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  • 1.
    Adams, A.
    et al.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
    Kalla, R.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
    Vatn, S.
    Institute of Clinical Medicine, EpiGen, University of Oslo, Oslo, Norway.
    Bonfiglio, F.
    BioCruces Health Research Institue, Bilbao, Spain.
    Nimmo, E.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
    Kennedy, N.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
    Ventham, N.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
    Vatn, M.
    Institute of Clinical Medicine, EpiGen, University of Oslo, Oslo, Norway.
    Ricanek, P.
    Department of Gastroenterology, Akershus University, Akershus, Norway.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Söderholm, J.
    Department of Surgery, Linköping University Hospital, Linköping, Sweden;.
    Pierik, M.
    Department of Gastroenterology and Hepatology, Maastricht University Medical Center (MUMC), Maastricht, Netherlands.
    Törkvist, L.
    Department of Clinical Science, Intervention and Technology, Karolinska Institute, Stockholm, Sweden.
    Gomollon, F.
    University Hospital Clinic Lozano Blesa, Zaragoza, Spain.
    Gut, I.
    CNAG-CRG Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
    Jahnsen, J.
    Institute of Clinical Medicine, EpiGen, University of Oslo, Oslo, Norway.
    Satsangi, J.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, United Kingdom.
    Epigenetic alterations at diagnosis predict susceptibility, prognosis and treatment escalation in inflammatory bowel disease - IBD Character2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S108-S108Article in journal (Refereed)
  • 2.
    Agrawal, M.
    et al.
    The Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA.
    Shrestha, Sarita
    Örebro University, School of Medical Sciences.
    Corn, G.
    Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.
    Nielsen, N. M.
    Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.
    Frisch, M.
    Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.
    Colombel, J. F.
    The Dr Henry D. Janowitz Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York, USA.
    Jess, T.
    Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark.
    The epidemiology of inflammatory bowel diseases among immigrants to Denmark: A population-based cohort study2020In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 14, no Suppl. 1, p. S006-S007Article in journal (Other academic)
  • 3.
    Amcoff, Karin
    et al.
    Örebro University, School of Medical Sciences.
    Cao, Yang
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Zhulina, Yaroslava
    Örebro University Hospital. Örebro University, School of Medical Sciences.
    Lampinen, M.
    Dept Med Sci, Uppsala Univ, Uppsala, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Carlson, M.
    Dept Med Sci, Uppsala Univ, Uppsala, Sweden.
    Prognostic significance of eosinophil granule proteins in inflammatory bowel disease2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S181-S182Article in journal (Other academic)
  • 4.
    Amcoff, Karin
    et al.
    Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Joossens, Marie
    Department of Microbiology and Immunology, Rega Institute, Katholieke Universiteit, Leuven,Belgium; VIB Center for the Biology of Disease, Leuven, Belgium; Microbiology Unit, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit, Brussels, Belgium.
    Pierik, Marie J.
    Gastroenterology, University Hospital Maastricht, Maastricht, The Netherlands.
    Jonkers, Daisy
    Gastroenterology, University Hospital Maastricht, Maastricht, The Netherlands.
    Bohr, Johan
    Örebro University, School of Health Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Joossens, Sofie
    Gastroenterology, Catholic University of Leuven (KUL), Leuven, Belgium.
    Romberg-Camps, Mariëlle
    Department of Gastroenterology-Hepatology, Zuyderland Medical Center, Sittard, Netherlands.
    Nyhlin, Nils
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Wickbom, Anna
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Rutgeerts, Paul J.
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium.
    Tysk, Curt
    Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Bodin, Lennart
    Institute of Environmental Medicine, Unit of Intervention and Implementation Research, Karolinska Institute, Stockholm, Sweden.
    Colombel, Jean-Frederic
    Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York NY, USA.
    Vermeire, Severine
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Concordance in Anti-OmpC and Anti-I2 Indicate the Influence of Genetic Predisposition: Results of a European Study of Twins with Crohn's Disease2016In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 10, no 6, p. 695-702Article in journal (Refereed)
    Abstract [en]

    Background and Aims: An adaptive immunological response to microbial antigens has been observed in Crohn's disease (CD). Intriguingly, this serological response precedes the diagnosis in some patients and has also been observed in healthy relatives. We aimed to determine whether genetic factors are implicated in this response in a CD twin cohort.

    Methods: In total, 82 twin pairs (Leuven n = 13, Maastricht n = 8, Örebro n = 61) took part: 81 pairs with CD (concordant monozygotic n = 16, discordant monozygotic n = 22, concordant dizygotic n = 3, discordant dizygotic n = 40) and 1 monozygotic pair with both CD and ulcerative colitis. Serology for Pseudomonas fluorescens-related protein (anti-I2), Escherichia coli outer membrane porin C (anti-OmpC), CBir1flagellin (anti-CBir1) and antibodies to oligomannan (anti-Saccharomyces cerevisiae antibody [ASCA]) was determined by standardized enzyme-linked immunoassay.

    Results: All markers were more often present in CD twins than in their healthy twin siblings. Using the intraclass correlation coefficient (ICC), agreements in concentrations of anti-OmpC and anti-I2 were observed in discordant monozygotic but not in discordant dizygotic twin pairs with CD (anti-OmpC, ICC 0.80 and -0.02, respectively) and (anti-I2, ICC 0.56 and 0.05, respectively). In contrast, no agreements were found in anti-CBir, immunoglobulin (Ig) G ASCA and ASCA IgA.

    Conclusions: We show that anti-I2 and anti-CBir1 statuses have specificity for CD and confirm previous reported specificities for anti-OmpC and ASCA. Based on quantitative analyses and observed ICCs, genetics seems to predispose to the anti-OmpC and anti-I2 response but less to ASCA and anti-CBir1 responses.

  • 5.
    Andersson, Erik
    et al.
    Örebro University, School of Medical Sciences.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences.
    Kruse, Robert
    Örebro University, School of Medical Sciences.
    D'Amato, M.
    Department of Medicine, Karolinska Institutet Solna, Stockholm, Sweden.
    Repsilber, Dirk
    Örebro University, School of Medical Sciences.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Inflammatory biomarkers in serum discriminate Crohn's disease and ulcerative colitis from healthy controls2016In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 10, no Suppl. 1, p. S86-S87Article in journal (Other academic)
  • 6.
    Axelrad, J.
    et al.
    Department of Gastroenterology, New York University School of Medicine, New York, NY, USA.
    Olén, O.
    Department of Medicine, Karolinska Institute, Stockholm, Sweden.
    Sachs, M.
    Department of Medicine, Karolinska Institute, Stockholm, Sweden.
    Erichsen, R.
    Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
    Pedersen, L.
    Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Askling, J.
    Department of Medicine, Karolinska Institute, Stockholm, Sweden.
    Ekbom, A.
    Karolinska Inst, Dept Med, Stockholm, Sweden..
    Sørensen, H. T.
    Department of Clinical Epidemiology, Aarhus University, Aarhus, Denmark.
    Ludvigsson, Jonas F.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Medical Epidemiology and Biostatistics.
    Inflammatory bowel disease and risk of small bowel cancer: A binational population-based cohort study from Denmark and Sweden2020In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 14, no Suppl. 1, p. S007-S009Article in journal (Other academic)
  • 7.
    Axelrad, Jordan
    et al.
    Inflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, NYU School of Medicine, New York, New York, USA.
    Olén, Ola
    Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Sachs' Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden; Department of Clinical Science and Education Södersjukhuset, Karolinska Institutet, Stockholm, Sweden.
    Söderling, Jonas
    Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Roelstraete, Bjorn
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Khalili, Hamed
    Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
    Song, Mingyang
    Division of Gastroenterology, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA.
    Faye, Adam
    Inflammatory Bowel Disease Center at NYU Langone Health, Division of Gastroenterology, Department of Medicine, NYU School of Medicine, New York, New York, USA.
    Eberhardson, Michael
    Department of Gastroenterology and Hepatology, Linköping University Hospital, Linköping University, Linköping, Sweden; Karolinska Institutet, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Ludvigsson, Jonas F.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, New York, USA.
    Inflammatory Bowel Disease and Risk of Colorectal Polyps: A nationwide population-based cohort study from Sweden2023In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 17, no 9, p. 1395-1409Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Inflammatory bowel disease (IBD) has been linked to an increased risk of colorectal neoplasia. However, the types and risks of specific polyp types in IBD are less clear.

    METHODS: We identified 41,880 individuals with IBD [Crohn's disease (CD: n=12,850); Ulcerative colitis (UC): n=29,030)] from Sweden matched with 41,880 reference individuals. Using Cox regression, we calculated adjusted hazard ratios (aHRs) for neoplastic colorectal polyps (Tubular, Serrated/Sessile, Advanced and Villous) defined by histopathology codes.

    RESULTS: During follow-up, 1648 (3.9%) IBD patients and 1143 (2.7%) reference individuals had an incident neoplastic colorectal polyp, corresponding to an incidence rate of 46.1 and 34.2 per 10,000 person-years, respectively. This correlated to an aHR of 1.23 (95% CI 1.12-1.35) with the highest HRs seen for sessile serrated polyps (8.50, 95% CI 1.10-65.90) and traditional serrated adenomas (1.72, 95% CI 1.02-2.91). aHRs for colorectal polyps were particularly elevated in those diagnosed with IBD at a young age and after 10 years after diagnosis. Both absolute and relative risks of colorectal polyps were higher in UC than in CD (aHRs 1.31 vs. 1.06, respectively), with a 20-year cumulative risk differences of 4.4% in UC and 1.5% in CD, corresponding to one extra polyp in 23 patients with UC and one in 67 CD patients during the first 20 years after IBD diagnosis.

    CONCLUSIONS: In this nationwide population-based study, there was an increased risk of neoplastic colorectal polyps in IBD patients. Colonoscopic surveillance in IBD appears important, especially in UC and after 10 years of disease.

  • 8.
    Bazov, Igor
    et al.
    Örebro University, School of Medical Sciences.
    Kruse, Robert
    Örebro University, School of Medical Sciences.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Eriksson, Carl
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Hedin, C. R.
    Karolinska Institutet, Department of Medicine, Solna, Stockholm, Sweden; Karolinska University Hospital, Gastroenterology unit, Department of Gastroenterology, Dermatovenereology and Rheumatology, Stockholm, Sweden.
    Carlson, M.
    Uppsala University, Department of Medical Sciences, Uppsala, Sweden.
    van Nieuwenhoven, Michiel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Keita, Å. V.
    Linköping University, Department of Biomedical and Clinical Sciences, Linköping, Sweden.
    Magnusson, M. K.
    University of Gothenburg, Sahlgrenska Academy, Department of Microbiology and Immunology, Institute of Biomedicine, Gothenburg, Sweden.
    Almer, S.
    Karolinska Institutet, Department of Medicine, Solna, Stockholm, Sweden; Karolinska university hospital, Gastroenterology unit, Department of Gastroenterology, Dermatovenereology and Rheumatology, Stockholm, Sweden.
    Strid, H.
    Södra Älvsborgs Hospital, Department of Internal Medicine, Borås, Sweden.
    Mathisen, C. Bache-Wiig
    Oslo University Hospital, Department of Gastroenterology, Oslo, Norway; University of Oslo, Institute of Clinical Medicine, Oslo, Norway.
    Bengtsson, M. B.
    Vestfold Hospital Trust, Department of Gastroenterology, Tønsberg, Norway.
    Aabrekk, T. Bergene
    University of Oslo, Institute of Clinical Medicine, Oslo, Norway; Vestfold Hospital Trust, Department of Gastroenterology, Tønsberg, Norway.
    Medhus, A. W.
    Oslo University Hospital, Department of Gastroenterology, Oslo, Norway; University of Oslo, Institute of Clinical Medicine, Oslo, Norway.
    Detlie, T. E.
    Akershus University Hospital, Department of Gastroenterology, Lørenskog, Norway; University of Oslo, Insititute of Clinical Medicine, Oslo, Norway.
    Frigstad, S. O.
    Vestre Viken Hospital Trust- Bærum Hospital, Department of Internal Medicine, Bærum, Norway.
    Huppertz-Hauss, G.
    Telemark Hospital Trust, Skien, Department of Gastroenterology, Skien, Norway.
    Opheim, R.
    Oslo University Hospital, Department of Gastroenterology, Oslo, Norway; University of Oslo, Institute of Health and Society, Oslo, Norway.
    Ricanek, P.
    Akershus University Hospital, Department of Gastroenterology, Lørenskog, Norway; Lovisenberg Diaconal Hospital, Department of Gastroenterology, Oslo, Norway.
    Kristensen, V. A.
    Oslo University Hospital, Department of Gastroenterology, Oslo, Norway; Lovisenberg Diaconal Hospital, Unger-Vetlesen Institute, Oslo, Norway .
    Salihovic, Samira
    Örebro University, School of Medical Sciences.
    D'Amato, M.
    Karolinska Institutet, Clinical Epidemiology Division, Department of Medicine Solna, Stockholm, Sweden; IKERBASQUE, Basque Foundation for Science, Bilbao, Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Bilbao, Spain.
    Öhman, L.
    University of Gothenburg, Sahlgrenska Academy, Department of Microbiology and Immunology, Institute of Biomedicine, Gothenburg, Sweden.
    Söderholm, J. D.
    Linköping University, Department of Biomedical and Clinical Sciences, Linköping, Sweden.
    Lindqvist, C. M.
    Örebro University, School of Medical Sciences, Faculty of Medicine and Health, Örebro, Sweden.
    Repsilber, Dirk
    Örebro University, School of Medical Sciences.
    Høivik, M. L.
    Oslo University Hospital, Department of Gastroenterology, Oslo, Norway; University of Oslo, Institute of Clinical Medicine, Oslo, Norway.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    A novel serum protein signature as biomarker for Inflammatory Bowel Disease: A diagnostic performance and prediction modelling study using data from two independent inception cohorts2023In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 17, no Suppl. 1, p. I314-I315, article id P154Article in journal (Other academic)
  • 9.
    Bergman, David
    et al.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Khalili, Hamed
    Massachusetts General Hospital, Crohn’s and Colitis Center and Harvard Medical School, Boston MA, USA; Division of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Roelstraete, Bjorn
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Ludvigsson, Jonas F.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York NY, USA.
    Microscopic Colitis and Risk Of Cancer-AA Population-Based Cohort Study2021In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 15, no 2, p. 212-221Article in journal (Refereed)
    Abstract [en]

    Background and Aims: The association between microscopic colitis [MC] and cancer risk is unclear. Large, population-based studies are lacking.

    Methods: We conducted a nationwide cohort study of 11 758 patients with incident MC [diagnosed 1990-2016 in Sweden], 50 828 matched reference individuals, and 11 614 siblings to MC patients. Data were obtained through Sweden's pathology departments and from the Swedish Cancer Register. Adjusted hazard ratios [aHRs] were calculated using Cox proportional hazards models.

    Results: At the end of follow-up [mean: 6.7 years], 1239 [10.5%] of MC patients had received a cancer diagnosis, compared with 4815 [9.5%] of reference individuals (aHR 1.08 [95% confidence interval1.02-1.16]). The risk of cancer was highest during the first year of follow up. The absolute excess risks for cancer at 5, 10, and 20 years after MC diagnosis were + 1.0% (95% confidence interval [C1]0.4%-1.6%), +1.5% [0.4%-2.6%], and + 3.7% [-2.3-9.6%], respectively, equivalent to one extra cancer event in every 55 individuals with MC followed for 10 years. MC was associated with an increased risk of lymphoma (aHR 1.43 [1.06-1.92]) and lung cancer (aHR 1.32 [1.04-1.68]) but with decreased risks of colorectal (aHR 0.52 [0.40-0.66]) and gastrointestinal cancers (aHR 0.72 [0.60-0.85]). We found no association with breast or bladder cancer. Using siblings as reference group to minimise the impact of shared genetic and early environmental factors, patients with MC were still at an increased risk of cancer (HR 1.20 [1.06-1.36]).

    Conclusions: This nationwide cohort study demonstrated an 8% increased risk of cancer in MC patients. The risk was highest during the first year of follow-up.

