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  • 1.
    Ericson Jogsten, Ingrid
    et al.
    Örebro University, School of Science and Technology.
    Wang, Thanh
    Örebro University, School of Science and Technology.
    Geng, Dawei
    Örebro University, School of Science and Technology.
    Roos, A.
    Temporal trends of persistent organochlorine and bromine compounds in ringed seals from the Baltic Sea (Phoca hispida baltica) from year 1974 to 20152016In: Organohalogen Compounds, ISSN 1026-4892, Vol. 78Article in journal (Refereed)
  • 2.
    Gauthier, Marie-Soleil
    et al.
    Institut de Recherches Cliniques de Montréal, Montréal QC, Canada; Montreal Diabetes Research Centre, Centre de Recherche du Centre Hospitalier de L'Université de Montréal (CRCHUM), Montréal QC, Canada.
    Rabasa-Lhoret, Remi
    Institut de Recherches Cliniques de Montréal, Montréal QC, Canada; Montreal Diabetes Research Centre, Centre de Recherche du Centre Hospitalier de L'Université de Montréal (CRCHUM), Montréal QC, Canada; Nutrition Department, Université de Montréal, Montréal, Canada; Endocrinology Division, Montreal University Hospital, Montréal QC, Canada; School of Human Kinetics, Faculty of Health Sciences, University of Ottawa, Ottawa ON, Canada.
    Prud'homme, Denis
    Institut de Recherche de L'Hôpital Montfort, Ottawa ON, Canada .
    Karelis, Antony D.
    Department of Kinanthropology, Université du Québec À Montréal, Montréal QC, Canada .
    Geng, Dawei
    Örebro University, School of Science and Technology.
    van Bavel, Bert
    Örebro University, School of Science and Technology.
    Ruzzin, Jeorme
    Department of Biology, University of Bergen, Bergen, Norway.
    The Metabolically Healthy But Obese Phenotype Is Associated With Lower Plasma Levels of Persistent Organic Pollutants as Compared to the Metabolically Abnormal Obese Phenotype2014In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 99, no 6, p. E1061-E1066Article in journal (Refereed)
    Abstract [en]

    Context: Although obesity is strongly linked to insulin resistance and type 2 diabetes, a subset of obese individuals termed metabolically healthy but obese(MHO) appears relatively protected from the development of cardiometabolic complications. The origins of this metabolically healthy phenotype remain unclear. Recently, persistent organic pollutants (POPs) have emerged as potential endocrine disruptors.

    Objective: The aim of this study was to test the hypothesis that the MHO phenotype presents lower circulating levels of POPs as compared to the metabolically abnormal obese (MAO) phenotype.

    Design, Setting, and Patients: We conducted a cross-sectional study of 76 nondiabetic obese (body mass index >= 30 kg/m(2)) postmenopausal women.

    Main Outcome Measures: Plasma concentrations of 21 POPs as well as cardiometabolic risk factors were analyzed.

    Results: For similar age, body mass index, and fat mass index, MHO women (n = 40) showed higher insulin sensitivity levels and a more favorable cardiometabolic profile than MAO women (n = 36), as evidenced by a 2-fold increase in glucose disposal rates measured by the hyperinsulinemic-euglycemic clamp (P = .001). Among 18 detectable pollutants measured, MAO women had higher plasma concentrations of 12 POPs (fold increase, 1.4-2.9; P < .001-.036). Logistic regression analyses showed that the prevalence of the MAO phenotype was significantly associated with higher levels of total dioxin and non-dioxin-like polychlorinated biphenyls (odds ratio, 4.7; 95% confidence interval, 1.8-12.5; P = .002), as well as trans-nonachlor (odds ratio, 6.1; 95% CI, 2.2-16.4; P < .001).

    Conclusion: Our study demonstrates that the metabolically healthy and abnormal phenotypes have distinct plasma POP profiles.

  • 3.
    Geng, Dawei
    Örebro University, School of Science and Technology.
    Gas chromatography-atmospheric pressure chemical ionization-tandem mass spectrometry methods for the determination of environmental contaminants2016Doctoral thesis, comprehensive summary (Other academic)
    Abstract [en]

    The recent developments and improvements of instrumental methods for the analyses of the environmental contaminants, especially the persistent organic pollutants (POPs), have made it possible to detect and quantify these at very low concentrations in environmental and biotic matrices.

    The main objective of this thesis is to demonstrate the capability of the atmospheric pressure chemical ionization technique (APCI), using gas chromatography coupled to tandem mass spectrometry for the determination of a wide range of environmental contaminants, including the POPs regulated by Stockholm Convention, such as polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs), polychlorinated biphenyls (PCBs), polybrominated diphenyl ethers (PBDEs), but also the derivates of PBDEs and novel brominated flame retardants (NBFRs).

