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  • 1.
    Günther, Juliane
    et al.
    Research Institute for the Biology of Farm Animals (FBN), Molecular Biology Research Unit, Dummerstorf, Germany.
    Koczan, Dirk
    Institute for Immunology, Steinbeis Transfercenter for Proteome Analysis, Core Facility for Transcriptome Analysis, Rostock, Germany.
    Yang, Wei
    Research Institute for the Biology of Farm Animals (FBN), Molecular Biology Research Unit, Dummerstorf, Germany; Department of Anesthesiology, Duke University Medical Center, Durham, United States .
    Nürnberg, Gerd
    Research Institute for the Biology of Farm Animals (FBN), Molecular Biology Research Unit, Dummerstorf, Germany.
    Repsilber, Dirk
    Research Institute for the Biology of Farm Animals (FBN), Molecular Biology Research Unit, Dummerstorf, Germany.
    Schuberth, Hans-Joachim
    University of Veterinary Medicine, Immunology Unit, Hannover, Germany.
    Park, Zaneta
    AgResearch, Palmerston North, New Zealand.
    Maqbool, Nauman
    AgResearch, Ruakura Research Centre in Hamilton, New Zealand.
    Molenaar, Adrian
    AgResearch, Ruakura Research Centre in Hamilton, New Zealand.
    Seyfert, Hans-Martin
    Research Institute for the Biology of Farm Animals (FBN), Molecular Biology Research Unit, Dummerstorf, Germany.
    Assessment of the immune capacity of mammary epithelial cells: comparison with mammary tissue after challenge with Escherichia coli2009Inngår i: Veterinary research (Print), ISSN 0928-4249, E-ISSN 1297-9716, Vol. 40, nr 4, artikkel-id 31Artikkel i tidsskrift (Fagfellevurdert)
    Abstract [en]

    We examined the repertoire and extent of inflammation dependent gene regulation in a bovine mammary epithelial cell (MEC) model, to better understand the contribution of the MEC in the immune defence of the udder. We challenged primary cultures of MEC from cows with heat inactivated Escherichia coli pathogens and used Affymetrix DNA-microarrays to profile challenge related alterations in their transcriptome. Compared to acute mastitis, the most prominently activated genes comprise those encoding chemokines, interleukins, beta-defensins, serum amyloid A and haptoglobin. Hence, the MEC exert sentinel as well as effector functions of innate immune defence. E. coli stimulated a larger fraction of genes (30%) in the MEC belonging to the functional category Inflammatory Response than we recorded with the same microarrays during acute mastitis in the udder (17%). This observation underscores the exquisite immune capacity of MEC. To more closely examine the adequacy of immunological regulation in MEC, we compared the inflammation dependent regulation of factors contributing to the complement system between the udder versus the MEC. In the MEC we observed only up regulation of several complement factor-encoding genes. Mastitis, in contrast, in the udder strongly down regulates such genes encoding factors contributing to both, the classical pathway of complement activation and the Membrane Attack Complex, while the expression of factors contributing to the alternative pathway may be enhanced. This functionally polarized regulation of the complex complement pathway is not reflected in the MEC models.

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