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  • 1.
    Breimer, Lars H.
    Örebro University Hospital. Department of Laboratory Medicine, Clinical Chemistry Unit, Örebro University Hospital, Örebro, Sweden.
    Where Are We Now With Bilirubin as a Marker of Vascular Risk?2014In: Angiology, ISSN 0003-3197, E-ISSN 1940-1574, Vol. 65, no 3, p. 177-179Article in journal (Refereed)
  • 2.
    Breimer, Lars H.
    et al.
    Laboratoriemedicinska länskliniken, Örebro University Hospital, Region Örebro län, Örebro, Sweden.
    Eriksson, C. G.
    Laboratoriemedicinska länskliniken, Örebro universitetssjukhus, Örebro, Sweden.
    Nilsson, T. K.
    Laboratoriemedicinska länskliniken, Örebro universitetssjukhus, Örebro, Sweden; Hälsoakademin, Örebro universitet, Örebro, Sweden.
    Morgondagens laboratorium - redan i går2012In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 109, no 37, p. 1624-1624Article in journal (Refereed)
  • 3.
    Breimer, Lars H.
    et al.
    Fac Med & Hlth, Dept Lab Med, Örebro University Hospital, Örebro, Sweden.
    Nilsson, Torbjorn K.
    Dept Med Biosci, Clin Chem, Umeå Univ, Umeå, Sweden.
    Is Ferrotoxicity a New Great Public Health Challenge?2015In: Clinical Chemistry, ISSN 0009-9147, E-ISSN 1530-8561, Vol. 61, no 4, p. 667-668Article in journal (Refereed)
  • 4.
    Breimer, Lars H.
    et al.
    Fac Med & Hlth, Dept Lab Med, Örebro University Hospital, Örebro, Sweden.
    Nilsson, Torbjorn K.
    Dept Med Biosci, Clin Chem, Umeå Univ, Umeå, Sweden.
    Shedded cell membrane proteins in plasma: Pure waste, or informative biomarkers of pathophysiological processes?2015In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 75, no 6, p. 441-443Article in journal (Refereed)
  • 5.
    Breimer, Lars H.
    et al.
    Departments of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden.
    Nilsson, Torbjörn K.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Clinical Medicine, Biomedicine, Örebro University, Örebro, Sweden; Departments of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden.
    Has folate a role in the developing nervous system after birth and not just during embryogenesis and gestation?2012In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 72, no 3, p. 185-191Article, review/survey (Refereed)
    Abstract [en]

    It is now 30 years since the first publications stating that supplementation with folate could prevent neural tube defects appeared and 20 years since the definitive data, including prevention of other birth defects. Since then epidemiological studies and animal experiments have identified folate as a molecule at the crossroads of neural development. Fortification of food has greatly reduced the incidence of spina bifida. Much interest has focussed on long-term sequelae in children born to mothers severely deprived of folate (and other nutrients) such as during the Dutch Hunger Winter of 1944 and in poor parts of the world. In addition, deficiency in folate and B12 are increasingly discussed as a possible contributing factor in dementia and congenital orofacial and heart malformations. The year 2011 saw the publication of a study that implicated low folate intake in poorer school performance of adolescents as judged by school marks. This has enormous social implications but needs confirmation from other settings. This review assesses the current state of evidence and sets the data in context of whether folate has a role in the development and plasticity of the nervous system even after birth, with particular emphasis on childhood and adolescence.

