro, Sweden.
    Nilsson, Torbjorn K.
    Dept Med Biosci, Clin Chem, Umeå Univ, Umeå, Sweden.
    Is Ferrotoxicity a New Great Public Health Challenge?2015In: Clinical Chemistry, ISSN 0009-9147, E-ISSN 1530-8561, Vol. 61, no 4, p. 667-668Article in journal (Refereed)
  • 22.
    Breimer, Lars H.
    et al.
    Departments of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden.
    Nilsson, Torbjörn K.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Clinical Medicine, Biomedicine, Örebro University, Örebro, Sweden; Departments of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden.
    Has folate a role in the developing nervous system after birth and not just during embryogenesis and gestation?2012In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 72, no 3, p. 185-191Article, review/survey (Refereed)
    Abstract [en]

    It is now 30 years since the first publications stating that supplementation with folate could prevent neural tube defects appeared and 20 years since the definitive data, including prevention of other birth defects. Since then epidemiological studies and animal experiments have identified folate as a molecule at the crossroads of neural development. Fortification of food has greatly reduced the incidence of spina bifida. Much interest has focussed on long-term sequelae in children born to mothers severely deprived of folate (and other nutrients) such as during the Dutch Hunger Winter of 1944 and in poor parts of the world. In addition, deficiency in folate and B12 are increasingly discussed as a possible contributing factor in dementia and congenital orofacial and heart malformations. The year 2011 saw the publication of a study that implicated low folate intake in poorer school performance of adolescents as judged by school marks. This has enormous social implications but needs confirmation from other settings. This review assesses the current state of evidence and sets the data in context of whether folate has a role in the development and plasticity of the nervous system even after birth, with particular emphasis on childhood and adolescence.

  • 23.
    Brolin, Malin
    Örebro University, School of Health Sciences.
    Detektion av antikroppar mot Francisella tularensis i serum med chemiluminescence och immunokromatografiskt snabbtest2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 24.
    Burla, Bo
    et al.
    Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore.
    Arita, Makoto
    Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan; Division of Physiological Chemistry and Metabolism, Keio University Faculty of Pharmacy, Tokyo, Japan.
    Arita, Masanori
    National Institute of Genetics, Shizuoka, Japan and RIKEN Center for Sustainable Resource Science, Yokohama, Japan.
    Bendt, Anne K.
    Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore.
    Cazenave-Gassiot, Amaury
    Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore.
    Dennis, Edward A.
    Departments of Pharmacology and Chemistry and Biochemistry, School of Medicine, University of California at San Diego, La Jolla, CA, USA.
    Ekroos, Kim
    Lipidomics Consulting Ltd., Esbo, Finland.
    Han, Xianlin
    Barshop Institute for Longevity and Aging Studies and Department of Medicine-Diabetes, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
    Ikeda, Kazutaka
    Laboratory for Metabolomics, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan; Cellular and Molecular Epigenetics Laboratory, Graduate School of Medical Life Science, Yokohama City University, Yokohama, Japan.
    Liebisch, Gerhard
    Institute of Clinical Chemistry and Laboratory Medicine, University of Regensburg, Regensburg, Germany.
    Lin, Michelle K.
    Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore.
    Loh, Tze Ping
    Department of Laboratory Medicine, National University Hospital, Singapore.
    Meikle, Peter J.
    Baker Heart and Diabetes Institute, Melbourne, Victoria, Australia.
    Orešič, Matej
    Örebro University, School of Medical Sciences. Turku Centre for Biotechnology, University of Turku, Turku, Finland; Åbo Akademi University, Turku, Finland.
    Quehenberger, Oswald
    Departments of Pharmacology and Medicine, School of Medicine, University of California at San Diego, La Jolla, CA, USA.
    Shevchenko, Andrej
    Max Planck Institute of Molecular Cell Biology and Genetics, Dresden, Germany.
    Torta, Federico
    Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore.
    Wakelam, Michael J. O.
    Babraham Institute, Cambridge, United Kingdom.
    Wheelock, Craig E.
    Division of Physiological Chemistry 2, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden.
    Wenk, Markus R.
    Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore; Department of Biochemistry, YLL School of Medicine, National University of Singapore, Singapore.
    MS-based lipidomics of human blood plasma: a community-initiated position paper to develop accepted guidelines2018In: Journal of Lipid Research, ISSN 0022-2275, E-ISSN 1539-7262, Vol. 59, no 10, p. 2001-2017Article in journal (Refereed)
    Abstract [en]