    The APCI was operated in charge transfer condition, preferably producing molecular ions. Multiple reaction monitoring (MRM) experiments were optimized by adjusting cone voltage, collision energy and dwell time. Optimization of source parameters, such as gas flows and temperatures was also performed. Low concentration standards were analyzed, achieving a visible chromatographic peak for 2 fg 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) demonstrating the excellent sensitivity of the system. Adequate linearity and repeatability were observed for all the studied compounds. The performance of APCI methods was validated against the conventional methods using gas chromatography coupled to high resolution mass spectrometry for chlorinated compounds in a wide range of matrices including environmental, air, human and food matrices.

    The GC-APCI-MS/MS method was successfully applied to a set of 75 human serum samples to study the circulating levels of POPs in epidemiologic studies. Moreover the method was utilized to establish temporal trends of POPs in osprey eggs samples collected during the past five decades.

    List of papers
    1. Gas chromatography/atmospheric pressure chemical ionization/mass spectrometry for the analysis of organochlorine pesticides and polychlorinated biphenyls in human serum
    Open this publication in new window or tab >>Gas chromatography/atmospheric pressure chemical ionization/mass spectrometry for the analysis of organochlorine pesticides and polychlorinated biphenyls in human serum
    Show others...
    2016 (English)In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1453, p. 88-98Article in journal (Refereed) Published
    Abstract [en]

    A method using a novel atmospheric pressure chemical ionization source for coupling gas chromatography (GC/APCI) to triple quadrupole mass spectrometry (MS/MS) for the determination of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) regulated by the Stockholm Convention is presented. One microliter injection of a six-point calibration curve of native PCBs and OCPs, ranging from 0.04 to 300 pg/μL, was performed. The relative standard deviation (RSD) of the relative response factors (RRFs) was less than 15% with a coefficient of determination (r2) &gt;0.995. Meanwhile, two calibration solutions (CS), CS 2 (0.4 pg/μL) and CS 3 (4 pg/μL) were analyzed to study the repeatability calculated for both area and RRFs. The RSD for RRF ranged from 3.1 to 16% and 3.6 to 5.5% for CS 2 and CS 3, respectively. The limits of detection (LOD) determined by peak-to-peak signal-to-noise ratio (S/N) of 3 were compared between the GC/APCI/MS/MS and a GC coupled to high resolution mass spectrometry (GC/HRMS) system. GC/APCI/MS/MS resulted in lower LOD for most of the compounds, except for PCB#74, cis-chlordane and trans-chlordane. GC/APCI/MS/MS and GC/HRMS were also compared by performing analysis on 75 human serum samples together with eight QA/QC serum samples. The comparison between GC/APCI/MS/MS system and GC/HRMS system for 16 of the targeted compounds was carried out. No statistically significant difference was discovered. Due to increased sensitivity and user friendly operation under atmospheric pressure, GC/APCI/MS/MS is a powerful alternative technique that can easily meet the specification of GC/HRMS.

    Place, publisher, year, edition, pages
    Amsterdam, Netherlands: Elsevier, 2016
    Keywords
    PCBs, OCPs, atmospheric pressure chemical ionization (APCI), triple quadrupole mass spectrometry (MS/MS), high resolution mass spectrometry (GC/HRMS), human serum
    National Category
    Chemical Sciences
    Research subject
    Analytical Chemistry; Environmental Chemistry; Enviromental Science
    Identifiers
    urn:nbn:se:oru:diva-50854 (URN)10.1016/j.chroma.2016.05.030 (DOI)000378182800010 ()27236485 (PubMedID)2-s2.0-84969722268 (Scopus ID)
    Note

    Funding Agency:

    China Scholarship Council (CSC) under the Grant CSC 201206400003

    Available from: 2016-06-15 Created: 2016-06-14 Last updated: 2018-09-12Bibliographically approved
    2. Atmospheric-Pressure Chemical Ionization Tandem Mass Spectrometry (APGC/MS/MS) an Alternative to High-Resolution Mass Spectrometry (HRGC/HRMS) for the Determination of Dioxins
    Open this publication in new window or tab >>Atmospheric-Pressure Chemical Ionization Tandem Mass Spectrometry (APGC/MS/MS) an Alternative to High-Resolution Mass Spectrometry (HRGC/HRMS) for the Determination of Dioxins
    Show others...
    2015 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 87, no 17, p. 9047-9053Article in journal (Refereed) Published
    Abstract [en]

