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  • 1.
    Hyötyläinen, Tuulia
    VTT Technical Research Centre of Finland, Espoo, Finland.
    Analytical methodologies utilized in the search for chronic disease biomarkers2010In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 2, no 5, p. 919-923Article in journal (Refereed)
  • 2.
    Hyötyläinen, Tuulia
    et al.
    Steno Diabetes Center, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku, Åbo Akademi University, Turku, Finland.
    Orešič, Matej
    Steno Diabetes Center, Gentofte, Denmark; Turku Centre for Biotechnology, University of Turku, Åbo Akademi University, Turku, Finland.
    Bioanalytical techniques in nontargeted clinical lipidomics2016In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 8, no 4, p. 351-364Article in journal (Refereed)
    Abstract [en]

    Lipidomic analysis aims at comprehensive characterization of molecular lipids in biological systems. Due to the central role of lipid metabolism in many devastating diseases, lipidomics is being increasingly applied in biomedical research. Over the past years, advances in analytical techniques and bioinformatics enabled increasingly comprehensive and accurate coverage of lipids both in tissues and biofluids, yet many challenges remain. This review highlights recent progress in the domain of analytical lipidomics, with main emphasis on non-targeted methodologies for large scale clinical applications, as well as discusses some of the key challenges and opportunities in this field.

  • 3.
    Jørgenrud, Benedicte
    et al.
    Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.
    Jäntti, Sirkku
    Finnish Food Safety Authority Evira, Helsinki, Finland.
    Mattila, Ismo
    Steno Diabetes Center, Gentofte, Denmark.
    Pöhö, Päivi
    Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, Finland.
    Rønningen, Kjersti S.
    Department of Pediatric Research, Oslo University Hospital, Oslo, Norway.
    Yki-Järvinen, Hannele
    Division of Diabetes, Department of Medicine, University of Helsinki, Helsinki, Finland.
    Oresic, Matej
    Örebro University, School of Medical Sciences. Steno Diabetes Center, Gentofte, Denmark.
    Hyötyläinen, Tuulia
    Örebro University, School of Science and Technology. Steno Diabetes Center, Gentofte, Denmark.
    The influence of sample collection methodology and sample preprocessing on the blood metabolic profile.2015In: Bioanalysis, ISSN 1757-6180, E-ISSN 1757-6199, Vol. 7, no 8, p. 991-1006Article in journal (Refereed)
    Abstract [en]

    AIM: Blood serum and plasma have intrinsic differences in their composition and the preprocessing, such as clotting temperature in serum, and storage at room temperature may have further effect on metabolite concentrations.

    METHODS: The influence of sampling preprocessing on the metabolic profiles in serum and different types of plasma was investigated using liquid chromatography and comprehensive 2D gas chromatography coupled to a mass spectrometer.

    RESULTS: The profiles of polar metabolites were significantly dependent on the type of the sample, while lipid profiles were similar in serum and different types of plasma. Extended storage of plasma at room temperature resulted in degradation of lipids already after 1 day. Serum clotting at room temperature generally resulted in higher metabolite concentration compared with serum clotting on ice.

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