  • 10.
    Björkqvist, Olle
    et al.
    Örebro University, School of Medical Sciences.
    Repsilber, Dirk
    Örebro University, School of Medical Sciences.
    Seifert, M.
    Microbiol Tumor & Cell Biol, Karolinska Inst, Stockholm, Sweden.
    Engstrand, L.
    Microbiol Tumor & Cell Biol, Karolinska Inst, Stockholm, Sweden.
    Rangel, Ignacio
    Örebro University, School of Medical Sciences.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Increasing abundance of faecalibacterium prausnitzii is associated with decreased intestinal inflammation in Crohn's disease: A longitudinal study2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S468-S469Article in journal (Other academic)
  • 11.
    Burisch, J.
    et al.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Andersen, V.
    Dept Med, Viborg Reg Hosp, Viborg, Denmark; Dept Med, Hosp Southern Jutland, Aabenraa, Denmark.
    Cukovic-Cavka, S.
    Sch Med, Div Gastroenterol & Hepatol, Univ Hosp Ctr Zagreb, Univ Zagreb, Zagreb, Croatia.
    Lakatos, P. L.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    D'Inca, R.
    Dept Surg Oncol & Gastroenterol, Azienda Osped Padova, Padua, Italy.
    Magro, F.
    Inst Mol & Cell Biol, Univ Porto, Porto, Portugal; Dept Gastroenterol, Hosp Sao Joao, Porto, Portugal.; Inst Pharmacol & Therapeut, Oporto Med Sch, Porto, Portugal.
    Arebi, N.
    Gastroenterol, St Marks Hosp, London, England.
    Kievit, L.
    Dept Med, Herning Cent Hosp, Herning, Denmark.
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus.
    Valpiani, D.
    Dept Gastroenterol & Digest Endoscopy, Morgagni Hosp, Forli, Italy.
    Katsanos, K. H.
    Div Internal Med 1, Univ Hosp, Ioannina, Greece; Gastroenterol Unit, Ioannina, Greece.
    Vegh, Z.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Dahlerup, J. F.
    Dept Gastroenterol & Hepatol, Aarhus Univ Hosp, Aarhus, Denmark.
    Fumery, M.
    Epimad Registry, Gastroenterol Unit, Amiens Univ & Hosp, Amiens, France.
    Pedersen, N.
    Dept Gastroenterol, Slagelse Hosp, Slagelse, Denmark.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Belousova, E.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Isl, Torshavn, Denmark.
    Turcan, S.
    Dept Gastroenterol, State Univ Med & Pharm Republ Moldova, Kishinev, Moldova.
    Ellul, P.
    Div Gastroenterol, Mater Hosp, L Imsida, Malta.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Oksanen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Giannotta, M.
    Dept Gastroenterol, AOU Careggi Reg Referral Ctr Inflammatory Bowel D, Florence, Italy.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Hernandez, V.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Salupere, R.
    Div Gastroenterol & Endocrinol, Tartu Univ Hosp, Tartu, Estonia.
    Odes, S.
    Soroka Med Ctr, Beer Sheva, Israel; Dept Gastroenterol & Hepatol, Ben Gurion Univ Negev, Beer Sheva, Israel.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Munkholm, P.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Immunomodulators reduce the risk of surgery and hospitalisation in Crohn's disease in a prospective European population-based inception cohort: the Epi-IBD cohort2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S42-S43Article in journal (Other academic)
  • 12.
    Burisch, J.
    et al.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Ellul, P.
    Div Gastroenterol, Mater Dei Hosp, L Imsida, Malta.
    Arebi, N.
    Gastroenterol, St Marks Hosp, London, England.
    Kaimakliotis, I.
    D'Inca, R.
    Dept Surg Oncol & Gastroenterol, Azienda Osped Padova, Padua, Italy.
    Andersen, V.
    Med Dept, Viborg Reg Hosp, Viborg, Denmark; Med Dept, Hosp Southern Jutland, Aabenraa, Denmark.
    Belousova, E.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Hernandez, V.
    Gastroenterol Dept, Complexo Hosp Univ Vigo, Vigo, Spain.
    Vegh, Z.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Turcan, S.
    Dept Gastroenterol, State Univ Med & Pharm Republ Moldova, Kishinev, Moldova.
    Magro, F.
    Inst Mol & Cell Biol, Univ Porto, Porto, Portugal; Dept Gastroenterol, Hosp Sao Joao, Porto, Portugal; Inst Pharmacol & Therapeut, Oporto Med Sch, Porto, Portugal.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ of Hlth Sci, Kaunas, Lithuania.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Lakatos, P. L.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Kievit, L.
    Dept Med, Herning Cent Hosp, Herning, Denmark.
    Goldis, A.
    Clin Gastroenterol, Univ Med Victor Babes, Timisoara, Romania.
    Dahlerup, J. F.
    Dept Hepatol & Gastroenterol, Aarhus Univ Hosp, Aarhus, Denmark.
    Oksanen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Cukovic-Cavka, S.
    Div Gastroenterol & Hepatol, Sch Med, Univ Hosp Ctr Zagreb, Univ Zagreb, Zagreb, Croatia.
    Fumery, M.
    Gastroenterol Unit, Epimad Registry, Amiens Hosp & Univ, Amiens, France.
    Odes, S.
    Soroka Med Ctr, Beer Sheva, Israel; Dept Gastroenterol & Hepatol, Ben Gurion Univ Negev, Beer Sheva, Israel.
    Nielsen, K. R.
    Med Dept, Natl Hosp Faroe Isl, Torshavn, Denmark.
    Valpiani, D.
    Dept Gastroenterol & Digest Endoscopy, Morgagni Hosp, Forli, Italy.
    Pedersen, N.
    Dept Gastroenterol, Slagelse Hosp, Slagelse, Denmark.
    Giannotta, M.
    Reg Referral Ctr Inflammatory Bowel D, Dept Gastroenterol, AOU Careggi Florence, Italy.
    Salupere, R.
    Div Endocrinol & Gastroenterol, Tartu Univ Hosp, Tartu, Estonia.
    Katsanos, K. H.
    Div Internal Med 1, Univ Hosp Ioannina, Ioannina, Greece; Hepatogastroenterol Unit, Univ Hosp Ioannina, Ioannina, Greece.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Munkholm, P.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Natural disease course of inflammatory bowel disease unclassified in a prospective European population-based inception cohort-the Epi-IBD cohort2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S523-S524Article in journal (Other academic)
  • 13.
    Burisch, J.
    et al.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Gerdes, U.
    Ctr Qual, Region Southern Denmark, Middelfart, Denmark; Inst Reg Hlth Res, Univ Southern Denmark, Odense, Denmark.
    Almer, S.
    Dept Gastroenterol, University Hospital Linköping, County Council Östergötland, Linköping, Sweden.
    Cukovic-Cavka, S.
    Sch Med, Div Gastroenterol & Hepatol, Univ Hosp Ctr Zagreb, Univ Zagreb, Zagreb, Croatia.
    Sebastian, S.
    Hull Royal Infirm, Hull & East Yorkshire NHS Trust, Kingston Upon Hull, England; Hull & York Med Sch, Kingston Upon Hull, England.
    Kaimakliotis, I.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Pedersen, N.
    Dept Gastroenterol, Slagelse Hosp, Slagelse, Denmark.
    Salupere, R.
    Div Gastroenterol & Endocrinol, Tartu Univ Hosp, Tartu, Estonia.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Isl, Torshavn, Denmark; Genet Biobank, Torshavn, Faroe Islands, Danmark.
    Manninen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Katsanos, K. H.
    Div Internal Med 1, Univ Hosp, Ioannina, Greece; Hepatogastroenterol Unit, Univ Hosp, Ioannina, Greece.
    Odes, S.
    Soroka Med Ctr, Beer Sheva, Israel; Dept Gastroenterol & Hepatol, Ben Gurion Univ Negev, Beer Sheva, Israel.
    Andersen, V.
    Dept Med, Viborg Reg Hosp, Viborg, Denmark; Dept Med, Hosp Southern Jutland, Aabenraa, Denmark.
    D'Inca, R.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Turcan, S.
    Dept Gastroenterol, State Univ Med & Pharm Republ Moldova, Kishinev, Moldova.
    Magro, F.
    Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal; Dept Gastroenterol, Hosp Sao Joao, Oporto, Portugal; Inst Pharmacol & Therapeut, Oporto Med Sch, Oporto, Portugal.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Vinding, K. Kofod
    Dept Med, Amager Hosp, Amager, Denmark.
    Belousova, E.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Ladefoged, K.
    Dept Med, Dronning Ingrids Hosp, Nuuk, Greenland.
    Bailey, Y.
    Dept Gastroenterol, Adelaide & Meath Hosp, Trinity College Dublin, Dublin, Ireland.
    Hernandez, V.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Arebi, N.
    Gastroenterol, St Marks Hosp, London, England.
    Shonova, O.
    Dept Gastroenterol, Nemocnice Ceske Budejovice, Ceske Budejovice, Czech Republic.
    Hoivik, M. L.
    Dept Gastroenterol, Oslo Univ Hosp, Oslo, Norway.
    Moum, B.
    Dept Gastroenterol, Oslo Univ Hosp, Oslo, Norway.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Lakatos, P. L.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Munkholm, P.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Dahlerup, J. F.
    Dept Gastroenterol & Hepatol, Aarhus Univ Hosp, Aarhus, Denmark.
    Frequency of anaemia and anaemia subtypes in east-west European inception cohort: an ECCO-EpiCom cohort study2016In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 10, no Suppl. 1, p. S453-S454Article in journal (Other academic)
  • 14.
    Burisch, J.
    et al.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark..
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastronterology, Örebro University Hospital, Örebro, Sweden.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Hernandez, V.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus..
    Valpiani, D.
    Dept Gastroenterol & Digest Endoscopy, Morgagni Hosp, Forli, Italy.
    Pedersen, N.
    Dept Gastroenterol, Slagelse Hosp, Slagelse, Denmark.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ Prague, Prague, Czech Republic.
    Kievit, L.
    Dept Med, Herning Cent Hosp, Herning, Denmark.
    Dahlerup, J. F.
    Dept Gastroenterol & Hepatol, Aarhus Univ Hosp, Aarhus, Denmark.
    Fumery, M.
    Gastroenterol Unit, Epimad Registry, Amiens Univ & Hosp, Amiens, France.
    Salupere, R.
    Div Gastroenterol & Endocrinol, Tartu Univ Hosp, Tartu, Estonia.
    Arebi, N.
    Gastroenterol, St Marks Hosp, London, England.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Isl, Torshavn, Denmark.
    Giannotta, M.
    Dept Gastroenterol, AOU Careggi, Regional Referral Centre of Inflammatory Bowel, Florence, Italy.
    Oksanen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Katsanos, K. H.
    Div Internal Med 1, Univ Hosp, Ioannina, Greece; Hepatogastroenterol Unit, Univ Hosp, Ioannina, Greece.
    Vegh, Z.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Ellul, P.
    Div Gastroenterol, Mater Dei Hosp, LImsida, Malta.
    Schwartz, D.
    Soroka Med Ctr, Beer Sheva, Israel; Dept Gastroenterol & Hepatol, Ben Gurion Univ Negev, Beer Sheva, Israel.
    Cukovic-Cavka, S.
    Sch Med, Div Gastroenterol & Hepatol, Univ Hosp Ctr , Univ Zagreb, Zagreb, Croatia.
    D'Inca, R.
    Dept Surg Oncol & Gastroenterol, Azienda Osped Padova, Padua, Italy.
    Turcan, S.
    Dept Gastroenterol, State Univ Med Pharm, Kishinev, Moldova.
    Magro, F.
    Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal; Dept Gastroenterol, Hosp Sao Joao, Oporto, Portugal; Inst Pharmacol & Therapeut, Oporto Med Sch, Oporto, Portugal.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark..
    Lakatos, P. L.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Munkholm, P.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Change in Crohn's disease behavior in a prospective European population-based inception cohort - the ECCO-EpiCom cohort2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S452-S453Article in journal (Refereed)
  • 15.
    Burisch, J.
    et al.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Hernandez, V.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus.
    Valpiani, D.
    Dept Gastroenterol & Digest Endoscopy, Morgagni Hosp, Forli, Italy.
    Pedersen, N.
    Dept Gastroenterol, Slagelse Hosp, Slagelse, Denmark.
    Duricova, D.
    IBD Ctr ISCARE, Prague, Charles Univ Prague, Czech Republic.
    Kievit, L.
    Dept Med, Herning Cent Hosp, Herning, Denmark.
    Dahlerup, J. F.
    Dept Gastroenterol & Hepatol, Aarhus Univ Hosp, Aarhus, Denmark.
    Fumery, M.
    Epimad Registry, Gastroenterol Unit, Amiens Univ & Hosp, Amiens, France.
    Salupere, R.
    Div Gastroenterol & Endocrinol, Tartu Univ Hosp, Tartu, Estonia.
    Arebi, N.
    Gastroenterol, St Marks Hosp, London, England.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Islands, Torshavn, Denmark..
    Giannotta, M.
    Inflammatory Bowel D, Dept Gastroenterol, AOU Careggi Regional Referral Centre, Florence, Italy.
    Oksanen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Katsanos, K. H.
    Div Internal Med 1, Univ Hosp Ioannina, Ioannina, Greece; Hepatogastroenterol Unit, Univ Hosp Ioannina, Ioannina, Greece.
    Vegh, Z.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Ellul, P.
    Div Gastroenterol, Mater Dei Hosp, Limsida, Malta.
    Schwartz, D.
    Soroka Med Ctr, Beer Sheva, Israel; Dept Gastroenterol & Hepatol, Ben Gurion Univ Negev, Beer Sheva, Israel.
