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  • 1.
    Hurtig-Wennlöf, Anita
    et al.
    Örebro University, School of Health and Medical Sciences.
    Hagströmer, Maria
    Karolinska institutet, Stockholm, Sweden.
    Olsson, Lovisa A.
    Örebro University Hospital, Örebro, Sweden.
    The International Physical Activity Questionnaire modified for the elderly: aspects of validity and feasibility2010In: Public Health Nutrition, ISSN 1368-9800, E-ISSN 1475-2727, Vol. 13, no 11, p. 1847-1854Article in journal (Refereed)
    Abstract [en]

    OBJECTIVE: To modify the self-administered, short version of the International Physical Activity Questionnaire (IPAQ) for adults to be used in the elderly (aged 65 years and above), and to validate this modified IPAQ for the elderly (IPAQ-E).

    DESIGN: A direct validity study using accelerometer-measured physical activity (PA) as the criterion measure, and an indirect criterion validity study using high-sensitivity C-reactive protein (hs-CRP) as a biological marker of activity.

    SETTING: Organisations for retired persons in Sweden.

    SUBJECTS: The direct validity study consisted of fifty-four participants and the indirect criterion validity study consisted of 359 participants. All participants were retired persons (66-91 years) living independently.

    RESULTS: All self-reported activity domains (sitting, walking, moderate and vigorous) were positively correlated with the corresponding variable objectively assessed by an accelerometer (rho = 0.277-0.471), but a systematic error was observed. The specificity of IPAQ-E to identify low-active participants was 85 %, and the sensitivity to identify the more active participants was 81 %. A main effect of IPAQ-E category (Low, Moderate or High) was observed for hs-CRP (P = 0.041).

    CONCLUSIONS: We found this modified version of IPAQ, the IPAQ-E, to be well accepted by our sample of socially active elderly. It provided acceptable estimates of PA, well in line with other questionnaires, even though it had a systematic error. The IPAQ-E was able to identify an expected response of a biomarker (hs-CRP) to PA. We recommend the use of the IPAQ-E to classify participants aged 65 years and above into PA categories, to rank individuals or to identify individuals meeting certain PA criteria.

  • 2. Labayen, Idoia
    et al.
    Ortega, Francisco B.
    Sjöström, Michael
    Nilsson, Torbjörn K.
    Örebro University, School of Health and Medical Sciences.
    Olsson, Lovisa A.
    Örebro University, School of Health and Medical Sciences.
    Ruiz, Jonatan R.
    Association of common variants of UCP2 gene with low-grade inflammation in Swedish children and adolescents: the European Youth Heart Study2009In: Pediatric Research, ISSN 0031-3998, E-ISSN 1530-0447, Vol. 66, no 3, p. 350-354Article in journal (Refereed)
    Abstract [en]

    We examined the associations of two functional variants 866G>A and DEL/INS polymorphisms of UCP2 gene with low-grade inflammatory proteins (C-reactive protein, fibrinogen, complement C3 [C3], and complement C4 [C4]) in 131 children (52.7% boys, aged 9.5 +/- 0.4 y) and 118 adolescents (44.1% males, aged 15.5 +/- 0.4 y) selected from the European Youth Heart Study. Differences in inflammatory markers among the genotype variants of the two UCP2 gene polymorphisms were analyzed after adjusting for sex, age, pubertal stage, fitness, and fatness. The results showed that fibrinogen, C3, and C4 were higher in GG carriers than in subjects carrying the A allele of the 866G>A polymorphism of the UCP2 gene (UCP2 -866G>A) polymorphism (all p < 0.05). The DEL/DEL genotype of 45nt deletion/insertion variant polymorphism of the UCP2 gene (UCP2 DEL/INS) was associated with higher C3 (p < 0.05) than DEL/INS and INS/INS genotypes. This study provides evidence of a role of UCP2 -866G>A in modifying low-grade inflammatory state in apparently healthy children and adolescents. Given the implication of complement factors on atherosclerosis process, these results contribute to explain the reduced cardiovascular risk associated with the A allele of the UCP2 -866G>A polymorphism.