    The use of a new atmospheric-pressure chemical ionization source for gas chromatography (APGC) coupled with a tandem quadrupole mass spectrometry (MS/MS) system, as an alternative to high-resolution mass spectrometry (HRMS), for the determination of PCDDs/PCDFs is described. The potential of using atmospheric-pressure chemical ionization (APCI) coupled to a tandem quadrupole analyzer has been validated for the identification and quantification of dioxins and furans in different complex matrices. The main advantage of using the APCI source is the soft ionization at atmospheric pressure, which results in very limited fragmentation. APCI mass spectra are dominated by the molecular ion cluster, in contrast with the high energy ionization process under electron ionization (El). The use of the molecular ion as the precursor ion in MS/MS enhances selectivity and, consequently, sensitivity by increasing the signal-to-noise ratios (S/N). For standard solutions of 2,3,7,8-TCDD, injections of 10 fg in the splitless mode on 30- or 60-m-length, 0.25 mm inner diameter (id), and 25 mu m film thickness low-polarity capillary columns (DB5MS type), signal-to-noise (S/N) ratios of >10:1 were routinely obtained. Linearity was achieved in the region (correlation coefficient of r(2) > 0.998) for calibration curves ranging from 100 fg/mu L, to 1000 pg/mu L. The results from a wide variety of complex samples, including certified and standard reference materials and samples from several QA/QC studies, which were previously analyzed by EI HRGC/HRMS, were compared with the results from the APGC/MS/MS system. Results between instruments showed good agreement both in individual congeners and toxic equivalence factors (TEQs). The data show that the use of APGC in combination with MS/MS for the analysis of dioxins has the same potential, in terms of sensitivity and selectivity, as the traditional HEMS instrumentation used for this analysis. However, the APCI/MS/MS system, as a benchtop system, is much easier to use.

    National Category
    Analytical Chemistry
    Research subject
    Analytical Chemistry
    Identifiers
    urn:nbn:se:oru:diva-46035 (URN)10.1021/acs.analchem.5b02264 (DOI)000360773100062 ()26267710 (PubMedID)2-s2.0-84940971553 (Scopus ID)
    Note

    Funding Agencies:

    Generalitat Valenciana, as research group of excellence PROMETEO/2009/054

    Serveis Centrals d'Instrumentacio Cientifica (SCIC) of the University Jaume I

    China Scholarship Council 201206400003

    Available from: 2015-10-07 Created: 2015-10-07 Last updated: 2018-07-02Bibliographically approved
    3. Analysis of Novel and Legacy Brominated Flame Retardants Including Their Derivates by Atmospheric Pressure Chemical Ionization Using Gas Chromatography Coupled to Triple Quadrupole Mass Spectrometry
    Open this publication in new window or tab >>Analysis of Novel and Legacy Brominated Flame Retardants Including Their Derivates by Atmospheric Pressure Chemical Ionization Using Gas Chromatography Coupled to Triple Quadrupole Mass Spectrometry
    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Chemistry Topics
    Research subject
    Chemistry
    Identifiers
    urn:nbn:se:oru:diva-52072 (URN)
    Available from: 2016-09-09 Created: 2016-09-09 Last updated: 2017-10-17Bibliographically approved
    4. Temporal Trends of Polychlorinated Biphenyls, Organochlorine Pesticides and Polybrominated Diphenyl Ethers in Osprey Eggs in Sweden over the Years 1966 – 2013
    Open this publication in new window or tab >>Temporal Trends of Polychlorinated Biphenyls, Organochlorine Pesticides and Polybrominated Diphenyl Ethers in Osprey Eggs in Sweden over the Years 1966 – 2013
    Show others...
    (English)Manuscript (preprint) (Other academic)
    National Category
    Other Chemistry Topics
    Research subject
    Chemistry
    Identifiers
    urn:nbn:se:oru:diva-52073 (URN)
    Available from: 2016-09-09 Created: 2016-09-09 Last updated: 2017-10-17Bibliographically approved
  • 4.
    Geng, Dawei
    et al.
    Örebro University, School of Science and Technology.
    Ericson Jogsten, Ingrid
    Örebro University, School of Science and Technology.
    Dunstan, Jody
    Waters Corporation, Manchester, United Kingdom.
    Hagberg, Jessika
    Örebro University, School of Science and Technology. Department of Occupational and Environmental Medicine, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Wang, Thanh
    Örebro University, School of Science and Technology.
    Ruzzin, Jerome
    Department of Biology, University of Bergen, Bergen, Norway.
    Rabasa-Lhoret, Rémi
    Institut de Recherches Cliniques de Montréal, Montréal QC, Canada; Montreal Diabetes Research Centre at the Centre de Recherche du Centre Hospitalier de l’Université de Montréal (CRCHUM) Montréal QC, Canada; Nutrition Department of Université de Montréal, Montréal QC, Canada; Endocrinology Division, Montreal University Hospital, Montréal QC, Canada.
    van Bavel, Bert
    Örebro University, School of Science and Technology. Norwegian Institute for Water Research (NIVA), Oslo, Norway.
    Gas chromatography/atmospheric pressure chemical ionization/mass spectrometry for the analysis of organochlorine pesticides and polychlorinated biphenyls in human serum2016In: Journal of Chromatography A, ISSN 0021-9673, E-ISSN 1873-3778, Vol. 1453, p. 88-98Article in journal (Refereed)
    Abstract [en]

