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  • 1.
    Breimer, Lars H.
    Örebro University Hospital. Department of Laboratory Medicine, Clinical Chemistry Unit, Örebro University Hospital, Örebro, Sweden.
    Where Are We Now With Bilirubin as a Marker of Vascular Risk?2014In: Angiology, ISSN 0003-3197, E-ISSN 1940-1574, Vol. 65, no 3, p. 177-179Article in journal (Refereed)
  • 2.
    Dreifaldt, Mats
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Department of Thoracic and Cardiovascular Surgery, Örebro University Hospital, Region rebro County, Örebro, Sweden.
    Souza, Domingos S. R.
    Department of Thoracic and Cardiovascular Surgery, Örebro University Hospital, Region Örebro County, Örebro, Sweden.
    Bodin, Lennart
    Department of Statistics, Örebro University Hospital, Region Örebro County, Örebro, Sweden.
    Shi-Wen, Xu
    Department of Rheumatology, Royal Free and University College Medical School, London, UK.
    Dooley, Audrey
    Department of Rheumatology, Royal Free and University College Medical School, London, UK.
    Muddle, John
    Department of Neurological Science, Royal Free and University College Medical School, London, UK.
    Loesch, Andrzej
    Division of Medicine, Royal Free and University College Medical School, London, UK.
    Dashwood, Michael R.
    Division of Medicine, Royal Free and University College Medical School, London, UK.
    The Vasa Vasorum and Associated Endothelial Nitric Oxide Synthase is More Important for Saphenous Vein Than Arterial Bypass Grafts2013In: Angiology, ISSN 0003-3197, E-ISSN 1940-1574, Vol. 64, no 4, p. 293-299Article in journal (Refereed)
    Abstract [en]

    No-touch (NT) saphenous vein (SV) grafts are superior to SVs harvested by the conventional technique (CT), with a patency comparable with the internal thoracic artery (ITA). Preservation of the vasa vasorum is implicated in the success of NT harvesting. We compared the vasa vasorum and endothelial nitric oxide synthase (eNOS) in NT SV with ITA and radial artery (RA) grafts. Skeletonized SV (SSV) was also analyzed. The NT SV had a higher number and larger vasa vasorum compared with ITA (P = .0001) and RA (P = .0004) that correlated with eNOS protein. Activity of eNOS in SSV grafts was significantly lower than NT SV grafts (P = 004). Since a high proportion of the vasa vasorum are removed in SSV using the CT, we suggest that preservation of the vasa vasorum and eNOS-derived NO contributes to the high patency for NT as compared with SSV grafts.

  • 3.
    Laaksonen, Reijo
    et al.
    Science Center, Tampere University Hospital, Tampere, Finland; Zora Biosciences Oy, Espoo, Finland.
    Jänis, Minna T.
    Zora Biosciences Oy, Espoo, Finland.
    Oresic, Matej
    Zora Biosciences Oy, Espoo, Finland; VTT Technical Research Centre of Finland, Espoo, Finland.
    Lipidomics-based safety biomarkers for lipid-lowering treatments2008In: Angiology, ISSN 0003-3197, E-ISSN 1940-1574, Vol. 59, no 2 Suppl, p. 65S-68SArticle in journal (Refereed)
    Abstract [en]

    Recent data suggest that aggressive lipid-lowering treatment results in significant reductions of atherosclerotic complications, ie, strokes, heart attacks, or peripheral vascular diseases. Thus, more patients will be titrated to higher doses of statins in order to reach the aggressive targets of low-density lipoprotein- cholesterol reduction. However, aggressive treatment with high statin doses has increased the risk of statin-induced myopathy. The incidence of myopathy in cohort studies and in randomized trials has been low, supporting the good safety profile of statin drugs. However, muscle effects seem to be more frequent in clinical practice. Of all statin users, approximately 1% to 5% suffers from muscular symptoms caused by medication. This potentially reduces the compliance toward treatment and number of patients reaching their treatment targets due to withdrawal of therapy. Thus, novel biomarkers are needed for prediction or improved diagnoses of statin-induced side effects. This would potentially increase the quality of life of patients and improve treatment results. Using lipidomic analysis, we found that the plasma lipidomic changes following simvastatin treatment correlate with the muscle expression of the arachidonate 5-lipoxygenase-activating protein. Intriguingly, these results suggest that the plasma lipidomic profile may serve as a highly sensitive biomarker of statin-induced metabolic alterations in muscle and may thus allow us to identify patients who should be treated with a lower dose to prevent a possible toxicity.

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