    Cukovic-Cavka, S.
    Sch Med, Div Gastroenterol & Hepatol, Univ Hosp Ctr Zagreb, Univ Zagreb, Zagreb, Croatia.
    D'Inca, R.
    Dept Surg Oncol & Gastroenterol, Azienda Osped Padova, Padua, Italy.
    Turcan, S.
    Dept Gastroenterol, State Univ Med & Pharm, Kishinev, Moldova..
    Magro, F.
    Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal; Dept Gastroenterol, Hosp Sao Joao, Oporto, Portugal; Inst Pharmacol & Therapeut, Oporto Med Sch, Oporto, Portugal.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Lakatos, P. L.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Munkholm, P.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Disease course during the first five years following diagnosis in a prospective European population-based inception cohort - the ECCO-EpiCom cohort2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S435-S436Article in journal (Refereed)
  • 16.
    Burisch, J.
    et al.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastronterology, Örebro University Hospital, Örebro, Sweden.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Hernandez, V.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus.
    Valpiani, D.
    Dept Gastroenterol & Digest Endoscopy, Morgagni Hosp, Forli, Italy.
    Pedersen, N.
    Dept Gastroenterol, Slagelse Hosp, Slagelse, Denmark.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ Prague, Prague, Czech Republic.
    Kievit, L.
    Dept Med, Herning Cent Hosp, Herning, Denmark.
    Dahlerup, J. F.
    Dept Gastroenterol & Hepatol, Aarhus Univ Hosp, Aarhus, Denmark.
    Fumery, M.
    Epimad Registry, Gastroenterol Unit, Amiens Univ & Hosp, Amiens, France.
    Salupere, R.
    Div Gastroenterol & Endocrinol, Tartu Univ Hosp, Tartu, Estonia.
    Arebi, N.
    Gastroenterol, St Marks Hosp, London, England.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Islands, Torshavn, Denmark.
    Giannotta, M.
    Dept Gastroenterol, AOU Careggi, Regional Referral Centre of Inflammatory Bowel Disease, Florence, Italy.
    Oksanen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Katsanos, K. H.
    Div Internal Med 1, Univ Hosp Ioannina, Ioannina, Greece; Hepatogastroenterol Unit, Univ Hosp, Ioannina, Greece.
    Vegh, Z.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Ellul, P.
    Div Gastroenterol, Mater Dei Hosp, Limsida, Malta.
    Schwartz, D.
    Soroka Med Ctr, Beer Sheva, Israel; Dept Gastroenterol & Hepatol, Ben Gurion Univ Negev,Beer Sheva, Israel.
    Cukovic-Cavka, S.
    Sch Med, Div Gastroenterol & Hepatol, Univ Hosp Ctr Zagreb, Univ Zagreb, Zagreb, Croatia.
    D'Inca, R.
    Dept Surg Oncol & Gastroenterol, Azienda Osped Padova, Padua, Italy.
    Turcan, S.
    Dept Gastroenterol, State Univ Med & Pharm Republ Moldova, Kishinev, Moldova.
    Magro, F.
    Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal; Dept Gastroenterol, Hosp Sao Joao, Oporto, Portugal; Inst Pharmacol & Therapeut, Oporto Med Sch, Oporto, Portugal.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Lakatos, P. L.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Munkholm, P.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    The risk of proximal disease extension in patients with limited ulcerative colitis in a prospective European population-based inception cohort - the ECCO-EpiCom cohort2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S436-S436Article in journal (Refereed)
  • 17.
    Burisch, J.
    et al.
    Gastrounit, Medical section, Hvidovre University Hospital, Hvidovre, Denmark.
    Kaimakliotis, I.
    Nicosia Private practice, Nicosia, Cyprus.
    Duricova, D.
    IBD Center ISCARE, Charles University, Prague, Czech Republic.
    Kievit, L.
    Department of medicine, Herning Central Hospital, Herning, Denmark.
    Dahlerup, J. F.
    Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
    Salupere, R.
    Division of Endocrinology and Gastroenterology, Tartu University Hospital, Tartu, Estonia.
    Nielsen, K. R.
    Medical Department, The National Hospital of the Faroe Islands, Thorshavn, Denmark.
    Manninen, P.
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
    Tsianos, E. V.
    1st Division of Internal Medicine and Hepato-Gastroenterology Unit, University Hospital, Ioannina, Greece.
    Vegh, Z.
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Odes, S.
    Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
    D'Inca, R.
    EpiCom Northern Italy, Florence, Forlì and Padova, Italy.
    Kupcinskas, L.
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Turcan, S.
    Department of Gastroenterology, Chisinau, State University of Medicine and Pharmacy of the Republic of Moldova, Moldova, Republic of Moldova.
    Magro, F.
    Institute for molecular and cell biology, University of Porto, Porto, Portugal; Department of Gastroenterology, Hospital de São João, Porto, Portugal; Institute of Pharmacology and Therapeutics, Oporto Medical School, Porto, Portugal.
    Goldis, A.
    Clinic of Gastroenterology, University of Medicine Victor Babes, Timisoara, Romania.
    Hernandez, V.
    Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
    Halfvarson, Jonas
    Örebro University, School of Medicine, Örebro University, Sweden.
    Arebi, N.
    Gastroenterology, St Mark's Hospital, London, United Kingdom.
    Langholz, E.
    Department of Medical Gastroenterology, Gentofte Hospital, Copenhagen, Denmark.
    Lakatos, P. L.
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Munkholm, P.
    Department of gastroenterology, Herlev University Hospital, Herlev, Denmark.
    EpiCom Northern Italy, Group author
    Unchanged surgery and hospitalization rates in an East-West European inception cohort despite differences in use of biologicals-3-year follow-up of the ECCO-EpiCom cohort2015In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 9, p. S5-S6Article in journal (Other academic)
  • 18.
    Burisch, J.
    et al.
    Dept Gastroenterol, Herlev Univ Hosp, Herlev, Denmark.
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Thorsgaard, N.
    Dept Med, Herning Cent Hosp, Herning, Denmark.
    Andersen, V.
    Dept Med, Viborg Reg Hosp, Viborg, Denmark; Inst Reg Hlth Res, Univ Southern Denmark, Odense, Denmark; Dept Med, Hosp Southern Jutland, Aabenraa, Denmark.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Islands, Torshavn, Denmark.
    Tsianos, E. V.
    Div Internal Med 1, Univ Hosp, Ioannina, Greece; Hepatogastroenterol Unit, Ioannina, Greece.
    Ladefoged, K.
    Dept Med, Dronning Ingrids Hosp, Nuuk, Greenland.
    Bailey, Y.
    Dept Gastroenterol, Adelaide & Meath Hosp, Trinity College, Dublin, Ireland.
    D'Inca, R.
    UO Gastroenterol, Azienda Osped, Univ Padua, Padua, Italy; EpiCom Northern Italy Ctr Based Crema & Cremona, Forli, Italy; EpiCom Northern Italy Ctr Based Crema & Cremona, Reggio Emilia, Italy.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Turcan, S.
    Dept Gastroenterol, State University of Medicine and Pharmacy "Nicolae Testemitanu", Kishinev, Moldova.
    Magro, F.
    Inst Pharmacol & Therapeut, Oporto Med Sch, Oporto, Portugal; Dept Gastroenterol, Hosp Sao Joao, Oporto, Portugal; Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Belousova, E.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Hernandez, V.
    Gastroenterol, Complejo Hosp Univ Vigo, Vigo, Spain.
    Almer, S.
    Dept Gastroenterol, Uiveraity Hospital, Cty Council Östergötland, Linköping, Sweden; Div Gastroenterol & Hepatol, Karolinska Inst, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Dept Med 24, Div Gastroenterol, Örebro Univ Hosp, Örebro, Sweden .
    Sebastian, S.
    Hull Royal Infirm, Hull & East Yorkshire NHS Trust, Kingston Upon Hull, England; Hull & York Med Sch, Kingston Upon Hull, England.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Odes, S.
    Soroka Med Ctr, Beer Sheva, Israel; Dept Gastroenterol & Hepatol, Ben Gurion Univ Negev, Beer Sheva, Israel.
    Munkholm, P.
    Dept Gastroenterol, Herlev Univ Hosp, Herlev, Denmark.
    The cost of investigations and medical treatment including biological therapy in a European inception cohort from the biological era: An ECCO-EpiCom study2014In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no Suppl. 1, p. S5-S6Article in journal (Refereed)
  • 19.
    Burisch, J.
    et al.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Pedersen, N.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Cukovic-Cavka, S.
    Div Gastroenterol & Hepatol, Sch Med, Univ Hosp Ctr Zagreb, Univ Zagreb, Zagreb, Croatia.
    Turk, N.
    Div Gastroenterol & Hepatol, Sch Med, Univ Hosp Ctr Zagreb, Univ Zagreb, Zagreb, Croatia.
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Bortlik, M.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Shonova, O.
    Dept Gastroenterol, Hosp Ceske Budejovice, Ceske Budejovice, Czech Republic.
    Vind, I.
    Dept Med, Amager Hosp, Amager, Denmark.
    Avnstrom, S.
    Dept Med, Amager Hosp, Amager, Denmark.
    Thorsgaard, N.
    Dept Med, Herning Cent Hosp, Herning, Denmark.
    Krabbe, S.
    Dept Med, Viborg Reg Hosp, Viborg, Denmark.
    Andersen, V.
    Dept Med, Viborg Reg Hosp, Viborg, Denmark; Organ Ctr, Hosp Southern Jutland, Aabenraa, Denmark; Inst Reg Hlth Res, Univ Southern Denmark, Odense, Denmark.
    Dahlerup, J. F.
    Dept Med Hepatol & Gastroenterol, Aarhus Univ Hosp, Aarhus, Denmark.
    Kjeldsen, J.
    Dept Med Gastroenterol, Odense Univ Hosp, Odense, Denmark.
    Salupere, R.
    Olsen, J.
    Div Gastroenterol & Endocrinol, Tartu Univ Hosp, Tartu, Estonia; , Dept Med, Natl Hosp Faroe Islands, Torshavn, Denmark.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Islands, Torshavn, Denmark.
    Manninen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Collin, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Katsanos, K. H.
    Div Internal Med, Univ Hosp, Ioannina, Greece; Hepatogastroenterol Unit, Univ Hosp, Ioannina, Greece.
    Tsianos, E. V.
    Div Internal Med, Univ Hosp, Ioannina, Greece; Hepatogastroenterol Unit, Univ Hosp, Ioannina, Greece.
    Ladefoged, K.
    Dept Med, Dronning Ingrids Hosp, Nuuk, Greenland.
    Lakatos, L.
    Dept Med, Semmelweis Univ, Budapest, Hungary.
    Ragnarsson, G.
    Sect Gastroenterol & Hepatol, Dept Internal Med, Natl Univ Hosp Reykjavik, Reykjavik, Iceland.
    Björnsson, E.
    Sect Gastroenterol & Hepatol, Dept Internal Med, Natl Univ Hosp Reykjavik, Reykjavik, Iceland.
    Bailey, Y.
    Dept Gastroenterol, TCD, Adelaide & Meath Hosp, Dublin, Ireland.
    O'Morain, C.
    Dept Gastroenterol, TCD, Adelaide & Meath Hosp, Dublin, Ireland.
    Schwartz, D.
    Dept Gastroenterol & Hepatol, Soroka Med Ctr, Beer Sheva, Israel; Ben Gurion Univ Negev, Beer Sheva, Israel.
    Odes, S.
    Dept Gastroenterol & Hepatol, Soroka Med Ctr, Beer Sheva, Israel; Ben Gurion Univ Negev, Beer Sheva, Israel.
    Giannotta, M.
    Gastroenterol Unit, Careggi Hosp, Florence, Italy.
    Girardin, G.
    UO Gastroenterol, Azienda Osped Univ Padova, Padua, Italy.
    Kiudelis, G.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Turcan, S.
    Dept Gastroenterol, State Univ Med & Pharm Republ Moldova, Kishinev, Moldova.
    Barros, L.
    Hosp de Vale de Sousa, Oporto, Portugal.
    Magro, F.
    Dept Gastroenterol, Hosp Sao Joao, Oporto, Portugal; Inst Pharmacol & Therapeut, Oporto Med Sch, Oporto, Portugal; Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal.
    Lazar, D.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Nikulina, I.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Belousova, E.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Martinez-Ares, D.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Hernandez, V.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Almer, S.
    Div Gastroenterol & Hepatol, Karolinska Inst, Stockholm, Sweden; Dept Gastroenterol UHL, Cty Council Östergötland, Linköping, Sweden.
    Zhulina, Yaroslava
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Div Gastroenterol, Dept Med.
    Halfvarson, Jonas
    Örebro University Hospital. Div Gastroenterol, Dept Med.
    Arebi, N.
    St Marks Hosp, Univ London Imperial Coll Sci Technol & Med, London, England.
    Tsai, H. H.
    Hull Royal Infirm, Hull & York Med Sch, Hull & East Yorkshire NHS Trust, Kingston Upon Hull, N Humberside, England.
    Sebastian, S.
    Hull Royal Infirm, Hull & York Med Sch, Hull & East Yorkshire NHS Trust, Kingston Upon Hull, N Humberside, England.
    Lakatos, P. L.
    Dept Med, Semmelweis Univ, Budapest, Hungary.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Munkholm, P.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe: An ECCO-EpiCom study2014In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no 7, p. 607-616Article in journal (Refereed)
    Abstract [en]