    Human blood is a self-regenerating lipid-rich biological fluid that is routinely collected in hospital settings. The inventory of lipid molecules found in blood plasma (plasma lipidome) offers insights into individual metabolism and physiology in health and disease. Disturbances in the plasma lipidome also occur in conditions that are not directly linked to lipid metabolism; therefore, plasma lipidomics based on MS is an emerging tool in an array of clinical diagnostics and disease management. However, challenges exist in the translation of such lipidomic data to clinical applications. These relate to the reproducibility, accuracy, and precision of lipid quantitation, study design, sample handling, and data sharing. This position paper emerged from a workshop that initiated a community-led process to elaborate and define a set of generally accepted guidelines for quantitative MS-based lipidomics of blood plasma or serum, with harmonization of data acquired on different instrumentation platforms across independent laboratories as an ultimate goal. We hope that other fields may benefit from and follow such a precedent.

  • 25.
    Byström, Klara
    Örebro University, School of Health Sciences.
    Uttryck av virus-lika partiklar specifika för Yellow fever virus, Tick-born encephalitis och Langat virus i cellkultur2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 26.
    Bäcklund, Madeleine
    Örebro University, School of Health and Medical Sciences.
    Molekylärgenetisk typning av Propionibacterium acnes isolerade från prostata, perineum och panna hos patienter med prostatacancer2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 27.
    Bülow, Katrin
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Jämförelse av selektivitet för Clostridium difficile mellan två olika odlingsmedier2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 28.
    Carlsson, Lars
    Örebro University, Department of Clinical Medicine.
    Impedanskardiografi med Physio flow kontra ”Fick´s direkt” för beräkning av hjärtminutvolym på elitskidåkare under stakning.2007Independent thesis Basic level (professional degree), 10 credits / 15 HE creditsStudent thesis
    Abstract [sv]

    Trots tidigare oenighet bland forskare är den allmänna uppfattningen idag att det är hjärtminutvolymen (HMV) som är den enskilt största begränsande faktorn för maximalt syreupptag under arbete. Fortfarande råder dock osäkerhet bland arbetsfysiologer huruvida slagvolymen (SV) planar ut, minskar eller stiger vid maximalt arbete. En av de största utmaningarna inom arbetsfysiologin är utvecklandet av en tillförlitlig, billig och enkel non-invasiv utrustning i syfte att kunna mäta dessa parametrar. Detta har lett fram till metoden impedanskardiografi som baseras på motståndet av elektriska signaler som skickas genom thorax. Tidigare studier har visat på hög validitet mellan den impedanskardiografiska utrustningen Physio flowTM och den invasiva metoden ”Fick´s direkt” i vila och under cykelarbete på otränade. I detta arbete har ett första försök på elitskidåkare (n = 6) gjorts i syfte att jämföra metoderna under stakning, dessutom jämfördes resultaten av slagvolymen från impedansutrustningen mellan submaximalt och maximalt arbete. Resultatet visade att inte heller denna studie med säkerhet kunde skilja metoderna åt, vare sig under submaximalt arbete (p = 0,43) eller vid maximalt arbete (p = 0,17). Det ska dock poängteras att Fick´s beräkningsmetod modifierats i syfte att undvika katetrar genom hjärtat under maximal stakning, vilket kan ha påverkat resultatet. En intressant observation gällande SV gjordes mellan submaximal och maximal stakning. Här noterades en ökning från 150,1 till 175,5 ml (p = 0,01) vilket motsäger Åstrands klassiska ”platåteori” från 1964.

  • 29.
    Chaillou, Thomas
    et al.
    Karolinska Institutet, Stockholm, Sweden.
    Cheng, Arthur J.
    Karolinska Institutet, Stockholm, Sweden.
    Integrative biology is needed to understand exercise adaptions from the whole body to the cellular level2016In: Journal of applied physiology, ISSN 8750-7587, E-ISSN 1522-1601, Vol. 121, no 2, p. 598-599Article in journal (Refereed)
  • 30.
    Dammström, Magdalena
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Användning av Small interfering RNA med syftet att minska uttrycket av insulin like growth factor-1 receptor hos melanomceller2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 31.
    Diab, Zeina
    Örebro University, School of Health and Medical Sciences.
    Referensvärdesbestämning av fraktionerad sensorisk nervus medianusmätning över karpaltunneln2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 32.
    Dobos, Rebecca
    Örebro University, School of Health Sciences.
    Extremitetelektrodernas inverkan på QRS-amplituden och den elektriska axeln i ett elektrokardiogram2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 33.
    Donà, Valentina
    et al.
    Institute for Infectious Diseases, University of Bern, Bern, Switzerland.
    Low, Nicola
    Institute of Social and Preventive Medicine, University of Bern, Bern, Switzerland.
    Golparian, Daniel
    Örebro University, School of Medical Sciences. WHO Collaborating Centre for Gonorrhoea, Örebro University Hospital, Örebro, Sweden.
    Unemo, Magnus
    WHO Collaborating Centre for Gonorrhoea, Örebro University Hospital, Örebro, Sweden.
    Recent advances in the development and use of molecular tests to predict antimicrobial resistance in Neisseria gonorrhoeae2017In: Expert Review of Molecular Diagnostics, ISSN 1473-7159, E-ISSN 1744-8352, Vol. 17, no 9, p. 845-859Article in journal (Refereed)
    Abstract [en]

