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  • 1.
    Almroth, Henrik
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Cardiology, Örebro University Hospital, Örebro, Sweden.
    Andersson, Torbjorn
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Cardiology, Örebro University Hospital, Örebro, Sweden.
    Fengsrud, Espen
    Örebro universitet, Institutionen för hälsovetenskaper. Department of Cardiology, Örebro University Hospital, Örebro, Sweden.
    Friberg, Leif
    Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
    Linde, P.
    Department of Cardiology, Örebro University Hospital, Örebro, Sweden.
    Rosenqvist, Mårten
    Stockholm South Hospital, Karolinska Institutet, Stockholm, Sweden.
    Englund, A.
    Stockholm South Hospital, Karolinska Institutet, Stockholm, Sweden.
    The safety of flecainide treatment of atrial fibrillation: long-term incidence of sudden cardiac death and proarrhythmic events2011Ingår i: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796, Vol. 270, nr 3, s. 281-290Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objective:To assess the safety of long-term treatment with flecainide in patients with atrial fibrillation (AF), particularly with regard to sudden cardiac death (SCD) andproarrhythmic events.

    Design: Retrospective,observational cohort study.Setting.Single-centre study at Örebro University Hospital, Sweden.

    Setting: Single-centre study at Orebro University Hospital, Sweden.

    Subjects: A total of 112 patients with paroxysmal (51%) or persistent (49%) AF (mean age 60 ± 11 years) were included after identifying all patients with AF who initiated oral flecainide treatment (mean dose 203 ± 43 mg per day) between 1998 and 2006. Standard exclusion⁄inclusion criteria for flecainide were used,andflecainidetreatmentwasusually combined withanatrioventricular-blocking agent (89%).

    Main outcome measure: Death was classified as sudden or nonsudden according to standard definitions. Proarrhythmia was defined as cardiac syncope or lifethreatening arrhythmia.

    Results: Eight deaths were reported during a mean follow- up of 3.4 ± .4 years. Compared to the general population, the standardized mortality ratios were 1.57 (95% confidence interval (CI) 0.68–3.09) for allcause mortality and 4.16 (95% CI 1.53–9.06) for death from cardiovascular disease. Three deaths were classified as SCDs. Proarrhythmic events occurred in six patients (two each with wide QRS tachycardia, 1 : 1 conducted atrial flutter and syncope during exercise).

    Conclusion: We found an increased incidence of SCD or proarrhythmic events in this real-world study of flecainide used for the treatment of AF. The findings suggest that further investigation into the safety of flecainide for the treatment of patients with AF is warranted.

  • 2.
    Andersson, Torbjörn
    Örebro universitet, Hälsoakademin.
    Den digitala röntgenavdelningen2008Ingår i: Radiologi / [ed] Peter Aspelin, Holger Pettersson, Lund: Studentlitteratur , 2008, s. 125-134Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • 3.
    Andersson, Torbjörn
    Örebro universitet, Hälsoakademin.
    The development of ultrasound in radiology in Sweden2012Ingår i: Ultrasound in clinical diagnosis: from pioneering developments in Lund to global application in medicine / [ed] Bo Eklöf, Kjell Lindström, Stig Persson, Oxford: Oxford University Press, 2012, s. 121-128Kapitel i bok, del av antologi (Övrigt vetenskapligt)
  • 4.
    Hultgren Hörnquist, Elisabet
    et al.
    Örebro universitet, Hälsoakademin.
    Nilsson, Kerstin
    Örebro universitet, Hälsoakademin.
    Andersson, T.
    Örebro universitet, Hälsoakademin.
    Tidefelt, Ulf
    Örebro universitet, Hälsoakademin.
    Lidskog, Marie
    Örebro universitet, Hälsoakademin.
    Building a PBL-based integrated curriculum for a new medical school in Sweden2011Konferensbidrag (Övrigt vetenskapligt)
  • 5. Jansson, Margareta
    et al.
    Geijer, H.
    Andersson, Torbjörn
    Örebro universitet, Hälsoakademin.
    Bowel preparation for excretory urography is not necessary: a randomized trial2007Ingår i: British Journal of Radiology, ISSN 0007-1285, E-ISSN 1748-880X, Vol. 80, nr 956, s. 617-624Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Despite the fact that computed tomography is becoming more commonly used to investigate the genitourinary tract, intravenous urography still plays an important role in uroradiology. The aim of this study was to compare bowel purgation and two other preparation methods - dietary restrictions and no preparations at all - in an attempt to find the optimal procedure for uniform practice. 210 consecutive patients were randomised to three preparation groups with 70 in each group. Group 1 received standard bowel purgation, Group 2 was instructed to fast, while Group 3 had no preparation at all. Irrespective of preparation, all patients underwent the same examination procedure. The examining radiographer and evaluating radiologists were unaware of the type of preparation given. Image quality was assessed according to European Commission criteria for excretory urography. The effectiveness of bowel purgation and the amount of residual gas were scored separately. There was no statistically significant difference in the proportions with fulfilled criteria between preparation Groups 1 and 2 and Groups 1 and 3. A criterion was regarded as fulfilled only when all three observers agreed. Assessment of the amount of residual faeces proved the effectiveness of our standard bowel purgation. The results of our study show equality of the evaluated preparation methods and cannot justify further use of bowel purgation before excretory urography.