    A method using a novel atmospheric pressure chemical ionization source for coupling gas chromatography (GC/APCI) to triple quadrupole mass spectrometry (MS/MS) for the determination of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) regulated by the Stockholm Convention is presented. One microliter injection of a six-point calibration curve of native PCBs and OCPs, ranging from 0.04 to 300 pg/μL, was performed. The relative standard deviation (RSD) of the relative response factors (RRFs) was less than 15% with a coefficient of determination (r2) &gt;0.995. Meanwhile, two calibration solutions (CS), CS 2 (0.4 pg/μL) and CS 3 (4 pg/μL) were analyzed to study the repeatability calculated for both area and RRFs. The RSD for RRF ranged from 3.1 to 16% and 3.6 to 5.5% for CS 2 and CS 3, respectively. The limits of detection (LOD) determined by peak-to-peak signal-to-noise ratio (S/N) of 3 were compared between the GC/APCI/MS/MS and a GC coupled to high resolution mass spectrometry (GC/HRMS) system. GC/APCI/MS/MS resulted in lower LOD for most of the compounds, except for PCB#74, cis-chlordane and trans-chlordane. GC/APCI/MS/MS and GC/HRMS were also compared by performing analysis on 75 human serum samples together with eight QA/QC serum samples. The comparison between GC/APCI/MS/MS system and GC/HRMS system for 16 of the targeted compounds was carried out. No statistically significant difference was discovered. Due to increased sensitivity and user friendly operation under atmospheric pressure, GC/APCI/MS/MS is a powerful alternative technique that can easily meet the specification of GC/HRMS.

  • 5.
    Geng, Dawei
    et al.
    Örebro University, School of Science and Technology.
    Ericson Jogsten, Ingrid
    Örebro University, School of Science and Technology.
    Kukucka, Petr
    Örebro University, School of Science and Technology. RECETOX Masaryk University, Brno, Czech Republic.
    Eriksson, Ulrika
    Örebro University, School of Science and Technology.
    Ekblad, Alf
    Örebro University, School of Science and Technology.
    Grahn, Hans
    Örebro University, School of Science and Technology.
    Roos, Anna
    Department for Environmental Research and Monitoring, Swedish Museum of Natural History, Stockholm, Sweden.
    Temporal Trends of Polychlorinated Biphenyls, Organochlorine Pesticides and Polybrominated Diphenyl Ethers in Osprey Eggs in Sweden over the Years 1966 – 2013Manuscript (preprint) (Other academic)
  • 6.
    Geng, Dawei
    et al.
    Örebro University, School of Science and Technology.
    Ericson Jogsten, Ingrid
    Örebro University, School of Science and Technology.
    Kukucka, Petr
    MTM Research Centre, School of Science and Technology, Örebro University, Örebro, Sweden; Research Centre for Toxic Compounds in the Environment, Faculty of Science, Masaryk University, Brno, Czech Republic.
    Hagberg, Jessika
    Örebro University, School of Science and Technology.
    Roos, Anna
    Department for Environmental Research and Monitoring , Swedish Museum of Natural History, Stockholm, Sweden .
    van Bavel, Bert
    Örebro University, School of Science and Technology.
    Comparison on atmospheric pressure gas chromatography-tandem mass spectrometry (APGC-MS/MS) and high resolution mass spectrometry for the analysis of polybrominated diphenyl ethers (PBDEs)2014In: Organohalogen Compounds, ISSN 1026-4892, Vol. 76, p. 1593-1596Article in journal (Refereed)
  • 7.
    Geng, Dawei
    et al.
    Örebro University, School of Science and Technology.
    Ericson Jogsten, Ingrid
    Örebro University, School of Science and Technology.
    Salihovic, Samira
    Örebro University, School of Science and Technology.
    Dunstan, J.
    Ruzzin, J.
    Rémi, RL.
    van Bavel, Bert
    Örebro University, School of Science and Technology.
    Atmospheric pressure gas chromatography (APGC) coupled to triple quadrupole mass spectrometry (MS/MS) for the quantitative analysis of pesticides and PCBs regulated by the Stockholm Convention2013In: Organohalogen Compounds, ISSN 1026-4892, Vol. 75Article in journal (Refereed)
  • 8.
    Geng, Dawei
    et al.
    Örebro University, School of Science and Technology.
    Kukucka, Petr
    Örebro University, School of Science and Technology. RECETOX Masaryk University, Brno, Czech Republic.
    Ericson Jogsten, Ingrid
    Örebro University, School of Science and Technology.
    Analysis of brominated flame retardants and their derivatives by atmospheric pressure chemical ionization using gas chromatography coupled to tandem quadrupole mass spectrometry2017In: Talanta: The International Journal of Pure and Applied Analytical Chemistry, ISSN 0039-9140, E-ISSN 1873-3573, Vol. 162, p. 618-624Article in journal (Refereed)
    Abstract [en]

