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  • 1.
    Canova, Cristina
    et al.
    Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy.
    Ludvigsson, Jonas F.
    Örebro universitet, Institutionen för medicinska vetenskaper. Region Örebro län. Department Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden; Division of Epidemiology and Public Health, School of Medicine, University of Nottingham, Nottingham, UK; Department of Medicine, Columbia University College of Physicians and Surgeons, New York, USA.
    Baldo, Vincenzo
    Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy.
    Amidei, Claudio Barbiellini
    Department of Cardio-Thoraco-Vascular Sciences and Public Health, University of Padua, Padua, Italy.
    Zanier, Loris
    Epidemiological Service, Health Directorate, Udine, Italy.
    Zingone, Fabiana
    Department of Surgery, Oncology and Gastroenterology, Gastroenterology Section, University Hospital of Padua, Padua, Italy.
    Risk of bacterial pneumonia and pneumococcal infection in youths with celiac disease - A population-based study2019Ingår i: Digestive and Liver Disease, ISSN 1590-8658, E-ISSN 1878-3562, Vol. 51, nr 8, s. 1101-1105Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective: Assess the risk of hospitalizations for bacterial pneumonia or pneumococcal infections, in a cohort of young individuals with celiac disease (CD) compared to matched references.

    Study design: The cohort consists of 213,635 individuals, born in 1989-2012 and resident in Friuli-Venezia Giulia (Italy). Through pathology reports, hospital discharge records or co-payment exemptions, we identified 1294 CD patients and 6470 reference individuals matched by gender and birth year. We considered hospital admissions for first episodes of bacterial pneumonia and pneumococcal infections. Hazard ratios (HRs) for episodes after CD diagnosis were calculated with Cox regression and odds ratios (OR) for the ones before CD diagnosis with conditional logistic regression. Further analyses were performed on unvaccinated follow-up periods.

    Results: 14 CD patients (in 9450 person-years) and 42 references (in 48,335 person-years) experienced a first episode of bacterial pneumonia, with an increased risk among CD patients (HR 1.82; 95% CI 0.98-3.35). Risks of bacterial pneumonia were significantly increased before CD diagnosis and especially the year before CD diagnosis (OR 6.00, 95% CI 1.83-19.66). Risks of pneumococcal infections showed a non-significant increase in CD patients.

    Conclusions: CD children and youth showed an increased risk of bacterial pneumonia, especially in proximity to CD diagnosis. Anti-pneumococcal vaccination should be recommended to all young CD patients. (C) 2019 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

  • 2.
    Ludvigsson, Jonas F.
    et al.
    Region Örebro län. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Paediatrics, Örebro University Hospital, Örebro, Sweden.
    Bai, Julio C.
    Dept Med, Dr C Bonorino Udaondo Gastroenterol Hosp, Salvador Univ, Buenos Aires DF, Argentina.
    Biagi, Federico
    Dept Internal Med 1, Coeliac Ctr, IFdn IRCCS Policlin San Matteo, Univ Pavia, Pavia, Italy.
    Card, Timothy R.
    Dept Epidemiol & Publ Hlth, City Hosp Nottingham, Univ Nottingham, Nottingham, England..
    Ciacci, Carolina
    Dept Med & Surg, Univ Salerno, Salerno, Italy.
    Ciclitira, Paul J.
    Div Nutr Sci, Rayne Inst, St Thomas Hosp, Kings College, London, England.
    Green, Peter H. R.
    Coeliac Dis Ctr, Columbia Univ, New York NY, USA.
    Hadjivassiliou, Marios
    Royal Hallamshire Hosp, Dept Neurol, Royal Hallamshire Hosp, Sheffield, England.
    Holdoway, Anne
    British Dietet Assoc, Bath, England.
    van Heel, David A.
    Blizard Inst, Barts & London Sch Med & Dent, Queen Mary Univ, London, England.
    Kaukinen, Katri
    Sch Med, Univ Tampere, Tampere, Finland; Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland; Dept Med, Seinajoki Cent Hosp, Seinajoki, Finland.
    Leffler, Daniel A.
    Beth Israel Deaconess Med Ctr, Sch Med, Div Gastroenterol, Harvard Univ, Boston MA, USA.
    Leonard, Jonathan N.
    Dept Dermatol, St Marys Hosp, Imperial Coll NHS Healthcare Trust, London, England.
    Lundin, Knut E. A.
    Dept Gastroenterol,Ctr Immune Regulat, Oslo Univ Hosp, Univ Oslo, Oslo, Norway.
    McGough, Norma
    Apollo Ctr, Coeliac UK, London, England..
    Davidson, Mike
    Coeliac UK, Sheffield, England.
    Murray, Joseph A.
    Dept Immunol, Div Gastroenterol & Hepatol, Mayo Clin, Rochester MN, USA.
    Swift, Gillian L.
    Dept Gastroenterol, Univ Hosp, Llandough, UK.
    Walker, Marjorie M.
    Fac Hlth & Med, Sch Med & Publ Hlth, Univ Newcastle, Callaghan NSW, Australia.
    Zingone, Fabiana
    Dept Med & Surg, Univ Salerno, Salerno, Italy.
    Sanders, David S.
    Gastroenterol & Liver Unit, Royal Hallamshire Hosp, Sheffield, England; Univ Sheffield, Sheffield, England.
    Diagnosis and management of adult coeliac disease: guidelines from the British Society of Gastroenterology2014Ingår i: Gut, ISSN 0017-5749, E-ISSN 1468-3288, Vol. 63, nr 8, s. 1210-1228Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    A multidisciplinary panel of 18 physicians and 3 non-physicians from eight countries (Sweden, UK, Argentina, Australia, Italy, Finland, Norway and the USA) reviewed the literature on diagnosis and management of adult coeliac disease (CD). This paper presents the recommendations of the British Society of Gastroenterology. Areas of controversies were explored through phone meetings and web surveys. Nine working groups examined the following areas of CD diagnosis and management: classification of CD; genetics and immunology; diagnostics; serology and endoscopy; follow-up; gluten-free diet; refractory CD and malignancies; quality of life; novel treatments; patient support; and screening for CD.