    Background and Aims: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes in environmental factors towards a more "westernised" standard of Living. The aim of this study was to investigate differences in exposure to environmental factors prior to diagnosis in Eastern and Western European IBD patients.

    Methods: The EpiCom cohort is a population-based, prospective inception cohort of 1560 unselected IBD patients from 31 European countries covering a background population of 10.1 million. At the time of diagnosis patients were asked to complete an 87-item questionnaire concerning environmental factors.

    Results: A total of 1182 patients (76%) answered the questionnaire, 444 (38%) had Crohn's disease (CD), 627 (53%) ulcerative colitis (UC), and 111 (9%) IBD unclassified. No geographic differences regarding smoking status, caffeine intake, use of oral contraceptives, or number of first-degree relatives with IBD were found. Sugar intake was higher in CD and UC patients from Eastern Europe than in Western Europe while fibre intake was lower (p < 0.01). Daily consumption of fast food as well as appendectomy before the age of 20 was more frequent in Eastern European than in Western European UC patients (p < 0.01). Eastern European CD and UC patients had received more vaccinations and experienced fewer childhood infections than Western European patients (p < 0.01).

    Conclusions: In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differed in environmental factors prior to diagnosis. Eastern European patients exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle. (C) 2013 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

  • 20.
    Burisch, J.
    et al.
    North Zealand University Hospital, Frederikssund, Denmark.
    Vardi, H.
    Ben Gurion University of the Negev, Beer Sheva, Israel.
    Schwartz, D.
    Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel.
    Krznaric, Z.
    University Hospital Center Zagreb, Zagreb, Croatia.
    Lakatos, P. L.
    Semmelweis University, Budapest, Hungary.
    Fumery, M.
    Amiens University and Hospital, Amiens, France.
    Kupcinskas, L.
    Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Magro, F.
    Hospital de São João, Porto, Portugal.
    Belousova, E.
    Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
    Oksanen, P.
    Tampere University Hospital, Tampere, Finland.
    Arebi, N.
    Imperial College London, London, UK.
    Langholz, E.
    Herlev University Hospital, Herlev, Denmark.
    Turcan, S.
    State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
    D'Inca, R.
    Azienda Ospedaliera di Padova, Padova, Italy.
    Hernandez, V.
    Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
    Valpiani, D.
    Morgagni Hospital, Forli, Italy.
    Vegh, Z.
    Semmelweis University, Budapest, Hungary.
    Giannotta, M.
    Careggi Regional Referral Center for Inflammatory Bowel Disease, Florence, Italy.
    Katsanos, K. H.
    University Hospital, Ioannina, Greece.
    Duricova, D.
    Charles University, Prague, Czech Republic.
    Nielsen, K. R.
    National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
    Kievit, H. A. L.
    Herning Hospital, Herning, Denmark.
    Ellul, P.
    Mater Dei Hospital, Msida, Malta.
    Salupere, R.
    Tartu University Hospital, Tartu, Estonia.
    Goldis, A.
    University of Medicine ‘Victor Babes’, Timisoara, Romania.
    Kaimakliotis, I.
    American Gastroenterology center, Nicosia, Cyprus.
    Pedersen, N.
    Slagelse Hospital, Department of medicine, Denmark.
    Andersen, V.
    Regional Hospital of Viborg, Viborg, Denmark.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Sebastian, S.
    Hull and East Yorkshire NHS Trust, Hull, UK.
    Dahlerup, J. F.
    Aarhus University Hospital, Aarhus, Denmark.
    Munkholm, P.
    North Zealand University Hospital, Frederikssund, Denmark.
    Odes, S.
    Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel.
    Cost analysis in a prospective European population-based inception cohort: is there a cost-saving effect of biological therapy?2019In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 13, no Suppl. 1, p. S9-S10Article in journal (Other academic)
  • 21.
    Burisch, J.
    et al.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Vegh, Z.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark; Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Pedersen, N.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Cukovic-Cavka, S.
    Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Univ Zagreb Sch Med, Zagreb, Croatia.
    Turk, N.
    Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Univ Zagreb Sch Med, Zagreb, Croatia.
    Kaimakliotis, I.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Bortlik, M.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Shonova, O.
    Dept Gastroenterol, Hosp Ceske Budejovice, Ceske Budejovice, Czech Republic.
    Thorsgaard, N.
    Dept Med, Cent Hosp, Herning, Denmark.
    Krabbe, S.
    Dept Med, Reg Hosp, Viborg, Denmark.
    Andersen, V.
    Dept Med, Reg Hosp, Viborg, Denmark; Dept Med, Hosp Southern Jutland, Aabenraa, Denmark; Inst Reg Hlth Res, Univ Southern Denmark, Odense, Denmark.
    Dahlerup, J. F.
    Dept Med Hepatol & Gastroenterol 5, Aarhus Univ Hosp, Aarhus, Denmark.
    Kjeldsen, J.
    Dept Med Gastroenterol, Univ Hosp, Odense, Denmark.
    Salupere, R.
    Div Gastroenterol & Endocrinol, Univ Hosp, Tartu, Estonia.
    Olsen, J.
    Dept Med, Natl Hosp Faroe Isl, Torshavn, Denmark.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Isl, Torshavn, Denmark.
    Manninen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Univ Hosp, Tampere, Finland.
    Collin, P.
    Dept Gastroenterol & Alimentary Tract Surg, Univ Hosp, Tampere, Finland.
    Katsanos, K. H.
    Sch Med, Div Internal Med 1, Univ Ioannina, Ioannina, Greece; Sch Med, Div Gastroenterol, Univ Ioannina, Ioannina, Greece.
    Tsianos, E. V.
    Sch Med, Div Internal Med 1, Univ Ioannina, Ioannina, Greece; Sch Med, Div Gastroenterol, Univ Ioannina, Ioannina, Greece.
    Ladefoged, K.
    Dept Med, Dronning Ingrids Hosp, Nuuk, Greenland.
    Ragnarsson, G.
    Sect Gastroenterol & Hepatol, Dept Internal Med, Natl Univ Hosp, Reykjavik, Iceland.
    Björnsson, E.
    Sect Gastroenterol & Hepatol, Dept Internal Med, Natl Univ Hosp, Reykjavik, Iceland.
    Bailey, Y.
    Dept Gastroenterol, Adelaide & Meath Hosp, Trinity College Dublin, Dublin, Ireland.
    O'Morain, C.
    Dept Gastroenterol, Adelaide & Meath Hosp, Trinity College Dublin, Dublin, Ireland.
    Schwartz, D.
    Odes, S.
    Dept Gastroenterol & Hepatol, Soroka Med Ctr, Beer Sheva, Israel; Ben Gurion Univ Negev, Beer Sheva, Israel .
    Politi, S. P.
    UO Med Interna & Gastroenterol, Azienda Osped Istituti Ospitalieri Cremona, Cremona, Italy; EpiCom Northern Italy Ctr, Crema Cremona, Italy; EpiCom Northern Italy Ctr, Florence, Italy; EpiCom Northern Italy Ctr, Forli, Italy; EpiCom Northern Italy Ctr, Padua, Italy; EpiCom Northern Italy Ctr, Reggio Emilia, Italy .
    Santini, A.
    Gastroenterol Unit, Careggi Hosp, Florence, Italy; EpiCom Northern Italy Ctr, Crema Cremona, Italy; EpiCom Northern Italy Ctr, Florence, Italy; EpiCom Northern Italy Ctr, Forli, Italy; EpiCom Northern Italy Ctr, Padua, Italy; EpiCom Northern Italy Ctr, Reggio Emilia, Italy .
    Kiudelis, G.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Turcan, S.
    State Univ Med & Pharm Republ Moldova, Dept Gastroenterol, Kishinev, Moldova.
    Magro, F.
    Hosp Sao Joao, Dept Gastroenterol, Oporto, Portugal; Inst Pharmacol & Therapeut, Oporto Med Sch, Oporto, Portugal; Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal.
    Barros, L.
    Hosp Vale Sousa, Oporto, Portugal.
    Lazar, D.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Nikulina, I.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Belousova, E.
    Moscow Reg Res Clin Inst, Dept Gastroenterol, Moscow, Russia.
    Sanroman, L.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Martinez-Ares, D.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Almer, S.
    Dept Med, Div Gastroenterol & Hepatol, Karolinska Inst, Stockholm, Sweden; Dept Gastroenterol UHL, Cty Council Ostergötland, Linköping, Sweden .
    Zhulina, Yaroslava
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Div Gastroenterol, Dept Med, Örebro Univ Hosp, Örebro, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medicine, Örebro University, Sweden. Div Gastroenterol, Dept Med, Örebro Univ Hosp, Örebro, Sweden.
    Arebi, N.
    St Marks Hosp, Sir Alan Parks Physiol Unit, Univ London Imperial Coll Sci Technol & Med, London, England.
    Houston, Y.
    Hull & East Yorkshire HNS Trust, Dept Gastroenterol, Kingston Upon Hull, N Humberside, England.
    Sebastian, S.
    Hull & East Yorkshire NHS Trust, Hull Royal Infirm, Kingston Upon Hull, England; Hull & York Med Sch, Hull Royal Infirm, Kingston Upon Hull, England.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Lakatos, P. L.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Munkholm, P.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Health care and patients' education in a European inflammatory bowel disease inception cohort: an ECCO-EpiCom study2014In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no 8, p. 811-818Article in journal (Refereed)
    Abstract [en]

    Background and Aims: The EpiCom study and inception cohort was initiated in 2010 in 31 centers from 14 Western and 8 Eastern European countries, covering a 10.1 million person background population. Our aim was to investigate whether there is a difference between Eastern and Western Europe in health care and education of patients with inflammatory bowel disease (IBD).

    Methods: A quality of care (QoC) questionnaire was developed in the EpiCom group consisting of 16 questions covering 5 items: time interval between the onset of symptoms and diagnosis, information, education, empathy and access to health care providers.

    Results: Of 1,515 patients, 947 (217 east/730 west) answered the QoC questionnaire. Only 23% of all patients had knowledge about IBD before diagnosis. In Eastern Europe, significantly more patients searched out information about IBD themselves (77% vs. 68%, p < 0.05), the main source was the Internet (92% vs. 88% p = 0.23). In Western Europe, significantly more patients were educated by nurses (19% vs. 1%, p < 0.05), while in Eastern Europe, gastroenterologists were easier to contact (80% vs. 68%, p < 0.05).

    Conclusion: Health care differed significantly between Eastern and Western Europe in all items, but satisfaction rates were high in both geographic regions. Because of the low awareness and the rising incidence of IBD, general information should be the focus of patient organizations and medical societies. In Western Europe IBD nurses play a very important role in reducing the burden of patient management. (c) 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

  • 22.
    Burisch, J.
    et al.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
    Weimers, P.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
    Pedersen, N.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
    Cukovic-Cavka, S.
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia .
    Vucelic, B.
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia .
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus.
    Duricova, D.
    IBD Center ISCARE, Charles University, Prague, Czech Republic.
    Bortlik, M.
    IBD Center ISCARE, Charles University, Prague, Czech Republic.
    Shonová, O.
    Gastroenterology Department, Hospital České Budějovice, České Budějovice, Czech Republic.
    Vind, I.
    Department of Medicine, Amager Hospital, Amager, Denmark .
    Avnstrøm, S.
    Department of Medicine, Amager Hospital, Amager, Denmark .
    Thorsgaard, N.
    Department of Medicine, Herning Central Hospital, Herning, Denmark .
    Krabbe, S.
    Medical Department, Viborg Regional Hospital, Viborg, Denmark .
    Andersen, V.
    Medical Department, Viborg Regional Hospital, Viborg, Denmark ; Medical Department, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark .
    Dahlerup, J. F.
    Department of Medicine V, Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark .
    Kjeldsen, J.
    Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark .
    Salupere, R.
    Division of Endocrinology and Gastroenterology, Tartu University Hospital, Tartu, Estonia .
    Olsen, J.
    Medical Department, The National Hospital of the Faroe Islands, Torshavn, Denmark.
    Nielsen, K. R.
    Medical Department, The National Hospital of the Faroe Islands, Torshavn, Denmark.
    Manninen, P.
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland .
    Collin, P.
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland .
    Katsanos, K. H.
    1st Division of Internal Medicine and Division of Gastroenterology, Medical School, University of Ioannina, Ioannina, Greece .
    Tsianos, E. V.
    1st Division of Internal Medicine and Division of Gastroenterology, Medical School, University of Ioannina, Ioannina, Greece .
    Ladefoged, K.
    Medical Department, Dronning Ingrids Hospital, Nuuk, Greenland .
    Lakatos, L.
    Department of Medicine, Csolnoky F. Province Hospital, Veszprem, Hungary .
    Ragnarsson, G.
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital, Reykjavik, Iceland .
    Björnsson, E.
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital, Reykjavik, Iceland .
    Bailey, Y.
    Department of Gastroenterology, Adelaide and Meath Hospital, Trinity College Dublin, Dublin, Ireland .
    O'Morain, C.
    Department of Gastroenterology, Adelaide and Meath Hospital, Trinity College Dublin, Dublin, Ireland .
    Schwartz, D.
    Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel ; Department of Gastroenterology and Hepatology, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Odes, S.
    Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel ; Department of Gastroenterology and Hepatology, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Valpiani, D.
    U.O. Gastroenterologia ed Endoscopia Digestiva, Ospedale Morgagni - Pierantoni, Forlì, Italy.
    Boni, M. C.
    U.O. Medicina 3 e Gastroenterologia, Azienda Ospedaliera Arcispedale S. Maria Nuova, Reggio Emilia, Italy .
    Jonaitis, L.
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania .
    Kupcinskas, L.
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania .
    Turcan, S.
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Moldova.
    Barros, L.
    Hospital de Vale de Sousa, Porto, Portugal .
    Magro, F.
    Department of Gastroenterology, Hospital São João, Porto, Portugal; Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal; IBMC - Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal.
    Lazar, D.
    Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania .
    Goldis, A.
    Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania .
    Nikulina, I.
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation .
    Belousova, E.
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation .
    Fernandez, A.
    Gastroenterology Department, POVISA Hospital, Vigo, Spain .
    Sanroman, L.
    Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain .
    Almér, S.
    Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden;Department of Gastroenterology/UHL, County Council of Östergötland, Linköping, Sweden.
    Zhulina, Yaroslava
    Örebro University Hospital. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Arebi, N.
    St. Mark's Hospital, Imperial College London, London, United Kingdom.
    Diggory, T.
    Hull and East Yorkshire NHS Trust, Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom; Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom .
    Sebastian, S.
    Hull and East Yorkshire NHS Trust, Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom; Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom .
    Lakatos, P. L.
    1st Department of Medicine, Semmelweis University, Budapest, Hungary .
    Langholz, E.
    Department of Medical Gastroenterology, Gentofte Hospital, Copenhagen, Denmark .
    Munkholm, P.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
    Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study2014In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no 9, p. 1030-1042Article in journal (Refereed)
    Abstract [en]

    Background & Aims: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.

    Methods: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.

    Results: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.

    Conclusion: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

  • 23. Burisch, Johan
    et al.
    Cukovic-Cavka, Silvija
    Kaimakliotis, Ioannis
    Shonová, Olga
    Andersen, Vibeke
    Dahlerup, Jens F
    Elkjaer, Margarita
    Langholz, Ebbe
    Pedersen, Natalia
    Salupere, Riina
    Kolho, Kaija-Leena
    Manninen, Pia
    Lakatos, Peter Laszlo
    Shuhaibar, Mary
    Odes, Selwyn
    Martinato, Matteo
    Mihu, Ion
    Magro, Fernando
    Belousova, Elena
    Fernandez, Alberto
    Almer, Sven
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences.
    Hart, Ailsa
    Munkholm, Pia
    Construction and validation of a web-based epidemiological database for inflammatory bowel diseases in Europe an EpiCom study2011In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 5, no 4, p. 342-349Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The EpiCom-study investigates a possible East-West-gradient in Europe in the incidence of IBD and the association with environmental factors. A secured web-based database is used to facilitate and centralize data registration.

    AIM: To construct and validate a web-based inception cohort database available in both English and Russian language.

    METHOD: The EpiCom database has been constructed in collaboration with all 34 participating centers. The database was translated into Russian using forward translation, patient questionnaires were translated by simplified forward-backward translation. Data insertion implies fulfillment of international diagnostic criteria, disease activity, medical therapy, quality of life, work productivity and activity impairment, outcome of pregnancy, surgery, cancer and death. Data is secured by the WinLog3 System, developed in cooperation with the Danish Data Protection Agency. Validation of the database has been performed in two consecutive rounds, each followed by corrections in accordance with comments.

    RESULTS: The EpiCom database fulfills the requirements of the participating countries' local data security agencies by being stored at a single location. The database was found overall to be "good" or "very good" by 81% of the participants after the second validation round and the general applicability of the database was evaluated as "good" or "very good" by 77%. In the inclusion period January 1st -December 31st 2010 1336 IBD patients have been included in the database.

    CONCLUSION: A user-friendly, tailor-made and secure web-based inception cohort database has been successfully constructed, facilitating remote data input. The incidence of IBD in 23 European countries can be found at www.epicom-ecco.eu.

  • 24.
    Burisch, Johan
    et al.
    Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark.
    Katsanos, Konstantinos H.
    Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece.
    Christodoulou, Dimitrios K.
    Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece.
    Barros, Luisa
    Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal.
    Magro, Fernando
    Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal; Department of Biomedicine, Institute of Pharmacology, Faculty of Medicine of Porto University, Porto, Portugal.
    Pedersen, Natalia
    Gastroenterology Department, Slagelse Hospital, Slagelse, Denmark.
    Kjeldsen, Jens
    Gastroenterology Department, Odense University Hospital, Odense, Denmark.
    Vegh, Zsuzsanna
    First Department of Medicine, Semmelweis University, Budapest, Hungary.
    Lakatos, Peter L.
    First Department of Medicine, Semmelweis University, Budapest, Hungary; Division of Gastroenterology, McGill University Health Center, Montreal, QC, Canada.
    Eriksson, Carl
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Fumery, Mathurin
    Gastroenterology Unit, Epimad Registry, CHU Amiens Sud, Amiens University Hospital, Amiens, France.
    Gower-Rousseau, Corinne
    Public Health, Epidemiology and Economic Health, Registre Epimad, Lille University and Hospital, Lille, France; Lille Inflammation Research International Center LIRIC, Lille University, Lille, France.
    Brinar, Marko
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia.
    Čuković-Čavka, Silvija
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia; School of Medicine, University of Zagreb, Zagreb, Croatia.
    Nikulina, Inna
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
    Belousova, Elena
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
    Myers, Sally
    IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK.
    Sebastian, Shaji
    IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK.
    Kiudelis, Gediminas
    Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Kupcinskas, Limas
    Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Schwartz, Doron
    Department of Gastroenterology and Hepatology, Soroka Medical Center, Beer Sheva, Israel; Ben Gurion University of the Negev; Beer Sheva, Israel.
    Odes, Selwyn
    Department of Gastroenterology and Hepatology, Soroka Medical Center, Beer Sheva, Israel; Ben Gurion University of the Negev; Beer Sheva, Israel.
    Kaimakliotis, Ioannis P.
    Nicosia Private Practice, Nicosia, Cyprus.
    Valpiani, Daniela
    U.O. Gastroenterologia ed Endoscopia digestiva, Hospital Morgagni Pierantoni, Forlì, Italy.
    D'Incà, Renata
    Department of Surgical, Oncological and Gastroenterological Sciences, Azienda, University of Padua, Padova, Italy.
    Salupere, Riina
    Division of Gastroenterology, Tartu University Hospital, University of Tartu, Tartu, Estonia.
    Zammit, Stefania Chetcuti
    Division of Gastroenterology, Mater Dei Hospital, Msida, Malta.
    Ellul, Pierre
    Division of Gastroenterology, Mater Dei Hospital, Msida, Malta.
    Duricova, Dana
    IBD Clinical and Research Centre, ISCARE, Prague, Czech Republic.
    Bortlik, Martin
    IBD Clinical and Research Centre, ISCARE, Prague, Czech Republic; Institute of Pharmacology, First Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
    Goldis, Adrian
    Clinic of Gastroenterology, University of Medicine ‘Victor Babes’, Timisoara, Romania.
    Kievit, Hendrika Adriana Linda
    Department of Medicine, Herning Central Hospital, Herning, Denmark.
    Toca, Alina
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
    Turcan, Svetlana
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
    Midjord, Jóngerð
    Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
    Nielsen, Kári Rubek
    Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
    Andersen, Karina Winther
    Medical Department, Regional Hospital of Viborg, Viborg, Denmark.
    Andersen, Vibeke
    Medical Department, Regional Hospital of Viborg, Viborg, Denmark; Focused Research Unit for Molecular Diagnostic and Clinical Research [MOK], IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
    Misra, Ravi
    IBD Department, St Mark’s Hospital, London, UK.
    Arebi, Naila
    IBD Department, St Mark’s Hospital, London, UK.
    Oksanen, Pia
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland.
    Collin, Pekka
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland.
    de Castro, Luisa
    Department of Gastroenterology, Hospital Alvaro Cunqueiro, Instituto Investigación Sanitaria Galicia Sur, EOXI de Vigo, Vigo, Spain.
    Hernandez, Vicent
    Department of Gastroenterology, Hospital Alvaro Cunqueiro, Instituto Investigación Sanitaria Galicia Sur, EOXI de Vigo, Vigo, Spain.
    Langholz, Ebbe
    Department of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark.
    Munkholm, Pia
    Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark.
    Natural Disease Course of Ulcerative Colitis During the First Five Years of Follow-up in a European Population-based Inception Cohort-An Epi-IBD Study2019In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 13, no 2, p. 198-208Article in journal (Refereed)
    Abstract [en]

    Background and Aims: Few population-based cohort studies have assessed the disease course of ulcerative colitis [UC] in the era of biological therapy and widespread use of immunomodulators. The aim of this study was to assess the 5-year outcome and disease course of patients with UC in the Epi-IBD cohort.