  • 6. Jansson, Margareta
    et al.
    Geijer, Håkan
    Örebro universitet, Institutionen för klinisk medicin.
    Persliden, Jan
    Örebro universitet, Institutionen för klinisk medicin.
    Andersson, Torbjörn
    Örebro universitet, Institutionen för klinisk medicin.
    Reducing dose in urography while maintaining image quality - a comparison of storage phosphor plates and a flat-panel detector2006Ingår i: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 16, nr 1, s. 221-226Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The introduction of new flat-panel detector technology often forces us to accept too high dose levels as proposed by the manufacturers. We need a tool to compare the image quality of a new system with the accepted standard. The aim of this study was to obtain a comparable image quality for two systems-storage phosphor plates and a flat-panel system using intravenous urography (IVU) as a clinical model. The image quality figure was calculated using a contrast-detail phantom (CDRAD) for the two evaluated systems. This allowed us to set a dose for the flat-panel system that gave equivalent image quality to the storage phosphor plates. This reduced detector dose was used in an evaluation of clinical images to find out if the dose reduction from the phantom study indeed resulted in images of equal clinical image quality. The image quality was assessed using image criteria of the European guidelines for IVU with visual grading analysis. Equivalent image quality in image pairs was achieved at 30% of the dose. The CDRAD contrast-detail phantom makes it possible to find dose levels that give equal image quality using different imaging systems.

  • 7.
    Krauss, Wolfgang
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Gunnarsson, Martin
    Örebro universitet, Institutionen för läkarutbildning.
    Andersson, Torbjorn
    Örebro universitet, Institutionen för läkarutbildning.
    Thunberg, Per
    Department of Medical Physics, Faculty of Medicine and Health, Örebro University, Örebro, Sweden.
    Accuracy and reproducibility of a quantitative magnetic resonance imaging method for concurrent measurements of tissue relaxation times and proton density2015Ingår i: Magnetic Resonance Imaging, ISSN 0730-725X, E-ISSN 1873-5894, Vol. 33, nr 5, s. 584-591Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Purpose: To evaluate the accuracy and reproducibility of a quantitative magnetic resonance (qMR) imaging method (QRAPMASTER) for simultaneous measurements of T1 and T2 relaxation times, and proton density (PD).

    Materials and Methods: Measurements of T1, T2, and PD with qMR were performed using phantoms with different relaxation times and concentrations of heavy water. Healthy volunteers were examined with different head coils. Regional measurements were performed in normal-appearing white and gray matter from the healthy control subjects, and in multiple sclerosis (MS) patients.

    Results: In phantom measurements, QRAPMASTER slightly underestimated T1, and T2 variations between repeated measurements were modest. PD was generally overestimated. The overall relative difference was 1.2 5.3% (T1), 6.6 1.9% (12), and 0.7 5.1% (PD). In healthy volunteers, there were no statistically significant differences of T1, T2 or PD using different head coils. Values of T1, T2, and PD obtained in healthy controls and MS patients were within reference ranges. However, significant differences were found in normal-appearing gray and white matter.

    Conclusion: QRAPMASTER can be considered a sufficiently accurate and reproducible method for use in clinical practice. Neuropathology in normal-appearing brain tissue may be revealed using this MR method, with putative implications for quantification of tissue damage in neurological diseases. (C) 2015 Elsevier Inc. All rights reserved.

