oru.sePublications
Change search
Refine search result
1234 1 - 50 of 193
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf
Rows per page
  • 5
  • 10
  • 20
  • 50
  • 100
  • 250
Sort
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
  • Standard (Relevance)
  • Author A-Ö
  • Author Ö-A
  • Title A-Ö
  • Title Ö-A
  • Publication type A-Ö
  • Publication type Ö-A
  • Issued (Oldest first)
  • Issued (Newest first)
  • Created (Oldest first)
  • Created (Newest first)
  • Last updated (Oldest first)
  • Last updated (Newest first)
  • Disputation date (earliest first)
  • Disputation date (latest first)
Select
The maximal number of hits you can export is 250. When you want to export more records please use the 'Create feeds' function.
  • 1.
    Adams, A.
    et al.
    University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom.
    Kalla, R.
    University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom.
    Vatn, S.
    University of Oslo, Institute of Clinical Medicine, EpiGen, Campus Ahus, Oslo, Norway.
    Bonfiglio, F.
    BioCruces Health Research Institue, Bilbao, Spain.
    Nimmo, E.
    University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom.
    Kennedy, N.
    University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom.
    Ventham, N.
    University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom.
    Vatn, M.
    University of Oslo, Institute of Clinical Medicine, EpiGen, Campus Ahus, Oslo, Norway.
    Ricanek, P.
    Akershus University, Department of Gastroenterology, Akershus, Norway.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Söderholm, J.
    Linköping University Hospital, Department of Surgery, Linköping, Sweden;.
    Pierik, M.
    Maastricht University Medical Center (MUMC), Department of Gastroenterology and Hepatology, Maastricht, Netherlands.
    Törkvist, L.
    Karolinska Institute, Department of Clinical Science, Intervention and Technology, Stock-holm, Sweden.
    Gomollon, F.
    University Hospital Clinic Lozano Blesa, Zaragoza, Spain.
    Gut, I.
    CNAG-CRG Centre for Genomic Regulation, Barcelona Institute of Science and Technology, Barcelona, Spain.
    Jahnsen, J.
    University of Oslo, Institute of Clinical Medicine, EpiGen, Campus Ahus, Oslo, Norway.
    Satsangi, J.
    University of Edinburgh, Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom.
    Epigenetic alterations at diagnosis predict susceptibility, prognosis and treatment escalation in inflammatory bowel disease - IBD Character2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S108-S108Article in journal (Refereed)
  • 2. Almer, Sven
    et al.
    Befrits, Ragnar
    Eriksson, Anders S
    Halfvarson, Jonas
    Hindorf, Ulf
    Löfberg, Robert
    Modern läkemedelsterapi vid Crohn  [Current drug therapy in Crohn disease]: nationella riktlinjer [national guidelines]2009In: Läkartidningen, ISSN 0023-7205, E-ISSN 1652-7518, Vol. 106, no 45, p. 2988-2993Article in journal (Refereed)
  • 3. Amcoff, K.
    et al.
    Joossens, M.
    Pierik, M. J.
    Jonkers, D.
    Bohr, J.
    Joossens, S
    Romberg-Camp, M.
    Nyhlin, Nils
    Wickbom, A.
    Rutgeerts, P. J.
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Bodin, L.
    Colombel, J. F.
    Vermeire, S.
    Halfvarson, Jonas
    Arvets inverkan på serologiska markörer hos tvillingar med IBD2012In: Gastrokuriren, ISSN 1651-0453, Vol. 17, no 26, p. MP-06-MP-06Article in journal (Other academic)
  • 4.
    Amcoff, Karin
    et al.
    Örebro University, School of Medical Sciences.
    Bergenmalm, Daniel
    University Hospital Maastricht, Maastricht, The Netherlands.
    Pierik, Marie J.
    University Hospital Maastricht, Maastricht, The Netherlands.
    Colombel, Jean-Frederic
    University Hospital Gasthuisberg, Leuven, Belgium.
    Vermeire, Severine
    Karolinska Institute, Stockholm, Sweden.
    Bodin, Lennart
    Icahn School of Medicine at Mount Sinai, New York, NY, USA.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Environmental and genetic factors in the development of perinuclear-antineutrophil cytoplasmic antibody (pANCA) positive ulcerative colitis: a European twin studyManuscript (preprint) (Other academic)
  • 5.
    Amcoff, Karin
    et al.
    Örebro University, School of Medical Sciences.
    Cao, Yang
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Zhulina, Yaroslava
    Örebro University Hospital. Örebro University, School of Medical Sciences.
    Lampinen, M.
    Uppsala Univ, Dept Med Sci, Uppsala, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Carlson, M.
    Uppsala Univ, Dept Med Sci, Uppsala, Sweden.
    Prognostic significance of eosinophil granule proteins in inflammatory bowel disease2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S181-S182Article in journal (Other academic)
  • 6.
    Amcoff, Karin
    et al.
    Örebro University, School of Medical Sciences.
    Cao, Yang
    Örebro University, School of Medical Sciences. Karolinska Institutet, Stockholm, Sweden.
    Zhulina, Yaroslava
    Örebro University, School of Medical Sciences.
    Lampinen, Maria
    Uppsala University, Uppsala, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Carlson, Marie
    Uppsala University, Uppsala, Sweden.
    Prognostic significance of eosinophile granule proteins in inflammatory bowel diseaseManuscript (preprint) (Other academic)
  • 7. Amcoff, Karin
    et al.
    Joossens, Marie
    Pierik, Marie J.
    Jonkers, Daisy
    Bohr, Johan
    Joossens, Sofie
    Romberg-Camps, Marielle
    Nyhlin, Nils
    Wickbom, Anna K.
    Rutgeerts, Paul J.
    Tysk, Curt
    Bodin, Lennart
    Colombel, Jean-Frederic
    Vermeire, Severine
    Halfvarson, Jonas
    Örebro University, School of Medicine, Örebro University, Sweden.
    Influence of genetics in the expression of serological markers in twins with IBD2012In: Gastroenterology, ISSN 0016-5085, E-ISSN 1528-0012, Vol. 142, no 5, p. S881-S881Article in journal (Other academic)
  • 8.
    Amcoff, Karin
    et al.
    Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Joossens, Marie
    Department of Microbiology and Immunology, Rega Institute, Katholieke Universiteit, Leuven,Belgium; VIB Center for the Biology of Disease, Leuven, Belgium; Microbiology Unit, Faculty of Sciences and Bioengineering Sciences, Vrije Universiteit, Brussels, Belgium.
    Pierik, Marie J.
    Gastroenterology, University Hospital Maastricht, Maastricht, The Netherlands.
    Jonkers, Daisy
    Gastroenterology, University Hospital Maastricht, Maastricht, The Netherlands.
    Bohr, Johan
    Örebro University, School of Health Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Joossens, Sofie
    Gastroenterology, Catholic University of Leuven (KUL), Leuven, Belgium.
    Romberg-Camps, Mariëlle
    Department of Gastroenterology-Hepatology, Zuyderland Medical Center, Sittard, Netherlands.
    Nyhlin, Nils
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Wickbom, Anna
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Rutgeerts, Paul J.
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium.
    Tysk, Curt
    Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Bodin, Lennart
    Institute of Environmental Medicine, Unit of Intervention and Implementation Research, Karolinska Institute, Stockholm, Sweden.
    Colombel, Jean-Frederic
    Division of Gastroenterology, Icahn School of Medicine at Mount Sinai, New York NY, USA.
    Vermeire, Severine
    Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Concordance in Anti-OmpC and Anti-I2 Indicate the Influence of Genetic Predisposition: Results of a European Study of Twins with Crohn's Disease2016In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 10, no 6, p. 695-702Article in journal (Refereed)
    Abstract [en]

    Background and Aims: An adaptive immunological response to microbial antigens has been observed in Crohn's disease (CD). Intriguingly, this serological response precedes the diagnosis in some patients and has also been observed in healthy relatives. We aimed to determine whether genetic factors are implicated in this response in a CD twin cohort.

    Methods: In total, 82 twin pairs (Leuven n = 13, Maastricht n = 8, Örebro n = 61) took part: 81 pairs with CD (concordant monozygotic n = 16, discordant monozygotic n = 22, concordant dizygotic n = 3, discordant dizygotic n = 40) and 1 monozygotic pair with both CD and ulcerative colitis. Serology for Pseudomonas fluorescens-related protein (anti-I2), Escherichia coli outer membrane porin C (anti-OmpC), CBir1flagellin (anti-CBir1) and antibodies to oligomannan (anti-Saccharomyces cerevisiae antibody [ASCA]) was determined by standardized enzyme-linked immunoassay.

    Results: All markers were more often present in CD twins than in their healthy twin siblings. Using the intraclass correlation coefficient (ICC), agreements in concentrations of anti-OmpC and anti-I2 were observed in discordant monozygotic but not in discordant dizygotic twin pairs with CD (anti-OmpC, ICC 0.80 and -0.02, respectively) and (anti-I2, ICC 0.56 and 0.05, respectively). In contrast, no agreements were found in anti-CBir, immunoglobulin (Ig) G ASCA and ASCA IgA.

    Conclusions: We show that anti-I2 and anti-CBir1 statuses have specificity for CD and confirm previous reported specificities for anti-OmpC and ASCA. Based on quantitative analyses and observed ICCs, genetics seems to predispose to the anti-OmpC and anti-I2 response but less to ASCA and anti-CBir1 responses.

  • 9.
    Amcoff, Karin
    et al.
    Örebro University Hospital. Department of Gastroenterology, Örebro University Hospital, Örebro, sweden.
    Stridsberg, Mats
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
    Lampinen, Maria
    Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
    Magnuson, Anders
    Örebro University Hospital. Clinical Epidemiology and Biostatistics, School of Medical Sciences, Örebro University, Örebro, Sweden.
    Carlson, Marie
    Department of Medical Sciences, Gastroenterology Research Group, Uppsala University, Uppsala, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Clinical implications of assay specific differences in f-calprotectin when monitoring inflammatory bowel disease activity over time2017In: Scandinavian Journal of Gastroenterology, ISSN 0036-5521, E-ISSN 1502-7708, Vol. 52, no 3, p. 344-350Article in journal (Refereed)
    Abstract [en]

    Objective: With several faecal calprotectin (FC) assays on the market, it has been difficult to define a uniform threshold for discriminating between remission and active disease in patients with inflammatory bowel disease (IBD). We aimed to compare the results of different FC-assays in IBD patients, followed over time.

    Material and methods: IBD patients provided faecal samples and reported clinical activity every third month prospectively over a two year period. FC was measured with two ELISA - (Bühlmann and Immunodiagnostik) and one automated fluoroimmunoassay (Phadia).

    Results: In total, 13 patients provided 91 faecal samples. The median (IQR) concentration of FC was higher at active disease than at remission for all assays: Bühlmann 845 (1061-226) μg/g versus 62 (224-39) μg/g, Phadia 369 (975-122) μg/g versus 11 (52-11) μg/g, and Immundiagnostik 135 (302-69) μg/g versus 8 (56-4) μg/g. The Bühlmann assay produced the largest absolute difference but the corresponding relative difference seemed to be more pronounced when analysed by the Phadia - (ratio of means 8.5; 95% CI 3.3-21.9) or the Immundiagnostik assay (ratio of means 7.4; 95% CI 3.1-17.6) than by the Bühlmann assay (ratio of means 5.3; 95% CI 2.7-10.6). Consequently, the specificity for discriminating active disease from remission varied between assays (34-75%) when the cut-off 50 μg/g was used, whereas the differences in sensitivity were less pronounced.

    Conclusions: Cross-comparisons revealed overall poor agreement between the assays as well as differences in the dynamics of FC. These findings suggest that standardisation of the method is needed to implement FC as a disease monitoring tool at large-scale.

  • 10.
    Andersen, Vibeke
    et al.
    Medical Department, Sygehus Sønderjylland Aabenraa, Aabenraa, Denmark; Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark.
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Department of Internal Medicine, Örebro University Hospital, Örebro University, Örebro, Sweden.
    Vogel, Ulla
    National Research Centre for the Working Environment, Copenhagen, Denmark.
    Colorectal cancer in patients with inflammatory bowel disease: can we predict risk?2012In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 18, no 31, p. 4091-4094Article in journal (Refereed)
    Abstract [en]

    The inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis (UC), may be complicated by colorectal cancer (CRC). In a recent population-based cohort study of 47 347 Danish patients with IBD by Tine Jess and colleagues 268 patients with UC and 70 patients with CD developed CRC during 30 years of observation. The overall risk of CRC among patients with UC and CD was comparable with that of the general population. However, patients diagnosed with UC during childhood or as adolescents, patients with long duration of disease and those with concomitant primary sclerosing cholangitis were at increased risk. In this commentary, we discuss the mechanisms underlying carcinogenesis in IBD and current investigations of genetic susceptibility in IBD patients. Further advances will depend on the cooperative work by epidemiologist and molecular geneticists in order to identify genetic polymorphisms involved in IBD-associated CRC. The ultimate goal is to incorporate genotypes and clinical parameters into a predictive model that will refine the prediction of risk for CRC in colonic IBD. The challenge will be to translate these new findings into clinical practice and to determine appropriate preventive strategies in order to avoid CRC in IBD patients. The achieved knowledge may also be relevant for other inflammation-associated cancers.

  • 11.
    Anderson, Carl A.
    et al.
    Wellcome Trust Genome Campus Hinxton, Wellcome Trust Sanger Institute, Cambridge, United Kingdom.
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences.
    Rioux, John D.
    Inflammatory Bowel Diseases, Queensland Institute of Medical Research, Brisbane, Australia.
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 472011In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 43, no 3, p. 246-252Article in journal (Refereed)
    Abstract [en]

    Genome-wide association studies and candidate gene studies in ulcerative colitis have identified 18 susceptibility loci. We conducted a meta-analysis of six ulcerative colitis genome-wide association study datasets, comprising 6,687 cases and 19,718 controls, and followed up the top association signals in 9,628 cases and 12,917 controls. We identified 29 additional risk loci (P < 5 × 10(-8)), increasing the number of ulcerative colitis-associated loci to 47. After annotating associated regions using GRAIL, expression quantitative trait loci data and correlations with non-synonymous SNPs, we identified many candidate genes that provide potentially important insights into disease pathogenesis, including IL1R2, IL8RA-IL8RB, IL7R, IL12B, DAP, PRDM1, JAK2, IRF5, GNA12 and LSP1. The total number of confirmed inflammatory bowel disease risk loci is now 99, including a minimum of 28 shared association signals between Crohn's disease and ulcerative colitis.

  • 12.
    Andersson, Erik
    et al.
    Örebro University, School of Medical Sciences.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences.
    Kruse, Robert
    Örebro University, School of Medical Sciences.
    D'Amato, M.
    Department of Medicine, Karolinska Institutet Solna, Stockholm, Sweden.
    Repsilber, Dirk
    Örebro University, School of Medical Sciences.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Inflammatory biomarkers in serum discriminate Crohn's disease and ulcerative colitis from healthy controls2016In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 10, no Suppl. 1, p. S86-S87Article in journal (Other academic)
  • 13.
    Andersson, Erik
    et al.
    Örebro University, School of Medical Sciences. School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Bergemalm, Daniel
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Kruse, Robert
    Örebro University, School of Medical Sciences. Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Neumann, Gunter
    School of Medical Sciences, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    D'Amato, Mauro
    Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden; BioDonostia Health Research Institute, San Sebastian, Spain; IKERBA SQUE Basque Foundation for Science, Bilbao, Spain.
    Repsilber, Dirk
    Örebro University, School of Medical Sciences. Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Subphenotypes of inflammatory bowel disease are characterized by specific serum protein profiles2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 10, article id e0186142Article in journal (Refereed)
    Abstract [en]

    Objective: Genetic and immunological data indicate that inflammatory bowel disease (IBD) are characterized by specific inflammatory protein profiles. However, the serum proteome of IBD is still to be defined. We aimed to characterize the inflammatory serum protein profiles of Crohn's disease (CD) and ulcerative colitis (UC), using the novel proximity extension assay.

    Methods: A panel of 91 inflammatory proteins were quantified in a discovery cohort of CD (n = 54), UC patients (n = 54), and healthy controls (HCs; n = 54). We performed univariate analyses by t-test, with false discovery rate correction. A sparse partial least-squares (sPLS) approach was used to identify additional discriminative proteins. The results were validated in a replication cohort.

    Results: By univariate analysis, 17 proteins were identified with significantly different abundances in CD and HCs, and 12 when comparing UC and HCs. Additionally, 64 and 45 discriminant candidate proteins, respectively, were identified with the multivariate approach. Correspondingly, significant cross-validation error rates of 0.12 and 0.19 were observed in the discovery cohort. Only FGF-19 was identified from univariate comparisons of CD and UC, but 37 additional discriminant candidates were identified using the multivariate approach. The observed cross-validation error rate for CD vs. UC remained significant when restricting the analyses to patients in clinical remission. Using univariate comparisons, 16 of 17 CD-associated proteins and 8 of 12 UC-associated proteins were validated in the replication cohort. The area under the curve for CD and UC was 0.96 and 0.92, respectively, when the sPLS model from the discovery cohort was applied to the replication cohort.

    Conclusions: By using the novel PEA method and a panel of inflammatory proteins, we identified proteins with significantly different quantities in CD patients and UC patients compared to HCs. Our data highlight the potential of the serum IBD proteome as a source for identification of future diagnostic biomarkers.

  • 14. Anedda, Francesca
    et al.
    Zucchelli, Marco
    Schepis, Danika
    Hellquist, Anna
    Corrado, Lucia
    D'Alfonso, Sandra
    Achour, Adnane
    McInerney, Gerald
    Bertorello, Alejandro
    Lordal, Mikael
    Befrits, Ragnar
    Bjork, Jan
    Bresso, Francesca
    Torkvist, Leif
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences.
    Kere, Juha
    D'Amato, Mauro
    Multiple polymorphisms affect expression and function of the neuropeptide S receptor (NPSR1)2011In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 6, no 12, p. e29523-Article in journal (Refereed)
    Abstract [en]

    Background: neuropeptide S (NPS) and its receptor NPSR1 act along the hypothalamic-pituitary-adrenal axis to modulate anxiety, fear responses, nociception and inflammation. The importance of the NPS-NPSR1 signaling pathway is highlighted by the observation that, in humans, NPSR1 polymorphism associates with asthma, inflammatory bowel disease, rheumatoid arthritis, panic disorders, and intermediate phenotypes of functional gastrointestinal disorders. Because of the genetic complexity at the NPSR1 locus, however, true causative variations remain to be identified, together with their specific effects on receptor expression or function. To gain insight into the mechanisms leading to NPSR1 disease-predisposing effects, we performed a thorough functional characterization of all NPSR1 promoter and coding SNPs commonly occurring in Caucasians (minor allele frequency >0.02). Principal Findings: we identified one promoter SNP (rs2530547 [-103]) that significantly affects luciferase expression in gene reporter assays and NPSR1 mRNA levels in human leukocytes. We also detected quantitative differences in NPS-induced genome-wide transcriptional profiles and CRE-dependent luciferase activities associated with three NPSR1 non-synonymous SNPs (rs324981 [Ile107Asn], rs34705969 [Cys197Phe], rs727162 [Arg241Ser]), with a coding variant exhibiting a loss-of-function phenotype (197Phe). Potential mechanistic explanations were sought with molecular modelling and bioinformatics, and a pilot study of 2230 IBD cases and controls provided initial support to the hypothesis that different cis-combinations of these functional SNPs variably affect disease risk. Significance: these findings represent a first step to decipher NPSR1 locus complexity and its impact on several human conditions NPS antagonists have been recently described, and our results are of potential pharmacogenetic relevance.