    Methods: In a prospective, population-based inception cohort of unselected patients with UC, patients were followed up from the time of their diagnosis, which included the collection of their clinical data, demographics, disease activity, medical therapy, and rates of surgery, cancers, and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.

    Results: A total of 717 patients were included in the study. During follow-up, 43 [6%] patients underwent a colectomy and 163 [23%] patients were hospitalised. Of patients with limited colitis [distal to the left flexure], 90 [21%] progressed to extensive colitis. In addition, 92 [27%] patients with extensive colitis experienced a regression in disease extent, which was associated with a reduced risk of hospitalisation (hazard ratio [HR]: 0.5 95% CI: 0.3-0.8]. Overall, patients were treated similarly in both geographical regions; 80 [11%] patients needed biological therapy and 210 [29%] patients received immunomodulators. Treatment with immunomodulators was found to reduce the risk of hospitalisation [HR: 0.5 95% CI: 0.3-0.8].

    Conclusions: Although patients in this population-based cohort were treated more aggressively with immunomodulators and biological therapy than in cohorts from the previous two decades, their disease outcomes, including colectomy rates, were no different. However, treatment with immunomodulators was found to reduce the risk of hospitalisation.

  • 25.
    Burisch, Johan
    et al.
    Department of Gastroenterology, North Zealand University Hospital, Frederikssund, Denmark.
    Vegh, Zsuzsanna
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Katsanos, Konstantinnos H
    1st Division of Internal Medicine and Hepato-Gastroenterology Unit, University Hospital, Ioannina, Greece.
    Christodoulou, Dimitrios K
    1st Division of Internal Medicine and Hepato-Gastroenterology Unit, University Hospital, Ioannina, Greece.
    Lazar, Daniela
    Clinic of Gastroenterology, University of Medicine ‘Victor Babes’, Timisoara, Romania.
    Goldis, Adrian
    Clinic of Gastroenterology, University of Medicine ‘Victor Babes’, Timisoara, Romania.
    O'Morain, Colm
    Department of Gastroenterology, Adelaide and Meath Hospital, Trinity College Dublin, Dublin, Ireland.
    Fernandez, Alberto
    Department of Gastroenterology. POVISA Hospital, Vigo, Spain.
    Pereira, Santos
    Department of Gastroenterology. Instituto de Investigación Sanitaria Galicia Sur, Estrutura Organizativa de Xestión Integrada de Vigo, Vigo, Spain.
    Myers, Sally
    IBD Unit, Hull & East Yorkshire NHS Trust, Hull, UK.
    Sebastian, Shaji
    IBD Unit, Hull & East Yorkshire NHS Trust, Hull, UK.
    Pedersen, Natalia
    Gastroenterology Department, Slagelse Hospital, Slagelse, Denmark.
    Olsen, Jóngerð
    Medical Department, National Hospital of the Faroe Islands, Torshavn, Denmark.
    Nielsen, Kári Rubek
    Medical Department, National Hospital of the Faroe Islands, Torshavn, Denmark.
    Schwartz, Doron
    Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Odes, Selwyn
    Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Almer, Sven
    Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Turk, Niksa
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb,Zagreb, Croatia.
    Cukovic-Cavka, Silvja
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb,Zagreb, Croatia.
    Nikulina, Inna
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
    Belousova, Elena
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
    Duricova, Dana
    IBD Clinical and Research Centre ISCARE, Charles University, Prague, Czech Republic.
    Bortlik, Martin
    IBD Clinical and Research Centre ISCARE, Charles University, Prague, Czech Republic; Institute of Pharmacology, 1st Medical Faculty, Charles University, Prague, Czech Republic.
    Shonová, Olga
    Gastroenterology Department, Hospital České Budějovice, České Budějovice, Czech Republic.
    Salupere, Riina
    Division of Gastroenterology, Tartu University Hospital,Tartu, Estonia.
    Barros, Louisa
    Department of Medicine, Hospital de Vale de Sousa, Porto, Portugal.
    Magro, Fernando
    Department of Gastroenterology, Hospital de São João, Porto, Portugal; Institute of Pharmacology and Therapeutics, Oporto Medical School, Porto, Portugal; Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal.
    Jonaitis, Laimas
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Kupcinskas, Limas
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Turcan, Svetlana
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
    Kaimakliotis, Ioannis
    Nicosia private practice, Nicosia, Cyprus.
    Ladefoged, Karin
    Medical Department, Dronning Ingrids Hospital Greenland, Nuuk, Denmark.
    Kudsk, Karen
    Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
    Andersen, Vibeke
    Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Laboratory Center, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
    Vind, Ida
    Gastrounit, Medical Division, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
    Thorsgaard, Niels
    Department of Medicine, Herning Central Hospital, Herning, Denmark.
    Oksanen, Pia
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
    Collin, Pekka
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
    Dal Piaz, Giulia
    Dipartimento Medicina Specialistica Gastroenterologia ed Endoscopia Digestiva, Ospedale Morgagni-Pierantoni, Forlì, Italy.
    Santini, Alessia
    Gastroenterology Unit, Careggi Hospital, Florence, Italy.
    Niewiadomski, Ola
    Department of Gastroenterology, St Vincent’s Hospital, Melbourne VIC, Australia.
    Bell, Sally
    Department of Gastroenterology, St Vincent’s Hospital, Melbourne VIC, Australia.
    Moum, Bjørn
    Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.
    Arebi, Naila
    St Mark’s Hospital, Imperial College London, London, UK.
    Kjeldsen, Jens
    Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark.
    Carlsen, Katrine
    Department of Pediatrics, Hvidovre University Hospital, Hvidovre, Denmark.
    Langholz, Ebbe
    Department of Gastroenterology, Herlev Univerisity Hospital, Herlev, Denmark.
    Lakatos, Peter Laszlo
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Munkholm, Pia
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Gerdes, Lars Ulrik
    Center for Quality, Region of Southern Denmark, Middelfart, Denmark.
    Dahlerup, Jens Frederik
    Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
    The EpiCom study group, Group author
    Occurrence of anaemia in the first year of inflammatory bowel disease in a European population-based inception cohort: An ECCO-EpiCom study2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no 10, p. 1213-1222Article in journal (Refereed)
    Abstract [en]

    Background and aims: Anaemia is an important complication of inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of anaemia and the practice of anaemia screening during the first year following diagnosis in a European prospective population-based inception cohort.

    Methods: Newly diagnosed IBD patients were included and followed prospectively for one year in 29 European and 1 Australian centre. Clinical data including demographics, medical therapy, surgery and blood samples were collected. Anaemia was defined according to the World Health Organization.

    Results: A total of 1,871 patients (CD: 686, 88%; UC: 1,021, 87%; IBDU 164. 81%) were included in the study. The prevalence of anaemia was higher in CD than in UC patients and overall, 49% of CD and 39% of UC patients had at least one instance of anaemia during the first 12 months after diagnosis. UC patients with more extensive disease and those from Eastern European countries, and CD patients with penetrating disease or colonic disease location, had higher risks of anaemia. CD and UC patients in need of none or only mild anti-inflammatory treatment had a lower risk of anaemia. In a significant proportion of patients, anaemia was not assessed until several months after diagnosis, and in almost half of all cases of anaemia a thorough work-up was not performed.

    Conclusions: Overall, 42% of patients had at least one instance of anaemia during the first year following diagnosis. Most patients were assessed for anaemia regularly; however, a full anaemia work-up was frequently neglected in this community setting.

  • 26.
    Burke, Kristin E.
    et al.
    Gastroenterology Unit, Massachusetts General Hospital, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA; Harvard Medical School, Boston MA, USA.
    Ananthakrishnan, Ashwin N.
    Gastroenterology Unit, Massachusetts General Hospital, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, BostonMA, USA; Harvard Medical School, Boston MA, USA.
    Lochhead, Paul
    Gastroenterology Unit, Massachusetts General Hospital, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA; Harvard Medical School, Boston MA, USA.
    Olen, Ola
    Pediatric Gastroenterology and Nutrition Unit, Sachs' Children's Hospital, Stockholm, Sweden; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Ludvigsson, Jonas F.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Pediatrics, Örebro University Hospital, Örebro, Sweden; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Richter, James M.
    Gastroenterology Unit, Massachusetts General Hospital, Boston MA, USA; Harvard Medical School, Boston MA, USA.
    Chan, Andrew T.
    Gastroenterology Unit, Massachusetts General Hospital, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA; Harvard Medical School, Boston MA, USA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston MA, USA.
    Khalili, Hamed
    Gastroenterology Unit, Massachusetts General Hospital, Boston MA, USA; Clinical and Translational Epidemiology Unit, Massachusetts General Hospital, Boston MA, USA; Harvard Medical School, Boston MA, USA; Karolinska Clinical Epidemiology Unit, Karolinska Institutet, Solna, Sweden.
    Smoking is Associated with an Increased Risk of Microscopic Colitis: Results From Two Large Prospective Cohort Studies of US Women2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no 5, p. 559-567Article in journal (Refereed)
    Abstract [en]

    Introduction: Long-term data on the influence of smoking on risk of microscopic colitis are limited. We therefore sought to examine and characterize the association between smoking and risk of incident microscopic colitis in two large prospective cohorts of women.

    Methods: We conducted a prospective study of 231,015 women enrolled in the Nurses' Health Study (NHS) and NHSII. Information regarding smoking, other lifestyle factors, and medications were collected biennially from 1976 to 2012 in NHS and 1989 to 2013 in NHSII. Incident cases of microscopic colitis were confirmed through physician medical record review. We used Cox proportional hazards modeling to examine the association between smoking and risk of microscopic colitis.

    Results: We documented 166 incident cases of microscopic colitis over 6,122,779 person-years of follow up. Compared to non-smokers, the multivariable-adjusted hazard ratio (HR) for microscopic colitis was 2.52 (95% CI 1.59 - 4.00) amongst current smokers and 1.54 (95% CI 1.09 - 2.17) amongst past smokers. The risk increased with higher pack-years of smoking (Ptrend = 0.001) and diminished following smoking cessation (Ptrend = 0.017). Current smoking appeared to be more strongly associated with risk of collagenous colitis (3.68; 95% CI 1.94 - 6.97) than lymphocytic colitis (HR 1.71; 95% CI 0.83 - 3.53).

    Conclusion: In two large prospective cohort studies, we observed an association between current smoking and risk of microscopic colitis. Risk of microscopic colitis appeared to increase with higher pack-years and diminish following smoking cessation. Future studies focused on characterizing the biologic mechanisms underlying these associations are warranted.

  • 27.
    Busch, Katharina
    et al.
    Dept Med Solna, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden.
    da Silva, Simone A.
    Dept Prevent Med, Univ Sao Paulo, Sao Paulo, Brazil.
    Holton, Michelle
    Lorimer Enterprises Inc, Red Deer AB, Canada.
    Rabacow, Fabiana M.
    Dept Prevent Med, Univ Sao Paulo, Sao Paulo, Brazil.
    Khalili, Named
    Digest Healthcare Ctr, Massachusetts Gen Hosp, Boston, USA.
    Ludvigsson, Jonas F.
    Örebro University Hospital. Dept Pediat, Örebro University Hospital, Örebro, Sweden; Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden.
    Sick leave and disability pension in inflammatory bowel disease: A systematic review2014In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no 11, p. 1362-1377Article, review/survey (Refereed)
    Abstract [en]

    Background & aims: Inflammatory bowel disease has considerable effects on work-related outcomes and leads to high societal costs due to sick leave and disability pension. The aims of this study were to systematically review evidence on work-related outcomes that are relevant to productivity losses and to evaluate whether medical or surgical interventions have a positive impact on patients work ability.

    Methods: A systematic literature search in PubMed was conducted in June 2013. Abstracts were screened by two independent reviewers, and full-text articles describing the frequency of work-related outcomes were retrieved. Two independent reviewers extracted data according to the PRISMA Statement for Reporting Systematic Reviews and Meta-Analyses. Findings were organized by study design (non-interventional/interventional). Non-interventional studies were structured according to whether they presented data in comparison to control groups or not and interventional studies were summarized according to type of intervention.

    Results: This review included 30 non-interventional (15 with comparison groups and 15 without comparison group) and 17 interventional studies (9 surgical and 8 medical). The majority of the studies reported a high burden of work:related outcomes among inflammatory bowel disease patients regardless of the methodology used. While biologic agents showed positive effect on work absenteeism and presenteeism in randomized clinical trials, the impact of surgical interventions needs further evaluation.

    Conclusions: Inflammatory bowel disease patients experience a high burden in work-related outcomes. Additional data on productivity losses and the long-term impact of interventions is needed to help inform decision-makers about treatment options and their benefits in reducing productivity losses in inflammatory bowel disease patients. (C) 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

  • 28.
    Chen, Jie
    et al.
    Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Centre for Global Health, Zhejiang University School of Medicine, Hangzhou, China; Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
    Zhou, Yajing
    Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
    Sun, Yuhao
    Centre for Global Health, Zhejiang University School of Medicine, Hangzhou, China.
    Yuan, Shuai
    Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China; Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
    Kalla, Rahul
    Edinburgh IBD Science Unit, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
    Sun, Jing
    Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
    Zhao, Jianhui
    Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
    Wang, Lijuan
    Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
    Chen, Xuejie
    Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
    Zhou, Xuan
    Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
    Dai, Siqi
    Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.
    Zhang, Yu
    Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University, Hangzhou, China.
    Ho, Gwo-Tzer
    Edinburgh IBD Science Unit, Centre for Inflammation Research, University of Edinburgh, Edinburgh, UK.
    Xia, Dajing
    Department of Toxicology of School of Public Health, & Center of Immunology & Infection, Zhejiang University School of Medicine, Hangzhou, China.
    Cao, Qian
    Department of Gastroenterology, Sir Run Run Shaw Hospital, College of Medicine Zhejiang University, Hangzhou, China.
    Liu, Zhanju
    Center for IBD Research, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China.
    Larsson, Susanna C.
    Unit of Cardiovascular and Nutritional Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; Unit of Medical Epidemiology, Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
    Wang, Xiaoyan
    Department of Gastroenterology, The Third Xiangya Hospital, Central South University, Changsha, China.
    Ding, Kefeng
    Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital, Zhejiang University School of Medicine, Zhejiang, China.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Li, Xue
    Department of Big Data in Health Science, School of Public Health and The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China.
    Theodoratou, Evropi
    Centre for Global Health, Usher Institute, University of Edinburgh, Edinburgh, UK; Cancer Research UK Edinburgh Centre, Medical Research Council Institute of Genetics and Cancer, University of Edinburgh, Edinburgh, UK.
    Satsangi, Jack
    Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, UK.
    Bidirectional Mendelian randomization analysis provides evidence for the causal involvement of dysregulation of CXCL9, CCL11 and CASP8 in the pathogenesis of ulcerative colitis2023In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 17, no 5, p. 777-785Article in journal (Refereed)
    Abstract [en]

    BACKGROUND AND AIMS: Systemic inflammation is well-recognized to be associated with ulcerative colitis (UC), but whether these effects are causal or consequential remains unclear. We aimed to define potential causal relationship of cytokine dysregulation with different tiers of evidence.

    METHODS: We firstly synthesized serum proteomic profiling data from two multi-centered observational studies, in which a panel of systemic inflammatory proteins was analyzed to examine their associations with UC risk. To further dissect observed associations, we then performed a bidirectional two-sample Mendelian randomization (TSMR) analysis from both forward and reverse directions using five genome-wide association study (GWAS) summary level data for serum proteomic profiles and the largest GWAS of 28,738 European-ancestry individuals for UC risk.