  • 8.
    Kähäri, Anders
    et al.
    Department of Radiology, Örebro University Hospital, Örebro, Sweden.
    Emilsson, Kent
    Department of Clinical Physiology, Örebro Universitetssjukhus, Örebro, Sweden.
    Danielewicz, Mikael
    Department of Cardiology, Örebro University Hospital, Örebro, Sweden.
    Andersson, Torbjörn
    Department of Radiology, Örebro University Hospital, Örebro, Sweden.
    Wandt, Birger
    Department of Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden.
    Circumflex artery motion: a new angiographic method for assessment of left ventricular function2003Ingår i: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 37, nr 2, s. 80-86Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE: To evaluate the usefulness of circumflex artery motion (CAM) for assessment of left ventricular (LV) function.

    DESIGN: Seventy-three consecutive patients referred for coronary angiography and LV angiography were included. Ejection fraction (EF) was calculated from LV angiography and CAM was measured from coronary angiography.

    RESULTS: The ratio between CAM and the end-diastolic length of the ventricle, which can be denominated long-axis fractional shortening (FS(L)), was found to be a better index of LV function than CAM per se. There was a significant linear correlation between EF and FS(L) (r = 0.81, SEE = 8.2, p < 0.001). When values of FS(L) > or =10% were selected to define a normal EF (> or =50%) there was a sensitivity of 95% and a specificity of 93%. Visual estimation of EF from CAM was not as good as the use of calculated FS(L) but may me useful as a fast screening method.

    CONCLUSION: LV systolic function can be assessed by studying CAM recorded by coronary angiography.

  • 9.
    Kähäri, Anders
    et al.
    Department of Radiology, Örebro University Hospital, Örebro, Sweden.
    Thunberg, Per
    Department of Biomedical Engineering, Örebro University Hospital, Örebro, Sweden.
    Emilsson, Kent
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Clinical Physiology, Karlskoga Hospital, Karlskoga, Sweden.
    Geijer, Håkan
    Department of Radiology, Örebro University Hospital, Örebro, Sweden.
    Andersson, Torbjörn
    Wandt, Birger
    Assessment of left ventricular function from M-mode measurement of circumflex artery motion recorded by coronary angiography.2003Ingår i: Scandinavian Cardiovascular Journal, ISSN 1401-7431, E-ISSN 1651-2006, Vol. 37, nr 5, s. 259-265Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    OBJECTIVE: To evaluate the usefulness of M-mode measurement of circumflex artery motion (CAM) for assessment of left ventricular (LV) function.

    DESIGN: Seventy-two patients referred for coronary angiography and LV angiography were included. Ejection fraction (EF) was calculated from LV angiography and systolic and diastolic parameters of CAM were measured by M-mode from coronary angiography. Twenty-three patients, examined by echocardiography of mitral annulus motion (MAM) within 24 h before the angiographic examination, formed a subgroup for comparison between angiographic M-mode of CAM and echocardiographic M-mode of MAM.

    RESULTS: In addition to previous reported CAM amplitude and longitudinal fractional shortening (FSL) the maximal systolic velocity of CAM can be reliably recorded by M-mode. The diastolic indices, atrial contribution to the total amplitude and maximal early and late diastolic velocities, are also well monitored by M-mode of CAM in comparison with echocardiographic MAM.

    CONCLUSION: LV systolic and diastolic function can be assessed by M-mode of CAM.