    Introduction: The number of genetic tests, mostly real-time PCRs, to detect antimicrobial resistance (AMR) determinants and predict AMR in Neisseria gonorrhoeae is increasing. Several of these assays are promising, but there are important shortcomings and few assays have been adequately validated and quality assured.

    Areas covered: Recent advances, focusing on publications since 2012, in the development and use of molecular tests to predict gonococcal AMR for surveillance and for clinical use, advantages and disadvantages of these tests and of molecular AMR prediction compared with phenotypic AMR testing, and future perspectives for effective use of molecular AMR tests for different purposes.

    Expert commentary: Several challenges for direct testing of clinical, especially extra-genital, specimens remain. The choice of molecular assay needs to consider the assay target, quality controls, sample types, limitations intrinsic to molecular technologies, and specific to the chosen methodology, and the intended use of the test. Improved molecular- and particularly genome-sequencing-based methods will supplement AMR testing for surveillance purposes, and translate into point-of-care tests that will lead to personalized treatments, while sparing the last available empiric treatment option (ceftriaxone). However, genetic AMR prediction will never completely replace phenotypic AMR testing, which detects also AMR due to unknown AMR determinants.

  • 34.
    Dulaimi, Omar Ali Hussein
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Ingen association mellan polymorfismen rs7169289 i genen för retinalaldehydrogenas ALDH1A2 och hjärtinfarkt2012Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 35.
    El Chami El Bayrakdar, Abir
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Polymorfismen rs1130864 i genen för C-reaktivt protein(CRP) och dess betydelse för CRP-expressionen2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 36.
    Eldaoi, Zainab
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Diagnostik samt visualisering av Chlamydia som orsak till luftvägssjukdom2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 37.
    Evehäll, Martin
    Örebro University, School of Health Sciences.
    Parathyreoideascintigrafi och parathyreoideaektomi: En jämförelse av resultat vid Centralsjukhuset i Karlstad2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 38.
    Ezelius, Erika
    Örebro University, School of Health and Medical Sciences.
    Cysteinproteaser från den parodontala patogenen Porphyromonas gingivalis höjer cytostoliskt kalcium i trobocyter2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 39.
    Forsberg, Magdalena
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Absolut kvantifiering av DNA från Streptococcus pneumoniae och Escherichia coli i blodprover från sepsispatienter med hjälp av Droplet Digital PCR-teknik2015Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 40.
    Fredriksson, Daniel
    Örebro University, School of Health Sciences.
    Bakteriocinen gallidermin förstärker den bakteriostatiska och den bakteriocidala effekten hos vankomycin och gentamicin mot meticillinkänsliga Staphylococcus aureus. 2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 41.
    Friberg, Sara
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Detektion av IVS1-5 bp deletion i α2-genen vid alfa-thalassemi med sekvensering2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 42.
    Gao, Li
    et al.
    Örebro University, School of Science and Technology.
    Tu, Yaoquan
    Örebro University, School of Science and Technology.
    Wegman [Palmebäck-Wegman], Pia
    Örebro University, School of Health and Medical Sciences.
    Wingren, Sten
    Örebro University, School of Health and Medical Sciences.
    Eriksson, Leif A.
    A mechanistic hypothesis for the cytochrome P450-catalyzed cis-trans isomerization of 4-hydroxytamoxifen: an unusual redox reaction2011In: Journal of Chemical Information and Modeling, ISSN 1549-9596, E-ISSN 1549-960X, Vol. 51, no 9, p. 2293-2301Article in journal (Refereed)
    Abstract [en]

    We provide a detailed description of the cis-trans isomerization of 4-hydroxytamoxifen/endoxifen catalyzed by several isoforms from the cytochrome P450 (CYP) superfamily, including CYP1B1, CYP2B6, and CYP2C19. We show that the reactions mainly involve redox processes catalyzed by CYP, DFT calculation results strongly suggest that the isomerization occurs via a cationic intermediate. The cationic cis-isomer is more than 3 kcal/mol more stable than the trans form, resulting in an easier conversion from trans-to-cis than cis-to-trans. The cis-trans isomerization is a rarely reported CYP reaction and is ascribed to the lack of a second abstractable proton on the ethenyl group of the triarylvinyl class of substrates. The cationic intermediates thus formed instead of the stable dehydrogenation products allow for isomerization to occur. As a comparison, the reactions for the tamoxifen derivatives are compared to those of other substrates, 4-hydroxyacetanilide and raloxifene, for which the stable dehydrogenation products are formed.