  • 15.
    Angelison, L.
    et al.
    Helsingborg, Sweden.
    Almer, S.
    Stockholm, Sweden.
    Eriksson, A.
    Gothenburg, Sweden.
    Karling, P.
    Umeå, Sweden.
    Fagerberg, U.
    Västeras, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Thörn, M.
    Uppsala, Sweden.
    Björk, J.
    Stockholm, Sweden.
    Hindorf, U.
    Lund, Sweden.
    Löfberg, R.
    Stockholm, Sweden.
    Bajor, A.
    Gothenburg, Sweden.
    Hjortswang, H.
    Linköping, Sweden.
    Hammarlund, P.
    Ängelholm, Sweden.
    Grip, O.
    Malmö, Sweden.
    Torp, J.
    Kristianstad, Sweden.
    Marsal, J.
    Lund, Sweden.
    Hertervig, E.
    Lund, Sweden.
    Long-term outcome of infliximab treatment in chronic active ulcerative colitis: a Swedish multicentre study of 250 patients2017In: Alimentary Pharmacology and Therapeutics, ISSN 0269-2813, E-ISSN 1365-2036, Vol. 45, no 4, p. 519-532Article in journal (Refereed)
    Abstract [en]

    Background: Real-life long-term data on infliximab treatment in ulcerative colitis are limited.

    Aim: To study the long-term efficacy and safety of infliximab in chronic active ulcerative colitis and possible predictors of colectomy and response were also examined.

    Methods: A retrospective multi-centre study of infliximab treatment in 250 patients with chronic active ulcerative colitis with inclusion criteria: age ≥18 years, ambulatory treated, steroid-dependent or intolerant and/or immunomodulator refractory or intolerant.

    Results: Steroid-free clinical remission was achieved by 123/250 patients (49.2%) at 12 months and in 126/250 patients at a median follow-up of 2.9 years (50.4%). Primary response at 3 months was achieved by 190/250 (76.0%) patients and associated with a high probability of response 168/190 (88.4%) at 12 months and 143/190 (75.3%) at follow-up. Long-term rate of colectomy in primary responders was 6/190 (3.2%) at 12 months and 27/190 (14.2%) at last follow-up. Failure to achieve response at 3 months was associated with a high risk of subsequent colectomy, 29/60 (48.3%) at 12 months and 41/60 (68.3%) at follow-up. Response at 12 months was associated with a low risk of subsequent colectomy, 14/181 (7.7%) compared with non-response 19/34 (55.9%) (P < 0.0001). Non-response at 3 months was an independent predictor of subsequent colectomy (HR = 9.40, 95% CI = 5.10-17.35, P < 0.001). Concomitant azathioprine therapy did not influence outcome in terms of colectomy.

    Conclusions: Long-term efficacy of infliximab treatment in chronic active ulcerative colitis is excellent especially in patients who respond to induction treatment. Conversely, non-response at 3 months predicts a poor outcome, with a high risk of subsequent colectomy.

  • 16.
    Assadi, G.
    et al.
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
    Saleh, R.
    Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Hadizadeh, F.
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
    Vesterlund, L.
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
    Bonfiglio, F.
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Törkvist, L.
    Gastrocentrum, Karolinska University Hospital, StockhoCrohn'slm, Sweden.
    Eriksson, A. S.
    Gatroenterology Unit, Department of Internal Medicine, Sahlgren's University Hospital/Östra, Göteborg, Sweden.
    Harris, H. E.
    Department of Medicine Solna, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    Sundberg, E.
    Department of Women's and Children's Health, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden.
    D'Amato, M.
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden; BioCruces Health Research Institute and IKERBASQUE, Basque Foundation for Science, Bilbao, Spain.
    LACC1 polymorphisms in inflammatory bowel disease and juvenile idiopathic arthritis2016In: Genes and Immunity, ISSN 1466-4879, E-ISSN 1476-5470, Vol. 17, no 4, p. 261-264Article in journal (Refereed)
    Abstract [en]

    The function of the Laccase domain-containing 1 (LACC1) gene is unknown, but genetic variation at this locus has been reported to consistently affect the risk of Crohn's disease (CD) and leprosy. Recently, a LACC1 missense mutation was found in patients suffering from monogenic forms of CD, but also systemic juvenile idiopathic arthritis. We tested the hypothesis that LACC1 single nucleotide polymorphisms (SNPs), in addition to CD, are associated with juvenile idiopathic arthritis (JIA, non-systemic), and another major form of inflammatory bowel disease, ulcerative colitis (UC). We selected 11 LACC1 tagging SNPs, and tested their effect on disease risk in 3855 Swedish individuals from three case-control cohorts of CD, UC and JIA. We detected false discovery rate corrected significant associations with individual markers in all three cohorts, thereby expanding previous results for CD also to UC and JIA. LACC1's link to several inflammatory diseases suggests a key role in the human immune system and justifies further characterization of its function(s).

  • 17.
    Assadi, Ghazaleh
    et al.
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden .
    Vesterlund, Liselotte
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
    Bonfiglio, Ferdinando
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
    Mazzurana, Luca
    Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
    Cordeddu, Lina
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden.
    Schepis, Danika
    Rheumatology unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden .
    Mjösberg, Jenny
    Center for Infectious Medicine, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden .
    Ruhrmann, Sabrina
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
    Fabbri, Alessia
    Department of Therapeutic Research and Medicines Evaluation, Istituto Superiore di Sanità, Rome, Italy .
    Vukojevic, Vladana
    Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden .
    Percipalle, Piergiorgio
    Biology Program, New York University Abu Dhabi, Abu Dhabi, United Arab Emirates; Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, Stockholm, Sweden.
    Salomons, Florian A.
    Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden.
    Laurencikiene, Jurga
    Lipid laboratory, Department of Medicine Huddinge, Karolinska Institutet, Stockholm, Sweden.
    Törkvist, Leif
    Gastrocentrum, Karolinska University Hospital, Stockholm, Sweden .
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    D'Amato, Mauro
    Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden; BioDonostia Health Research Institute, San Sebastian and IKERBASQUE, Basque Foundation for Science, Bilbao, Spain .
    Functional Analyses of the Crohn's Disease Risk Gene LACC12016In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 11, no 12, article id e0168276Article in journal (Refereed)
    Abstract [en]

    Background: Genetic variation in the Laccase (multicopper oxidoreductase) domain-containing 1 (LACC1) gene has been shown to affect the risk of Crohn's disease, leprosy and, more recently, ulcerative colitis and juvenile idiopathic arthritis. LACC1 function appears to promote fatty-acid oxidation, with concomitant inflammasome activation, reactive oxygen species production, and anti-bacterial responses in macrophages. We sought to contribute to elucidating LACC1 biological function by extensive characterization of its expression in human tissues and cells, and through preliminary analyses of the regulatory mechanisms driving such expression.

    Methods: We implemented Western blot, quantitative real-time PCR, immunofluorescence microscopy, and flow cytometry analyses to investigate fatty acid metabolism-immune nexus (FAMIN; the LACC1 encoded protein) expression in subcellular compartments, cell lines and relevant human tissues. Gene-set enrichment analyses were performed to initially investigate modulatory mechanisms of LACC1 expression. A small-interference RNA knockdown in vitro model system was used to study the effect of FAMIN depletion on peroxisome function.

    Results: FAMIN expression was detected in macrophage-differentiated THP-1 cells and several human tissues, being highest in neutrophils, monocytes/macrophages, myeloid and plasmacytoid dendritic cells among peripheral blood cells. Subcellular co-localization was exclusively confined to peroxisomes, with some additional positivity for organelle endomembrane structures. LACC1 co-expression signatures were enriched for genes involved in peroxisome proliferator-activated receptors (PPAR) signaling pathways, and PPAR ligands downregulated FAMIN expression in in vitro model systems.

    Conclusion: FAMIN is a peroxisome-associated protein with primary role(s) in macrophages and other immune cells, where its metabolic functions may be modulated by PPAR signaling events. However, the precise molecular mechanisms through which FAMIN exerts its biological effects in immune cells remain to be elucidated.

  • 18.
    Beaudoin, Melissa
    et al.
    Montreal Heart Institute, Research Center, Montreal QC, Canada.
    Goyette, Philippe
    Montreal Heart Institute, Research Center, Montreal QC, Canada.
    Boucher, Gabrielle
    Montreal Heart Institute, Research Center, Montreal QC, Canada.
    Lo, Ken Sin
    Montreal Heart Institute, Research Center, Montreal QC, Canada.
    Rivas, Manuel A.
    Center for the Study of IBD (CSIBD) Genetics, The Broad Institute, Cambridge MA, United States.
    Stevens, Christine
    Center for the Study of IBD (CSIBD) Genetics, The Broad Institute, Cambridge MA, United States.
    Alikashani, Azadeh
    Montreal Heart Institute, Research Center, Montreal QC, Canada.
    Ladouceur, Martin
    Montreal Heart Institute, Research Center, Montreal QC, Canada.
    Ellinghaus, David
    Christian-Albrechts-University, Kiel, Germany.
    Törkvist, Leif
    Karolinska Institutet, Stockholm, Sweden.
    Goel, Gautam
    Harvard School of Medicine, Boston MA, USA.
    Lagace, Caroline
    Montreal Heart Institute, Research Center, Montreal QC, Canada.
    Annese, Vito
    Ospedale Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy; Unit of Gastroenterology SOD2, Azienda Ospedaliero Universitaria (AOU) Careggi, Florence, Italy.
    Bitton, Alain
    McGill University Health Centre, Royal Victoria Hospital, Montreal QC, Canada.
    Begun, Jakob
    Harvard School of Medicine, Boston MA, USA.
    Brant, Steve R.
    Johns Hopkins University, Baltimore MD, USA.
    Bresso, Francesca
    Karolinska University Hospital, Solna, Sweden.
    Cho, Judy H.
    Yale University, New Haven CT, USA.
    Duerr, Richard H.
    University of Pittsburgh, Graduate School of Public Health, Pittsburgh PA, USA.
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital.
    McGovern, Dermot P. B.
    Cedars-Sinai Medical Center, Los Angeles CA, USA.
    Radford-Smith, Graham
    University of Queensland, Brisbane, Australia.
    Schreiber, Stefan
    Christian-Albrechts-University, Kiel, Germany.
    Schumm, Philip L.
    University of Chicago, Chicago ILL, USA.
    Sharma, Yashoda
    Yale University, New Haven CT, USA.
    Silverberg, Mark S.
    University of Toronto, Toronto ON, Canada.
    Weersma, Rinse K.
    University of Groningen and University Medical Center Groningen, Groningen, The Netherlands.
    D'Amato, Mauro
    Karolinska Institutet, Stockholm, Sweden.
    Vermeire, Severine
    University Hospital Gasthuisberg, Leuven, Belgium.
    Franke, Andre
    Christian-Albrechts-University, Kiel, Germany.
    Lettre, Guillaume
    Montreal Heart Institute, Research Center, Montreal QC, Canada; Universite de Montreal, Montreal QC, Canada .
    Xavier, Ramnik J.
    Harvard School of Medicine, Boston MA, USA; Broad Institute of MIT and Harvard University, Cambridge MA, USA .
    Daly, Mark J.
    Massachusetts General Hospital, Harvard Medical School, Boston MA, USA.
    Rioux, John D.
    Montreal Heart Institute, Research Center, Montreal QC, Canada; Universite de Montreal, Montreal QC, Canada.
    Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis2013In: PLOS Genetics, ISSN 1553-7390, E-ISSN 1553-7404, Vol. 9, no 9, p. e1003723-Article in journal (Refereed)
    Abstract [en]

    Genome-wide association studies and follow-up meta-analyses in Crohn's disease (CD) and ulcerative colitis (UC) have recently identified 163 disease-associated loci that meet genome-wide significance for these two inflammatory bowel diseases (IBD). These discoveries have already had a tremendous impact on our understanding of the genetic architecture of these diseases and have directed functional studies that have revealed some of the biological functions that are important to IBD (e.g. autophagy). Nonetheless, these loci can only explain a small proportion of disease variance (similar to 14% in CD and 7.5% in UC), suggesting that not only are additional loci to be found but that the known loci may contain high effect rare risk variants that have gone undetected by GWAS. To test this, we have used a targeted sequencing approach in 200 UC cases and 150 healthy controls (HC), all of French Canadian descent, to study 55 genes in regions associated with UC. We performed follow-up genotyping of 42 rare non-synonymous variants in independent case-control cohorts (totaling 14,435 UC cases and 20,204 HC). Our results confirmed significant association to rare non-synonymous coding variants in both IL23R and CARD9, previously identified from sequencing of CD loci, as well as identified a novel association in RNF186. With the exception of CARD9 (OR = 0.39), the rare non-synonymous variants identified were of moderate effect (OR = 1.49 for RNF186 and OR = 0.79 for IL23R). RNF186 encodes a protein with a RING domain having predicted E3 ubiquitin-protein ligase activity and two transmembrane domains. Importantly, the disease-coding variant is located in the ubiquitin ligase domain. Finally, our results suggest that rare variants in genes identified by genome-wide association in UC are unlikely to contribute significantly to the overall variance for the disease. Rather, these are expected to help focus functional studies of the corresponding disease loci.

  • 19.
    Bergemalm, Daniel
    et al.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Örebro University, School of Health Sciences. Department of Gastroenterology, Faculty of Medicine and Health, University of Örebro, Örebro, Sweden.
    Kruse, Robert
    Örebro University, School of Medical Sciences. School of Medical Sciences, Faculty of Medicine and Health, University of Örebro, Örebro, Sweden.
    Sapnara, Maria
    Department of Microbiology and Immunology, Institute of Biomedicine, University of Gothenburg, Gothenburg, Sweden; Department of Internal Medicine and Clinical Nutrition, Institute of Medicine, University of Gothenburg, Gothenburg, Sweden .
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology, Faculty of Medicine and Health, University of Örebro, Örebro, Sweden .
    Hultgren Hörnquist, Elisabeth
    Örebro University Hospital. Örebro University, School of Medical Sciences. School of Medical Sciences, Faculty of Medicine and Health, University of Örebro, Örebro, Sweden .
    Elevated fecal peptidase D at onset of colitis in Galphai2-/- mice, a mouse model of IBD.2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 3, article id e0174275Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The identification of novel fecal biomarkers in inflammatory bowel disease (IBD) is hampered by the complexity of the human fecal proteome. On the other hand, in experimental mouse models there is probably less variation. We investigated the fecal protein content in mice to identify possible biomarkers and pathogenic mechanisms.

    METHODS: Fecal samples were collected at onset of inflammation in Galphai2-/- mice, a well-described spontaneous model of chronic colitis, and from healthy littermates. The fecal proteome was analyzed by two-dimensional electrophoresis and quantitative mass spectrometry and results were then validated in a new cohort of mice.

    RESULTS: As a potential top marker of disease, peptidase D was found at a higher ratio in Galphai2-/- mouse feces relative to controls (fold change 27; p = 0.019). Other proteins found to be enriched in Gαi2-/- mice were mainly pancreatic proteases, and proteins from plasma and blood cells. A tendency of increased calprotectin, subunit S100-A8, was also observed (fold change 21; p = 0.058). Proteases are potential activators of inflammation in the gastrointestinal tract through their interaction with the proteinase-activated receptor 2 (PAR2). Accordingly, the level of PAR2 was found to be elevated in both the colon and the pancreas of Galphai2-/- mice at different stages of disease.

    CONCLUSIONS: These findings identify peptidase D, an ubiquitously expressed intracellular peptidase, as a potential novel marker of colitis. The elevated levels of fecal proteases may be involved in the pathogenesis of colitis and contribute to the clinical phenotype, possibly by activation of intestinal PAR2.

  • 20.
    Bergemalm, Daniel
    et al.
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Kruse, Robert
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Sapnara, Maria
    Department of Microbiology and Immunology, University of Gothenburg, Institute of Biomedicine, Gothenburg, Sweden; Department of Internal Medicine and Clinical Nutrition, University of Gothenburg, Institute of Medicine, Gothenburg, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastroenterology.
    Hultgren Hörnquist, Elisabeth
    Örebro University, School of Medical Sciences.
    Elevated fecal peptidase D at onset of colitis in Galphai2(-/-) mice, a mouse model of IBD2017In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 12, no 3, article id e0174275Article in journal (Refereed)
    Abstract [en]

    Background: The identification of novel fecal biomarkers in inflammatory bowel disease (IBD) is hampered by the complexity of the human fecal proteome. On the other hand, in experimental mouse models there is probably less variation. We investigated the fecal protein content in mice to identify possible biomarkers and pathogenic mechanisms.

    Methods: Fecal samples were collected at onset of inflammation in Galphai2(-/-) mice, a well-described spontaneous model of chronic colitis, and from healthy littermates. The fecal proteome was analyzed by two-dimensional electrophoresis and quantitative mass spectrometry and results were then validated in a new cohort of mice.

    Results: As a potential top marker of disease, peptidase D was found at a higher ratio in Galphai24mouse feces relative to controls (fold change 27; p = 0.019). Other proteins found to be enriched in Gai2(-/-) mice were mainly pancreatic proteases, and proteins from plasma and blood cells. A tendency of increased calprotectin, subunit S100-A8, was also observed (fold change 21; p = 0.058). Proteases are potential activators of inflammation in the gastrointestinal tract through their interaction with the proteinase-activated receptor 2 (PAR2). Accordingly, the level of PAR2 was found to be elevated in both the colon and the pancreas of Galphai24- mice at different stages of disease.

    Conclusions: These findings identify peptidase D, an ubiquitously expressed intracellular peptidase, as a potential novel marker of colitis. The elevated levels of fecal proteases may be involved in the pathogenesis of colitis and contribute to the clinical phenotype, possibly by activation of intestinal PAR2.

  • 21.
    Björkqvist, Olle
    et al.
    Örebro University, School of Medical Sciences.
    Repsilber, Dirk
    Örebro University, School of Medical Sciences.
    Seifert, M.
    Karolinska Inst, Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    Engstrand, L.
    Karolinska Inst, Microbiol Tumor & Cell Biol, Stockholm, Sweden.
    Rangel, Ignacio
    Örebro University, School of Medical Sciences.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Increasing abundance of faecalibacterium prausnitzii is associated with decreased intestinal inflammation in Crohn's disease: A longitudinal study2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S468-S469Article in journal (Other academic)
  • 22. Blom, Kristin
    et al.
    Rubin, Jenny
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Division of Gastroenterology, Department of Intestinal Medicine, Örebro University Hospital, Örebro, Sweden.
    Törkvist, Leif
    Rönnblom, Anders
    Sangfelt, Per
    Lördal, Mikael
    Jönsson, Ulla-Britt
    Sjöqvist, Urban
    Håkansson, Lena Douhan
    Venge, Per
    Carlson, Marie
    Eosinophil associated genes in the inflammatory bowel disease 4 region: correlation to inflammatory bowel disease revealed2012In: World Journal of Gastroenterology, ISSN 1007-9327, E-ISSN 2219-2840, Vol. 18, no 44, p. 6409-6419Article in journal (Refereed)
    Abstract [en]

    AIM: To study the association between inflammatory bowel disease (IBD) and genetic variations in eosinophil protein X (EPX) and eosinophil cationic protein (ECP).

    METHODS: DNA was extracted from ethylene diamine tetraacetic acid blood of 587 patients with Crohn's disease (CD), 592 with ulcerative colitis (UC) and 300 healthy subjects. The EPX405 (G > C, rs2013109), ECP434 (G > C, rs2073342) and ECP562 (G > C, rs2233860) gene polymorphisms were analysed, by the 5'-nuclease allelic discrimination assay. For determination of intracellular content of EPX and ECP in granulocytes, 39 blood samples was collected and extracted with a buffer containing cetyltrimethylammonium bromide. The intracellular content of EPX was analysed using an enzyme-linked immunosorbent assay. The intracellular content of ECP was analysed with the UniCAP(®) system as described by the manufacturer. Statistical tests for calculations of results were χ(2) test, Fisher's exact test, ANOVA, Student-Newman-Keuls test, and Kaplan-Meier survival curve with Log-rank test for trend, the probability values of P < 0.05 were considered statistically significant.