  • 10.
    Lidén, Mats
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Radiology, Örebro University Hospital, Örebro, Sweden.
    Andersson, Torbjörn
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Broxvall, Mathias
    Örebro universitet, Institutionen för naturvetenskap och teknik.
    Thunberg, Per
    Örebro universitet, Institutionen för hälsovetenskap och medicin. Department of Medical Physics, Örebro University Hospital, Örebro, Sweden.
    Geijer, Håkan
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Urinary stone size estimation: a new segmentation algorithm-based CT method2012Ingår i: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 22, nr 4, s. 731-737Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The size estimation in CT images of an obstructing ureteral calculus is important for the clinical management of a patient presenting with renal colic. The objective of the present study was to develop a reader independent urinary calculus segmentation algorithm using well-known digital image processing steps and to validate the method against size estimations by several readers. Fifty clinical CT examinations demonstrating urinary calculi were included. Each calculus was measured independently by 11 readers. The mean value of their size estimations was used as validation data for each calculus. The segmentation algorithm consisted of interpolated zoom, binary thresholding and morphological operations. Ten examinations were used for algorithm optimisation and 40 for validation. Based on the optimisation results three segmentation method candidates were identified. Between the primary segmentation algorithm using cubic spline interpolation and the mean estimation by 11 readers, the bias was 0.0 mm, the standard deviation of the difference 0.26 mm and the Bland-Altman limits of agreement 0.0 +/- 0.5 mm. The validation showed good agreement between the suggested algorithm and the mean estimation by a large number of readers. The limit of agreement was narrower than the inter-reader limit of agreement previously reported for the same data. The size of kidney stones is usually estimated manually by the radiologist. An algorithm for computer-aided size estimation is introduced. The variability between readers can be reduced. A reduced variability can give better information for treatment decisions.

  • 11.
    Lidén, Mats
    et al.
    Örebro universitet, Hälsoakademin.
    Andersson, Torbjörn
    Örebro universitet, Hälsoakademin.
    Geijer, Håkan
    Örebro universitet, Hälsoakademin.
    Alternative user interface devices for improved navigation of CT datasets2011Ingår i: Journal of digital imaging, ISSN 0897-1889, E-ISSN 1618-727X, Vol. 24, nr 1, s. 126-134Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    The workflow in radiology departments has changed dramatically with the transition to digital PACS, especially with the shift from tile mode to stack mode display of volumetric images. With the increasing number of images in routinely captured datasets, the standard user interface devices (UIDs) become inadequate. One basic approach to improve the navigation of the stack mode datasets is to take advantage of alternative UIDs developed for other domains, such as the computer game industry. We evaluated three UIDs both in clinical practice and in a task-based experiment. After using the devices in the daily image interpretation work, the readers reported that both of the tested alternative UIDs were better in terms of ergonomics compared to the standard mouse and that both alternatives were more efficient when reviewing large CT datasets. In the task-based experiment, one of the tested devices was faster than the standard mouse, while the other alternative was not significantly faster. One of the tested alternative devices showed a larger number of traversed images during the task. The results indicate that alternative user interface devices can improve the navigation of stack mode datasets and that radiologists should consider the potential benefits of alternatives to the standard mouse.

  • 12.
    Lidén, Mats
    et al.
    Örebro universitet, Hälsoakademin.
    Andersson, Torbjörn
    Örebro universitet, Institutionen för läkarutbildning.
    Geijer, Håkan
    Örebro universitet, Hälsoakademin.
    Making renal stones change size: impact of CT image post processing and reader variability2011Ingår i: European Radiology, ISSN 0938-7994, E-ISSN 1432-1084, Vol. 21, nr 10, s. 2218-2225Artikel i tidskrift (Refereegranskat)
    Abstract [en]

    Objectives The objectives of this study were to quantify the impact of image post-processing parameters on the apparent renal stone size, and to quantify the intra- and inter-reader variability in renal stone size estimation. Methods Fifty CT datasets including a renal or ureteral stone were included retrospectively during a prospective inclusion period. Each of the CT datasets was post-processed in different ways regarding slice thickness, slice increment and window setting. In the first part of the study a single reader repeated size estimations for the renal stones using different post-processing parameters. In the intra-reader variability experiment one reader reported size estimations for the same images with a one-week interval. The inter-reader variability data were obtained from 11 readers reporting size estimations for the same renal stones. Results The apparent stone size differed according to image post-processing parameters with the largest mean differences seen with regard to the window settings experiment (1.5 mm, p < 0.001) and slice thickness (0.8 mm, p < 0.001). Changes in parameters introduced a bias and a pseudo-random variability. The inter-reader variability was considerably larger than the intra-reader variability. Conclusion Our results indicate a need for the standardisation of making measurements on CT images.

  • 13.
    Lidén, Mats
    et al.
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Andersson, Torbjörn
    Örebro universitet, Institutionen för läkarutbildning.
    Geijer, Håkan
    Örebro universitet, Institutionen för hälsovetenskap och medicin.
    Urinary stone size estimation: Can we reduce the reader variations?Manuskript (preprint) (Övrigt vetenskapligt)
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