    RESULTS: Pooled analysis of serum proteomic data identified 14 proteins to be associated with the risk of UC. Forward MR analysis using only cis-acting protein quantitative trait loci (cis-pQTLs) or trans-pQTLs further validated causal associations of two chemokines and the increased risk of UC: C-X-C motif chemokine ligand 9 (CXCL9) (OR, 1.45, 95% CI, 1.08-1.95, P=.012) and C-C motif chemokine ligand 11 (CCL11) (OR, 1.14, 95%CI: 1.09-1.18, P=3.89×10  -10). Using both cis- and trans-acting pQTLs, an association of caspase-8 (CASP8) (OR, 1.04, 95% CI, 1.03-1.05, P= 7.63×10  -19) was additionally identified. Reverse MR did not find any influence of genetic predisposition to UC on any of these three inflammation proteins.

    CONCLUSIONS: Pre-existing elevated levels of CXCL9, CCL11 and CASP8 may play a role in the pathogenesis of UC.

  • 29.
    Eriksson, Carl
    et al.
    Örebro University, School of Medical Sciences.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences.
    Vigren, L.
    Dept Med, Div Gastroenterol, Hosp Trelleborg, Trelleborg, Sweden.
    Nilsson, L.
    Dept Internal Med, Danderyd Hosp, Stockholm, Sweden.
    Visuri, Isabella
    Örebro University, School of Medical Sciences.
    Hjortswang, H.
    Dept Gastroenterol, Linköping Univ, Linköping, Sweden; Dept Clin & Expt Med, Linköping, Sweden.
    Udumyan, Ruzan
    Örebro University, School of Medical Sciences.
    Almer, S.
    Dept Med, Gastrocentrum, Karolinska Inst, Stockholm, Sweden.
    Seddighzadeh, M.
    Merck Sharp & Dohme Ltd, Stockholm, Sweden.
    Hertervig, E.
    Dept Gastroenterol, Skane Univ Hosp, Lund, Sweden.
    Karlen, P.
    Dept Internal Med, Danderyd Hosp, Stockholm, Sweden.
    Strid, H.
    Dept Internal Med, Södra Älvsborgs Hosp, Borås, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Clinical effectiveness of golimumab: Interim analysis of the observational study of patients with ulcerative colitis on golimumab in the Swedish National Quality Registry for IBD-GO-SWIBREG2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S409-S410Article in journal (Other academic)
  • 30.
    Eriksson, Carl
    et al.
    Örebro University, School of Medical Sciences.
    Rundquist, Sara
    Örebro University, School of Medical Sciences.
    Cao, Yang
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Montgomery, Scott
    Örebro University, School of Medical Sciences.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    The impact of thiopurine drugs on the natural history and surgical outcome of ulcerative colitis: A cohort study2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S481-S481Article in journal (Other academic)
  • 31.
    Eriksson, Carl
    et al.
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Rundquist, Sara
    Örebro University, School of Medical Sciences.
    Lykiardopoulos, B.
    Department of Gastroenterology, Linköping University, Linköping, Sweden.
    Karlén, P.
    Department of Internal Medicine, Danderyd Hospital, Stockholm, Sweden.
    Grip, O.
    Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden.
    Söderman, C.
    Department of Internal Medicine, St Göran Hospital, Stockholm, Sweden.
    Almer, S.
    Department of Medicine, Center for Digestive Diseases, Karolinska University Hospital, Karolinska Institute, Stockholm, Sweden.
    Hertervig, E.
    Department of Gastroenterology, Skåne University Hospital, Lund, Sweden.
    Gunnarsson, J.
    Department of Internal Medicine, Kungsbacka Hospital, Kungsbacka, Sweden.
    Delin, J.
    Department of Gastroenterology, Ersta hospital, Stockholm, Sweden.
    Strid, H.
    Department of Internal Medicine, Södra Älvsborgs Sjukhus, Borås, Sweden.
    Sjöberg, M.
    Department of Internal Medicine, Skaraborgs Hospital, Lidköping, Sweden.
    Öberg, D.
    Department of Internal Medicine, Sunderby Hospital, Sunderbyn, Sweden.
    Hjortswang, H.
    Department of Gastroenterology, Linköping University, Linköping, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    A Swedish observational study (SVEAH) on vedolizumab assessing effectiveness and healthcare resource utilization in patients with inflammatory bowel disease2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S262-S263Article in journal (Refereed)
  • 32.
    Eriksson, Carl
    et al.
    Örebro University, School of Medical Sciences.
    Rundquist, Sara
    Örebro University, School of Medical Sciences.
    Lykiardopoulos, V.
    Dept Gastroenterol, Linköping Univ, Linköping, Sweden.
    Karlen, P.
    Dept Internal Med, Danderyd Hosp, Stockholm, Sweden.
    Grip, O.
    Dept Gastroenterol, Skane Univ Hosp, Malmö, Sweden.
    Söderman, C.
    Dept Internal Med, St Goran Hosp, Stockholm, Sweden.
    Almer, S.
    Dept Med, Karolinska Inst, Stockholm, Sweden.
    Hertervig, E.
    Dept Gastroenterol, Skåne Univ Hosp, Lund, Sweden.
    Gunnarsson, J.
    Dept Internal Med, Kungsbacka Hosp, Kungsbacka, Sweden.
    Malmgren, C.
    Takeda Pharma AB, Solna, Sweden.
    Delin, J.
    Dept Gastroenterol, Ersta Hosp, Stockholm, Sweden.
    Strid, H.
    Dept Internal Med, Södra Älvsborgs Hosp, Borås, Sweden.
    Sjöberg, M.
    Dept Internal Med, Skaraborgs Hosp, Lidköping, Sweden.
    Öberg, D.
    Dept Internal Med, Sunderby Hosp, Sunderbyn, Sweden.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences.
    Udumyan, Ruzan
    Örebro University, School of Medical Sciences.
    Hjortswang, H.
    Dept Gastroenterol, Linköping Univ, Linöping, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Clinical effectiveness of vedolizumab: Interim analysis of the Swedish observational study on vedolizumab assessing effectiveness and healthcare resource utilisation in patients with Crohn's disease (SVEAH CD)2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S494-S495Article in journal (Other academic)
  • 33.
    Eriksson, Carl
    et al.
    Örebro University, School of Medical Sciences.
    Rundquist, Sara
    Örebro University, School of Medical Sciences.
    Lykiardopoulos, V.
    Dept Gastroenterol, Linköping Univ, Linköping, Sweden.
    Karlen, P.
    Dept Internal Med, Danderyd Hosp, Stockholm, Sweden.
    Grip, O.
    Dept Gastroenterol, Skåne Univ Hosp, Malmö, Sweden.
    Söderman, C.
    Dept Internal Med, St Göran Hosp, Stockholm, Sweden.
    Almer, S.
    Dept Med, Karolinska Inst, Stockholm, Sweden.
    Hertervig, E.
    Dept Gastroenterol, Skåne Univ Hosp, Lund, Sweden.
    Gunnarsson, J.
    Dept Internal Med, Kungsbacka Hosp, Kungsbacka, Sweden.
    Malmgren, C.
    Takeda Pharma AB, Solna, Sweden.
    Delin, J.
    Dept Gastroenterol, Ersta Hosp, Stockholm, Sweden.
    Strid, H.
    Dept Internal Med, Södra Älvsborgs Hosp, Borås, Sweden.
    Sjöberg, M.
    Dept Internal Med, Skaraborgs Hosp, Lidköping, Sweden.
    Öberg, D.
    Dept Internal Med, Sunderby Hosp, Sunderbyn, Sweden.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences.
    Udumyan, Ruzan
    Örebro University, School of Medical Sciences.
    Hjortswang, H.
    Dept Gastroenterol, Linköping Univ, Linköping, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Clinical effectiveness of vedolizumab: Interim analysis of the Swedish observational study on vedolizumab assessing effectiveness and healthcare resource utilisation in patients with ulcerative colitis (SVEAH UC)2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S382-S383Article in journal (Other academic)
  • 34.
    Eriksson, Carl
    et al.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Rundquist, Sara
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Lykiardopoulos, V.
    Department of Gastroenterology, Linköping University, Linköping, Sweden.
    Udumyan, Ruzan
    Örebro University, School of Medical Sciences. Clinical Epidemiology and Biostatistics.
    Karlén, P.
    Department of Internal Medicine, Danderyd Hospital, Stockholm, Sweden.
    Grip, O.
    Department of Gastroenterology, Skåne University Hospital, Malmö, Sweden.
    Söderman, C.
    Department of Internal Medicine, St Göran Hospital, Stockholm, Sweden.
    Almer, S.
    BD-Unit-Gastroenterology, Karolinska University Hospital, Stockholm, Sweden.
    Hertervig, E.
    Department of Gastroenterology, Skåne University Hospital, Lund, Sweden.
    Gunnarsson, J.
    Department of Internal Medicine, Kungälv Hospital, Kungälv, Sweden.
    Malmgren, C.
    Takeda Pharma AB, Takeda, Stockholm, Sweden.
    Delin, J.
    Department of Gastroenterology, Ersta Hospital, Stockholm, Sweden.
    Strid, H.
    Department of Internal Medicine, Södra Älvsborgs Hospital, Borås, Sweden.
    Sjöberg, M.
    Department of Internal Medicine, Skaraborgs Hospital, Lidköping, Sweden.
    Öberg, D.
    Department of Internal Medicine, Sunderby Hospital, Sunderbyn, Sweden.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Hjortswang, H.
    Department of Gastroenterology, Linköping University, Linköping, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Real-world effectiveness of vedolizumab in ulcerative colitis: Week 52 results from the Swedish multi-centre, prospective, observational SVEAH UC study2020In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 14, no Suppl. 1, p. S576-S577Article in journal (Other academic)
  • 35.
    Everhov, Åsa H.
    et al.
    Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Bruze, Gustaf
    Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Söderling, Jonas
    Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Askling, Johan
    Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Westberg, Karin
    Dept. of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Division of surgery, Danderyd Hospital, Stockholm, Sweden.
    Malmborg, Petter
    Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Nordenvall, Caroline
    Dept. of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Dept. of Pelvic Cancer, Karolinska University Hospital, Stockholm, Sweden.
    Ludvigsson, Jonas F.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden.
    Olén, Ola
    Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Pediatric Gastroenterology and Nutrition, Sachs' Children and Youth Hospital, Stockholm, Sweden.
    Women's earnings are more affected by inflammatory bowel disease than men's: a register-based Swedish cohort study2021In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 15, no 6, p. 980-987Article in journal (Refereed)
    Abstract [en]

    BACKGROUND/AIM: Patients with inflammatory bowel disease (IBD) have more work disability than the general population. We aimed to estimate the monetary cost of IBD for the individual through assessment of earnings in relation to diagnosis.

    METHODS: Through linkage of national registers we identified patients aged 30-55 years at first IBD diagnosis in Sweden 2002-2011, and same-sex IBD-free siblings. We estimated taxable earnings and disposable income from 5 years before to 5 years after diagnosis.

    RESULTS: The 5,961 patients (27% Crohn's disease, 68% ulcerative colitis, 4.3% IBD unclassified) had similar taxable earnings as their 7,810 siblings until the year of diagnosis, when earnings decreased and remained lower than in siblings during follow-up. The adjusted difference in earnings over the entire 5-year period after diagnosis was -5% (-8,212€; 95%CI: -11,458 to-4,967). The difference was larger in women than in men, and larger in Crohn's disease than in ulcerative colitis. When stratifying for sex and IBD subtype and comparing earnings during each year of follow-up, the median annual earnings were lower in women with Crohn's disease and ulcerative colitis than in their sisters during all years of follow-up, whereas the men had similar annual taxable earnings as their brothers. The disposable income was similar between patients and siblings during the investigated time period.

    CONCLUSION: From the year of diagnosis and at least 5 years onwards, patients with IBD had 5% lower earnings than siblings, mainly explained by differences between women with IBD and their sisters. However, there were no differences in disposable income.

  • 36.
    Everhov, Åsa H.
    et al.
    Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Khalili, Hamed
    Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Gastroenterology Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
    Askling, Johan
    Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Myrelid, Pär
    Division of Surgery, Department of Clinical and Experimental Medicine, Faulty of Health Sciences, Linköping University, Linköping, Sweden; Department of Surgery, County Council of Östergötland, Linköping, Sweden.
    Ludvigsson, Jonas F.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Nordenvall, C.
    Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden; Center for Digestive Disease, Division of Coloproctology, Karolinska University Hospital, Stockholm, Sweden.
    Söderling, Jonas
    Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Olén, Ola
    Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet, Stockholm, Sweden; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Department of Pediatric gastroenterology and Nutrition, Sachs' Children and Youth Hospital, Stockholm, Sweden.
    Neovius, Martin
    Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Sick Leave and Disability Pension in Prevalent Patients With Crohn's Disease2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no 12, p. 1418-1428Article in journal (Refereed)
    Abstract [en]

    Background and Aims: Crohn's disease may affect the ability to work and lead to permanent disability. We aimed to investigate work loss in prevalent patients.

    Methods: We identified patients with Crohn's disease and general population comparators matched by sex, birth year, healthcare region and education. We assessed days of sick leave and disability pension retrieved from the Swedish Social Insurance Agency and estimated the absolute and relative risk of receiving disability pension [minimum 25% work impairment].

    Results: In 2014, the 20638 Crohn's disease patients [median age 44 years] had more than twice as many mean lost workdays [disability pension: 44; sick leave: 19] as the 102038 comparators [disability pension: 20; sick leave: 8], mean difference 35 days [95% confidence interval 33-37]. However, the majority had no lost workdays [68% of patients and 85% of comparators]. The proportion of patients receiving disability pension was 15% (6.5% in the comparators, risk ratio 2.34 [2.25-2.43]) and was higher in all subgroups, especially in female patients [28% vs 13% in the comparators], in those with ≤9 years of education [41% vs 23%] and in ages 60-64 years [46% vs 25%]. The relative risk of disability pension within the patient cohort [adjusted for age, sex, region and education] was higher in patients with complicated disease behaviour, extraintestinal manifestations, need of surgery or treatment with biologics. The differences between patients and comparators remained when comparing other calendar years [2006-2013].

    Conclusion: Work loss was found in approximately one-third of patients. The mean number of lost workdays was twice as high as in the comparators.