  • 43.
    Garp, Sandra
    Örebro University, School of Health Sciences.
    Detektion av antibiotikaresistenta E.coli i fecalfloran hos patienter som genomgår prostatabiopsi – aspekter på screening2017Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 44.
    Gebremariam, Natsinet
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Detecting P53 mutation in paraffin embedded tissue from bone marrow samples in MDS del (5q) patients by Pyrosequencin2013Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 45.
    Ghandehari, Hadi
    Örebro University, School of Health and Medical Sciences.
    Förändringar i tarmfloran i en musmodell för kolit: Fokus på Clostridium leptum group och Bifidobacterium spp i olika delar av tarmkanalen samt i avföring2011Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 46.
    Gillberg, Johannes
    Örebro University, School of Health Sciences.
    Utökad screening för Lynch Syndrom vid kolorektal cancer – en förstudie2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 47.
    Gjerdås, Madelen
    Örebro University, School of Health Sciences.
    Frequency of haemolysis and the possibility of changing the HI cut-off for potassium at USÖ2019Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 48.
    Grönqvist, Ina
    Örebro University, School of Health Sciences.
    Validering av ett automatiserat system för multiplex detektion av luftvägspatogener som orsakar samhällsförvärvad pneumoni2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 49.
    Grönqvist, Ina
    Örebro University, School of Health Sciences.
    Validering av ett automatiserat system för multiplex detektion av luftvägspatogener som orsakar samhällsförvärvad pneumoni2018Independent thesis Basic level (degree of Bachelor), 10 credits / 15 HE creditsStudent thesis
  • 50.
    Göranzon, C.
    et al.
    Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Kumawat, Ashok Kumar
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Hultgren-Hörnqvist, Elisabeth
    Örebro University, School of Medicine, Örebro University, Sweden.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden.
    Eriksson, S.
    Department of Pathology, Örebro University Hospital, Örebro, Sweden.
    Bohr, Johan
    School of Health and Medical Sciences, Örebro University, Örebro, Sweden; Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Region Örebro County, Örebro, Sweden.
    Nyhlin, Nils
    Örebro University Hospital. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Immunohistochemical characterization of lymphocytes in microscopic colitis2013In: Journal of Crohn's and Colitis, ISSN 1197-4982, Vol. 7, no 10, p. e434-e442Article in journal (Refereed)
    Abstract [en]

    Background and Aims: Microscopic colitis (MC), encompassing the subgroups collagenous colitis (CC) and lymphocytic colitis (LC), is characterized by macroscopically normal or near-normal colonic mucosa, and an increased number of intraepithelial lymphocytes (IELs) and mononuclear cell infiltration in the underlying lamina propria (LP), in addition to an increased collagen layer in CC. This study aimed to characterize the inflammatory cells involved in mucosal inflammation, using immunohistochemistry.

    Methods Paraffin-embedded biopsies from 23 untreated patients with MC (CC = 13, LC = 10) and 17 controls were stained with antibodies against CD3, CD4, CD8, CD20, CD30, Foxp3, CD45RO and Ki67. Computerized image analysis was used to calculate areas of stained lymphocytes in the surface and crypt epithelia as well as in the LP.

    Results In CC and LC, an increase of predominantly CD8+ lymphocytes was seen in both the epithelium and the lamina propria, whereas a decreased amount of CD4+ lymphocytes was found in the lamina propria. CD45RO+ and Foxp3+ cells were more abundant in all areas in both patient groups compared to controls, as were CD20+ areas, although more scarce. Ki67+ areas were only more abundant in the epithelium, whereas CD30+ areas were more abundant in the lamina propria of both patient groups compared to controls.

    Conclusions This study confirms an increased amount of CD8+ lymphocytes in the epithelium. Lymphocytic proliferation and activation markers were more abundant, whereas a decreased amount of CD4+ lymphocytes was seen in the LP. Further studies are needed to reveal the underlying mechanism(s).

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