    RESULTS: The genotype frequency for males with UC and with an age of disease onset of ≥ 45 years (n = 57) was for ECP434 and ECP562, GG = 37%, GC = 60%, CC = 4% and GG = 51%, GC = 49%, CC = 0% respectively. This was significantly different from the healthy subject's genotype frequencies of ECP434 (GG = 57%, GC = 38%, CC = 5%; P = 0.010) and ECP562 (GG = 68%, GC = 29%,CC = 3%; P = 0.009). The genotype frequencies for females, with an age of disease onset of ≥ 45 years with CD (n = 62), was for the ECP434 and ECP562 genotypes GG = 37%, GC = 52%, CC = 11% and GG = 48%, GC = 47% and CC = 5% respectively. This was also statistically different from healthy controls for both ECP434 (P = 0.010) and ECP562 (P = 0.013). The intracellular protein concentration of EPX and ECP was calculated in μg/10(6) eosinophils and then correlated to the EPX 405 genotypes. The protein content of EPX was highest in the patients with the CC genotype of EPX405 (GG = 4.65, GC = 5.93, and CC = 6.57) and for ECP in the patients with the GG genotype of EPX405 (GG = 2.70, GC = 2.47 and CC = 1.90). ANOVA test demonstrated a difference in intracellular protein content for EPX (P = 0.009) and ECP (P = 0.022). The age of disease onset was linked to haplotypes of the EPX405, ECP434 and ECP562 genotypes. Kaplan Maier curve showed a difference between haplotype distributions for the females with CD (P = 0.003). The highest age of disease onset was seen in females with the EPX405CC, ECP434GC, ECP562CC haplotype (34 years) and the lowest in females with the EPX405GC, ECP434GC, ECP562GG haplotype (21 years). For males with UC there was also a difference between the highest and lowest age of the disease onset (EPX405CC, ECP434CC, ECP562CC, mean 24 years vs EPX405GC, ECP434GC, ECP562GG, mean 34 years, P = 0.0009). The relative risk for UC patients with ECP434 or ECP562-GC/CC genotypes to develop dysplasia/cancer was 2.5 (95%CI: 1.2-5.4, P = 0.01) and 2.5 (95%CI: 1.1-5.4, P = 0.02) respectively, compared to patients carrying the GG-genotypes.

    CONCLUSION: Polymorphisms of EPX and ECP are associated to IBD in an age and gender dependent manner, suggesting an essential role of eosinophils in the pathophysiology of IBD.

  • 23.
    Bodea, Corneliu A.
    et al.
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA; Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
    Neale, Benjamin M.
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
    Ripke, Stephan
    Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Department of Psychiatry and Psychotherapy, Charite, Campus Mitte, Berlin, Germany.
    International IBD Genetics, Consortium
    Daly, Mark J.
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA; Analytical and Translational Genetics Unit, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA; Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
    Devlin, Bernie
    Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
    Roeder, Kathryn
    Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA; Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA.
    A Method to Exploit the Structure of Genetic Ancestry Space to Enhance Case-Control Studies2016In: American Journal of Human Genetics, ISSN 0002-9297, E-ISSN 1537-6605, Vol. 98, no 5, p. 857-868Article in journal (Refereed)
    Abstract [en]

    One goal of human genetics is to understand the genetic basis of disease, a challenge for diseases of complex inheritance because risk alleles are few relative to the vast set of benign variants. Risk variants are often sought by association studies in which allele frequencies in case subjects are contrasted with those from population-based samples used as control subjects. In an ideal world we would know population-level allele frequencies, releasing researchers to focus on case subjects. We argue this ideal is possible, at least theoretically, and we outline a path to achieving it in reality. If such a resource were to exist, it would yield ample savings and would facilitate the effective use of data repositories by removing administrative and technical barriers. We call this concept the Universal Control Repository Network (UNICORN), a means to perform association analyses without necessitating direct access to individual-level control data. Our approach to UNICORN uses existing genetic resources and various statistical tools to analyze these data, including hierarchical clustering with spectral analysis of ancestry; and empirical Bayesian analysis along with Gaussian spatial processes to estimate ancestry-specific allele frequencies. We demonstrate our approach using tens of thousands of control subjects from studies of Crohn disease, showing how it controls false positives, provides power similar to that achieved when all control data are directly accessible, and enhances power when control data are limiting or even imperfectly matched ancestrally. These results highlight how UNICORN can enable reliable, powerful, and convenient genetic association analyses without access to the individual-level data.

  • 24. Bodger, K.
    et al.
    Halfvarson, Jonas
    Dodson, A. R.
    Campbell, F.
    Wilson, S.
    Lee, R.
    Lindberg, E.
    Järnerot, G.
    Tysk, Curt
    Örebro University, Department of Clinical Medicine.
    Rhodes, J. M.
    Altered colonic glycoprotein expression in unaffected monozygotic twins of inflammatory bowel disease patients2006In: Gut, ISSN 0017-5749, E-ISSN 1468-3288, Vol. 55, no 7, p. 973-977Article in journal (Refereed)
    Abstract [en]

    BACKGROUND AND AIMS: Previous chromatographic analysis of colonic mucins from monozygotic twins with inflammatory bowel disease (IBD) suggested a genetic mucin alteration in ulcerative colitis (UC). This study explores this further by assessing mucosal expression of the oncofetal carbohydrate antigen TF (galactose beta1, 3 N-acetylgalactosamine alpha-), among the same IBD twins. MATERIALS AND METHODS: Formalin fixed paraffin embedded rectal biopsies were studied from 22 monozygotic twin pairs with IBD. These included eight UC twin pairs and 14 Crohn's disease (CD) twin pairs, with six pairs concordant for disease and 16 unaffected twin siblings. Closely adjacent sections were assessed by peanut lectin histochemistry for TF expression and immunohistochemically for nuclear factor kappaB (NFkappaB) activation with investigators blinded to the diagnosis. RESULTS: Unaffected twins were almost all TF positive (15/16) compared with 5/29 histologically normal controls (p<0.0001). Unaffected UC (7/8) and CD twins (8/8) were similarly TF positive. TF positivity was confined mainly to the superficial epithelium and absent from the stem cell compartment of the lower crypts, suggesting that glycosylation changes are acquired rather than genetically determined. Activated NFkappaB was present in the surface epithelium of mucosal biopsies from 13/14 unaffected IBD twins but in only 6/22 histologically normal controls (p=0.0004). All 22 affected IBD twins were TF positive and 18 were positive for activated NFkappaB. CONCLUSIONS: Altered mucosal glycosylation in unaffected identical twins of IBD patients was confirmed in this study. This occurred in both UC and CD twins. The changes are probably acquired rather than congenital and may reflect "preinflammatory" NFkappaB activation.