  • 37.
    Fart, Frida
    et al.
    Örebro University, School of Medical Sciences.
    Salihovic, Samira
    Örebro University, School of Medical Sciences.
    McGlinchey, Aidan J
    Örebro University, School of Medical Sciences.
    Oresic, Matej
    Örebro University, School of Medical Sciences. Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Hyötyläinen, Tuulia
    Örebro University, School of Science and Technology.
    Schoultz, Ida
    Örebro University, School of Medical Sciences.
    Per- and polyfluoroalkyl substances (PFAS) are significantly increased in patients with late-onset of ulcerative colitis2020In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 14, no Suppl. 1, p. S138-S139Article in journal (Other academic)
  • 38.
    Halfvarson, Jonas
    et al.
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Ludvigsson, Jonas F.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Medical Epidemiology and Biostatistics.
    Sachs, M.
    Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Askling, J.
    Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Olén, O.
    Clinical Epidemiology Division, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Age determines the risk of familial IBD: A nationwide case-control study2020In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 14, no Suppl. 1, p. S592-S593Article in journal (Other academic)
  • 39.
    Hansen, S. Hyll
    et al.
    Oslo University Hospital, Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo, Norway; Oslo University Hospital, Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo, Norway; University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, Norway.
    Maseng, M. Gjerstad
    University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, Norway; Bio-Me, Oslo, Norway; Oslo University Hospital, Department of Gastroenterology, Oslo, Norway.
    Björkqvist, Olle
    Örebro University, School of Medical Sciences.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Bang, C.
    Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany.
    Detlie, T. E.
    University of Oslo, University of Oslo, Oslo, Norway; Akershus University Hospital, Department of Gastroenterology, Lørenskog, Norway.
    Huppertz-Hauss, G.
    Telemark Hospital, Department of Gastroenterology, Skien, Norway.
    Kristensen, V.
    Oslo University Hospital, Department of Gastroenterology, Oslo, Norway; Lovisenberg Diaconal Hospital, Unger-Vetlesen Insitute, Oslo, Norway.
    Opheim, R.
    Oslo University Hospital, Department of Gastroenterology, Oslo, Norway; University of Oslo, Department of Public Health, Institute of Health and Society, Oslo, Norway.
    Perminow, G.
    Oslo University Hospital, Pediatric Department, Oslo, Norway.
    Asak, Ø.
    Innlandet Hospital Trust, Medical Department, Oslo, Norway.
    Bengtson, M. B.
    Akershus University Hospital, Department of Gastroenterology, Lørenskog, Norway.
    Cetinkaya, R. Boyar
    Diakonhjemmet Hospital, Department of Medicine, Oslo, Norway.
    Henriksen, M.
    Østfold Hospital Trust, Department of Gastroenterology, Grålum, Norway.
    Hovde, Ø.
    University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, Norway; Innlandet Hospital Trust, Department of Medicine, Gjøvik, Norway.
    Medhus, A. W.
    University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, Norway; Oslo University Hospital, Department of Gastroenterology, Oslo, Norway.
    Pallenschat, J.
    Sørlandet Hospital Flekkefjord, Department of Medicine, Flekkefjord, Norway.
    Strande, V.
    University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, Norway; Lovisenberg Diaconal Hospital, Department of Medicine/Gastroenterology, Oslo, Norway; Lovisenberg Diaconal Hospital, Unger-Vetlesen Institute, Oslo, Norway.
    Valeur, J.
    Lovisenberg Diaconal HospitaLovisenberg Diaconal Hospital, Unger-Vetlesen Institute, Oslo, Norway.
    Vatn, S. Svendsen
    Akershus University Hospital, Department of Gastroenterology, Lørenskog, Norway.
    Aabrekk, T. Bergene
    Vestfold Hospital Trust, Medical Department, Tønsberg, Norway.
    Høivik, M. L.
    Oslo University Hospital, Department of Gastroenterology, Oslo, Norway.
    Hov, J. R.
    Oslo University Hospital, Norwegian PSC Research Center, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo, Norway; Oslo University Hospital, Research Institute of Internal Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo, Norway; University of Oslo, Institute of Clinical Medicine, Faculty of Medicine, Oslo, Norway; Oslo University Hospital, Section of Gastroenterology, Department of Transplantation Medicine, Division of Surgery, Inflammatory Diseases and Transplantation, Oslo, Norway.
    Gut microbiota at diagnosis is associated with clinical features and future disease course in Inflammatory Bowel Disease: Data from IBSEN III, a new large Norwegian population-based inception cohort2023In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 17, no Suppl. 1, p. 1028-1029, article id P920Article in journal (Other academic)
  • 40.
    Heap, Graham A.
    et al.
    BD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, Exeter, UK; Precision Medicine Exeter, University of Exeter, Exeter, UK .
    Halfvarson, Jonas
    Örebro University, School of Medicine, Örebro University, Sweden. Department of Gastroenterology, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
    Ahmad, Tariq
    BD Pharmacogenetics, Royal Devon and Exeter Foundation Trust, Exeter, UK; Precision Medicine Exeter, University of Exeter, Exeter, UK .
    Clinical Features and HLA Association of 5-Aminosalicylate (5-ASA)-induced Nephrotoxicity in Inflammatory Bowel Disease2016In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 10, no 2, p. 149-158Article in journal (Refereed)
    Abstract [en]

    Background and Aims: Nephrotoxicity is a rare idiosyncratic reaction to 5-aminosalicylate (5-ASA) therapies. The aims of this study were to describe the clinical features of this complication and identify clinically useful genetic markers so that these drugs can be avoided or so that monitoring can be intensified in high-risk patients.

    Methods: Inflammatory bowel disease patients were recruited from 89 sites around the world. Inclusion criteria included normal renal function prior to commencing 5-ASA, >= 50% rise in creatinine any time after starting 5-ASA, and physician opinion implicating 5-ASA strong enough to justify drug withdrawal. An adjudication panel identified definite and probable cases from structured case report forms. A genome-wide association study was then undertaken with these cases and 4109 disease controls.

    Results: After adjudication, 151 cases of 5-ASA-induced nephrotoxicity were identified. Sixty-eight percent of cases were males, with nephrotoxicity occurring at a median age of 39.4 years (range 6-79 years). The median time for development of renal injury after commencing 5-ASA was 3.0 years (95% confidence interval [CI] 2.3-3.7). Only 30% of cases recovered completely after drug withdrawal, with 15 patients requiring permanent renal replacement therapy. A genome-wide association study identified a suggestive association in the HLA region (p = 1 x 10(-7)) with 5-ASA-induced nephrotoxicity. A sub-group analysis of patients who had a renal biopsy demonstrating interstitial nephritis (n = 55) significantly strengthened this association (p = 4 x 10(-9), odds ratio 3.1).

    Conclusions: This is the largest and most detailed study of 5-ASA-induced nephrotoxicity to date. It highlights the morbidity associated with this condition and identifies for the first time a significant genetic predisposition to drug-induced renal injury.

  • 41.
    Juzenas, S.
    et al.
    Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany; Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Hübenthal, M.
    Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany.
    Zeissig, S.
    Department of Medicine, TU Dresden, Dresden, Germany.
    Strüning, N.
    Department of Internal Medicine, University Hospital Schleswig-Holstein, Kiel, Germany.
    Keller, A.
    Chair for Clinical Bioinformatics, Saarland University, Saarbrücken, Germany.
    Schulte, D.
    Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
    D'Amato, M.
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden; Basque Foundation for Science, BioCruces Health Research Institute and IKERBASQUE, Bilbao, Spain.
    Lindqvist, Carl Mårten
    Örebro University, School of Medical Sciences.
    Kupcinskas, J.
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Schreiber, S.
    Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany; Department of Internal Medicine, University Hospital Schleswig-Holstein, Kiel, Germany.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Hemmrich-Stanisak, G.
    Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany.
    Franke, A.
    Christian-Albrechts-University of Kiel, Institute of Clinical Molecular Biology, Kiel, Germany.
    Sequencing-based hematopoietic miRNA landscape reveals common and distinct features of autoimmune inflammatory phenotypes2019In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 13, no Suppl. 1, p. S614-S614Article in journal (Other academic)
    Abstract [en]

    Background: MiRNAs represent a class of small non-coding RNAs which are involved in regulation of protein-coding gene expression. Being implicated in various processes such as development and regu-latory circuits of cells, miRNAs also play an important role in the etiology of a variety of diseases. Imbalance of the regulatory pro-cesses within immune system development and response may lead to disturbed production of pro-inflammatory cytokines and over-reactivity of the immune cells, thus causing relapsing inflamma-tion, a characteristic feature of inflammatory bowel disease (IBD). Recent studies of colonic miRNAs employed NGS for the distinction between CD, UC and healthy controls, or among different CD sub-types. However, NGS-based profiles of blood-circulating miRNAs have thus far not been investigated in the context of IBD together with other immune-mediated diseases, including ankylosing spon-dylitis, psoriasis, systemic lupus erythematosus, rheumatoid arthritis and sarcoidosis, as well as non-immune hemolytic-uremic syndrome.

    Methods: Study participants were recruited in Germany and Sweden, where peripheral blood samples (PAXgene) as well as phenotypical and clinical information (such as treatment status, dis-ease activity and location) was collected. Small RNA transcriptomes of 680 individuals (Figure 1) were sequenced using Illumina NGS platform. Small RNA-seq data preprocessing and quantification were performed using cutadapt and miraligner (ref. miRBase v22), respectively. Differential expression analysis (DESeq2) and correla-tion (Spearman) analysis have been performed to identify disease activity-, trait- and treatment-specific miRNA signatures. These sig-natures were then utilized in a machine-learning approach to build classification models for IBD diagnostics.

    Results: The results of multiple pairwise differential expression anal-yses among different immune-mediated inflammatory conditions and healthy controls revealed inflammation-specific as well and dis-ease-specific deregulation of miRNAs. Correlation analysis identified miRNAs positively and negatively correlated with IBD activity. The preliminary results of machine learning classifiers based on miRNA profiles showed that median Matthews correlation coefficient for all model types showed remarkable predictive performance estimated as being 1.00 (median over main diagnoses), as well as ranging from 0.68 to 0.76 (median over CD location) and from 0.69 to 0.77 (median over UC extent).

    Conclusions: Immune-mediated inflammatory diseases share com-mon and distinct differentially expressed miRNAs, which have a potential to be used in the diagnostics of IBD, including the evalua-tion of the disease activity.

  • 42.
    Juzenas, Simonas
    et al.
    Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; Institute of Biotechnology, Life Science Centre, Vilnius University, Vilnius, Lithuania.
    Hübenthal, Matthias
    Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; Department of Dermatology, Quincke Research Center, University Hospital Schleswig-Holstein, Kiel, Germany.
    Lindqvist, Carl Mårten
    Örebro University, School of Medical Sciences. Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
    Kruse, Robert
    Örebro University, School of Medical Sciences. Department of Clinical Research Laboratory.
    Steiert, Tim Alexander
    Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
    Degenhardt, Frauke
    Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
    Schulte, Dominik
    Division of Endocrinology, Diabetes and Clinical Nutrition, Department of Medicine I, University Hospital of Schleswig-Holstein, Kiel, Germany; Institute of Diabetes and Clinical Metabolic Research, Kiel University, Kiel, Germany.
    Nikolaus, Susanna
    Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
    Zeissig, Sebastian
    Medical Department 1, University Hospital Dresden, Technische Universität Dresden (TU Dresden), Dresden, Germany; Center for Regenerative Therapies Dresden (CRTD), Technische Universität (TU) Dresden, Dresden, Germany.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Almer, Sven
    Department of Medicine, Karolinska Institutet, Solna, and Division of Gastroenterology, Karolinska University Hospital, Stockholm, Sweden.
    Hjortswang, Henrik
    Department of Gastroenterology and Hepatology, Linköping University, Linköping, Sweden; Department of Health, Medicine, and Caring Sciences, Linköping University, Linköping, Sweden.
    Bresso, Francesca
    Department of Medicine, Karolinska Institutet, Solna, and Division of Gastroenterology, Karolinska University Hospital, Stockholm, Sweden.
    Strüning, Nina
    Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
    Kupcinskas, Juozas
    Department of Gastroenterology and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Keller, Andreas
    Chair for Clinical Bioinformatics, Saarland University, Saarbrücken, Germany; Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA, USA.
    Lieb, Wolfgang
    Institute of Epidemiology, Christian-Albrechts-University of Kiel, Kiel, Germany.
    Rosenstiel, Philip
    Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
    Schreiber, Stefan
    Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; Department of Internal Medicine I, University Hospital Schleswig-Holstein, Kiel, Germany.
    D'Amato, Mauro
    Unit of Clinical Epidemiology, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; Gastrointestinal Genetics Lab, CIC bioGUNE - BRTA, Derio, Spain; Ikerbasque, Basque Foundation for Science, Bilbao, Spain.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Hemmrich-Stanisak, Georg
    Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany.
    Franke, Andre
    Institute of Clinical Molecular Biology, Christian-Albrechts-University of Kiel, Kiel, Germany; University Hospital of Schleswig-Holstein (UKSH), Kiel Campus, Kiel, Germany .
    Detailed transcriptional landscape of peripheral blood points to increased neutrophil activation in treatment-naïve inflammatory bowel disease2022In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 16, no 7, p. 1097-1109Article in journal (Refereed)
    Abstract [en]

    BACKGROUND AND AIMS: Inflammatory bowel disease (IBD) is a chronic relapsing disorder of the gastrointestinal tract, which generally manifests as Crohn's disease (CD) or ulcerative colitis (UC). These subtypes are heterogeneous in terms of disease location and histological features, while sharing common clinical presentation, genetic associations and thus, common immune regulatory pathways.

    METHODS: Using miRNA and mRNA coupled transcriptome profiling and systems biology approaches, we report a comprehensive analysis of blood transcriptomes from treatment-naïve (n=110) and treatment-exposed (n=177) IBD patients as well as symptomatic- (n=65) and healthy controls (n=95).

    RESULTS: Broadly, the peripheral blood transcriptomes of CD and UC patients were similar. However, there was an extensive gene deregulation in the blood of IBD patients, while only a slight deregulation in symptomatic controls, when compared with healthy controls. The deregulated mRNAs and miRNAs are mainly involved in the innate immunity and are especially enriched in neutrophil activation-related pathways. Oxidative phosphorylation and neutrophil activation-related modules were found to be differentially co-expressed among treatment-naïve IBD as compared to healthy controls. In the deregulated neutrophil activation-related co-expression module, the IL1B was identified as the central gene. The co-expression levels among IL1B and chemosensing receptor (CXCR1/2 and FPR1/2) genes were reduced in the blood of IBD patients when compared with healthy controls.

    CONCLUSIONS: Immune dysregulation seen in peripheral blood transcriptomes of treatment-naïve IBD patients is mainly driven by neutrophil activation.

  • 43.
    Kalla, R.
    et al.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, United Kingdom.
    Adams, A. T.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Vatn, S.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.
    Kennedy, N. A.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; Exeter IBD and Pharmacogenetics group, University of Exeter, United Kingdom.
    Ricanek, P.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
    Lindstrom, J.
    Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
    Ocklind, A.
    Olink Proteomics, Uppsala, Sweden.
    Hjelm, F.
    Olink Proteomics, Uppsala, Sweden.
    Ventham, N. T.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom.
    Ho, G. T.
    MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, United Kingdom.
    Petren, C.
    Olink Proteomics, Uppsala, Sweden.
    Repsilber, Dirk
    Örebro University, School of Medical Sciences.
    Söderholm, J.
    Department of Surgery and Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Pierik, M.
    Maastricht University Medical Centre (MUMC), Department of Gastroenterology and Hepatology, Maastricht, Netherlands.
    D'Amato, M.
    Biocruces Health Research Institute, Molecular Genetics of Digestive Diseases, Cruces, Bilbao, Spain; School of Biological Sciences, Monash University, Victoria, Australia.
    Gomollón, F.
    HCU "Lozano Blesa," IIS Aragón, Zaragoza, Spain.
    Olbjorn, C.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
    Jahnsen, J.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
    Vatn, M. H.
    Department of Gastroenterology, Akershus UnInstitute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Satsangi, J.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
    Serum proteomic profiling at diagnosis predicts clinical course, and need for intensification of treatment in inflammatory bowel disease2021In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 15, no 5, p. 699-708Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Success in personalised medicine in complex disease is critically dependent on biomarker discovery. We profiled serum proteins using a novel proximity extension assay (PEA) to identify diagnostic and prognostic biomarkers in inflammatory bowel disease (IBD).

    METHODS: We conducted a prospective case-control study in an inception cohort of 552 patients (328 IBD, 224 non-IBD), profiling proteins recruited across 6 centres. Treatment escalation was characterised by the need for biological agents or surgery after initial disease remission. Nested leave-one-out cross validation was used to examine the performance of diagnostic and prognostic proteins.

    RESULTS: A total of 66 serum proteins differentiated IBD from symptomatic non-IBD controls including MMP-12 (Holm adjusted p=4.1×10 -23 ) and OSM (p=3.7×10 -16). Nine of these proteins associate with cis- germline variation (59 independent SNPs). Fifteen proteins, all members of TNF independent pathways including IL-1 and OSM predicted escalation, over a median follow-up of 518 (IQR 224-756) days. Nested cross-validation of the entire data set allows characterisation of 5-protein-models (96% comprising five core proteins ITGAV, EpCAM, IL18, SLAMF7, and IL8) which define a high-risk subgroup in IBD (HR 3.90, CI: 2.43-6.26), or allows distinct 2, and 3 protein models for UC and CD respectively.

    CONCLUSION: We have characterised a simple oligo-protein panel that has the potential to identify IBD from symptomatic controls and to predict future disease course. Further prospective work is required to validate our findings.