  • 3.
    Ludvigsson, Jonas F.
    et al.
    Region Örebro län. Dept Paediat, Örebro University Hospital, Örebro, Sweden; Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden.
    Card, Timothy R.
    Dept Epidemiol & Publ Hlth, Univ Nottingham, Nottingham, England.
    Kaukinen, Katri
    Sch Med, Univ Tampere, Tampere, Finland; Dept Internal Med, Tampere Univ Hosp, Tampere, Finland;Dept Internal Med, Seinajoki Cent Hosp, Seinajoki, Finland.
    Bai, Julio
    Dept Med, C Bonorino Udaondo Gastroenterol Hosp,Univ Salvador, Buenos Aires DF, Argentina.
    Zingone, Fabiana
    Dept Med & Surg, Univ Salerno, Salerno, Italy.
    Sanders, David S.
    Reg GI & Liver Unit, Royal Hallamshire Hosp, Sheffield, England.
    Murray, Joseph A.
    Coll Med, Dept Immunol, Dept Med, Mayo Clin, Rochester MN, USA.
    Screening for celiac disease in the general population and in high-risk groups2015Ingår i: United European Gastroenterology journal, ISSN 2050-6406, E-ISSN 2050-6414, Vol. 3, nr 2, s. 106-120Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Background: Celiac disease (CD) occurs in approximately 1% of the Western population. It is a lifelong disorder that is associated with impaired quality of life (QOL) and an excessive risk of comorbidity and death. Objectives: To review the literature on screening for CD in relation to the current World Health Organization (WHO) criteria for mass screening. Methods: We performed a PubMed search to identify indexed papers on CD screening with a publication date from 1900 until 1 June 2014. When we deemed an abstract relevant, we read the corresponding paper in detail. Results: CD fulfills several WHO criteria for mass screening (high prevalence, available treatment and difficult clinical detection), but it has not yet been established that treatment of asymptomatic CD may reduce the excessive risk of severe complications, leading to higher QOL nor that it is cost-effective. Conclusions: Current evidence is not sufficient to support mass screening for CD, but active case-finding may be appropriate, as we recognize that most patients with CD will still be missed by this strategy. Although proof of benefit is still lacking, screening for CD may be appropriate in high-risk groups.

