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  • 1.
    Boknas, N.
    et al.
    Linköping University, Linköping, Sweden.
    Faxalv, L.
    Linköping University, Linköping, Sweden.
    Lindahl, T. L.
    Linköping University, Linköping, Sweden.
    Ramström, Sofia
    Linköping University, Linköping, Sweden.
    Contact activation: important to consider when measuring the contribution of tissue factor-bearing microparticles to thrombin generation using phospholipid-containing reagents2014In: Journal of Thrombosis and Haemostasis, ISSN 1538-7933, E-ISSN 1538-7836, Vol. 12, no 4, p. 515-518Article in journal (Refereed)
    Abstract [en]

    Background: A commercial MP reagent containing phospholipids is used for thrombin generation (TG) measurements to estimate the procoagulant activity of microparticles (MPs). Previous reports have shown that contact activation affects TG when TF levels are low, and that addition of phospholipids might augment this effect.

    Objectives: To quantify the impact of contact activation on TG in the presence of phospholipids and low/no TF, as is the case using a commercially available MP-reagent. Methods Thrombin generation was analyzed using MP- or platelet-rich plasma (PRP)-reagent in the presence and absence of corn trypsin inhibitor and anti-TF antibodies, respectively. To quantify the impact of different experimental parameters on contact activation, microparticle-depleted plasma was analyzed in the presence of different concentrations of phospholipids, TF and/or contact activating agents (kaolin).

    Results: Even with low contact activating blood collection tubes, substantial thrombin generation was observed with the MP-reagent, but this was completely inhibited by addition of corn trypsin inhibitor. Control experiments illustrate that the phospholipids in the reagent play a major role in enhancing TG initiated by FXIIa. Even with the PRP-reagent, which is recommended for determining the content of phospholipids from MPs, TG was partly dependent on contact activation.

    Conclusions: Contact activation plays a major role in TG when using reagents/samples containing phospholipids but little or no tissue factor. This needs to be considered and accounted for in future clinical studies using TG to assess the procoagulant activity of MPs.

  • 2.
    Boknäs, N.
    et al.
    Linköping University, Linköping, Sweden.
    Faxälv, L.
    Linköping University, Linköping, Sweden.
    Ramström, Sofia
    LLinköping University, Linköping, Sweden.
    Lindahl, T.
    Linköping University, Linköping, Sweden.
    Thrombin generation in plasma measured with a commercial reagent for the detection of microparticle-derived tissue factor is heavily influenced by contact activation2013In: Journal of Thrombosis and Haemostasis, ISSN 1538-7933, E-ISSN 1538-7836, Vol. 11, no S1, p. 401-402Article in journal (Refereed)
  • 3.
    Lindahl, T. L.
    et al.
    Linköping University, Linköping, Sweden.
    Macwan, A. S.
    Linköping University, Linköping, Sweden.
    Ramström, Sofia
    Linköping University, Linköping, Sweden.
    Protease-activated receptor 4 is more important than protease-activated receptor 1 for the thrombin-induced procoagulant effect on platelets2016In: Journal of Thrombosis and Haemostasis, ISSN 1538-7933, E-ISSN 1538-7836, Vol. 14, no 8, p. 1639-1641Article in journal (Refereed)
  • 4.
    Lindgren, M.
    et al.
    Dilaforette AB, Solna, Sweden.
    Meijers, J. C. M.
    University of Amsterdam, Amsterdam, Netherlands.
    Biemond, B. J.
    University of Amsterdam, Amsterdam, Netherlands.
    Ramström, Sofia
    Linköping University, Linköping, Sweden.
    Lindahl, T. L.
    Linköping University, Linköping, Sweden.
    Eriksson, P-O
    Dilaforette AB, Solna, Sweden.
    Leitgeb, A. M.
    Dilaforette AB, Solna, Sweden.
    Wahlgren, M.
    Karolinska Institute, Stockholm, Sweden.
    Hogwood, J.
    The National Institute for Biological Standards and Control (NIBSC), South Mimms, England.
    Gray, E.
    The National Institute for Biological Standards and Control (NIBSC), South Mimms, England.
    Holmer, E.
    Dilaforette AB, Solna, Sweden.
    Sevuparin: effects on hemostasis of a novel polysaccharide drug derived from heparin2015In: Journal of Thrombosis and Haemostasis, ISSN 1538-7933, E-ISSN 1538-7836, Vol. 13, no S2, p. 369-369Article in journal (Refereed)
  • 5.
    Lopez, A.
    et al.
    Molecular and Cellular Therapeutics (MCT), Royal College of Surgeons, Dublin, Ireland.
    Kenny, D.
    Royal College of Surgeons in Ireland (RCSI), Dublin, Ireland.
    Basabe-Desmonts, L.
    Molecular and Cellular Therapeutics (MCT), Royal College of Surgeons, Dublin, Ireland.
    Ramström, Sofia
    Biomedical Diagnostics Institute (BDI), Dublin City University, Dublin, Ireland.
    Jose, B.
    Biomedical Diagnostics Institute (BDI), Dublin City University, Dublin, Ireland.
    Somers, M.
    Biomedical Diagnostics Institute (BDI), Dublin City University, Dublin, Ireland.
    A novel platelet assay that measures the effect of clopidogrel in vivo2013In: Journal of Thrombosis and Haemostasis, ISSN 1538-7933, E-ISSN 1538-7836, Vol. 11, no S2, p. 73-73Article in journal (Refereed)
  • 6.
    Södergren, A. L.
    et al.
    Linköping University, Linköping, Sweden.
    Ollinger, K.
    Linköping University, Linköping, Sweden.
    Ramström, Sofia
    Linköping University, Linköping, Sweden.
    Subdivision according to size is necessary for correct interpretation of data regarding platelet expression of active GPIIb/IIIa and phosphatidylserine2013In: Journal of Thrombosis and Haemostasis, ISSN 1538-7933, E-ISSN 1538-7836, Vol. 11, no S1, p. 498-498Article in journal (Refereed)
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