  • 44.
    Kalla, R.
    et al.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, United Kingdom.
    Adams, A. T.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom .
    Nowak, J. K.
    Department of Paediatric Gastroenterology and Metabolic Diseases, Poznan University of Medical Sciences, Poznan, Poland.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Vatn, S.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.
    Ventham, N. T.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom.
    Kennedy, N. A.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; Exeter IBD and Pharmacogenetics group, University of Exeter, United Kingdom .
    Ricanek, P.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Medical Research Council Integrative Epidemiology Unit (MRC IEU), School of Social and Community Medicine, University of Bristol, Bristol, UK .
    Lindstrom, J.
    Medical Research Council Integrative Epidemiology Unit (MRC IEU), School of Social and Health Services Research Unit, Akershus University Hospital, Lørenskog, Norway; Community Medicine, University of Bristol, Bristol, UK.
    Söderholm, J.
    Department of Surgery and Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.
    Pierik, M.
    Maastricht University Medical Centre (MUMC), Department of Gastroenterology and Hepatology, Maastricht, Netherlands.
    D'Amato, M.
    CIC bioGUNE - BRTA, Derio, Spain and IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
    Gomollón, F.
    HCU "Lozano Blesa," IIS Aragón, CIBEREHD, Zaragoza, Spain.
    Olbjorn, C.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway .
    Richmond, R.
    Medical Research Council Integrative Epidemiology Unit (MRC IEU), School of Social and Community Medicine, University of Bristol, Bristol, UK.
    Relton, C. L.
    Medical Research Council Integrative Epidemiology Unit (MRC IEU), School of Social and Community Medicine, University of Bristol, Bristol, UK.
    Jahnsen, J.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway .
    Vatn, M. H.
    Institute of Clinical Medicine, Campus Ahus, University of Oslo, Oslo, Norway .
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Satsangi, J.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom; Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom .
    Analysis of systemic epigenetic alterations in inflammatory bowel disease: defining geographical, genetic, and immune-inflammatory influences on the circulating methylome2023In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 17, no 2, p. 170-184Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Epigenetic alterations may provide valuable insights into gene-environment interactions play in the pathogenesis of Inflammatory Bowel Disease (IBD).

    METHODS: Genome-wide methylation was measured from peripheral blood using the Illumina 450k platform in a case-control study in an inception cohort (295 controls, 154 CD, 161 UC, 28 IBD-U) with covariates of age, sex, and cell counts, deconvoluted by the Houseman method. Genotyping was performed using Illumina HumanOmniExpressExome-8 BeadChips and gene expression using Ion AmpliSeq Human Gene Expression Core Panel. Treatment escalation was characterised by the need for biological agents or surgery after initial disease remission.

    RESULTS: A total of 137 differentially methylated positions (DMP) were identified in IBD, including VMP1/MIR21 (p=9.11×10 -15) and RPS6KA2 (6.43×10 -13); with consistency seen across Scandinavia and UK. Dysregulated loci demonstrate strong genetic influence, notably VMP1 (p=1.53×10 -15). Age acceleration is seen in IBD (coefficient 0.94, p<2.2x10 -16). Several immuno-active genes demonstrated highly significant correlations between methylation and gene expression in IBD, in particular OSM: IBD r -0.32, p 3.64×10 -7 vs. non-IBD r -0.14, p=0.77). Multi-omic integration of methylome, genome and transcriptome also implicate specific pathways that associate with immune activation, response and regulation at disease inception. At follow up, a signature of 3 DMPs (TAP1, TESPA1, RPTOR) associated with treatment escalation to biological agents or surgery (hazard ratio of 5.19 (CI:2.14-12.56, logrank p=9.70×10 -4).

    CONCLUSION: These data demonstrate consistent epigenetic alterations at diagnosis in European patients with IBD, providing insights into the pathogenetic importance and translational potential of epigenetic mapping in complex disease.

  • 45.
    Kalla, R.
    et al.
    MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, United Kingdom.
    Adams, A. T.
    Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom.
    Ventham, N. T.
    Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom.
    Kennedy, N. A.
    Exeter IBD and Pharmacogenetics group, University of Exeter, United Kingdom.
    White, R.
    Institute of Immunology and Infection Research and Centre for Immunity, Infection & Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
    Clarke, C.
    LifeArc, Nine Edinburgh Bioquarter, Edinburgh, United Kingdom.
    Ivens, A.
    Institute of Immunology and Infection Research and Centre for Immunity, Infection & Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Vatn, S.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.
    Lopez-Jimena, B.
    LifeArc, Nine Edinburgh Bioquarter, Edinburgh, United Kingdom.
    Ricanek, P.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway; Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Vatn, M. H.
    Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Söderholm, J.
    Linköping University Hospital, Department of Surgery, Linköping, Sweden.
    Gomollón, F.
    HCU "Lozano Blesa," IIS Aragón, Zaragoza, Spain.
    Nowak, J. K.
    Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; Department of Paediatric Gastroenterology and Metabolic diseases, Poznan University of Medical Sciences, Poznan, Poland.
    Jahnsen, J.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    McTaggart, S.
    LifeArc, Nine Edinburgh Bioquarter, Edinburgh, United Kingdom.
    Ho, G. T.
    MRC Centre for Inflammation Research, Queens Medical Research Institute, University of Edinburgh, United Kingdom.
    Buck, A.
    Institute of Immunology and Infection Research and Centre for Immunity, Infection & Evolution, School of Biological Sciences, University of Edinburgh, Edinburgh, United Kingdom.
    Satsangi, J.
    Translational Gastroenterology Unit, Nuffield Department of Medicine, Experimental Medicine Division, University of Oxford, John Radcliffe Hospital, Oxford, United Kingdom; Institute of Genetics and Molecular Medicine, University of Edinburgh, United Kingdom.
    Whole blood profiling of T-cell derived miRNA allows the development of prognostic models in inflammatory bowel disease2020In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 14, no 12, p. 1724-1733Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: MicroRNAs (miRNAs) are cell-specific small non-coding RNAs that can regulate gene expression and have been implicated in Inflammatory Bowel Disease (IBD) pathogenesis. In our study, we define the cell-specific miRNA profiles and investigate its biomarker potential in IBD.

    METHODS: In a 2-stage prospective multi-centre case control study, Next Generation sequencing was performed on a discovery cohort of immunomagnetically separated leucocytes from 32 patients (9 CD, 14 UC, 8 healthy controls) and differentially expressed signals were validated in whole blood in 294 patients (97 UC, 98 CD, 98 non-IBD) using quantitative PCR. Correlations were analysed with phenotype, including need for early treatment escalation as a marker of progressive disease using Cox proportional hazards.

    RESULTS: In stage 1, each leucocyte subset (CD4+ and CD8+ T-cells and CD14+ monocytes) was analysed in IBD and controls. Three specific miRNAs differentiated IBD from controls in CD4+ T-cells, including miR-1307-3p (p=0.01), miR-3615 (p=0.02) and miR-4792 (p=0.01). In the extension cohort, in stage 2, miR-1307-3p was able to predict disease progression in IBD (HR 1.98, IQR:1.20-3.27;logrank p=1.80×10-3), in particular CD (HR 2.81; IQR: 1.11-3.53, p=6.50×10-4). Using blood-based multimarker miRNA models, the estimated chance of escalation in CD was 83% if 2 or more criteria were met and 90% for UC if 3 or more criteria are met.

    INTERPRETATION: We have identified and validated unique CD4+ T-cell miRNAs that are differentially regulated in IBD. These miRNAs may be able to predict treatment escalation and have the potential for clinical translation; further prospective evaluation is now indicated.

  • 46.
    Kalla, R.
    et al.
    Gastroenterology, University of Edinburgh, Edinburgh, United Kingdom.
    Adams, A.
    Gastroenterology, University of Edinburgh, Edinburgh, United Kingdom.
    Vatn, S.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterolog, Örebro University Hospital, Örebro, Sweden.
    Ricanek, P.
    Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Lindström, J.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.
    Ocklind, A.
    Olink Proteomics, Uppsala, Sweden.
    Nordberg, N.
    Olink Proteomics, Uppsala, Sweden.
    Kennedy, N.
    Gastroenterology, University of Edinburgh, Edinburgh, United Kingdom.
    Ventham, N.
    Gastroenterology, University of Edinburgh, Edinburgh, United Kingdom.
    Vatn, M.
    Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
    Söderholm, J.
    Gastroenterology, Linköping University, Linköping, Sweden.
    Pierik, M.
    Maastricht University Medical Center (MUMC), Department of Gastroenterology and Hepatology, Maastricht, Netherlands.
    Törkvist, L.
    Department of Clinical Science, Intervention and Technology, Karolinska Instituet, Karolinska Institute, Stockholm, Sweden.
    Gomollon, F.
    Instituto de Investigación Sanitaria Aragón (IIS Aragón), Centro de Investigación Biomédica en Red en el Área temática de Enfermedades Hepáticas (CIBEREHD), Hospital Clínico Universitario (HCU) “Lozano Blesa”, Zaragosa, Spain.
    Jahnsen, J.
    Department of Gastroenterology, Akershus University Hospital, Lørenskog, Norway.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Satsangi, J.
    Gastroenterology, University of Edinburgh, Edinburgh, United Kingdom.
    Proximity extension assay based proteins show immune cell specificity and can diagnose and predict outcomes in inflammatory bowel diseases: IBD Character study2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S13-S13Article in journal (Refereed)
  • 47.
    Kalla, R.
    et al.
    Gastrointestinal Unit, Univ Edinburgh, Edinburgh, UK.
    Kennedy, N.
    Gastrointestinal Unit, Univ Edinburgh, Edinburgh, UK.
    Hjelm, F.
    Olink Bioscience AB, Uppsala, Sweden.
    Modig, E.
    Olink Bioscience AB, Uppsala, Sweden.
    Sundell, M.
    Olink Bioscience AB, Uppsala, Sweden.
    Andreassen, B.
    Inst Clin Med, Univ Oslo, Oslo, Norway.
    Bergemalm, Daniel
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Ricanek, P.
    Dept Gastroenterol, Akershus Univ Hosp, Lorenskog, Norway.
    Söderholm, J.
    Gastroenterol, Linköping Univ, Linköping, Sweden.
    Vatn, M.
    Inst Clin Med, Univ Oslo, Oslo, Norway.
    Halfvarson, Jonas
    Örebro University, School of Medicine, Örebro University, Sweden.
    Gullberg, M.
    Olink, Biosci, Uppsala, Sweden.
    Satsangi, J.
    Gastrointestinal Unit, Univ Edinburgh, Edinburgh, UK.
    Proximity Extension Assay technology identifies novel serum biomarkers for predicting Inflammatory Bowel Disease: IBD Character Consortium2015In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 9, p. S146-S147Article in journal (Other academic)
  • 48.
    Kalla, R.
    et al.
    Gastroenterol, Univ Edinburgh, Edinburgh, UK.
    Ocklind, A.
    Olink Bioscience AB, Uppsala, Sweden.
    Petren, C.
    Olink Bioscience AB, Uppsala, Sweden.
    Nordberg, N.
    Olink Bioscience AB, Uppsala, Sweden.
    Kennedy, N.
    Gastroenterol, Univ Edinburgh, Edinburgh, UK.
    Ventham, N.
    Gastroenterol, Univ Edinburgh, Edinburgh, UK.
    Pettersson, E.
    Olink Bioscience AB, Uppsala, Sweden.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences.
    Lindstrom, J.
    Dept Gastroenterol, Oslo Univ Hosp, Oslo, Norway.
    Vatn, S.
    Dept Gastroenterol, Oslo Univ Hosp, Oslo, Norway.
    Hjortswang, H.
    Dept Gastroenterol, Linköping Univ Hosp, Linköping, Sweden.
    Nimmo, E.
    Univ Edinburgh, Gastroenterol, Edinburgh, UK..
    Drummond, H.
    Univ Edinburgh, Gastroenterol, Edinburgh, UK.
    Ricanek, P.
    Deprtment Gastroenterol, Akershus Univ Hosp, Lorenskog, Norway..
    Dahl, F.
    Dept Gastroenterol, Oslo Univ Hosp, Oslo, Norway..
    Wilson, D.
    Gastroenterol, Univ Edinburgh, Edinburgh, UK.
    Jahnsen, J.
    Dept Gastroenterol, Oslo Univ Hosp, Oslo, Norway.
    Gomollon, F.
    Gastroenterol, Univ Zaragosa, Zaragoza, Spain.
    Pierik, M.
    Dept Gastroenterol & Hepatol, Maastricht University Medical Centre (MUMC), Maastricht, Netherlands.
    Soderholm, J.
    Dept Surg, Linköping Univ Hosp, Linköping, Sweden.
    Vatn, M.
    Dept Gastroenterol, Oslo Univ Hosp, Oslo, Norway.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Satsangi, J.
    Gastroenterol, Univ Edinburgh, Edinburgh, UK.
    Proximity extension assay immunoassay technology identifies novel serum biomarkers that can diagnose and classify inflammatory bowel diseases: IBD Character Consortium2016In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 10, no Suppl. 1, p. S82-S82Article in journal (Other academic)
  • 49.
    Kalman, D.
    et al.
    Faulty Hlth Sci, Dept Clin & Expt Med, Div Surg, Linköping Univ, Linköping, Sweden.; Dept Surg, Cty Council Östergötland, Linköping, Sweden.
    Nordenvall, C.
    Dept Mol Med & Surg, Karolinska Inst, Stockholm, Sweden; Ctr Digest Dis, Div Coloproctol, Karolinska Univ Hosp, Stockholm, Sweden.
    Everhov, A. Hallqvist
    Södersjukhuset, Dept Clin Sci & Educ, Karolinska Inst, Stockholm, Sweden;Dept Med Solna, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden.
    Ludvigsson, Jonas F.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden; Sch Med, Div Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England; Dept Med, Columbia Univ Coll Phys & Surg, New York NY, USA.
    Sachs, M. C.
    Inst Environm Med, Karolinska Inst, Stockholm, Sweden.
    Ekbom, A.
    Dept Med Solna, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden.
    Olen, O.
    Dept Clin Sci & Educ, Södersjukhuset, Karolinska Inst, Stockholm, Sweden; Dept Med Solna, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden; Dept Pediat Gastroenterol & Nutr, Sachs Children & Youth Hosp, Stockholm, Sweden.
    Myrelid, P.
    Faulty Hlth Sci, Dept Clin & Expt Med, Div Surg, Linköping Univ, Linköping, Sweden; Dept Surg, Cty Council Östergötland, Linköping, Sweden.
    Need for primary abdominal surgery, but not repeated surgery, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990-20142018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S11-S12Article in journal (Other academic)
  • 50.
    Kalman, D.
    et al.
    Div Surg, Dept Clin & Expt Med, Fac Hlth Sci, Linköping Univ, Linköping, Sweden; Dept Surg, Cty Council Östergötland, Linköping, Sweden.
    Nordenvall, C.
    Dept Mol Med & Surg, Karolinska Inst, Stockholm, Sweden; Div Coloproctol, Ctr Digest Dis, Karolinska Univ Hosp, Stockholm, Sweden.
    Everhov, A. Hallqvist
    Dept Clin Sci & Educ, Södersjukhuset, Karolinska Inst, Stockholm, Sweden; Dept Med Solna, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden.
    Sachs, M. C.
    Inst Environm Med, Karolinska Inst, Stockholm, Sweden.
    Ludvigsson, Jonas F.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden; Sch Med, Div Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England; Dept Med, Columbia Univ Coll Phys & Surg, New York NY, USA.
    Ekbom, A.
    Dept Med Solna, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden.
    Myrelid, P.
    Div Surg, Dept Clin & Expt Med, Fac Hlth Sci, Linköping Univ, Linköping, Sweden; Dept Surg, Cty Council Östergötland, Linköping, Sweden.
    Olen, O.
    Dept Clin Sci & Educ, Södersjukhuset, Karolinska Inst, Stockholm, Sweden; Dept Med Solna, Clin Epidemiol Unit, Karolinska Inst, Stockholm, Sweden; Dept Pediat Gastroenterol & Nutr, Sachs Children & Youth Hosp, Stockholm, Sweden.
    Need for ileocaecal resections, but not ileo-colic re-resections, has decreased: a nationwide study of temporal trends in Crohn surgery in Sweden 1990-20142018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S60-S61Article in journal (Other academic)
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