    A validated method using an atmospheric pressure chemical ionization source for coupling gas chromatography (GC-APCI) to tandem quadrupole mass spectrometry (MS/MS) for the determination of brominated flame retardants (BFRs) is presented. Polybrominated diphenyl ethers (PBDEs), their methoxylated derivatives (MeO-PBDEs) and other emerging BFRs were included in this study. The method showed good linearity and repeatability. The relative standard deviation (RSD) of the relative response factors (RRFs) of all compounds was less than 16%. Repeatability for BFRs was tested on one or two concentration levels of calibration standardswith RSDs for RRFs below 16%. The lowest calibration standards (0.075 –0.1 pg/μL for emerging BFRs, BDE 209 and MeO-PBDEs mixtures, 0.625 –6.25 pg/μL for Br1-9 PBDEs mixtures) were used as instrument detection limits (IDL). The method was applied on biotic samples, including fish, osprey, and seal. In general, BDE209 and decabromodiphenyl ethane (DBDPE) were detected in 50% of the seal samples. A 100% detection rate was achieved for 6-MeO-BDE47 in all the samples (72 –580 pg/g ww in osprey samples, 24 000 –96 000 pg/g ww in seal samples and 78–99 pg/g ww in fish samples). AllBr3-6PBDEs (BDE28, 47, 99, 100, 153, 154) were detected in all the samples (ranging from 12 to 20 000 pg/g ww), while BDE183 was detected in 60% of the osprey eggs, 20% of the seal samples and below MDL in all fish samples. The results presented indicate the capability of the GC-APCI-MS/MS system for the detection and quantification of BFRs.

  • 9.
    Geng, Dawei
    et al.
    Örebro University, School of Science and Technology.
    Kukucka, Petr
    Örebro University, School of Science and Technology. RECETOX Masaryk University, Brno, Czech Republic.
    Ericson Jogsten, Ingrid
    Örebro University, School of Science and Technology.
    Analysis of Novel and Legacy Brominated Flame Retardants Including Their Derivates by Atmospheric Pressure Chemical Ionization Using Gas Chromatography Coupled to Triple Quadrupole Mass SpectrometryManuscript (preprint) (Other academic)
  • 10.
    Geng, Dawei
    et al.
    Örebro University, School of Science and Technology.
    Kukucka, Petr
    Örebro University, School of Science and Technology.
    van Bavel, Bert
    Örebro University, School of Science and Technology.
    Ericson Jogsten, Ingrid
    Örebro University, School of Science and Technology.
    Roos, A.
    Temporal Trends of Polychlorinated Biphenyls, Organochlorine Pesticides and Polybrominated Diphenyl Ethers in Osprey Eggs in Sweden over the Years 1966 – 20132016In: Organohalogen Compounds, ISSN 1026-4892, Vol. 78Article in journal (Refereed)
  • 11.
    Geng, Dawei
    et al.
    Örebro University, School of Science and Technology.
    Musse, Ayan Au
    School of Science and Technology, Örebro University, Örebro, Sweden.
    Wigh, Viktoria
    School of Science and Technology, Örebro University, Örebro, Sweden.
    Carlsson, Cecilia
    School of Science and Technology, Örebro University, Örebro, Sweden.
    Engwall, Magnus
    Örebro University, School of Science and Technology.
    Oresic, Matej
    Örebro University, School of Medical Sciences. Turku Centre for Biotechnology, University of Turku and Åbo Akademi University, Turku, Finland.
    Scherbak, Nikolai
    Örebro University, School of Science and Technology.
    Hyötyläinen, Tuulia
    Örebro University, School of Science and Technology.
    Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo2019In: Ecotoxicology and Environmental Safety, ISSN 0147-6513, E-ISSN 1090-2414, Vol. 170, p. 691-698Article in journal (Refereed)
    Abstract [en]