  • 6.
    Breimer, Lars
    et al.
    Örebro University Hospital.
    Nilsson, T.
    Sverige bör bergunda ett utspel i PNAS: Sweden should contemplate article in PNAS2014In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 111, no 46, p. 2045-Article in journal (Refereed)
  • 7.
    Gustafsson, Dan
    et al.
    Departments of Pediatrics, Örebro University Hospital, Örebro, Sweden.
    Breimer, Lars H.
    Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden;.
    Isaksson, Helena S.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden; Department of Clinical Medicine and Biomedicine, Örebro University, Örebro, Sweden.
    Nilsson, Torbjörn K.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden; Department of Clinical Medicine and Biomedicine, Örebro University, Örebro, Sweden.
    Tissue zinc levels in a child with hypercalprotectinaemia and hyperzincaemia: a case report and a review of the literature2012In: Scandinavian Journal of Clinical and Laboratory Investigation, ISSN 0036-5513, E-ISSN 1502-7686, Vol. 72, no 1, p. 34-38Article, review/survey (Refereed)
    Abstract [en]

    Background: A girl suffering from a rare syndrome of unknown aetiology, termed hypercalprotectinaemia, was evaluated for tissue zinc status, because calprotectin is a protein which chelates Zn at multiple binding-sites, which might have affected the distribution of Zn in her body.

    Methods: Measurement of serum, urine, hair and nail zinc (Zn) concentration, complemented with measurement of total Zn in ultrafiltrates of plasma.

    Results: Her serum Zn concentration was 105-133 mu mol/L. Zn levels in her hair (102 mu g/g), nail (90 mu g/g) and urine (3-12 mu mol/L; 20-80 mu g/dL) were all at the lower end of the reference intervals described in the sparse literature. Zn concentrations in ultrafiltrates of plasma were below the detection limit (<100 nmol/L). Thus, the elevated serum Zn did not translate into a similarly increased level of Zn in any of the tissues tested, nor in free Zn concentrations. Instead it appeared to be a result of Zn being chelated to binder proteins, most probably calprotectin.

    Conclusion: Her grossly elevated serum calprotectin concentration is probably able to raise circulating total Zn concentrations without raising ionized concentrations, but this Zn remains confined to the circulating blood as well as to excreted body fluids, particularly faeces.

  • 8.
    Jonsson, Thomas Björn
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Surgery, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
    Nilsson, T. K.
    Dept Med Biosci Clin Chem, Umeå Univ, Umeå, Sweden.
    Breimer, Lars H.
    Örebro University Hospital. Department of Laboratory Medicine, Örebro University Hospital, Örebro, Sweden.
    Schneede, J.
    Dept Clin Pharmacol, Umeå Univ, Umeå, Sweden.
    Arfvidsson, B.
    Department of Surgery, Örebro University Hospital, Örebro, Sweden.
    Norgren, Lars
    Örebro University, School of Health and Medical Sciences. Department of Surgery, Faculty of Health and Medical Sciences, Örebro University, Örebro, Sweden.
    Cloxacillin concentrations in serum, subcutaneous fat, and muscle in patients with chronic critical limb ischemia2014In: European Journal of Clinical Pharmacology, ISSN 0031-6970, E-ISSN 1432-1041, Vol. 70, no 8, p. 957-963Article in journal (Refereed)
    Abstract [en]

    Patients suffering from critical limb ischemia (CLI) have poor wound healing in the ankle and foot areas. Secondary wound infections are frequent and often treated with prolonged courses of antibiotics.

    This study set out to investigate to what extent the unbound fraction of 4 g of cloxacillin i.v. reaches its target organ in poorly vascularized tissues, i.e., the calf and foot of patients suffering from CLI.

    Cloxacillin concentrations were measured by HPLC in serum and in microdialysis samples from skin and muscle of the lower part of the calf and as reference subcutaneously at the pectoral level in eight patients suffering from CLI (four males, four females, mean age 78 years, range 66-85 years) and in three healthy controls (two females, one male, mean age 67, range 66-68 years).

    In patients suffering from CLI, the tissue penetration of cloxacillin after a single 4 g dose was comparable to that of healthy controls, despite impaired blood circulation.

    The reduced blood flow in the peripheral vessels of the CLI patients presented here apparently is not the rate-limiting factor for delivery or tissue penetration of cloxacillin.

1 - 8 of 8
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