  • 4.
    Ludvigsson, Jonas F.
    et al.
    Region Örebro län. Clin Epidemiol Unit, Dept Med, Karolinska Inst, Stockholm, Sweden; Dept Paediat, Örebro University Hospital, Örebro, Sweden.
    Leffler, Daniel A.
    Sch Med, Beth Israel Deaconess Med Ctr, Div Gastroenterol, Harvard Univ, Boston MA, USA.
    Bai, Julio C.
    Dept Med, Dr C Bonorino Udaondo Gastroenterol Hosp, Del Salvador Univ, Buenos Aires DF, Argentina.
    Biagi, Federico
    Dept Internal Med 1, Coeliac Ctr, Univ Pavia, Pavia, Italy.
    Fasano, Alessio
    Sch Med, Ctr Coeliac Res, Univ Maryland, Baltimore MD, USA.
    Green, Peter H. R.
    Coeliac Dis Ctr, Columbia Univ, New York NY, USA.
    Hadjivassiliou, Marios
    Dept Neurol, Royal Hallamshire Hosp, Sheffield, England.
    Kaukinen, Katri
    School of Medicine, University Tampere, Tampere, Finland.
    Kelly, Ciaran P.
    Sch Med, Beth Israel Deaconess Med Ctr, Div Gastroenterol, Harvard University, Boston MA, USA.
    Leonard, Jonathan N.
    Dept Dermatol, St Marys Hosp, Imperial Coll, NHS Healthcare Trust, London, England.
    Lundin, Knut Erik Aslaksen
    Dept Gastroenterol, Oslo University Hosp, Oslo, Norway; Center of Immune Regulation, Oslo University Hospital, Oslo, Norway.
    Murray, Joseph A.
    Dept Gastroenterol & Hepatol, Mayo Clinic, Rochester MN, USA.
    Sanders, David S.
    Gastroenterol & Liver Unit, Royal Hallamshire Hosp, University Sheffield, Sheffield, England; University of London Imperial Coll Sci Technol & Med, London, England; Fac Med, Ctr Pathol, St Marys Hosp, London, England.
    Walker, Marjorie M.
    Sci Technol & Med, St Marys Hosp, Fac Med, Ctr Pathol, Imperial College, London, England.
    Zingone, Fabiana
    Dept Clin & Expt Med, Univ Naples Federico II, Naples, Italy.
    Ciacci, Carolina
    Dept Gastroenterol, Univ Salerno, Salerno, Italy.
    The Oslo definitions for coeliac disease and related terms2013Ingår i: Gut, ISSN 0017-5749, E-ISSN 1468-3288, Vol. 62, nr 1, s. 43-52Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective The literature suggests a lack of consensus on the use of terms related to coeliac disease (CD) and gluten. Design A multidisciplinary task force of 16 physicians from seven countries used the electronic database PubMed to review the literature for CD-related terms up to January 2011. Teams of physicians then suggested a definition for each term, followed by feedback of these definitions through a web survey on definitions, discussions during a meeting in Oslo and phone conferences. In addition to 'CD', the following descriptors of CD were evaluated (in alphabetical order): asymptomatic, atypical, classical, latent, non-classical, overt, paediatric classical, potential, refractory, silent, subclinical, symptomatic, typical, CD serology, CD autoimmunity, genetically at risk of CD, dermatitis herpetiformis, gluten, gluten ataxia, gluten intolerance, gluten sensitivity and gliadin-specific antibodies. Results CD was defined as 'a chronic small intestinal immune-mediated enteropathy precipitated by exposure to dietary gluten in genetically predisposed individuals'. Classical CD was defined as 'CD presenting with signs and symptoms of malabsorption. Diarrhoea, steatorrhoea, weight loss or growth failure is required.' 'Gluten-related disorders' is the suggested umbrella term for all diseases triggered by gluten and the term gluten intolerance should not to be used. Other definitions are presented in the paper. Conclusion This paper presents the Oslo definitions for CD-related terms.

  • 5.
    Zingone, Fabiana
    et al.
    Dept Med & Surg, Univ Salerno, Salerno, Italy.
    Swift, Gillian L.
    Dept Gastroenterol, Univ Hosp Llandough, Cardiff, UK.
    Card, Timothy R.
    Div Epidemiol & Publ Hlth, City Hosp Nottingham, Univ Nottingham, Nottingham, England.
    Sanders, David S.
    Dept Gastroenterol, Royal Hallamshire Hosp, Sheffield, England; Univ Sheffield, Sheffield, England.
    Ludvigsson, Jonas F.
    Region Örebro län. Dept Pediat, Örebro University Hospital, Örebro, Sweden; Dept Med Epidemiol & Biostat, Karolinska Inst, Stockholm, Sweden.
    Bai, Julio C.
    Dept Med, C Bonorino Udaondo Gastroenterol Hosp, Univ Salvador, Buenos Aires DF, Argentina.
    Psychological morbidity of celiac disease: A review of the literature2015Ingår i: United European Gastroenterology journal, ISSN 2050-6406, E-ISSN 2050-6414, Vol. 3, nr 2, s. 136-145Artikel, forskningsöversikt (Refereegranskat)
    Abstract [en]

    Background: Celiac disease has been linked to decreased quality of life and certain mood disorders. The effect of the gluten free diet on these psychological aspects of the disease is still unclear. Objectives: The objective of this article is to review the literature on psychological morbidity of celiac disease. Methods: We performed a PubMed search for the time period from 1900 until June 1, 2014, to identify papers on psychological aspects of celiac disease looking specifically at quality of life, anxiety, depression and fatigue. Results: Anxiety, depression and fatigue are common complaints in patients with untreated celiac disease and contribute to lower quality of life. While aspects of these conditions may improve within a few months after starting a gluten-free diet, some patients continue to suffer from significant psychological morbidity. Psychological symptoms may affect the quality of life and the dietary adherence. Conclusion: Health care professionals need to be aware of the ongoing psychological burden of celiac disease in order to support patients with this disease.

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