    Perfluorooctanesulfonate (PFOS) is a well-known contaminant in the environment and it has shown to disrupt multiple biological pathways, particularly those related with lipid metabolism. In this study, we have studied the impact of in ovo exposure to PFOS on lipid metabolism in livers in developing chicken embryos using lipidomics for detailed characterization of the liver lipidome. We used an avian model (Gallus gallus domesticus) for in ovo treatment at two levels of PFOS. The lipid profile of the liver of the embryo was investigated by ultra-high performance liquid chromatography combined with quadrupole-time-of-flight mass spectrometry and by gas chromatography mass spectrometry. Over 170 lipids were identified, covering phospholipids, ceramides, di- and triacylglycerols, cholesterol esters and fatty acid composition of the lipids. The PFOS exposure caused dose dependent changes in the lipid levels, which included upregulation of specific phospholipids associated with the phosphatidylethanolamine N-methyltransferase (PEMT) pathway, triacylglycerols with low carbon number and double bond count as well as of lipotoxic ceramides and diacylglycerols. Our data suggest that at lower levels of exposure, mitochondrial fatty acid β-oxidation is suppressed while the peroxisomal fatty acid β -oxidation is increased. At higher doses, however, both β -oxidation pathways are upregulated.

  • 12.
    Li, Honghua
    et al.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
    Zhang, Qinghua
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
    Wang, Pu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
    Li, Yingming
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
    Lv, Jianxia
    Weifang Entry-Exit Inspection and Quarantine Bureau, Weifang, China.
    Chen, Weihai
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
    Geng, Dawei
    School of Energy Resources, China University of Geosciences, Beijing, China .
    Wang, Yawei
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
    Wang, Thanh
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
    Jiang, Guibin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China .
    Levels and distribution of hexabromocyclododecane (HBCD) in environmental samples near manufacturing facilities in Laizhou Bay area, East China2012In: Journal of Environmental Monitoring, ISSN 1464-0325, E-ISSN 1464-0333, Vol. 14, no 10, p. 2591-2597Article in journal (Refereed)
    Abstract [en]

    A total of 55 samples including soil, sediment, plants (cypress, reed and seepweed) and aquatic species were collected at locations around hexabromocyclododecane (HBCD) manufacturing facilities in Laizhou Bay area, East China. HBCD was determined at concentrations ranging between 0.88 and 6901 ng g(-1) dry weight (dw), 2.93-1029 ng g(-1) dw, 8.88-160241 ng g(-1) dw, and 7.09-815 ng g(-1) lipid weight (lw), respectively. Significant negative correlations (r(2) = 0.54, p = 0.006) were observed between HBCD concentrations in soils and the distance from the manufacturing facility, and the concentrations became constant when the distance was >4 km. The calculation results on the bioaccumulation factors (BAFs) suggested that HBCD may be accumulated in plants. Tissue-specific bioaccumulation of HBCD diastereoisomers was found in aquatic species. For example, in crabs the highest concentrations of HBCD (815 ng g(-1) lw for female and 446 ng g(-1) lw for male) were observed in the gill. Besides the gill, α-HBCD was more preferentially accumulated in the spermary and ovary, while β- and γ-HBCD were more accumulated in the muscle. A similar distribution was also observed in roe and muscle of goby fish.

  • 13.
    Li, YingMing
    et al.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Geng, Dawei
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; School of Energy Resources, China University of Geosciences (Beijing), Beijing, China.
    Hu, YongBiao
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; College of Resources and Environment, Huaz hong Agricultural University, Wuhan, China .
    Wang, Pu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Zhang, QingHua
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Jiang, GuiBin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Levels and distribution of polychlorinated biphenyls in the atmosphere close to Chinese Great Wall Station, Antarctica: Results from XAD-resin passive air sampling2012In: Chinese Science Bulletin, ISSN 1001-6538, E-ISSN 1861-9541, Vol. 57, no 13, p. 1499-1503Article in journal (Refereed)
    Abstract [en]

    Antarctica is an important research region for assessing persistence and long-range atmospheric transport (LRAT) of persistent organic pollutants (POPs). In this study, XAD-resin passive air sampling was conducted near the Chinese Great Wall Station, Antarctica, during a one-year sampling period in 2009-2010. The air concentrations of polychlorinated biphenyls (PCBs) were at a very low level, with total PCBs in the range of 26.74-45.08 pg m(-3). PCB profiles were dominated by tetra-PCBs, tri-PCBs and di-PCBs, indicating LRAT was responsible for the pollutants in the Antarctic atmosphere. The sampling site near the Chinese Great Wall Station did not show higher PCB levels than the other sites, suggesting that PCB sources associated with the Great Wall Station were negligible. PCB-11 is a non-Aroclor congener, which has specific sources compared to other Aroclor PCB congeners. PCB-11 was observed in all air samples, with an average concentration of 1.22 pg m(-3). To our knowledge, this study is the first investigation of PCB levels and distribution in the atmosphere around the Chinese Great Wall Station, Antarctica.