  • 25.
    Burisch, J.
    et al.
    North Zealand Univ Hosp, Dept Gastroenterol, Frederikssund, Denmark.
    Andersen, V.
    Viborg Reg Hosp, Dept Med, Viborg, Denmark; Hosp Southern Jutland, Dept Med, Aabenraa, Denmark.
    Cukovic-Cavka, S.
    Univ Zagreb, Sch Med, Div Gastroenterol & Hepatol, Univ Hosp Ctr Zagreb, Zagreb, Croatia.
    Lakatos, P. L.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary.
    D'Inca, R.
    Azienda Osped Padova, Dept Surg Oncol & Gastroenterol, Padua, Italy.
    Magro, F.
    Univ Porto, Inst Mol & Cell Biol, Porto, Portugal; Hosp Sao Joao, Dept Gastroenterol, Porto, Portugal.;Oporto Med Sch, Inst Pharmacol & Therapeut, Porto, Portugal.
    Arebi, N.
    St Marks Hosp, Gastroenterol, London, England.
    Kievit, L.
    Herning Cent Hosp, Dept Med, Herning, Denmark.
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus.
    Valpiani, D.
    Morgagni Hosp, Dept Gastroenterol & Digest Endoscopy, Forli, Italy.
    Katsanos, K. H.
    Univ Hosp, Div Internal Med 1, Ioannina, Greece; Gastroenterol Unit, Ioannina, Greece.
    Vegh, Z.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary.
    Dahlerup, J. F.
    Aarhus Univ Hosp, Dept Gastroenterol & Hepatol, Aarhus, Denmark.
    Fumery, M.
    Amiens Univ & Hosp, Epimad Registry, Gastroenterol Unit, Amiens, France.
    Pedersen, N.
    Slagelse Hosp, Dept Gastroenterol, Slagelse, Denmark.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Belousova, E.
    Moscow Reg Res Clin Inst, Dept Gastroenterol, Moscow, Russia.
    Nielsen, K. R.
    Natl Hosp Faroe Isl, Dept Med, Torshavn, Faroe Islands, Denmark.
    Turcan, S.
    State Univ Med & Pharm Republ Moldova, Dept Gastroenterol, Kishinev, Moldova.
    Ellul, P.
    Mater Hosp, Div Gastroenterol, L Imsida, Malta.
    Kupcinskas, L.
    Lithuanian Univ Hlth Sci, Inst Digest Res, Kaunas, Lithuania.
    Oksanen, P.
    Tampere Univ Hosp, Dept Gastroenterol & Alimentary Tract Surg, Tampere, Finland.
    Duricova, D.
    Charles Univ Prague, IBD Ctr ISCARE, Prague, Czech Republic.
    Giannotta, M.
    AOU Careggi Reg Referral Ctr Inflammatory Bowel D, Dept Gastroenterol, Florence, Italy.
    Goldis, A.
    Univ Med Victor Babes, Gastroenterol Clin, Timisoara, Romania.
    Hernandez, V.
    Complexo Hosp Univ Vigo, Dept Gastroenterol, Vigo, Spain.
    Salupere, R.
    Tartu Univ Hosp, Div Gastroenterol & Endocrinol, Tartu, Estonia.
    Odes, S.
    Soroka Med Ctr, Beer Sheva, Israel; Ben Gurion Univ Negev, Dept Gastroenterol & Hepatol, Beer Sheva, Israel.
    Langholz, E.
    Gentofte Univ Hosp, Dept Med Gastroenterol, Copenhagen, Denmark.
    Munkholm, P.
    North Zealand Univ Hosp, Dept Gastroenterol, Frederikssund, Denmark.
    Immunomodulators reduce the risk of surgery and hospitalisation in Crohn's disease in a prospective European population-based inception cohort: the Epi-IBD cohort2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S42-S43Article in journal (Other academic)
  • 26.
    Burisch, J.
    et al.
    North Zealand Univ Hosp, Dept Gastroenterol, Frederikssund, Denmark.
    Ellul, P.
    Mater Dei Hosp, Div Gastroenterol, L Imsida, Malta.
    Arebi, N.
    St Marks Hosp, Gastroenterol, London, England.
    Kaimakliotis, I.
    D'Inca, R.
    Azienda Osped Padova, Dept Surg Oncol & Gastroenterol, Padua, Italy.
    Andersen, V.
    Viborg Reg Hosp, Med Dept, Viborg, Denmark; Hosp Southern Jutland, Med Dept, Aabenraa, Denmark.
    Belousova, E.
    Moscow Reg Res Clin Inst, Dept Gastroenterol, Moscow, Russia.
    Hernandez, V.
    Complexo Hosp Univ Vigo, Gastroenterol Dept, Vigo, Spain.
    Vegh, Z.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary.
    Turcan, S.
    State Univ Med & Pharm Republ Moldova, Dept Gastroenterol, Kishinev, Moldova.
    Magro, F.
    Univ Porto, Inst Mol & Cell Biol, Porto, Portugal; Hosp Sao Joao, Dept Gastroenterol, Porto, Portugal.;Oporto Med Sch, Inst Pharmacol & Therapeut, Porto, Portugal.
    Kupcinskas, L.
    Lithuanian Univ Hlth Sci, Inst Digest Res, Kaunas, Lithuania.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Lakatos, P. L.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary.
    Duricova, D.
    Charles Univ Prague, IBD Ctr ISCARE, Prague, Czech Republic.
    Kievit, L.
    Herning Cent Hosp, Dept Med, Herning, Denmark.
    Goldis, A.
    Univ Med Victor Babes, Clin Gastroenterol, Timisoara, Romania.
    Dahlerup, J. F.
    Aarhus Univ Hosp, Dept Hepatol & Gastroenterol, Aarhus, Denmark.
    Oksanen, P.
    Tampere Univ Hosp, Dept Gastroenterol & Alimentary Tract Surg, Tampere, Finland.
    Cukovic-Cavka, S.
    Univ Zagreb, Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Sch Med, Zagreb, Croatia.
    Fumery, M.
    Amiens Univ & Hosp, Gastroenterol Unit, Epimad Registry, Amiens, France.
    Odes, S.
    Soroka Med Ctr, Beer Sheva, Israel; Ben Gurion Univ Negev, Dept Gastroenterol & Hepatol, Beer Sheva, Israel.
    Nielsen, K. R.
    Natl Hosp Faroe Isl, Med Dept, Torshavn, Faroe Islands, Denmark.
    Valpiani, D.
    Morgagni Hosp, Dept Gastroenterol & Digest Endoscopy, Forli, Italy.
    Pedersen, N.
    Slagelse Hosp, Dept Gastroenterol, Slagelse, Denmark.
    Giannotta, M.
    AOU Careggi Reg Referral Ctr Inflammatory Bowel D, Dept Gastroenterol, Florence, Italy.
    Salupere, R.
    Tartu Univ Hosp, Div Endocrinol & Gastroenterol, Tartu, Estonia.
    Katsanos, K. H.
    Univ Hosp Ioannina, Div Internal Med 1, Ioannina, Greece.;Univ Hosp Ioannina, Hepatogastroenterol Unit, Ioannina, Greece.
    Langholz, E.
    Gentofte Univ Hosp, Dept Med Gastroenterol, Copenhagen, Denmark.
    Munkholm, P.
    North Zealand Univ Hosp, Dept Gastroenterol, Frederikssund, Denmark.
    Natural disease course of inflammatory bowel disease unclassified in a prospective European population-based inception cohort-the Epi-IBD cohort2018In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 12, no Suppl. 1, p. S523-S524Article in journal (Other academic)
  • 27.
    Burisch, J.
    et al.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Gerdes, U.
    Ctr Qual, Region Southern Denmark, Middelfart, Denmark; Inst Reg Hlth Res, Univ Southern Denmark, Odense, Denmark.
    Almer, S.
    Dept Gastroenterol, University Hospital Linköping, County Council Östergötland, Linköping, Sweden.
    Cukovic-Cavka, S.
    Sch Med, Div Gastroenterol & Hepatol, Univ Hosp Ctr Zagreb, Univ Zagreb, Zagreb, Croatia.
    Sebastian, S.
    Hull Royal Infirm, Hull & East Yorkshire NHS Trust, Kingston Upon Hull, England; Hull & York Med Sch, Kingston Upon Hull, England.
    Kaimakliotis, I.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Pedersen, N.
    Dept Gastroenterol, Slagelse Hosp, Slagelse, Denmark.
    Salupere, R.
    Div Gastroenterol & Endocrinol, Tartu Univ Hosp, Tartu, Estonia.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Isl, Torshavn, Denmark; Genet Biobank, Torshavn, Faroe Islands, Danmark.
    Manninen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Katsanos, K. H.
    Div Internal Med 1, Univ Hosp, Ioannina, Greece; Hepatogastroenterol Unit, Univ Hosp, Ioannina, Greece.
    Odes, S.
    Soroka Med Ctr, Beer Sheva, Israel; Dept Gastroenterol & Hepatol, Ben Gurion Univ Negev, Beer Sheva, Israel.
    Andersen, V.
    Dept Med, Viborg Reg Hosp, Viborg, Denmark; Dept Med, Hosp Southern Jutland, Aabenraa, Denmark.
    D'Inca, R.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Turcan, S.
    Dept Gastroenterol, State Univ Med & Pharm Republ Moldova, Kishinev, Moldova.
    Magro, F.
    Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal; Dept Gastroenterol, Hosp Sao Joao, Oporto, Portugal; Inst Pharmacol & Therapeut, Oporto Med Sch, Oporto, Portugal.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Vinding, K. Kofod
    Dept Med, Amager Hosp, Amager, Denmark.
    Belousova, E.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Ladefoged, K.
    Dept Med, Dronning Ingrids Hosp, Nuuk, Greenland.
    Bailey, Y.
    Dept Gastroenterol, Adelaide & Meath Hosp, Trinity College Dublin, Dublin, Ireland.
    Hernandez, V.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences.
    Arebi, N.
    Gastroenterol, St Marks Hosp, London, England.
    Shonova, O.
    Dept Gastroenterol, Nemocnice Ceske Budejovice, Ceske Budejovice, Czech Republic.
    Hoivik, M. L.
    Dept Gastroenterol, Oslo Univ Hosp, Oslo, Norway.
    Moum, B.
    Dept Gastroenterol, Oslo Univ Hosp, Oslo, Norway.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Lakatos, P. L.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Munkholm, P.
    Dept Gastroenterol, North Zealand Univ Hosp, Frederikssund, Denmark.
    Dahlerup, J. F.
    Dept Gastroenterol & Hepatol, Aarhus Univ Hosp, Aarhus, Denmark.
    Frequency of anaemia and anaemia subtypes in east-west European inception cohort: an ECCO-EpiCom cohort study2016In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 10, no Suppl. 1, p. S453-S454Article in journal (Other academic)
  • 28.
    Burisch, J.
    et al.
    North Zealand Univ Hosp, Dept Gastroenterol, Frederikssund, Denmark..
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastronterology.
    Kupcinskas, L.
    Lithuanian Univ Hlth Sci, Inst Digest Res, Kaunas, Lithuania..
    Hernandez, V.
    Complexo Hosp Univ Vigo, Dept Gastroenterol, Vigo, Spain..
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus..
    Valpiani, D.
    Morgagni Hosp, Dept Gastroenterol & Digest Endoscopy, Forli, Italy..
    Pedersen, N.
    Slagelse Hosp, Dept Gastroenterol, Slagelse, Denmark..
    Duricova, D.
    Charles Univ Prague, IBD Ctr ISCARE, Prague, Czech Republic..
    Kievit, L.
    Herning Cent Hosp, Dept Med, Herning, Denmark..
    Dahlerup, J. F.
    Aarhus Univ Hosp, Dept Gastroenterol & Hepatol, Aarhus, Denmark..
    Fumery, M.
    Amiens Univ & Hosp, Gastroenterol Unit, Epimad Registry, Amiens, France..
    Salupere, R.
    Tartu Univ Hosp, Div Gastroenterol & Endocrinol, Tartu, Estonia..
    Arebi, N.
    St Marks Hosp, Gastroenterol, London, England..
    Nielsen, K. R.
    Natl Hosp Faroe Isl, Dept Med, Torshavn, Faroe Islands, Denmark..
    Giannotta, M.
    AOU Careggi Reg Referral Ctr Inflammatory Bowel D, Dept Gastroenterol, Florence, Italy..
    Oksanen, P.
    Tampere Univ Hosp, Dept Gastroenterol & Alimentary Tract Surg, Tampere, Finland..
    Katsanos, K. H.
    Univ Hosp, Div Internal Med 1, Ioannina, Greece.;Univ Hosp, Hepatogastroenterol Unit, Ioannina, Greece..
    Vegh, Z.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary..
    Ellul, P.
    Mater Dei Hosp, Div Gastroenterol, L Imsida, Malta..
    Schwartz, D.
    Soroka Med Ctr, Beer Sheva, Israel.;Ben Gurion Univ Negev, Dept Gastroenterol & Hepatol, Beer Sheva, Israel..
    Cukovic-Cavka, S.
    Univ Zagreb, Sch Med, Div Gastroenterol & Hepatol, Univ Hosp Ctr Zagreb, Zagreb, Croatia..
    D'Inca, R.
    Azienda Osped Padova, Dept Surg Oncol & Gastroenterol, Padua, Italy..
    Turcan, S.
    State Univ Med Pharm Republ Moldova, Dept Gastroenterol, Kishinev, Moldova..
    Magro, F.
    Univ Porto, Inst Mol & Cell Biol, Oporto, Portugal.;Hosp Sao Joao, Dept Gastroenterol, Oporto, Portugal.;Oporto Med Sch, Inst Pharmacol & Therapeut, Oporto, Portugal..
    Goldis, A.
    Univ Med Victor Babes, Gastroenterol Clin, Timisoara, Romania..
    Langholz, E.
    Gentofte Univ Hosp, Dept Med Gastroenterol, Copenhagen, Denmark..
    Lakatos, P. L.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary..
    Munkholm, P.
    North Zealand Univ Hosp, Dept Gastroenterol, Frederikssund, Denmark..
    Change in Crohn's disease behavior in a prospective European population-based inception cohort - the ECCO-EpiCom cohort2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S452-S453Article in journal (Refereed)
  • 29.
    Burisch, J.
    et al.
    North Zealand Univ Hosp, Dept Gastroenterol, Frederikssund, Denmark..
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital.
    Kupcinskas, L.
    Lithuanian Univ Hlth Sci, Inst Digest Res, Kaunas, Lithuania..
    Hernandez, V.
    Complexo Hosp Univ Vigo, Dept Gastroenterol, Vigo, Spain..
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus..
    Valpiani, D.
    Morgagni Hosp, Dept Gastroenterol & Digest Endoscopy, Forli, Italy..
    Pedersen, N.
    Slagelse Hosp, Dept Gastroenterol, Slagelse, Denmark..
    Duricova, D.
    Charles Univ Prague, IBD Ctr ISCARE, Prague, Czech Republic..
    Kievit, L.
    Herning Cent Hosp, Dept Med, Herning, Denmark..
    Dahlerup, J. F.
    Aarhus Univ Hosp, Dept Gastroenterol & Hepatol, Aarhus, Denmark..
    Fumery, M.
    Amiens Univ & Hosp, Epimad Registry, Gastroenterol Unit, Amiens, France..
    Salupere, R.
    Tartu Univ Hosp, Div Gastroenterol & Endocrinol, Tartu, Estonia..
    Arebi, N.
    St Marks Hosp, Gastroenterol, London, England..
    Nielsen, K. R.
    Natl Hosp Faroe Islands, Dept Med, Torshavn, Faroe Islands, Denmark..
    Giannotta, M.
    AOU Careggi Reg Referral Ctr Inflammatory Bowel D, Dept Gastroenterol, Florence, Italy..
    Oksanen, P.
    Tampere Univ Hosp, Dept Gastroenterol & Alimentary Tract Surg, Tampere, Finland..
    Katsanos, K. H.
    Univ Hosp Ioannina, Div Internal Med 1, Ioannina, Greece.;Univ Hosp Ioannina, Hepatogastroenterol Unit, Ioannina, Greece..
    Vegh, Z.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary..
    Ellul, P.
    Mater Dei Hosp, Div Gastroenterol, Limsida, Malta..
    Schwartz, D.
    Soroka Med Ctr, Beer Sheva, Israel.;Ben Gurion Univ Negev, Dept Gastroenterol & Hepatol, Beer Sheva, Israel..
    Cukovic-Cavka, S.
    Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Div Gastroenterol & Hepatol, Zagreb, Croatia..
    D'Inca, R.
    Azienda Osped Padova, Dept Surg Oncol & Gastroenterol, Padua, Italy..
    Turcan, S.
    State Univ Med & Pharm Republ Moldova, Dept Gastroenterol, Kishinev, Moldova..
    Magro, F.
    Univ Porto, Inst Mol & Cell Biol, Oporto, Portugal.;Hosp Sao Joao, Dept Gastroenterol, Oporto, Portugal.;Oporto Med Sch, Inst Pharmacol & Therapeut, Oporto, Portugal..
    Goldis, A.
    Univ Med Victor Babes, Gastroenterol Clin, Timisoara, Romania..
    Langholz, E.
    Gentofte Univ Hosp, Dept Med Gastroenterol, Copenhagen, Denmark..
    Lakatos, P. L.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary..
    Munkholm, P.
    North Zealand Univ Hosp, Dept Gastroenterol, Frederikssund, Denmark..
    Disease course during the first five years following diagnosis in a prospective European population-based inception cohort - the ECCO-EpiCom cohort2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S435-S436Article in journal (Refereed)
  • 30.
    Burisch, J.
    et al.
    North Zealand Univ Hosp, Dept Gastroenterol, Frederikssund, Denmark..
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Örebro University Hospital. Department of Gastronterology.
    Kupcinskas, L.
    Lithuanian Univ Hlth Sci, Inst Digest Res, Kaunas, Lithuania..
    Hernandez, V.
    Complexo Hosp Univ Vigo, Dept Gastroenterol, Vigo, Spain..
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus..
    Valpiani, D.
    Morgagni Hosp, Dept Gastroenterol & Digest Endoscopy, Forli, Italy..
    Pedersen, N.
    Slagelse Hosp, Dept Gastroenterol, Slagelse, Denmark..
    Duricova, D.
    Charles Univ Prague, IBD Ctr ISCARE, Prague, Czech Republic..
    Kievit, L.
    Herning Cent Hosp, Dept Med, Herning, Denmark..
    Dahlerup, J. F.
    Aarhus Univ Hosp, Dept Gastroenterol & Hepatol, Aarhus, Denmark..
    Fumery, M.
    Amiens Univ & Hosp, Epimad Registry, Gastroenterol Unit, Amiens, France..
    Salupere, R.
    Tartu Univ Hosp, Div Gastroenterol & Endocrinol, Tartu, Estonia..
    Arebi, N.
    St Marks Hosp, Gastroenterol, London, England..
    Nielsen, K. R.
    Natl Hosp Faroe Islands, Dept Med, Torshavn, Faroe Islands, Denmark..
    Giannotta, M.
    AOU Careggi Reg Referral Ctr Inflammatory Bowel D, Dept Gastroenterol, Florence, Italy..
    Oksanen, P.
    Tampere Univ Hosp, Dept Gastroenterol & Alimentary Tract Surg, Tampere, Finland..
    Katsanos, K. H.
    Univ Hosp Ioannina, Div Internal Med 1, Ioannina, Greece.;Univ Hosp Ioannina, Hepatogastroenterol Unit, Ioannina, Greece..
    Vegh, Z.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary..
    Ellul, P.
    Mater Dei Hosp, Div Gastroenterol, Limsida, Malta..
    Schwartz, D.
    Soroka Med Ctr, Beer Sheva, Israel.;Ben Gurion Univ Negev, Dept Gastroenterol & Hepatol, Beer Sheva, Israel..
    Cukovic-Cavka, S.
    Univ Zagreb, Univ Hosp Ctr Zagreb, Sch Med, Div Gastroenterol & Hepatol, Zagreb, Croatia..
    D'Inca, R.
    Azienda Osped Padova, Dept Surg Oncol & Gastroenterol, Padua, Italy..
    Turcan, S.
    State Univ Med & Pharm Republ Moldova, Dept Gastroenterol, Kishinev, Moldova..
    Magro, F.
    Univ Porto, Inst Mol & Cell Biol, Oporto, Portugal.;Hosp Sao Joao, Dept Gastroenterol, Oporto, Portugal.;Oporto Med Sch, Inst Pharmacol & Therapeut, Oporto, Portugal..
    Goldis, A.
    Univ Med Victor Babes, Gastroenterol Clin, Timisoara, Romania..
    Langholz, E.
    Gentofte Univ Hosp, Dept Med Gastroenterol, Copenhagen, Denmark..
    Lakatos, P. L.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary..
    Munkholm, P.
    North Zealand Univ Hosp, Dept Gastroenterol, Frederikssund, Denmark..
    The risk of proximal disease extension in patients with limited ulcerative colitis in a prospective European population-based inception cohort - the ECCO-EpiCom cohort2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no Suppl. 1, p. S436-S436Article in journal (Refereed)
  • 31.
    Burisch, J.
    et al.
    Gastrounit, Medical section, Hvidovre University Hospital, Hvidovre, Denmark.
    Kaimakliotis, I.
    Nicosia Private practice, Nicosia, Cyprus.
    Duricova, D.
    IBD Center ISCARE, Charles University, Prague, Czech Republic.
    Kievit, L.
    Department of medicine, Herning Central Hospital, Herning, Denmark.
    Dahlerup, J. F.
    Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
    Salupere, R.
    Division of Endocrinology and Gastroenterology, Tartu University Hospital, Tartu, Estonia.
    Nielsen, K. R.
    Medical Department, The National Hospital of the Faroe Islands, Thorshavn, Denmark.
    Manninen, P.
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
    Tsianos, E. V.
    1st Division of Internal Medicine and Hepato-Gastroenterology Unit, University Hospital, Ioannina, Greece.
    Vegh, Z.
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Odes, S.
    Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
    D'Inca, R.
    EpiCom Northern Italy, Florence, Forlì, and Padova, Italy.
    Kupcinskas, L.
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Turcan, S.
    Department of Gastroenterology, Chisinau, State University of Medicine and Pharmacy of the Republic of Moldova, Moldova, Republic of Moldova.
    Magro, F.
    Institute for molecular and cell biology, University of Porto, Porto, Portugal; Department of Gastroenterology, Hospital de São João, Porto, Portugal; Institute of Pharmacology and Therapeutics, Oporto Medical School, Porto, Portugal.
    Goldis, A.
    Clinic of Gastroenterology, University of Medicine Victor Babes, Timisoara, Romania.
    Hernandez, V.
    Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
    Halfvarson, Jonas
    Örebro University, School of Medicine, Örebro University, Sweden.
    Arebi, N.
    Gastroenterology, St Mark's Hospital, London, United Kingdom.
    Langholz, E.
    Department of Medical Gastroenterology, Gentofte Hospital, Copenhagen, Denmark.
    Lakatos, P. L.
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Munkholm, P.
    Department of gastroenterology, Herlev University Hospital, Herlev, Denmark.
    EpiCom Northern Italy, Group author
    Unchanged surgery and hospitalization rates in an East-West European inception cohort despite differences in use of biologicals-3-year follow-up of the ECCO-EpiCom cohort2015In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 9, p. S5-S6Article in journal (Other academic)
  • 32.
    Burisch, J.
    et al.
    Dept Gastroenterol, Herlev Univ Hosp, Herlev, Denmark.
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Thorsgaard, N.
    Dept Med, Herning Cent Hosp, Herning, Denmark.
    Andersen, V.
    Dept Med, Viborg Reg Hosp, Viborg, Denmark; Inst Reg Hlth Res, Univ Southern Denmark, Odense, Denmark; Dept Med, Hosp Southern Jutland, Aabenraa, Denmark.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Islands, Torshavn, Denmark.
    Tsianos, E. V.
    Div Internal Med 1, Univ Hosp, Ioannina, Greece; Hepatogastroenterol Unit, Ioannina, Greece.
    Ladefoged, K.
    Dept Med, Dronning Ingrids Hosp, Nuuk, Greenland.
    Bailey, Y.
    Dept Gastroenterol, Adelaide & Meath Hosp, Trinity College, Dublin, Ireland.
    D'Inca, R.
    Azienda Osped, UO Gastroenterol, Univ Padua, Padua, Italy; EpiCom Northern Italy Ctr Based Crema & Cremona, Forli, Italy; EpiCom Northern Italy Ctr Based Crema & Cremona, Reggio Emilia, Italy.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Turcan, S.
    Dept Gastroenterol, State University of Medicine and Pharmacy "Nicolae Testemitanu", Kishinev, Moldova.
    Magro, F.
    Inst Pharmacol & Therapeut, Oporto, Oporto Med Sch, Portugal; Dept Gastroenterol, Hosp Sao Joao, Oporto, Portugal; Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Belousova, E.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Hernandez, V.
    Gastroenterol, Complejo Hosp Univ Vigo, Vigo, Spain.
    Almer, S.
    Dept Gastroenterol, Uiveraity Hospital, Cty Council Östergötland, Linköping, Sweden; Div Gastroenterol & Hepatol, Karolinska Inst, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Dept Med 24, Div Gastroenterol, Örebro Univ Hosp, Örebro, Sweden .
    Sebastian, S.
    Hull Royal Infirm, Hull & East Yorkshire NHS Trust, Kingston Upon Hull, England; Hull & York Med Sch, Kingston Upon Hull, England.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Odes, S.
    Soroka Med Ctr, Beer Sheva, Israel; Dept Gastroenterol & Hepatol, Ben Gurion Univ Negev, Beer Sheva, Israel.
    Munkholm, P.
    Dept Gastroenterol, Herlev Univ Hosp, Herlev, Denmark.
    The cost of investigations and medical treatment including biological therapy in a European inception cohort from the biological era: An ECCO-EpiCom study2014In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no Suppl. 1, p. S5-S6Article in journal (Refereed)
  • 33.
    Burisch, J.
    et al.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
    Pedersen, N.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
    Cukovic-Cavka, S.
    Division of Gastroenterology and Hepatology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
    Brinar, M.
    Division of Gastroenterology and Hepatology, University Hospital Centre Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
    Kaimakliotis, I.
    Nicosia private practice, Nicosia, Cyprus.
    Duricova, D.
    IBD Centre ISCARE, Charles University, Prague, Czech Republic.
    Shonova, O.
    Gastroenterology Department, Hospital České Budějovice, České Budějovice, Czech Republic.
    Vind, I.
    Department of Medicine, Amager Hospital, Amager, Denmark.
    Avnstrom, S.
    Department of Medicine, Amager Hospital, Amager, Denmark.
    Thorsgaard, N.
    Department of Medicine, Herning Central Hospital, Herning, Denmark.
    Andersen, V.
    Medical Department, Viborg Regional Hospital, Viborg, Denmark; Medical Department, Hospital of Southern Jutland, Aabenraa, Denmark; University of Southern Denmark, Odense, Denmark.
    Krabbe, S.
    Medical Department, Viborg Regional Hospital, Viborg, Denmark.
    Dahlerup, J. F.
    Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Arhus, Denmark.
    Salupere, R.
    Division of Endocrinology and Gastroenterology, Tartu University Hospital, Tartu, Estonia.
    Nielsen, K. R.
    Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
    Olsen, J.
    Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
    Manninen, P.
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
    Collin, P.
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
    Tsianos, E. V.
    1st Division of Internal Medicine and Hepato-Gastroenterology Unit, University Hospital, Ioannina, Greece.
    Katsanos, K. H.
    1st Division of Internal Medicine and Hepato-Gastroenterology Unit, University Hospital, Ioannina, Greece.
    Ladefoged, K.
    Medical Department, Dronning Ingrids Hospital, Nuuk, Greenland.
    Lakatos, L.
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Bjornsson, E.
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital, Reykjavik, Iceland.
    Ragnarsson, G.
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital, Reykjavik, Iceland.
    Bailey, Y.
    Department of Gastroenterology, Adelaide and Meath Hospital, TCD, Dublin, Ireland.
    Odes, S.
    Department of Gastroenterology and Hepatology, Soroka Medical Centre and Ben Gurion University of the Negev, Beer Sheva, Israel.
    Schwartz, D.
    Department of Gastroenterology and Hepatology, Soroka Medical Centre and Ben Gurion University of the Negev, Beer Sheva, Israel.
    Martinato, M.
    UO Gastroenterologia, Azienda Ospedaliera—Università di Padova, Padova, Italy.
    Lupinacci, G.
    UO di Medicina e Gastroenterologia, Az Ospedaliera Ospedale di Cremona, Cremona, Italy; UO di Gastroenterologia e Endoscopia Digestiva, Az Ospedaliera Ospedale Maggiore di Crema, Crema, Italy.
    Milla, M.
    Gastroenterology Unit, Careggi Hospital, Florence, Italy.
    De Padova, A.
    UO Gastroenterologia ed Endoscopia Digestiva, Ospedale Morgagni-Pierantoni, Forlì, Italy.
    D'lnca, R.
    UO Gastroenterologia, Azienda Ospedaliera-Università di Padova, Padova, Italy.
    Beltrami, M.
    UO Gastroenterologia ed Endoscopia Digestiva, Ospedale Morgagni-Pierantoni, Forlì, Italy.
    Kupcinskas, L.
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Kiudelis, G.
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Turcan, S.
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
    Tighineanu, O.
    Department of Paediatric Gastroenterology, Centre of Mother and Child, Chisinau, Republic of Moldova.
    Mihu, I.
    Department of Paediatric Gastroenterology, Centre of Mother and Child, Chisinau, Republic of Moldova.
    Magro, F.
    Department of Gastroenterology, Hospital de São João, Porto, Portugal; Institute of Pharmacology and Therapeutics, Oporto Medical School, Porto, Portugal; Hospital de Vale de Sousa, Porto, Portugal.
    Barros, L. F.
    Hospital de Vale de Sousa, Porto, Portugal.
    Goldis, A.
    Clinic of Gastroenterology, University of Medicine ‘Victor Babes’, Timisoara, Romania.
    Lazar, D.
    Clinic of Gastroenterology, University of Medicine ‘Victor Babes’, Timisoara, Romania.
    Belousova, E.
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russia.
    Nikulina, I.
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russia.
    Hernandez, V.
    Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
    Martinez-Ares, D.
    Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
    Almer, S.
    Division of Gastroenterology and Hepatology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden; Department of Gastroenterology/UHL, County Council of Östergötland, Linköping, Sweden.
    Zhulina, Yaroslava
    Örebro University Hospital. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Arebi, N.
    Sir Alan Park's Physiology Unit, St Mark's Hospital, Imperial College London, London, UK.
    Sebastian, S.
    Hull and East Yorkshire NHS Trust and Hull and York Medical School, Hull Royal Infirmary, Hull, UK.
    Lakatos, P. L.
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Langholz, E.
    Department of Medical Gastroenterology, Gentofte Hospital, Copenhagen, Denmark.
    Munkholm, P.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
    East-West gradient in the incidence of inflammatory bowel disease in Europe: the ECCO-EpiCom inception cohort2014In: Gut, ISSN 0017-5749, E-ISSN 1468-3288, Vol. 63, no 4, p. 588-597Article in journal (Refereed)
    Abstract [en]

    Objective: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe. The reasons for these changes remain unknown. The aim of this study was to investigate whether an East–West gradient in the incidence of IBD in Europe exists.

    Design: A prospective, uniformly diagnosed, population based inception cohort of IBD patients in 31 centres from 14 Western and eight Eastern European countries covering a total background population of approximately 10.1 million people was created. One-third of the centres had previous experience with inception cohorts. Patients were entered into a low cost, web based epidemiological database, making participation possible regardless of socioeconomic status and prior experience.

    Results: 1515 patients aged 15 years or older were included, of whom 535 (35%) were diagnosed with Crohn’s disease (CD), 813 (54%) with ulcerative colitis (UC) and 167 (11%) with IBD unclassified (IBDU). The overall incidence rate ratios in all Western European centres were 1.9 (95% CI 1.5 to 2.4) for CD and 2.1 (95% CI 1.8 to 2.6) for UC compared with Eastern European centres. The median crude annual incidence rates per 100 000 in 2010 for CD were 6.5 (range 0–10.7) in Western European centres and 3.1 (range 0.4–11.5) in Eastern European centres, for UC 10.8 (range 2.9–31.5) and 4.1 (range 2.4–10.3), respectively, and for IBDU 1.9 (range 0–39.4) and 0 (range 0–1.2), respectively. In Western Europe, 92% of CD, 78% of UC and 74% of IBDU patients had a colonoscopy performed as the diagnostic procedure compared with 90%, 100% and 96%, respectively, in Eastern Europe. 8% of CD and 1% of UC patients in both regions underwent surgery within the first 3 months of the onset of disease. 7% of CD patients and 3% of UC patients from Western Europe received biological treatment as rescue therapy. Of all European CD patients, 20% received only 5-aminosalicylates as induction therapy.

    Conclusions: An East–West gradient in IBD incidence exists in Europe. Among this inception cohort—including indolent and aggressive cases—international guidelines for diagnosis and initial treatment are not being followed uniformly by physicians.