  • 14.
    Li, Yingming
    et al.
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Geng, Dawei
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China; School of Energy Resources, China University of Geosciences, Beijing, China.
    Liu, Fubin
    National Marine Environmental Forecasting Center, Beijing, China.
    Wang, Thanh
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Wang, Pu
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Zhang, Qinghua
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Jiang, Guibin
    State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China.
    Study of PCBs and PBDEs in King George Island, Antarctica, using PUF passive air sampling2012In: Atmospheric Environment, ISSN 1352-2310, E-ISSN 1873-2844, Vol. 51, p. 140-145Article in journal (Refereed)
    Abstract [en]

    Polyurethane foam (PUF)-disk based passive air samplers were deployed in King George Island, Antarctica, during the austral summer of 2009-2010, to investigate levels, distributions and potential sources of polychlorinated biphenyls (PCBs) and polybrominated diphenyl ethers (PBDEs) in Antarctic air. The atmospheric levels of Sigma indicator PCBs and Sigma(14) PBDEs ranged from 1.66 to 6.50 pg m(-3) and from 0.67 to 2.98 pg m(-3), respectively. PCBs homologue profiles were dominated by di-PCBs, tri-PCBs and tetra-PCBs, whereas BDE-17 and BDE-28 were the predominant congeners of PBDEs, which could be explained by long-range atmospheric transport processes. However, the sampling sites close to the Antarctic research stations showed higher atmospheric concentrations of PCBs and PBDEs than the other sites, reflecting potential local sources from the Antarctic research stations. The non-Aroclor congener PCB-11 was found in all the air samples, with air concentrations of 3.60-31.4 pg m(-3) (average 15.2 pg m(-3)). Comparison between the results derived from PUF-disk passive air sampling and high-volume air sampling validates the feasibility of using the passive air samplers in Antarctic air. To our knowledge, this study is the first employment of PUF-disk based passive air samplers in Antarctic atmosphere.

  • 15.
    Mullin, Lauren
    et al.
    Waters Corporation, Milford, USA.
    Burgess, Jennifer A.
    Waters Corporation, Milford, USA.
    Jogsten, Ingrid Ericson
    Örebro University, School of Science and Technology.
    Geng, Dawei
    Örebro University, School of Science and Technology.
    Aubin, Andy
    Waters Corporation, Milford, USA.
    van Bavel, Bert
    Örebro University, School of Science and Technology.
    Rapid separation of hexabromocyclododecane diastereomers using a novel method combining convergence chromatography and tandem mass spectrometry2015In: Analytical Methods, ISSN 1759-9660, E-ISSN 1759-9679, Vol. 7, no 7, p. 2950-2958Article in journal (Refereed)
    Abstract [en]

    Analysis of the brominated flame retardant hexabromocyclododecane (HBCDD) is characterized by the separation of its three predominant diastereomers. This analysis is typically performed using reversed phase liquid chromatography (RPLC) coupled with mass spectrometric (MS) detection with analysis times in the order of 10 minutes or greater. Here we describe a rapid method using supercritical CO2 and methanol to baseline separate the three most abundant HBCDD diastereomers within a three minute run time using a High Strength Silica (HSS) C18 1.8 mu m particle size column. A unique elution order of the alpha-, beta- and gamma-HBCDD diastereomers using supercritical CO2 was observed, and can be used as an orthogonal separation for further confidence in diastereomer identification when used in conjuction with RPLC. A tandem quadrupole mass spectrometer with negative mode electrospray ionization was used for detection, operating in multiple reaction monitoring (MRM) mode. Ionization was enhanced by the addition of a make-up flow, which was introduced to the post-column effluent. Method limit of detection (LOD) and limit of quantification (LOQ) for alpha-, beta- and gamma-HBCDD were based on peak-to-peak signal to noise ratios of greater than 3 or 10, respectively. The LOD for all HBCDD diastereomers as solvent standards was 100 fg on-column, and LOQs 500 fg on-column for alpha- and gamma-HBCDD and 250 fg on-column for beta-HBCDD. In order to test the efficiency of this method, small subsets of complex human serum and whale blubber extracts were analyzed using this method, resulting in positive detections in samples of alpha-HBCDD.