  • 34.
    Burisch, J.
    et al.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Pedersen, N.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Cukovic-Cavka, S.
    Sch Med, Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Univ Zagreb, Zagreb, Croatia.
    Turk, N.
    Sch Med, Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Univ Zagreb, Zagreb, Croatia.
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Bortlik, M.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Shonova, O.
    Dept Gastroenterol, Hosp Ceske Budejovice, Ceske Budejovice, Czech Republic.
    Vind, I.
    Dept Med, Amager Hosp, Amager, Denmark.
    Avnstrom, S.
    Dept Med, Amager Hosp, Amager, Denmark.
    Thorsgaard, N.
    Dept Med, Herning Cent Hosp, Herning, Denmark.
    Krabbe, S.
    Dept Med, Viborg Reg Hosp, Viborg, Denmark.
    Andersen, V.
    Dept Med, Viborg Reg Hosp, Viborg, Denmark; Organ Ctr, Hosp Southern Jutland, Aabenraa, Denmark; Inst Reg Hlth Res, Univ Southern Denmark, Odense, Denmark.
    Dahlerup, J. F.
    Dept Med Hepatol & Gastroenterol 5, Aarhus Univ Hosp, Aarhus, Denmark.
    Kjeldsen, J.
    Dept Med Gastroenterol, Odense Univ Hosp, Odense, Denmark.
    Salupere, R.
    Olsen, J.
    Div Gastroenterol & Endocrinol, Tartu Univ Hosp, Tartu, Estonia; , Dept Med, Natl Hosp Faroe Islands, Torshavn, Denmark.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Islands, Torshavn, Denmark.
    Manninen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Collin, P.
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Katsanos, K. H.
    Div Internal Med 1, Univ Hosp, Ioannina, Greece; Hepatogastroenterol Unit, Univ Hosp, Ioannina, Greece.
    Tsianos, E. V.
    Div Internal Med 1, Univ Hosp, Ioannina, Greece; Hepatogastroenterol Unit, Univ Hosp, Ioannina, Greece.
    Ladefoged, K.
    Dept Med, Dronning Ingrids Hosp, Nuuk, Greenland.
    Lakatos, L.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Ragnarsson, G.
    Sect Gastroenterol & Hepatol, Dept Internal Med, Natl Univ Hosp Reykjavik, Reykjavik, Iceland.
    Björnsson, E.
    Sect Gastroenterol & Hepatol, Dept Internal Med, Natl Univ Hosp Reykjavik, Reykjavik, Iceland.
    Bailey, Y.
    Dept Gastroenterol, TCD, Adelaide & Meath Hosp, Dublin, Ireland.
    O'Morain, C.
    Dept Gastroenterol, TCD, Adelaide & Meath Hosp, Dublin, Ireland.
    Schwartz, D.
    Dept Gastroenterol & Hepatol, Soroka Med Ctr, Beer Sheva, Israel; Ben Gurion Univ Negev, Beer Sheva, Israel.
    Odes, S.
    Dept Gastroenterol & Hepatol, Soroka Med Ctr, Beer Sheva, Israel; Ben Gurion Univ Negev, Beer Sheva, Israel.
    Giannotta, M.
    Gastroenterol Unit, Careggi Hosp, Florence, Italy.
    Girardin, G.
    UO Gastroenterol, Azienda Osped Univ Padova, Padua, Italy.
    Kiudelis, G.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Kupcinskas, L.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Turcan, S.
    Dept Gastroenterol, State Univ Med & Pharm Republ Moldova, Kishinev, Moldova.
    Barros, L.
    Hosp de Vale de Sousa, Oporto, Portugal.
    Magro, F.
    Dept Gastroenterol, Hosp Sao Joao, Oporto, Portugal; Inst Pharmacol & Therapeut, Oporto Med Sch, Oporto, Portugal; Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal.
    Lazar, D.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Goldis, A.
    Gastroenterol Clin, Univ Med Victor Babes, Timisoara, Romania.
    Nikulina, I.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Belousova, E.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Martinez-Ares, D.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Hernandez, V.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Almer, S.
    Karolinska Inst, Div Gastroenterol & Hepatol, Stockholm, Sweden; Cty Council Östergötland, Dept Gastroenterol UHL, Linköping, Sweden.
    Zhulina, Yaroslava
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Div Gastroenterol, Dept Med.
    Halfvarson, Jonas
    Örebro University Hospital. Div Gastroenterol, Dept Med.
    Arebi, N.
    Univ London Imperial Coll Sci Technol & Med, St Marks Hosp, London, England.
    Tsai, H. H.
    Hull Royal Infirm, Hull & York Med Sch, Hull & East Yorkshire NHS Trust, Kingston Upon Hull, N Humberside, England.
    Sebastian, S.
    Hull Royal Infirm, Hull & York Med Sch, Hull & East Yorkshire NHS Trust, Kingston Upon Hull, N Humberside, England.
    Lakatos, P. L.
    Semmelweis Univ, Dept Med 1, Budapest, Hungary.
    Langholz, E.
    Gentofte Univ Hosp, Dept Med Gastroenterol, Copenhagen, Denmark.
    Munkholm, P.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Environmental factors in a population-based inception cohort of inflammatory bowel disease patients in Europe: An ECCO-EpiCom study2014In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no 7, p. 607-616Article in journal (Refereed)
    Abstract [en]

    Background and Aims: The incidence of inflammatory bowel disease (IBD) is increasing in Eastern Europe possibly due to changes in environmental factors towards a more "westernised" standard of Living. The aim of this study was to investigate differences in exposure to environmental factors prior to diagnosis in Eastern and Western European IBD patients.

    Methods: The EpiCom cohort is a population-based, prospective inception cohort of 1560 unselected IBD patients from 31 European countries covering a background population of 10.1 million. At the time of diagnosis patients were asked to complete an 87-item questionnaire concerning environmental factors.

    Results: A total of 1182 patients (76%) answered the questionnaire, 444 (38%) had Crohn's disease (CD), 627 (53%) ulcerative colitis (UC), and 111 (9%) IBD unclassified. No geographic differences regarding smoking status, caffeine intake, use of oral contraceptives, or number of first-degree relatives with IBD were found. Sugar intake was higher in CD and UC patients from Eastern Europe than in Western Europe while fibre intake was lower (p < 0.01). Daily consumption of fast food as well as appendectomy before the age of 20 was more frequent in Eastern European than in Western European UC patients (p < 0.01). Eastern European CD and UC patients had received more vaccinations and experienced fewer childhood infections than Western European patients (p < 0.01).

    Conclusions: In this European population-based inception cohort of unselected IBD patients, Eastern and Western European patients differed in environmental factors prior to diagnosis. Eastern European patients exhibited higher occurrences of suspected risk factors for IBD included in the Western lifestyle. (C) 2013 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

  • 35.
    Burisch, J.
    et al.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Vegh, Z.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark; Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Pedersen, N.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Cukovic-Cavka, S.
    Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Univ Zagreb Sch Med, Zagreb, Croatia.
    Turk, N.
    Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Univ Zagreb Sch Med, Zagreb, Croatia.
    Kaimakliotis, I.
    Duricova, D.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Bortlik, M.
    IBD Ctr ISCARE, Charles Univ, Prague, Czech Republic.
    Shonova, O.
    Dept Gastroenterol, Hosp Ceske Budejovice, Ceske Budejovice, Czech Republic.
    Thorsgaard, N.
    Dept Med, Cent Hosp, Herning, Denmark.
    Krabbe, S.
    Dept Med, Reg Hosp, Viborg, Denmark.
    Andersen, V.
    Dept Med, Reg Hosp, Viborg, Denmark; Dept Med, Hosp Southern Jutland, Aabenraa, Denmark; Inst Reg Hlth Res, Univ Southern Denmark, Odense, Denmark.
    Dahlerup, J. F.
    Dept Med Hepatol & Gastroenterol 5, Aarhus Univ Hosp, Aarhus, Denmark.
    Kjeldsen, J.
    Dept Med Gastroenterol, Univ Hosp, Odense, Denmark.
    Salupere, R.
    Div Gastroenterol & Endocrinol, Univ Hosp, Tartu, Estonia.
    Olsen, J.
    Dept Med, Natl Hosp Faroe Isl, Torshavn, Denmark.
    Nielsen, K. R.
    Dept Med, Natl Hosp Faroe Isl, Torshavn, Denmark.
    Manninen, P.
    Dept Gastroenterol & Alimentary Tract Surg, Univ Hosp, Tampere, Finland.
    Collin, P.
    Dept Gastroenterol & Alimentary Tract Surg, Univ Hosp, Tampere, Finland.
    Katsanos, K. H.
    Sch Med, Div Internal Med 1, Univ Ioannina, Ioannina, Greece; Sch Med, Div Gastroenterol, Univ Ioannina, Ioannina, Greece.
    Tsianos, E. V.
    Sch Med, Div Internal Med 1, Univ Ioannina, Ioannina, Greece; Sch Med, Div Gastroenterol, Univ Ioannina, Ioannina, Greece.
    Ladefoged, K.
    Dept Med, Dronning Ingrids Hosp, Nuuk, Greenland.
    Ragnarsson, G.
    Sect Gastroenterol & Hepatol, Dept Internal Med, Natl Univ Hosp, Reykjavik, Iceland.
    Björnsson, E.
    Sect Gastroenterol & Hepatol, Dept Internal Med, Natl Univ Hosp, Reykjavik, Iceland.
    Bailey, Y.
    Dept Gastroenterol, Adelaide & Meath Hosp, Trinity College Dublin, Dublin, Ireland.
    O'Morain, C.
    Dept Gastroenterol, Adelaide & Meath Hosp, Trinity College Dublin, Dublin, Ireland.
    Schwartz, D.
    Odes, S.
    Dept Gastroenterol & Hepatol, Soroka Med Ctr, Beer Sheva, Israel; Ben Gurion Univ Negev, Beer Sheva, Israel .
    Politi, S. P.
    UO Med Interna & Gastroenterol, Azienda Osped Istituti Ospitalieri Cremona, Cremona, Italy; EpiCom Northern Italy Ctr, Crema Cremona, Italy; EpiCom Northern Italy Ctr, Florence, Italy; EpiCom Northern Italy Ctr, Forli, Italy; EpiCom Northern Italy Ctr, Padua, Italy; EpiCom Northern Italy Ctr, Reggio Emilia, Italy .
    Santini, A.
    Gastroenterol Unit, Careggi Hosp, Florence, Italy; EpiCom Northern Italy Ctr, Crema Cremona, Italy; EpiCom Northern Italy Ctr, Florence, Italy; EpiCom Northern Italy Ctr, Forli, Italy; EpiCom Northern Italy Ctr, Padua, Italy; EpiCom Northern Italy Ctr, Reggio Emilia, Italy .
    Kiudelis, G.
    Inst Digest Res, Lithuanian Univ Hlth Sci, Kaunas, Lithuania.
    Kupcinskas, L.
    Lithuanian Univ Hlth Sci, Inst Digest Res, Kaunas, Lithuania.
    Turcan, S.
    State Univ Med & Pharm Republ Moldova, Dept Gastroenterol, Kishinev, Moldova.
    Magro, F.
    Hosp Sao Joao, Dept Gastroenterol, Oporto, Portugal; Oporto Med Sch, Inst Pharmacol & Therapeut, Oporto, Portugal; Univ Porto, Inst Mol & Cell Biol, Oporto, Portugal.
    Barros, L.
    Hosp Vale Sousa, Oporto, Portugal.
    Lazar, D.
    Univ Med Victor Babes, Gastroenterol Clin, Timisoara, Romania.
    Goldis, A.
    Univ Med Victor Babes, Gastroenterol Clin, Timisoara, Romania.
    Nikulina, I.
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Belousova, E.
    Moscow Reg Res Clin Inst, Dept Gastroenterol, Moscow, Russia.
    Sanroman, L.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Martinez-Ares, D.
    Dept Gastroenterol, Complexo Hosp Univ Vigo, Vigo, Spain.
    Almer, S.
    Dept Med, Div Gastroenterol & Hepatol, Karolinska Inst, Stockholm, Sweden; Dept Gastroenterol UHL, Cty Council Ostergötland, Linköping, Sweden .
    Zhulina, Yaroslava
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Div Gastroenterol, Dept Med, Örebro Univ Hosp, Örebro, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medicine, Örebro University, Sweden. Div Gastroenterol, Dept Med, Örebro Univ Hosp, Örebro, Sweden.
    Arebi, N.
    St Marks Hosp, Sir Alan Parks Physiol Unit, Univ London Imperial Coll Sci Technol & Med, London, England.
    Houston, Y.
    Hull & East Yorkshire HNS Trust, Dept Gastroenterol, Kingston Upon Hull, N Humberside, England.
    Sebastian, S.
    Hull & East Yorkshire NHS Trust, Hull Royal Infirm, Kingston Upon Hull, England; Hull & York Med Sch, Hull Royal Infirm, Kingston Upon Hull, England.
    Langholz, E.
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Lakatos, P. L.
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Munkholm, P.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Health care and patients' education in a European inflammatory bowel disease inception cohort: an ECCO-EpiCom study2014In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no 8, p. 811-818Article in journal (Refereed)
    Abstract [en]

    Background and Aims: The EpiCom study and inception cohort was initiated in 2010 in 31 centers from 14 Western and 8 Eastern European countries, covering a 10.1 million person background population. Our aim was to investigate whether there is a difference between Eastern and Western Europe in health care and education of patients with inflammatory bowel disease (IBD).

    Methods: A quality of care (QoC) questionnaire was developed in the EpiCom group consisting of 16 questions covering 5 items: time interval between the onset of symptoms and diagnosis, information, education, empathy and access to health care providers.

    Results: Of 1,515 patients, 947 (217 east/730 west) answered the QoC questionnaire. Only 23% of all patients had knowledge about IBD before diagnosis. In Eastern Europe, significantly more patients searched out information about IBD themselves (77% vs. 68%, p < 0.05), the main source was the Internet (92% vs. 88% p = 0.23). In Western Europe, significantly more patients were educated by nurses (19% vs. 1%, p < 0.05), while in Eastern Europe, gastroenterologists were easier to contact (80% vs. 68%, p < 0.05).

    Conclusion: Health care differed significantly between Eastern and Western Europe in all items, but satisfaction rates were high in both geographic regions. Because of the low awareness and the rising incidence of IBD, general information should be the focus of patient organizations and medical societies. In Western Europe IBD nurses play a very important role in reducing the burden of patient management. (c) 2014 European Crohn's and Colitis Organisation. Published by Elsevier B.V. All rights reserved.

  • 36.
    Burisch, J.
    et al.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
    Weimers, P.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
    Pedersen, N.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
    Cukovic-Cavka, S.
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia .
    Vucelic, B.
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia .
    Kaimakliotis, I.
    Nicosia Private Practice, Nicosia, Cyprus.
    Duricova, D.
    IBD Center ISCARE, Charles University, Prague, Czech Republic.
    Bortlik, M.
    IBD Center ISCARE, Charles University, Prague, Czech Republic.
    Shonová, O.
    Gastroenterology Department, Hospital České Budějovice, České Budějovice, Czech Republic.
    Vind, I.
    Department of Medicine, Amager Hospital, Amager, Denmark .
    Avnstrøm, S.
    Department of Medicine, Amager Hospital, Amager, Denmark .
    Thorsgaard, N.
    Department of Medicine, Herning Central Hospital, Herning, Denmark .
    Krabbe, S.
    Medical Department, Viborg Regional Hospital, Viborg, Denmark .
    Andersen, V.
    Medical Department, Viborg Regional Hospital, Viborg, Denmark ; Medical Department, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark .
    Dahlerup, J. F.
    Department of Medicine V, Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark .
    Kjeldsen, J.
    Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark .
    Salupere, R.
    Division of Endocrinology and Gastroenterology, Tartu University Hospital, Tartu, Estonia .
    Olsen, J.
    Medical Department, The National Hospital of the Faroe Islands, Torshavn, Denmark.
    Nielsen, K. R.
    Medical Department, The National Hospital of the Faroe Islands, Torshavn, Denmark.
    Manninen, P.
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland .
    Collin, P.
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland .
    Katsanos, K. H.
    1st Division of Internal Medicine and Division of Gastroenterology, Medical School, University of Ioannina, Ioannina, Greece .
    Tsianos, E. V.
    1st Division of Internal Medicine and Division of Gastroenterology, Medical School, University of Ioannina, Ioannina, Greece .
    Ladefoged, K.
    Medical Department, Dronning Ingrids Hospital, Nuuk, Greenland .
    Lakatos, L.
    Department of Medicine, Csolnoky F. Province Hospital, Veszprem, Hungary .
    Ragnarsson, G.
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital, Reykjavik, Iceland .
    Björnsson, E.
    Department of Internal Medicine, Section of Gastroenterology and Hepatology, The National University Hospital, Reykjavik, Iceland .
    Bailey, Y.
    Department of Gastroenterology, Adelaide and Meath Hospital, Trinity College Dublin, Dublin, Ireland .
    O'Morain, C.
    Department of Gastroenterology, Adelaide and Meath Hospital, Trinity College Dublin, Dublin, Ireland .
    Schwartz, D.
    Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel ; Department of Gastroenterology and Hepatology, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Odes, S.
    Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel ; Department of Gastroenterology and Hepatology, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Valpiani, D.
    U.O. Gastroenterologia ed Endoscopia Digestiva, Ospedale Morgagni - Pierantoni, Forlì, Italy.
    Boni, M. C.
    U.O. Medicina 3 e Gastroenterologia, Azienda Ospedaliera Arcispedale S. Maria Nuova, Reggio Emilia, Italy .
    Jonaitis, L.
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania .
    Kupcinskas, L.
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania .
    Turcan, S.
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Moldova.
    Barros, L.
    Hospital de Vale de Sousa, Porto, Portugal .
    Magro, F.
    Department of Gastroenterology, Hospital São João, Porto, Portugal; Institute of Pharmacology and Therapeutics, Faculty of Medicine, University of Porto, Porto, Portugal; IBMC - Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal.
    Lazar, D.
    Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania .
    Goldis, A.
    Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania .
    Nikulina, I.
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation .
    Belousova, E.
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation .
    Fernandez, A.
    Gastroenterology Department, POVISA Hospital, Vigo, Spain .
    Sanroman, L.
    Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain .
    Almér, S.
    Division of Gastroenterology and Hepatology, Department of Medicine, Karolinska Institutet, Stockholm, Sweden;Department of Gastroenterology/UHL, County Council of Östergötland, Linköping, Sweden.
    Zhulina, Yaroslava
    Örebro University Hospital. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden.
    Arebi, N.
    St. Mark's Hospital, Imperial College London, London, United Kingdom.
    Diggory, T.
    Hull and East Yorkshire NHS Trust, Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom; Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom .
    Sebastian, S.
    Hull and East Yorkshire NHS Trust, Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom; Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom .
    Lakatos, P. L.
    1st Department of Medicine, Semmelweis University, Budapest, Hungary .
    Langholz, E.
    Department of Medical Gastroenterology, Gentofte Hospital, Copenhagen, Denmark .
    Munkholm, P.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark .
    Health-related quality of life improves during one year of medical and surgical treatment in a European population-based inception cohort of patients with Inflammatory Bowel Disease: An ECCO-EpiCom study2014In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 8, no 9, p. 1030-1042Article in journal (Refereed)
    Abstract [en]

    Background & Aims: Health-related quality of life (HRQoL) is impaired in patients with Inflammatory Bowel Disease (IBD). The aim was prospectively to assess and validate the pattern of HRQoL in an unselected, population-based inception cohort of IBD patients from Eastern and Western Europe.

    Methods: The EpiCom inception cohort consists of 1560 IBD patients from 31 European centres covering a background population of approximately 10.1 million. Patients answered the disease specific Short Inflammatory Bowel Disease Questionnaire (SIBDQ) and generic Short Form 12 (SF-12) questionnaire at diagnosis and after one year of follow-up.

    Results: In total, 1079 patients were included in this study. Crohn's disease (CD) patients mean SIBDQ scores improved from 45.3 to 55.3 in Eastern Europe and from 44.9 to 53.6 in Western Europe. SIBDQ scores for ulcerative colitis (UC) patients improved from 44.9 to 57.4 and from 48.8 to 55.7, respectively. UC patients needing surgery or biologicals had lower SIBDQ scores before and after compared to the rest, while biological therapy improved SIBDQ scores in CD. CD and UC patients in both regions improved all SF-12 scores. Only Eastern European UC patients achieved SF-12 summary scores equal to or above the normal population.

    Conclusion: Medical and surgical treatment improved HRQoL during the first year of disease. The majority of IBD patients in both Eastern and Western Europe reported a positive perception of disease-specific but not generic HRQoL. Biological therapy improved HRQoL in CD patients, while UC patients in need of surgery or biological therapy experienced lower perceptions of HRQoL than the rest.