  • 16.
    Mullin, Lauren Gayle
    et al.
    Örebro University, School of Science and Technology.
    van Bavel, Bert
    Örebro University, School of Science and Technology.
    Burgess, J.
    Aubin, A.
    Ericson Jogsten, Ingrid
    Örebro University, School of Science and Technology.
    Geng, Dawei
    Örebro University, School of Science and Technology.
    Rapid separation of hexabromocyclododecane diastereomers and tetrabromobisphenol-A using a novel method combining convergence chromatography and MS/MS detection2013In: Organohalogen Compounds, ISSN 1026-4892, Vol. 75Article in journal (Refereed)
  • 17.
    van Bavel, Bert
    et al.
    Örebro University, School of Science and Technology.
    Geng, Dawei
    Örebro University, School of Science and Technology.
    Cherta, Laura
    Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain.
    Nacher-Mestre, Jaime
    Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain.
    Portoles, Tania
    Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain.
    Abalos, Manuela
    Laboratory of Dioxins, Department of Environmental Chemistry, IDAEA-CSIC, Barcelona, Spain.
    Saulo, Jordi
    Laboratory of Dioxins, Department of Environmental Chemistry, IDAEA-CSIC, Barcelona, Spain.
    Abad, Esteban
    Laboratory of Dioxins, Department of Environmental Chemistry, IDAEA-CSIC, Barcelona, Spain.
    Dunstan, Jody
    Waters Corporation, Manchester, United Kingdom.
    Jones, Rhys
    Waters Corporation, Manchester, United Kingdom.
    Kotz, Alexander
    EU Reference Laboratory (EURL) for Dioxins and PCBs in Feed and Food, State Institute for Chemical and Veterinary Analysis of Food, Freiburg, Germany.
    Winterhalter, Helmut
    EU Reference Laboratory (EURL) for Dioxins and PCBs in Feed and Food, State Institute for Chemical and Veterinary Analysis of Food, Freiburg, Germany.
    Malisch, Rainer
    EU Reference Laboratory (EURL) for Dioxins and PCBs in Feed and Food, State Institute for Chemical and Veterinary Analysis of Food, Freiburg, Germany.
    Traag, Wim
    RIKILT, Institute of Food Safety, Wageningen, Netherlands.
    Hagberg, Jessika
    Örebro University, School of Science and Technology.
    Ericson Jogsten, Ingrid
    Örebro University, School of Science and Technology.
    Beltran, Joaquim
    Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain.
    Hernandez, Felix
    Research Institute for Pesticides and Water (IUPA), University Jaume I, Castellón, Spain.
    Atmospheric-Pressure Chemical Ionization Tandem Mass Spectrometry (APGC/MS/MS) an Alternative to High-Resolution Mass Spectrometry (HRGC/HRMS) for the Determination of Dioxins2015In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 87, no 17, p. 9047-9053Article in journal (Refereed)
    Abstract [en]

    The use of a new atmospheric-pressure chemical ionization source for gas chromatography (APGC) coupled with a tandem quadrupole mass spectrometry (MS/MS) system, as an alternative to high-resolution mass spectrometry (HRMS), for the determination of PCDDs/PCDFs is described. The potential of using atmospheric-pressure chemical ionization (APCI) coupled to a tandem quadrupole analyzer has been validated for the identification and quantification of dioxins and furans in different complex matrices. The main advantage of using the APCI source is the soft ionization at atmospheric pressure, which results in very limited fragmentation. APCI mass spectra are dominated by the molecular ion cluster, in contrast with the high energy ionization process under electron ionization (El). The use of the molecular ion as the precursor ion in MS/MS enhances selectivity and, consequently, sensitivity by increasing the signal-to-noise ratios (S/N). For standard solutions of 2,3,7,8-TCDD, injections of 10 fg in the splitless mode on 30- or 60-m-length, 0.25 mm inner diameter (id), and 25 mu m film thickness low-polarity capillary columns (DB5MS type), signal-to-noise (S/N) ratios of >10:1 were routinely obtained. Linearity was achieved in the region (correlation coefficient of r(2) > 0.998) for calibration curves ranging from 100 fg/mu L, to 1000 pg/mu L. The results from a wide variety of complex samples, including certified and standard reference materials and samples from several QA/QC studies, which were previously analyzed by EI HRGC/HRMS, were compared with the results from the APGC/MS/MS system. Results between instruments showed good agreement both in individual congeners and toxic equivalence factors (TEQs). The data show that the use of APGC in combination with MS/MS for the analysis of dioxins has the same potential, in terms of sensitivity and selectivity, as the traditional HEMS instrumentation used for this analysis. However, the APCI/MS/MS system, as a benchtop system, is much easier to use.

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