  • 37. Burisch, Johan
    et al.
    Cukovic-Cavka, Silvija
    Kaimakliotis, Ioannis
    Shonová, Olga
    Andersen, Vibeke
    Dahlerup, Jens F
    Elkjaer, Margarita
    Langholz, Ebbe
    Pedersen, Natalia
    Salupere, Riina
    Kolho, Kaija-Leena
    Manninen, Pia
    Lakatos, Peter Laszlo
    Shuhaibar, Mary
    Odes, Selwyn
    Martinato, Matteo
    Mihu, Ion
    Magro, Fernando
    Belousova, Elena
    Fernandez, Alberto
    Almer, Sven
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences.
    Hart, Ailsa
    Munkholm, Pia
    Construction and validation of a web-based epidemiological database for inflammatory bowel diseases in Europe an EpiCom study2011In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 5, no 4, p. 342-349Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: The EpiCom-study investigates a possible East-West-gradient in Europe in the incidence of IBD and the association with environmental factors. A secured web-based database is used to facilitate and centralize data registration.

    AIM: To construct and validate a web-based inception cohort database available in both English and Russian language.

    METHOD: The EpiCom database has been constructed in collaboration with all 34 participating centers. The database was translated into Russian using forward translation, patient questionnaires were translated by simplified forward-backward translation. Data insertion implies fulfillment of international diagnostic criteria, disease activity, medical therapy, quality of life, work productivity and activity impairment, outcome of pregnancy, surgery, cancer and death. Data is secured by the WinLog3 System, developed in cooperation with the Danish Data Protection Agency. Validation of the database has been performed in two consecutive rounds, each followed by corrections in accordance with comments.

    RESULTS: The EpiCom database fulfills the requirements of the participating countries' local data security agencies by being stored at a single location. The database was found overall to be "good" or "very good" by 81% of the participants after the second validation round and the general applicability of the database was evaluated as "good" or "very good" by 77%. In the inclusion period January 1st -December 31st 2010 1336 IBD patients have been included in the database.

    CONCLUSION: A user-friendly, tailor-made and secure web-based inception cohort database has been successfully constructed, facilitating remote data input. The incidence of IBD in 23 European countries can be found at www.epicom-ecco.eu.

  • 38.
    Burisch, Johan
    et al.
    Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark.
    Kiudelis, Gediminas
    Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Kupcinskas, Limas
    Institute for Digestive Research, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania; Department of Gastroenterology, Medical Academy, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Kievit, Hendrika Adriana Linda
    Department of Medicine, Herning Central Hospital, Herning, Denmark.
    Andersen, Karina Winther
    Medical Department, Regional Hospital of Viborg, Viborg, Midtjylland, Denmark.
    Andersen, Vibeke
    Medical Department, Regional Hospital of Viborg, Viborg, Midtjylland, Denmark; Focused research unit for Molecular Diagnostic and Clinical Research (MOK), IRS-Center Sonderjylland, Hospital of Southern Jutland, Aabenraa, Denmark.
    Salupere, Riina
    Division of Gastroenterology, Tartu University Hospital, University of Tarty, Tartu, Estonia.
    Pedersen, Natalia
    Gastroenterology Department, Slagelse Hospital, Slagelse, Sjaelland, Denmark.
    Kjeldsen, Jens
    Gastroenterology Department, Odense University Hospital, Odense, Denmark.
    D'Incà, Renata
    Department of Surgical, Oncological and Gastroenterological Sciences, Azienda, University of Padua, Padova, Italy.
    Valpiani, Daniela
    U.O. Gastroenterologia ed Endoscopia digestiva, Hospital Morgagni Pierantoni, Forlì, Italy.
    Schwartz, Doron
    Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel.
    Odes, Selwyn
    Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel.
    Olsen, Jóngerð
    Medical Department, The National Hospital of the Faroe Islands, Thorshavn, Faroe Islands.
    Nielsen, Kári Rubek
    Medical Department, The National Hospital of the Faroe Islands, Thorshavn, Faroe Islands.
    Vegh, Zsuzsanna
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Lakatos, Peter Laszlo
    1st Department of Medicine, Semmelweis University, Budapest, Hungary; Division of Gastroenterology, McGill University Health Center, Montreal, Canada.
    Toca, Alina
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
    Turcan, Svetlana
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
    Katsanos, Konstantinos H.
    Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece.
    Christodoulou, Dimitrios K
    Department of Gastroenterology, University Hospital of Ioannina, Ioannina, Greece.
    Fumery, Mathurin
    Gastroenterology Unit, Epimad Registry, CHU Amiens Sud, Avenue Laennec-Salouel, Amiens University Hospital, Amiens, France.
    Gower-Rousseau, Corinne
    Public Health, Epidemiology and Economic Health, Registre Epimad, Lille University and Hospital, Lille, France; Lille Inflammation Research International Center LIRIC, Lille University, Lille, France.
    Zammit, Stefania Chetcuti
    Division of Gastroenterology, Mater Dei Hospital, Msida, Malta.
    Ellul, Pierre
    Division of Gastroenterology, Mater Dei Hospital, Msida, Malta.
    Eriksson, Carl
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Magro, Fernando Jose
    Department of Gastroenterology, Centro Hospitalar de São João EPE, Porto, Portugal; Department of Biomedicine, Institute of Pharmacology, Faculty of Medicine of Porto University, Porto, Portugal.
    Duricova, Dana
    IBD Clinical and Research Centre, ISCARE, Prague, Czech Republic.
    Bortlik, Martin
    IBD Clinical and Research Centre, ISCARE, Prague, Czech Republic; Institute of Pharmacology, 1st Faculty of Medicine, Charles University in Prague, Prague, Czech Republic.
    Fernandez, Alberto
    Department of Gastroenterology, Hospital POVISA, Vigo, Spain.
    Hernández, Vicent
    Department of Gastroenterology, Hospital Alvaro Cunqueiro. Instituto Investigación Sanitaria Galicia Sur. EOXI de Vigo, Vigo, Spain.
    Myers, Sally
    IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK.
    Sebastian, Shaji
    IBD Unit, Hull and East Yorkshire NHS Trust, Hull, UK.
    Oksanen, Pia
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland; University of Tampere, Tampere, Finland.
    Collin, Pekka
    University of Tampere, Tampere, Finland.
    Goldis, Adrian
    Clinic of Gastroenterology, University of Medicine 'Victor Babes', Timisoara, Romania.
    Misra, Ravi
    IBD Department, Imperial College London, London, UK.
    Arebi, Naila
    IBD Department, Imperial College London, London, UK.
    Kaimakliotis, Ioannis P.
    Nicosia private practice, Nicosia, Cyprus.
    Nikuina, Inna
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
    Belousova, Elena
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
    Brinar, Marko
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia.
    Cukovic-Cavka, Silvija
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, Zagreb, Croatia.
    Langholz, Ebbe
    Department of Gastroenterology, Herlev and Gentofte Hospital, University of Copenhagen, Herlev, Denmark.
    Munkholm, Pia
    Department of Gastroenterology, Nordsjællands Hospital, University of Copenhagen, Frederikssund, Denmark.
    Natural disease course of Crohn's disease during the first 5 years after diagnosis in a European population-based inception cohort: an Epi-IBD study2018In: Gut, ISSN 0017-5749, E-ISSN 1468-3288Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: The Epi-IBD cohort is a prospective population-based inception cohort of unselected patients with inflammatory bowel disease from 29 European centres covering a background population of almost 10 million people. The aim of this study was to assess the 5-year outcome and disease course of patients with Crohn's disease (CD).

    DESIGN: Patients were followed up prospectively from the time of diagnosis, including collection of their clinical data, demographics, disease activity, medical therapy, surgery, cancers and deaths. Associations between outcomes and multiple covariates were analysed by Cox regression analysis.

    RESULTS: In total, 488 patients were included in the study. During follow-up, 107 (22%) patients received surgery, while 176 (36%) patients were hospitalised because of CD. A total of 49 (14%) patients diagnosed with non-stricturing, non-penetrating disease progressed to either stricturing and/or penetrating disease. These rates did not differ between patients from Western and Eastern Europe. However, significant geographic differences were noted regarding treatment: more patients in Western Europe received biological therapy (33%) and immunomodulators (66%) than did those in Eastern Europe (14% and 54%, respectively, P<0.01), while more Eastern European patients received 5-aminosalicylates (90% vs 56%, P<0.05). Treatment with immunomodulators reduced the risk of surgery (HR: 0.4, 95% CI 0.2 to 0.6) and hospitalisation (HR: 0.3, 95% CI 0.2 to 0.5).

    CONCLUSION: Despite patients being treated early and frequently with immunomodulators and biological therapy in Western Europe, 5-year outcomes including surgery and phenotype progression in this cohort were comparable across Western and Eastern Europe. Differences in treatment strategies between Western and Eastern European centres did not affect the disease course. Treatment with immunomodulators reduced the risk of surgery and hospitalisation.

  • 39. Burisch, Johan
    et al.
    Pedersen, Natalia
    Cukovic-Cavka, Silvija
    Kaimakliotis, John
    Duricova, Dana.
    Shonova, Olga
    Vind, Ida
    Thorsgaard, Niels
    Andersen, Vibeke
    Dahlerup, Jens F.
    Salupere, Riina
    Nielsen, Kári R.
    Manninen, Pia
    Tsianos, Epameinondas V.
    Ladefoged, Karin
    Bailey, Yvonne
    D'Inca, Renata
    Kupcinskas, Limas
    Turcan, Svetlana
    Magro, Fernando
    Goldis, Adrian
    Belousova, Elena
    Hernandez, Vicent
    Almer, Sven
    Halfvarson, Jonas
    Sebastian, Shaji
    Lakatos, Peter L.
    Langholz, Ebbe
    Odes, Selwyn H.
    Munkholm, Pia
    The Cost of Medical Management, Surgery and Clinical Investigations in a European Population-Based Inception Cohort From the Biological Era: An ECCO-Epicom Study2014In: Gastroenterology, ISSN 0016-5085, E-ISSN 1528-0012, Vol. 146, no 5, Supplement 1, p. S203-S203Article in journal (Refereed)
  • 40.
    Burisch, Johan
    et al.
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Pedersen, Natalia
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    Cukovic-Cavka, Silvja
    Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Univ Zagreb School of Medicine, Zagreb, Croatia.
    Turk, Niksa
    Univ Hosp Ctr Zagreb, Div Gastroenterol & Hepatol, Univ Zagreb School of Medicine, Zagreb, Croatia.
    Kaimakliotis, Ioannis
    Nicosia Private Practice, Nicosia, Cyprus.
    Duricova, Dana
    IBD Ctr ISCARE, Charles Univ Prague, Prague, Czech Republic.
    Shonova, Olga
    Dept Gastroenterol, Hosp Ceske Budejovice, Ceske Budejovice, Czech Republic.
    Vind, Ida
    Dept Med, Amager Hosp, Amager, Denmark.
    Avnstrom, Soren
    Dept Med, Amager Hosp, Amager, Denmark.
    Thorsgaard, Niels
    Dept Med, Herning Cent Hosp, Herning, Denmark.
    Krabbe, Susanne
    Dept Med, Viborg Reg Hosp, Viborg, Denmark.
    Andersen, Vibeke
    Medical Department, Viborg Regional Hospital, Viborg, Denmark; Medical Department, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
    Jens, Frederik Dahlerup
    Dept Med Hepatol & Gastroenterol 5, Aarhus Univ Hosp, Aarhus, Denmark.
    Kjeldsen, Jens
    Dept Med Gastroenterol, Odense Univ Hosp, Odense, Denmark.
    Salupere, Riina
    Div Gastroenterol & Endocrinol, Tartu Univ Hosp, Tartu, Estonia.
    Olsen, Jongero
    Dept Med, Natl Hosp Faroe Islands, Torshavn, Denmark.
    Nielsen, Kari Rubek
    Dept Med, Natl Hosp Faroe Islands, Torshavn, Denmark.
    Manninen, Pia
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Collin, Pekka
    Dept Gastroenterol & Alimentary Tract Surg, Tampere Univ Hosp, Tampere, Finland.
    Katsanos, Konstantinnos H.
    Div Internal Med 1, Univ Hosp, Ioannina, Greece ; Hepatogastroenterol Unit, Univ Hosp, Ioannina, Greece.
    Tsianos, Epameinondas V.
    Div Internal Med 1, Univ Hosp, Ioannina, Greece ; Hepatogastroenterol Unit, Univ Hosp, Ioannina, Greece.
    Ladefoged, Karin
    Dept Med, Dronning Ingrids Hosp, Nuuk, Greenland.
    Lakatos, Laszlo
    Dept Med, Csolnoky F Prov Hosp, Veszprem, Hungary.
    Bailey, Yvonne
    Adelaide & Meath Hosp, Dept Gastroenterol, Trinity Coll Dublin, Dublin, Ireland.
    O'Morain, Colm
    Dept Gastroenterol, Adelaide & Meath Hosp, Dublin, Ireland.
    Schwartz, Doron
    Dept Gastroenterol & Hepatol, Soroka Med Ctr, Beer Sheva, Israel; Ben Gurion Univ of the Negev, Beer Sheva, Israel .
    Odes, Selwyn
    Dept Gastroenterol & Hepatol, Soroka Med Ctr, Beer Sheva, Israel; Ben Gurion Univ of the Negev, Beer Sheva, Israel .
    Martinato, Matteo
    U.O. Gastroenterologia, Azienda Ospedaliera, Università di Padova, Padova, Italy.
    Lombardini, Silvia
    UO Medicina 38 e Gastroenterologia, Azienda Ospedaliera Arcispedale S Maria Nuova, Reggio Emilia, Italy.
    Jonaitis, Laimas
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Kupcinskas, Limas
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Moldova.
    Turcan, Svetlana
    Dept Gastroenterol, State Univ Med & Pharm Republ Moldova, Kishinev, Moldova.
    Barros, Louisa
    Dept Med, Hosp Vale de Sousa, Oporto, Portugal.
    Magro, Fernando
    Dept Gastroenterol, Hosp Sao Joao, Oporto, Portugal ; Inst Pharmacol & Therapeut, Oporto Med Sch, Oporto, Portugal ; Inst Mol & Cell Biol, Univ Porto, Oporto, Portugal .
    Lazar, Daniela
    Gastroenterol Clin, Univ Med 'Victor Babes', Timisoara, Romania.
    Goldis, Adrian
    Gastroenterol Clin, Univ Med 'Victor Babes', Timisoara, Romania.
    Nikulina, Inna
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
    Belousova, Elena
    Dept Gastroenterol, Moscow Reg Res Clin Inst, Moscow, Russia.
    Fernandez, Alberto
    Dept Gastroenterol, POVISA Hosp, Vigo, Spain.
    Hernandez, Vicent
    Dept Gastroenterol, Complexo Hospitalario Univ Vigo, Vigo, Spain.
    Almer, Sven
    Div Gastroenterol & Hepatol, Karolinska Instutue, Stockholm, Sweden ; Dept Gastroenterol UHL, Cty Council Östergötland,Linköping, Sweden .
    Zhulina, Yaroslava
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Div Gastroenterol, Dept Med, Örebro University Hospital, Örebro, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medicine, Örebro University, Sweden. Örebro University Hospital. Div Gastroenterol, Dept Med, Örebro University Hospital, Örebro, Sweden.
    Tsai, Her-Hsin
    Hull and East Yorkshire NHS Trust, Kingston-Upon-Hull, UK; Hull and York Medical School, Kingston-Upon-Hull, UK; Hull Royal Infirmary, Kingston-Upon-Hull, UK.
    Sebastian, Shaji
    Hull and East Yorkshire NHS Trust, Kingston-Upon-Hull, UK; Hull and York Medical School, Kingston-Upon-Hull, UK; Hull Royal Infirmary, Kingston-Upon-Hull, UK.
    Lakatos, Peter Laszlo
    Dept Med 1, Semmelweis Univ, Budapest, Hungary.
    Langholz, Ebbe
    Dept Med Gastroenterol, Gentofte Univ Hosp, Copenhagen, Denmark.
    Munkholm, Pia
    Med Sect, Ctr Digest Dis, Herlev Univ Hosp, Copenhagen, Denmark.
    EpiCom Northern Italy Centre Based in Crema and Cremona, Padova and Reggio Emilia, Italy (Lombardini & Martinato, on behalf of ), Group author
    Initial Disease Course and Treatment in an Inflammatory Bowel Disease Inception Cohort in Europe: The ECCO-EpiCom Cohort2014In: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 20, no 1, p. 36-46Article in journal (Refereed)
    Abstract [en]

    Background:The EpiCom cohort is a prospective, population-based, inception cohort of inflammatory bowel disease (IBD) patients from 31 European centers covering a background population of 10.1 million. The aim of this study was to assess the 1-year outcome in the EpiCom cohort.

    Methods:Patients were followed-up every third month during the first 12 (3) months, and clinical data, demographics, disease activity, medical therapy, surgery, cancers, and deaths were collected and entered in a Web-based database (www.epicom-ecco.eu).

    Results:In total, 1367 patients were included in the 1-year follow-up. In western Europe, 65 Crohn's disease (CD) (16%), 20 ulcerative colitis (UC) (4%), and 4 IBD unclassified (4%) patients underwent surgery, and in eastern Europe, 12 CD (12%) and 2 UC (1%) patients underwent surgery. Eighty-one CD (20%), 80 UC (14%), and 13 (9%) IBD unclassified patients were hospitalized in western Europe compared with 17 CD (16%) and 12 UC (8%) patients in eastern Europe. The cumulative probability of receiving immunomodulators was 57% for CD in western (median time to treatment 2 months) and 44% (1 month) in eastern Europe, and 21% (5 months) and 5% (6 months) for biological therapy, respectively. For UC patients, the cumulative probability was 22% (4 months) and 15% (3 months) for immunomodulators and 6% (3 months) and 1% (12 months) for biological therapy, respectively in the western and eastern Europe.

    Discussion:In this cohort, immunological therapy was initiated within the first months of disease. Surgery and hospitalization rates did not differ between patients from eastern and western Europe, although more western European patients received biological agents and were comparable to previous population-based inception cohorts.

  • 41.
    Burisch, Johan
    et al.
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
    Vardi, Hillel
    Department of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Pedersen, Natalia
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
    Brinar, Marko
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
    Cukovic-Cavka, Silvja
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb, University of Zagreb School of Medicine, Zagreb, Croatia.
    Kaimakliotis, Ioannis
    Private Practice, Nicosia, Cyprus.
    Duricova, Dana
    IBD Center ISCARE, Charles University, Prague, Czech Republic.
    Bortlik, Martin
    IBD Center ISCARE, Charles University, Prague, Czech Republic.
    Shonová, Olga
    Department of Gastroenterology, Hospital Ceske Budejovice, Ceske Budejovice, Czech Republic.
    Vind, Ida
    Department of Medicine, Amager Hospital, Amager, Denmark.
    Avnstrøm, Søren
    Department of Medicine, Amager Hospital, Amager, Denmark.
    Thorsgaard, Niels
    Department of Medicine, Herning Central Hospital, Herning, Denmark.
    Krabbe, Susanne
    Medical Department, Viborg Regional Hospital, Viborg, Denmark.
    Andersen, Vibeke
    Medical Department, Viborg Regional Hospital, Viborg, Denmark; Organ Center, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
    Dahlerup, Jens F
    Department of Medicine V (Hepatology and Gastroenterology), Aarhus University Hospital, Arhus, Denmark.
    Kjeldsen, Jens
    Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark.
    Salupere, Riina
    Division of Endocrinology and Gastroenterology, Tartu University Hospital, Tartu, Estonia.
    Olsen, Jónger
    Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
    Nielsen, Kári R
    Medical Department, The National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
    Manninen, Pia
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
    Collin, Pekka
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
    Katsanos, Konstantinnos H
    First Division of Internal Medicine and Hepato-Gastroenterology Unit, University Hospital, Ioannina, Greece.
    Tsianos, Epameinondas V
    First Division of Internal Medicine and Hepato-Gastroenterology Unit, University Hospital, Ioannina, Greece.
    Ladefoged, Karin
    Medical Department, Dronning Ingrids Hospital, Nuuk, Greenland.
    Lakatos, Laszlo
    First Department of Medicine, Semmelweis University, Budapest, Hungary.
    Bailey, Yvonne
    Department of Gastroenterology, Adelaide and Meath Hospital, TCD, Dublin, Ireland.
    OʼMorain, Colm
    Department of Gastroenterology, Adelaide and Meath Hospital, TCD, Dublin, Ireland.
    Schwartz, Doron
    Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Lupinacci, Guido
    U.O. di Gastroenterologia e Endoscopia Digestiva, Az.Ospedaliera Ospedale Maggiore di Crema, Crema, Italy; EpiCom Northern Italy centre based in Crema and Cremona, Firenze, Forli, Padova and Reggio Emilia, Italy.
    De Padova, Angelo
    EpiCom Northern Italy centre based in Crema and Cremona, Firenze, Forli, Padova and Reggio Emilia, Italy; U.O. Gastroenterologia ed Endoscopia Digestiva, Ospedale Morgagni, Pierantoni, Forli, Italy.
    Jonaitis, Laimas
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Kupcinskas, Limas
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Turcan, Svetlana
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
    Barros, Louisa
    Department of Medicine, Hospital de Vale de Sousa, Porto, Portugal.
    Magro, Fernando
    Department of Gastroenterology, Hospital de Sao Joao, Porto, Portugal; Institute of Pharmacology and Therapeutics, Oporto Medical School, Porto, Portugal; Institute for molecular and cell biology, University of Porto, Porto, Portugal.
    Lazar, Daniela
    Clinic of Gastroenterology, University of Medicine "Victor Babes," Timisoara, Romania.
    Goldis, Adrian
    Clinic of Gastroenterology, University of Medicine "Victor Babes," Timisoara, Romania.
    Nikulina, Inna
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russia.
    Belousova, Elena
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russia.
    Fernandez, Alberto
    Gastroenterology Department, POVISA Hospital, Vigo, Spain.
    Pineda, Juan R
    Gastroenterology Department, Complexo Hospitalario Universitario de Vigo, Vigo, Spain.
    Almer, Sven
    GastroCentrum, Karolinska University Hospital, Stockholm, Sweden; Department of Medicine, Solna, Karolinska University Hospital, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medicine, Örebro University, Sweden. Department of Medicine, Division of Gastroenterology, Örebro University Hospital, Örebro, Sweden; School of Health and Medical Sciences, Örebro University, Örebro, Sweden.
    Tsai, Her-Hsin
    Hull and East Yorkshire NHS Trust and Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom.
    Sebastian, Shaji
    Hull and East Yorkshire NHS Trust and Hull and York Medical School, Hull Royal Infirmary, Hull, United Kingdom.
    Friger, Michael
    Department of Public Health, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Greenberg, Dan
    Department of Health Systems Management, Faculty of Health Sciences, Ben Gurion University of the Negev, Beer Sheva, Israel; Guilford Glazer Faculty of Business and Management, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Lakatos, Peter L
    First Department of Medicine, Semmelweis University, Budapest, Hungary.
    Langholz, Ebbe
    Department of Medical Gastroenterology, Gentofte Hospital, Copenhagen, Denmark.
    Odes, Selwyn
    Department of Gastroenterology and Hepatology, Soroka Medical Center, Ben Gurion University of the Negev, Beer Sheva, Israel.
    Munkholm, Pia
    Digestive Disease Centre, Medical Section, Herlev University Hospital, Copenhagen, Denmark.
    Costs and resource utilization for diagnosis and treatment during the initial year in a European inflammatory bowel disease inception cohort: an ECCO-EpiCom Study2015In: Inflammatory Bowel Diseases, ISSN 1078-0998, E-ISSN 1536-4844, Vol. 21, no 1, p. 121-131Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: No direct comparison of health care cost in patients with inflammatory bowel disease across the European continent exists. The aim of this study was to assess the costs of investigations and treatment for diagnostics and during the first year after diagnosis in Europe.

    METHODS: The EpiCom cohort is a prospective population-based inception cohort of unselected inflammatory bowel disease patients from 31 Western and Eastern European centers. Patients were followed every third month from diagnosis, and clinical data regarding treatment and investigations were collected. Costs were calculated in euros (&OV0556;) using the Danish Health Costs Register.

    RESULTS: One thousand three hundred sixty-seven patients were followed, 710 with ulcerative colitis, 509 with Crohn's disease, and 148 with inflammatory bowel disease unclassified. Total expenditure for the cohort was &OV0556;5,408,174 (investigations: &OV0556;2,042,990 [38%], surgery: &OV0556;1,427,648 [26%], biologicals: &OV0556;781,089 [14%], and standard treatment: &OV0556;1,156,520 [22%)]). Mean crude expenditure per patient in Western Europe (Eastern Europe) with Crohn's disease: investigations &OV0556;1803 (&OV0556;2160) (P = 0.44), surgery &OV0556;11,489 (&OV0556;13,973) (P = 0.14), standard treatment &OV0556;1027 (&OV0556;824) (P = 0.51), and biologicals &OV0556;7376 (&OV0556;8307) (P = 0.31). Mean crude expenditure per patient in Western Europe (Eastern Europe) with ulcerative colitis: investigations &OV0556;1189 (&OV0556;1518) (P < 0.01), surgery &OV0556;18,414 (&OV0556;12,395) (P = 0.18), standard treatment &OV0556;896 (&OV0556;798) (P < 0.05), and biologicals &OV0556;5681 (&OV0556;72) (P = 0.51).

    CONCLUSIONS: In this population-based unselected cohort, costs during the first year of disease were mainly incurred by investigative procedures and surgeries. However, biologicals accounted for >15% of costs. Long-term follow-up of the cohort is needed to assess the cost-effectiveness of biological agents.

  • 42.
    Burisch, Johan
    et al.
    Department of Gastroenterology, North Zealand University Hospital, Frederikssund, Denmark.
    Vegh, Zsuzsanna
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Katsanos, Konstantinnos H
    1st Division of Internal Medicine and Hepato-Gastroenterology Unit, University Hospital, Ioannina, Greece.
    Christodoulou, Dimitrios K
    1st Division of Internal Medicine and Hepato-Gastroenterology Unit, University Hospital, Ioannina, Greece.
    Lazar, Daniela
    Clinic of Gastroenterology, University of Medicine ‘Victor Babes’, Timisoara, Romania.
    Goldis, Adrian
    Clinic of Gastroenterology, University of Medicine ‘Victor Babes’, Timisoara, Romania.
    O'Morain, Colm
    Department of Gastroenterology, Adelaide and Meath Hospital, TCD, Dublin, Ireland.
    Fernandez, Alberto
    Department of Gastroenterology. POVISA Hospital, Vigo, Spain.
    Pereira, Santos
    Department of Gastroenterology. Instituto de Investigación Sanitaria Galicia Sur, Estrutura Organizativa de Xestión Integrada de Vigo, Vigo, Spain.
    Myers, Sally
    IBD Unit, Hull & East Yorkshire NHS Trust, Hull, UK.
    Sebastian, Shaji
    IBD Unit, Hull & East Yorkshire NHS Trust, Hull, UK.
    Pedersen, Natalia
    Gastroenterology Department, Slagelse Hospital, Slagelse, Denmark.
    Olsen, Jóngerð
    Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
    Nielsen, Kári Rubek
    Medical Department, National Hospital of the Faroe Islands, Torshavn, Faroe Islands.
    Schwartz, Doron
    Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel.
    Odes, Selwyn
    Department of Gastroenterology and Hepatology, Soroka Medical Center and Ben Gurion University of the Negev, Beer Sheva, Israel.
    Almer, Sven
    Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Turk, Niksa
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb,Zagreb, Croatia.
    Cukovic-Cavka, Silvja
    Division of Gastroenterology and Hepatology, University Hospital Center Zagreb,Zagreb, Croatia.
    Nikulina, Inna
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
    Belousova, Elena
    Department of Gastroenterology, Moscow Regional Research Clinical Institute, Moscow, Russian Federation.
    Duricova, Dana
    IBD Clinical and Research Centre ISCARE, Charles University, Prague, Czech Republic.
    Bortlik, Martin
    IBD Clinical and Research Centre ISCARE, Charles University, Prague, Czech Republic; Institute of Pharmacology, 1st Medical Faculty, Charles University, Prague, Czech Republic.
    Shonová, Olga
    Gastroenterology Department, Hospital České Budějovice, České Budějovice, Czech Republic.
    Salupere, Riina
    Division of Gastroenterology, Tartu University Hospital,Tartu, Estonia.
    Barros, Louisa
    Department of Medicine, Hospital de Vale de Sousa, Porto, Portugal.
    Magro, Fernando
    Department of Gastroenterology, Hospital de São João, Porto, Portugal; Institute of Pharmacology and Therapeutics, Oporto Medical School, Porto, Portugal; Institute for Molecular and Cell Biology, University of Porto, Porto, Portugal.
    Jonaitis, Laimas
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Kupcinskas, Limas
    Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Turcan, Svetlana
    Department of Gastroenterology, State University of Medicine and Pharmacy of the Republic of Moldova, Chisinau, Republic of Moldova.
    Kaimakliotis, Ioannis
    Nicosia private practice, Nicosia, Cyprus.
    Ladefoged, Karin
    Medical Department, Dronning Ingrids Hospital, Nuuk, Greenland.
    Kudsk, Karen
    Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark.
    Andersen, Vibeke
    Institute of Molecular Medicine, University of Southern Denmark, Odense, Denmark; Laboratory Center, Hospital of Southern Jutland, Aabenraa, Denmark; Institute of Regional Health Research, University of Southern Denmark, Odense, Denmark.
    Vind, Ida
    Gastrounit, Medical Division, Copenhagen University Hospital Hvidovre, Hvidovre, Denmark.
    Thorsgaard, Niels
    Department of Medicine, Herning Central Hospital, Herning, Denmark.
    Oksanen, Pia
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
    Collin, Pekka
    Department of Gastroenterology and Alimentary Tract Surgery, Tampere University Hospital, Tampere, Finland.
    Dal Piaz, Giulia
    Dipartimento Medicina Specialistica Gastroenterologia ed Endoscopia Digestiva, Ospedale Morgagni-Pierantoni, Forlì, Italy.
    Santini, Alessia
    Gastroenterology Unit, Careggi Hospital, Florence, Italy.
    Niewiadomski, Ola
    Department of Gastroenterology, St Vincent’s Hospital, Melbourne VIC, Australia.
    Bell, Sally
    Department of Gastroenterology, St Vincent’s Hospital, Melbourne VIC, Australia.
    Moum, Bjørn
    Department of Gastroenterology, Oslo University Hospital, Oslo, Norway.
    Arebi, Naila
    St Mark’s Hospital, Imperial College London, London, UK.
    Kjeldsen, Jens
    Department of Medical Gastroenterology, Odense University Hospital, Odense, Denmark.
    Carlsen, Katrine
    Department of Pediatrics, Hvidovre University Hospital, Hvidovre, Denmark.
    Langholz, Ebbe
    Department of Gastroenterology, Herlev Univerisity Hospital, Herlev, Denmark.
    Lakatos, Peter Laszlo
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Munkholm, Pia
    1st Department of Medicine, Semmelweis University, Budapest, Hungary.
    Gerdes, Lars Ulrik
    Center for Quality, Region of Southern Denmark, Denmark.
    Dahlerup, Jens Frederik
    Department of Hepatology and Gastroenterology, Aarhus University Hospital, Aarhus, Denmark.
    The EpiCom study group, Group author
    Occurrence of anaemia in the first year of inflammatory bowel disease in a European population-based inception cohort: An ECCO-EpiCom study2017In: Journal of Crohn's & Colitis, ISSN 1873-9946, E-ISSN 1876-4479, Vol. 11, no 10, p. 1213-1222Article in journal (Refereed)
    Abstract [en]

    Background and aims: Anaemia is an important complication of inflammatory bowel disease (IBD). The aim of this study was to determine the prevalence of anaemia and the practice of anaemia screening during the first year following diagnosis in a European prospective population-based inception cohort.

    Methods: Newly diagnosed IBD patients were included and followed prospectively for one year in 29 European and 1 Australian centre. Clinical data including demographics, medical therapy, surgery and blood samples were collected. Anaemia was defined according to the World Health Organization.

    Results: A total of 1,871 patients (CD: 686, 88%; UC: 1,021, 87%; IBDU 164. 81%) were included in the study. The prevalence of anaemia was higher in CD than in UC patients and overall, 49% of CD and 39% of UC patients had at least one instance of anaemia during the first 12 months after diagnosis. UC patients with more extensive disease and those from Eastern European countries, and CD patients with penetrating disease or colonic disease location, had higher risks of anaemia. CD and UC patients in need of none or only mild anti-inflammatory treatment had a lower risk of anaemia. In a significant proportion of patients, anaemia was not assessed until several months after diagnosis, and in almost half of all cases of anaemia a thorough work-up was not performed.

    Conclusions: Overall, 42% of patients had at least one instance of anaemia during the first year following diagnosis. Most patients were assessed for anaemia regularly; however, a full anaemia work-up was frequently neglected in this community setting.

  • 43. Burisch, Johan
    et al.
    Xia, Bing
    Cukovic-Cavka, Silvija
    Kaimakliotis, John
    Duricova, Dana
    Shonova, Olga
    Vind, Ida
    Pedersen, Natalia
    Langholz, Ebbe
    Thorsgaard, Niels
    Andersen, Vibeke
    Dahlerup, Jens F.
    Salupere, Riina
    Nielsen, Kari R.
    Manninen, Pia
    Tsianos, Epameinondas V.
    Ladefoged, Karin
    Bjornsson, Einar
    Bailey, Yvonne
    Odes, Selwyn H.
    Martinato, Matteo
    Kupcinskas, Limas
    Turcan, Svetlana I.
    Magro, Fernando
    Goldis, Adrian
    Belousova, Elena
    Hernandez, Vicent
    Almer, Sven
    Halfvarson, Jonas
    Arebi, Naila
    Sebastian, Shaji
    Lakatos, Peter L.
    Munkholm, Pia S.
    Is there an east-west gradient in the incidence of IBD in Europe?: and further far east in China? First results from the epicom study2012In: Gastroenterology, ISSN 0016-5085, E-ISSN 1528-0012, Vol. 142, no 5, p. S569-S570Article in journal (Other academic)
  • 44.
    Butwicka, Agnieszka
    et al.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Child Psychiatry, Medical University of Warsaw, Warsaw, Poland.
    Sariaslan, Amir
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Larsson, Henrik
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Myrelid, Pär E.
    Division of Surgery, Department of Clinical and Experimental Medicine, Faulty of Health Sciences, Linköping University, Linköping, Sweden; Department of Surgery, County Council of Östergötland, Linköping, Sweden.
    Olén, Ola
    Sachs' Children and Youth Hospital, Stockholm South General Hospital, Stockholm, Sweden; Clinical Epidemiology Unit, Department of Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
    Frisen, Louise
    Child and Adolescent Psychiatry Research Center, Stockholm, Sweden; Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden.
    Lichtenstein, Paul
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
    Ludvigsson, Jonas F.
    Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; Department of Pediatrics, Örebro University Hospital, Örebro University, Örebro, Sweden.
    No association between urbanisation, neighbourhood deprivation and IBD: a population-based study of 4 million individuals2018In: Gut, ISSN 0017-5749, E-ISSN 1468-3288, article id gutjnl-2018-316326Article in journal (Refereed)
  • 45.
    Cleynen, Isabelle
    et al.
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK; Department of Clinical and Experimental Medicine TARGID, KU Leuven, Leuven, Belgium.
    Boucher, Gabrielle
    Université de Montréal and the Montreal Heart Institute, Research Center, Montréal, Québec, Canada.
    Jostins, Luke
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK; Christ Church, University of Oxford, St Aldates, UK.
    Schumm, L. Philip
    Department of Public Health Sciences, University of Chicago, Chicago, IL, USA.
    Zeissig, Sebastian
    Department for General Internal Medicine, Christian-Albrechts-University, Kiel, Germany.
    Ahmad, Tariq
    Peninsula College of Medicine and Dentistry, Exeter, UK.
    Andersen, Vibeke
    Medical Department, Viborg Regional Hospital, Viborg, Denmark; Hospital of Southern Jutland Aabenraa, Aabenraa, Denmark.
    Andrews, Jane M.
    Inflammatory Bowel Disease Service, Department of Gastroenterology and Hepatology, Royal Adelaide Hospital, Adelaide, Australia; School of Medicine, University of Adelaide, Adelaide, Australia.
    Annese, Vito
    Unit of Gastroenterology, Istituto di Ricovero e Cura a Carattere Scientifico-Casa Sollievo della Sofferenza (IRCCS-CSS) Hospital, San Giovanni Rotondo, Italy; Azienda Ospedaliero Universitaria (AOU) Careggi, Unit of Gastroenterology SOD2, Florence, Italy.
    Brand, Stephan
    Department of Medicine II, University Hospital Munich-Grosshadern, Ludwig-Maximilians-University, Munich, Germany.
    Brant, Steven R.
    Meyerhoff Inflammatory Bowel Disease Center, Department of Medicine, School of Medicine, Johns Hopkins University, Baltimore, MD, USA; Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
    Cho, Judy H.
    Department of Genetics, Yale School of Medicine, New Haven, CT, USA.
    Daly, Mark J.
    Broad Institute of MIT and Harvard, Cambridge, MA, USA.
    Dubinsky, Marla
    Department of Pediatrics, Cedars Sinai Medical Center, Los Angeles, CA, USA.
    Duerr, Richard H.
    Division of Gastroenterology, Hepatology and Nutrition, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA; Department of Human Genetics, University of Pittsburgh Graduate School of Public Health, Pittsburgh, PA, USA.
    Ferguson, Lynnette R.
    School of Medical Sciences, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand.
    Franke, Andre
    Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany.
    Gearry, Richard B.
    Department of Medicine, University of Otago, Christchurch, New Zealand; Department of Gastroenterology, Christchurch Hospital, Christchurch, New Zealand.
    Goyette, Philippe
    Université de Montréal and the Montreal Heart Institute, Research Center, Montréal, Québec, Canada.
    Hakonarson, Hakon
    Center for Applied Genomics, Children's Hospital of Philadelphia, Philadelphia, PA, USA.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology.
    Hov, Johannes R.
    Norwegian PSC Research Center, Research Insitute of Internal Medicine and Department of Transplantation Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway.
    Huang, Hailang
    Broad Institute of MIT and Harvard, Cambridge, MA, USA.
    Kennedy, Nicholas A.
    Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
    Kupcinskas, Limas
    Department of Gastroenterology, Lithuanian University of Health Sciences, Kaunas, Lithuania.
    Lawrance, Ian C.
    Centre for Inflammatory Bowel Diseases, Saint John of God Hospital, Subiaco WA and School of Medicine and Pharmacology, University of Western Australia, Harry Perkins Institute for Medical Research, Murdoch, WA, Australia.
    Lee, James C.
    Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
    Satsangi, Jack
    Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
    Schreiber, Stephan
    Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany; Hospital of Southern Jutland Aabenraa, Aabenraa, Denmark.
    Théâtre, Emilie
    Unit of Animal Genomics, Groupe Interdisciplinaire de Genoproteomique Appliquee (GIGA-R) and Faculty of Veterinary Medicine, University of Liege, Liege, Belgium; Division of Gastroenterology, Centre Hospitalier Universitaire, Universite de Liege, Liege, Belgium.
    van der Meulen-de Jong, Andrea E.
    Department of Gastroenterology and Hepatology, Leiden University Medical Center, Leiden, Netherlands.
    Weersma, Rinse K.
    Department of Gastroenterology and Hepatology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands.
    Wilson, David C.
    Child Life and Health, University of Edinburgh, Edinburgh, UK; Royal Hospital for Sick Children, Paediatric Gastroenterology and Nutrition, Glasgow, UK.
    Parkes, Miles
    Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
    Vermeire, Severine
    Department of Clinical and Experimental Medicine TARGID, KU Leuven, Leuven, Belgium; Division of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium.
    Rioux, John D.
    Université de Montréal and the Montreal Heart Institute, Research Center, Montréal, Québec, Canada.
    Mansfield, John
    Institute of Human Genetics, Newcastle University, Newcastle upon Tyne, UK.
    Silverberg, Mark S.
    Mount Sinai Hospital Inflammatory Bowel Disease Centre, University of Toronto, Toronto, ON, Canada.
    Radford-Smith, Graham
    Inflammatory Bowel Diseases, Genetics and Computational Biology, Queensland Institute of Medical Research, Brisbane, Australia; Department of Gastroenterology, Royal Brisbane and Women's Hospital, and School of Medicine, University of Queensland, Brisbane, Australia.
    McGovern, Dermot P. B.
    F Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
    Barrett, Jeffrey C.
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK.
    Lees, Charlie W.
    Gastrointestinal Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK.
    Inherited determinants of Crohn's disease and ulcerative colitis phenotypes: a genetic association study2016In: The Lancet, ISSN 0140-6736, E-ISSN 1474-547X, Vol. 387, no 10014, p. 156-167Article in journal (Refereed)
    Abstract [en]

    Background: Crohn's disease and ulcerative colitis are the two major forms of inflammatory bowel disease; treatment strategies have historically been determined by this binary categorisation. Genetic studies have identified 163 susceptibility loci for inflammatory bowel disease, mostly shared between Crohn's disease and ulcerative colitis. We undertook the largest genotype association study, to date, in widely used clinical subphenotypes of inflammatory bowel disease with the goal of further understanding the biological relations between diseases.

    Methods This study included patients from 49 centres in 16 countries in Europe, North America, and Australasia. We applied the Montreal classification system of inflammatory bowel disease subphenotypes to 34,819 patients (19,713 with Crohn's disease, 14,683 with ulcerative colitis) genotyped on the Immunochip array. We tested for genotype-phenotype associations across 156,154 genetic variants. We generated genetic risk scores by combining information from all known inflammatory bowel disease associations to summarise the total load of genetic risk for a particular phenotype. We used these risk scores to test the hypothesis that colonic Crohn's disease, ileal Crohn's disease, and ulcerative colitis are all genetically distinct from each other, and to attempt to identify patients with a mismatch between clinical diagnosis and genetic risk profile.

    Findings: After quality control, the primary analysis included 29,838 patients (16,902 with Crohn's disease, 12,597 with ulcerative colitis). Three loci (NOD2, MHC, and MST1 3p21) were associated with subphenotypes of inflammatory bowel disease, mainly disease location (essentially fixed over time; median follow-up of 10·5 years). Little or no genetic association with disease behaviour (which changed dramatically over time) remained after conditioning on disease location and age at onset. The genetic risk score representing all known risk alleles for inflammatory bowel disease showed strong association with disease subphenotype (p=1·65 × 10(-78)), even after exclusion of NOD2, MHC, and 3p21 (p=9·23 × 10(-18)). Predictive models based on the genetic risk score strongly distinguished colonic from ileal Crohn's disease. Our genetic risk score could also identify a small number of patients with discrepant genetic risk profiles who were significantly more likely to have a revised diagnosis after follow-up (p=6·8 × 10(-4)).

    Interpretation: Our data support a continuum of disorders within inflammatory bowel disease, much better explained by three groups (ileal Crohn's disease, colonic Crohn's disease, and ulcerative colitis) than by Crohn's disease and ulcerative colitis as currently defined. Disease location is an intrinsic aspect of a patient's disease, in part genetically determined, and the major driver to changes in disease behaviour over time.

    Funding: International Inflammatory Bowel Disease Genetics Consortium members funding sources (see Acknowledgments for full list).

  • 46. Dicksved, Johan
    et al.
    Halfvarson, Jonas
    Rosenquist, Magnus
    Järnerot, Gunnar
    Tysk, Curt
    Örebro University, School of Health and Medical Sciences.
    Apajalahti, Juha
    Engstrand, Lars
    Jansson, Janet K.
    Molecular analysis of the gut microbiota of identical twins with Crohn's disease2008In: The ISME journal, ISSN 1751-7370, Vol. 2, no 7, p. 716-727Article in journal (Refereed)
    Abstract [en]

    Increasing evidence suggests that a combination of host genetics and the composition of the gut microbiota are important for development of Crohn's disease (CD). Our aim was to study identical twins with CD to determine microbial factors independent of host genetics. Fecal samples were studied from 10 monozygotic twin pairs with CD (discordant n=6 and concordant n=4) and 8 healthy twin pairs. DNA was extracted, 16S rRNA genes were PCR amplified and T-RFLP fingerprints generated using general bacterial and Bacteroides group-specific primers. The microbial communities were also profiled based on their percentage G+C contents. Bacteroides 16S rRNA genes were cloned and sequenced from a subset of the samples. The bacterial diversity in each sample and similarity indices between samples were estimated based on the T-RFLP data using a combination of statistical approaches. Healthy individuals had a significantly higher bacterial diversity compared to individuals with CD. The fecal microbial communities were more similar between healthy twins than between twins with CD, especially when these were discordant for the disease. The microbial community profiles of individuals with ileal CD were significantly different from healthy individuals and those with colonic CD. Also, CD individuals had a lower relative abundance of B. uniformis and higher relative abundances of B. ovatus and B. vulgatus. Our results suggest that genetics and/or environmental exposure during childhood, in part, determine the gut microbial composition. However, CD is associated with dramatic changes in the gut microbiota and this was particularly evident for individuals with ileal CD.

  • 47. Einarsdottir, Elisabet
    et al.
    Koskinen, Lotta L E
    Dukes, Emma
    Kainu, Kati
    Suomela, Sari
    Lappalainen, Maarit
    Ziberna, Fabiana
    Korponay-Szabo, Ilma R
    Kurppa, Kalle
    Kaukinen, Katri
    Adány, Róza
    Pocsai, Zsuzsa
    Széles, György
    Färkkilä, Martti
    Turunen, Ulla
    Halme, Leena
    Paavola-Sakki, Paulina
    Not, Tarcisio
    Vatta, Serena
    Ventura, Alessandro
    Löfberg, Robert
    Torkvist, Leif
    Bresso, Francesca
    Halfvarson, Jonas
    Mäki, Markku
    Kontula, Kimmo
    Saarialho-Kere, Ulpu
    Kere, Juha
    D'Amato, Mauro
    Saavalainen, Päivi
    IL23R in the Swedish, Finnish, Hungarian and Italian populations: association with IBD and psoriasis, and linkage to celiac disease2009In: BMC Medical Genetics, ISSN 1471-2350, E-ISSN 1471-2350, Vol. 10, no 8Article in journal (Refereed)
    Abstract [en]

    BACKGROUND: Association of the interleukin-23 receptor (IL23R) with inflammatory bowel disease (IBD) has been confirmed in several populations. IL23R also associates with psoriasis, suggesting that the gene may be an important candidate for many chronic inflammatory diseases.

    METHODS: We studied association of single-nucleotide variants in IL23R with IBD in Swedish patients, in both Crohn's disease (CD) and ulcerative colitis (UC) subsets. The same genetic variants were also studied in Finnish patients with psoriasis or celiac disease, and in Hungarian and Italian patients with celiac disease.

    RESULTS: Association of IL23R with IBD was replicated in our Swedish patients, and linkage and association of the IL23R region with psoriasis was found in the Finnish population. The IL23R region was also linked to celiac disease in Finnish families, but no association of IL23R variants with celiac disease was found in the Finnish, Hungarian or Italian samples.

    CONCLUSION: Our study is the first to demonstrate association of IL23R with CD and UC in Swedish patients with IBD. It is also the first study to report linkage and association of the IL23R region with psoriasis in the Finnish population. Importantly, this is the first report of linkage of the IL23R region to celiac disease, a chronic inflammatory condition in which IL23R has not been previously implicated.

  • 48.
    Ek, Weronica E
    et al.
    Karolinska Institutet, Stockholm, Sweden.
    D'Amato, Mauro
    Karolinska Institutet, Stockholm, Sweden.
    Halfvarson, Jonas
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital.
    The history of genetics in inflammatory bowel disease2014In: Annals of Gastroenterology, ISSN 1108-7471, E-ISSN 1792-7463, Vol. 27, no 4, p. 294-303Article, review/survey (Refereed)
    Abstract [en]

    The influence of genetics in the etiology of inflammatory bowel disease (IBD) was initially demonstrated by epidemiological data, including differences in prevalence among different ethnic groups, familial aggregation of IBD, concordance in twins, and association with genetic syndromes. These early observations paved the way to molecular genetics in IBD, and culminated in the identification of nucleotide-binding oligomerization domain containing 2 (NOD2) gene as an IBD risk gene in 2001. As in other complex diseases, the advent of Genome Wide Association studies has dramatically improved the resolution of the IBD genome and our understanding of the pathogenesis of IBD. However, the complexity of the genetic puzzle in IBD seems more pronounced today than ever previously. In total, 163 risk genes/loci have been identified, and the corresponding number of possible causal variants is challenging. The great majority of these loci are associated with both Crohn's disease and ulcerative colitis, suggesting that nearly all of the biological mechanisms involved in one disease play some role in the other. Interestingly, a large proportion of the IBD risk loci are also shared with other immune-mediated diseases, primary immunodeficiencies and mycobacterial diseases.

  • 49.
    Ellinghaus, David
    et al.
    Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
    Jostins, Luke
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
    Spain, Sarah L.
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
    Cortes, Adrian
    Nuffield Department of Clinical Neurosciences, Division of Clinical Neurology, John Radcliffe Hospital, University of Oxford, Oxford, UK; Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK.
    Bethune, Jörn
    Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
    Han, Buhm
    Department of Convergence Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea; Asan Institute for Life Sciences, Asan Medical Center, Seoul, Republic of Korea.
    Park, Yu Rang
    Asan Institute for Life Sciences, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.
    Raychaudhuri, Soumya
    Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston MA, United States; Division of Rheumatology, Brigham and Women's Hospital, Boston MA, United States.
    Pouget, Jennie G.
    Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada; Department of Psychiatry, University of Toronto, Toronto, Canada.
    Hübenthal, Matthias
    Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
    Folseraas, Trine
    Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine,Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway.
    Wang, Yunpeng
    Department of Neurosciences, University of California, San Diego, USA.
    Esko, Tonu
    Estonian Genome Center, University of Tartu, Tartu, Estonia; Division of Endocrinology, Boston Children's Hospital, Cambridge MA, USA; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge MA, USA.
    Metspalu, Andres
    Estonian Genome Center, University of Tartu, Tartu, Estonia.
    Westra, Harm-Jan
    Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge MA, United States; Division of Genetics, Brigham and Women's Hospital, Boston MA, United States; Division of Rheumatology, Brigham and Women's Hospital, Boston MA, United States; Department of Medicine, Harvard Medical School, Boston MA, United States.
    Franke, Lude
    University Medical Center Groningen, Department of Genetics, University of Groningen, Groningen, the Netherlands.
    Pers, Tune H.
    Program in Medical and Population Genetics, Broad Institute of mit and Harvard, Cambridge MA, United States; Center for Basic and Translational Obesity Research, Boston Children's Hospital, Cambridge MA, United States; Novo Nordisk Foundation, Centre for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark; Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
    Weersma, Rinse K.
    Department of Gastroenterology and Hepatology, University Medical Center, University of Groningen, Groningen, the Netherlands.
    Collij, Valerie
    Department of Gastroenterology and Hepatology, University Medical Center, University of Groningen, Groningen, the Netherlands.
    D'Amato, Mauro
    Department of Bioscience and Nutrition, Karolinska Institutet, Stockholm, Sweden; BioCruces Health Research Institute, Basque Foundation for Science (Ikerbasque), Bilbao, Spain.
    Halfvarson, Jonas
    Örebro University, School of Medical Sciences. Department of Gastroenterology, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Jensen, Anders Boeck
    Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Lieb, Wolfgang
    Institute of Epidemiology, University Hospital Schleswig-Holstein, Kiel, Germany; PopGen Biobank, University Hospital Schleswig-Holstein, Kiel, Germany.
    Degenhardt, Franziska
    Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
    Forstner, Andreas J.
    Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
    Hofmann, Andrea
    Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
    The International IBD Genetics Consortium, (IIBDGC)
    International Genetics of Ankylosing Spondylitis Consortium, (IGAS)
    International PSC Study Group, (IPSCSG)
    Genetic Analysis of Psoriasis Consortium, (GAPC)
    Psoriasis Association Genetics Extension, (PAGE)
    Schreiber, Stefan
    Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany; Institute of Human Genetics, University of Bonn, Bonn, Germany; Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany.
    Mrowietz, Ulrich
    Department of Dermatology, University Hospital, Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany.
    Juran, Brian D.
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester MN, USA.
    Lazaridis, Konstantinos N.
    Center for Basic Research in Digestive Diseases, Division of Gastroenterology and Hepatology, Mayo Clinic, College of Medicine, Rochester MN, USA.
    Brunak, Søren
    Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
    Dale, Anders M.
    Department of Neurosciences, University of California, San Diego, USA; Department of Radiology, University of California, San Diego, USA.
    Trembath, Richard C.
    Division of Genetics and Molecular Medicine, King's College London, London, UK.
    Weidinger, Stephan
    Department of Dermatology, University Hospital, Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany.
    Weichenthal, Michael
    Department of Dermatology, University Hospital, Schleswig-Holstein, Christian Albrechts University of Kiel, Kiel, Germany.
    Ellinghaus, Eva
    Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
    Elder, James T.
    Department of Dermatology, University of Michigan, Ann Arbor, USA; Ann Arbor Veterans Affairs Hospital, Ann Arbor, USA.
    Barker, Jonathan N. W. N.
    St. John's Institute of Dermatology, Division of Genetics and Molecular Medicine, King's College London, London, UK.
    Andreassen, Ole A.
    NORMENT, K.G. Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Division of Mental Health and Addiction, Oslo University Hospital Ullevål, Oslo, Norway.
    McGovern, Dermot P.
    F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, USA; Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, USA.
    Karlsen, Tom H.
    Norwegian PSC Research Center, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway; K.G. Jebsen Inflammation Research Centre, Institute of Clinical Medicine, University of Oslo, Oslo, Norway; Research Institute of Internal Medicine, Division of Cancer Medicine,Surgery and Transplantation, Oslo University Hospital, Oslo, Norway; Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital, Oslo, Norway.
    Barrett, Jeffrey C.
    Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
    Parkes, Miles
    Inflammatory Bowel Disease Research Group, Addenbrooke's Hospital, University of Cambridge, Cambridge, UK.
    Brown, Matthew A.
    University of Queensland Diamantina Institute, Translational Research Institute, Brisbane QLD, Australia; Institute of Health and Biomedical Innovation (IHBI), Translational Research Institute, Queensland University of Technology (QUT), Brisbane, QLD, Australia .
    Franke, Andre
    Institute of Clinical Molecular Biology, Christian Albrechts University of Kiel, Kiel, Germany.
    Analysis of five chronic inflammatory diseases identifies 27 new associations and highlights disease-specific patterns at shared loci2016In: Nature Genetics, ISSN 1061-4036, E-ISSN 1546-1718, Vol. 48, no 5, p. 510-518Article in journal (Refereed)
    Abstract [en]

    We simultaneously investigated the genetic landscape of ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis and ulcerative colitis to investigate pleiotropy and the relationship between these clinically related diseases. Using high-density genotype data from more than 86,000 individuals of European ancestry, we identified 244 independent multidisease signals, including 27 new genome-wide significant susceptibility loci and 3 unreported shared risk loci. Complex pleiotropy was supported when contrasting multidisease signals with expression data sets from human, rat and mouse together with epigenetic and expressed enhancer profiles. The comorbidities among the five immune diseases were best explained by biological pleiotropy rather than heterogeneity (a subgroup of cases genetically identical to those with another disease, possibly owing to diagnostic misclassification, molecular subtypes or excessive comorbidity). In particular, the strong comorbidity between primary sclerosing cholangitis and inflammatory bowel disease is likely the result of a unique disease, which is genetically distinct from classical inflammatory bowel disease phenotypes.

  • 50. Ellinghaus, David
    et al.
    Zhang, Hu
    Zeissig, Sebastian
    Lipinski, Simone
    Till, Andreas
    Jiang, Tao
    Stade, Bjoern
    Bromberg, Yana
    Ellinghaus, Eva
    Keller, Andreas
    Rivas, Manuel A.
    Skieceviciene, Jurgita
    Doncheva, Nadezhda T.
    Liu, Xiao
    Liu, Qing
    Jiang, Fuman
    Forster, Michael
    Mayr, Gabriele
    Albrecht, Mario
    Haesler, Robert
    Boehm, Bernhard O.
    Goodall, Jane
    Berzuini, Carlo R.
    Lee, James
    Andersen, Vibeke
    Vogel, Ulla
    Kupcinskas, Limas
    Kayser, Manfred
    Krawczak, Michael
    Nikolaus, Susanna
    Weersma, Rinse K.
    Ponsioen, Cyriel Y.
    Sans, Miquel
    Wijmenga, Cisca
    Strachan, David P.
    McAardle, Wendy L.
    Vermeire, Severine
    Rutgeerts, Paul
    Sanderson, Jeremy D.
    Mathew, Christopher G.
    Vatn, Morten H.
    Wang, Jun
    Noethen, Markus M.
    Duerr, Richard H.
    Buening, Carsten
    Brand, Stephan
    Glas, Juergen
    Winkelmann, Juliane
    Illig, Thomas
    Latiano, Anna
    Annese, Vito
    Halfvarson, Jonas
    Örebro University, School of Medicine, Örebro University, Sweden. Örebro University Hospital.
    D'Amato, Mauro
    Daly, Mark J.
    Nothnagel, Michael
    Karlsen, Tom H.
    Subramani, Suresh
    Rosenstiel, Philip
    Schreiber, Stefan
    Parkes, Miles
    Franke, Andre
    Association between variants of PRDM1 and NDP52 and Crohn's disease, based on exome sequencing and functional studies2013In: Gastroenterology, ISSN 0016-5085, E-ISSN 1528-0012, Vol. 145, no 2, p. 339-347Article in journal (Refereed)
    Abstract [en]

    BACKGROUND & AIMS: Genome-wide association studies (GWAS) have identified 140 Crohn's disease (CD) susceptibility loci. For most loci, the variants that cause disease are not known and the genes affected by these variants have not been identified. We aimed to identify variants that cause CD through detailed sequencing, genetic association, expression, and functional studies.

    METHODS: We sequenced whole exomes of 42 unrelated subjects with CD and 5 healthy subjects (controls) and then filtered single nucleotide variants by incorporating association results from meta-analyses of CD GWAS and in silico mutation effect prediction algorithms. We then genotyped 9348 subjects with CD, 2868 subjects with ulcerative colitis, and 14,567 control subjects and associated variants analyzed in functional studies using materials from subjects and controls and in vitro model systems.

    RESULTS: We identified rare missense mutations in PR domain-containing 1 (PRDM1) and associated these with CD. These mutations increased proliferation of T cells and secretion of cytokines on activation and increased expression of the adhesion molecule L-selectin. A common CD risk allele, identified in GWAS, correlated with reduced expression of PRDM1 in ileal biopsy specimens and peripheral blood mononuclear cells (combined P = 1.6 x 10(-8)). We identified an association between CD and a common missense variant, Val248Ala, in nuclear domain 10 protein 52 (NDP52) (P = 4.83 x 10(-9)). We found that this variant impairs the regulatory functions of NDP52 to inhibit nuclear factor kappa B activation of genes that regulate inflammation and affect the stability of proteins in Toll-like receptor pathways.

    CONCLUSIONS: We have extended the results of GWAS and provide evidence that variants in PRDM1 and NDP52 determine susceptibility to CD. PRDM1 maps adjacent to a CD interval identified in GWAS and encodes a transcription factor expressed by T and B cells. NDP52 is an adaptor protein that functions in selective autophagy of intracellular bacteria and signaling molecules, supporting the role of autophagy in the pathogenesis of CD.

1234 1 - 50 of 193
CiteExportLink to result list
Permanent link
Cite
Citation style
  • apa
  • ieee
  • modern-language-association-8th-edition
  • vancouver
  • Other style
More styles
Language
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Other locale
More languages
Output format
  • html
  • text
  • asciidoc
  • rtf