  • 3.
    Nilsson, Torbjörn K.
    et al.
    Örebro University, School of Health and Medical Sciences.
    Olsson, Lovisa A.
    Simultaneous genotyping of the three lactose tolerance-linked polymorphisms LCT –13907C>G, LCT –13910C>T and LCT –13915T>G with Pyrosequencing technology2008In: Clinical Chemistry and Laboratory Medicine, ISSN 1434-6621, E-ISSN 1437-4331, Vol. 46, no 1, p. 80-84Article in journal (Refereed)
    Abstract [en]

    Background: We required a new genotyping method for the diagnosis of adult hypolactasia, which would allow the simultaneous genotyping of three known polymorphic loci linked to lactose tolerance (LCT –13907C>G, LCT –13910C>T and LCT –13915T>G) in a single PCR/pyrosequencing test run.

    Method: We utilized Pyrosequencing™ technology, a DNA-sequence-by-synthesis technique.

    Results: The developed Pyrosequencing™ method allowed genotyping of the three loci LCT –13907C>G, LCT –13910C>T and LCT –13915T>G in a single PCR/pyrosequencing test run. A separate Pyrosequencing™ assay was developed for genotyping of the LCT –14010G>C mutation. The methods were evaluated in 116 clinical samples from patients of non-European descent, sent to the laboratory for diagnosis of adult hypolactasia. The “African” mutations LCT –13907C>G and LCT –13915T>G were found in subjects originating not only from Somalia, Ethiopia and Eritrea but also in Arabs and Iranians. Several compound heterozygotes LCT –13907CG/–13915TG were found among Ethiopian, Eritrean and Somalian subjects. No subject with the LCT –14010G>C mutation was found among the studied subjects. Advantages compared to the other genotyping methods are less staff hands-on time than, e.g., restriction fragment length polymorphism (RFLP) analyses, avoiding radioactivity as in the originally described isotope-minisequencing and in addition, Pyrosequencing™ is a direct DNA sequencing technique which gives unambiguous genotyping results as well as some redundant sequence information beyond the single nucleotide polymorphism (SNP) position, which serves as a valuable internal control obtained for each sample.

    Conclusions: Pyrosequencing™ is a robust genotyping modality suitable for clinical genotyping of patients not only of European, but also of African or Middle Eastern descent, who may harbor any combination of the three LCT mutations, LCT –13907C>G, LCT –13910C>T, LCT –13915T>G.

  • 4.
    Olsson, Lovisa A.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Subjective well-being in old age and its association with biochemical and genetic biomarkers and with physical activity2015Doctoral thesis, comprehensive summary (Other academic)
    List of papers
    1. Subjective well-being in Swedish active seniors or seniors with cognitive complaints and its relation to commonly available biomarkers
    Open this publication in new window or tab >>Subjective well-being in Swedish active seniors or seniors with cognitive complaints and its relation to commonly available biomarkers
    2013 (English)In: Archives of gerontology and geriatrics (Print), ISSN 0167-4943, E-ISSN 1872-6976, Vol. 56, no 2, p. 303-308Article in journal (Refereed) Published
    Abstract [en]

    Well-being (WB) is a complex variable in its relation to physical health and other personal and social characteristics. The aim was to study subjective well-being (SWB) and its possible associations with traditional biomarkers of cardiovascular risk or dementia, in Swedish seniors. SWB was estimated by the Psychological General Well-Being (PGWB) index in two study groups. The active seniors (AS) group consisted of community-dwelling elderly Swedes leading an active life (n=389). The DGM cohort (n=300) consisted of subjects referred to the Memory Unit at the Department of Geriatrics, the cognitive problems had to be subjective, mild or moderate (MMSE≥10). There were differences in all six subdimensions of SWB or distress, and in the sum of PGWB scores, between the two study groups (p<0.001 for all), and adjustment for differences in biomarkers of somatic health (age, sex, blood pressure, BMI, HDL cholesterol, ApoB/ApoA1 ratio, creatinine, and homocysteine) did not attenuate these differences. In addition, cognition as assessed by the Clock-Drawing Test (CDT) showed independent associations with four of the PGWB subdimensions and with the PGWB sum. Among the subjects in the DGM cohort, SWB was equally low among subjects with an MCI (minor cognitive impairment) diagnosis or without a dementia diagnosis as among subjects diagnosed with dementia disorder. We conclude that the nosological grouping variable (AS vs. DGM cohort) and a cognitive factor were the main independent predictors of SWB in this sample of elderly Swedes, whereas biomarkers of somatic health played a subordinated role.

    National Category
    Geriatrics
    Research subject
    Medicine
    Identifiers
    urn:nbn:se:oru:diva-27347 (URN)10.1016/j.archger.2012.07.009 (DOI)000313700100003 ()22906470 (PubMedID)2-s2.0-84872494066 (Scopus ID)
    Available from: 2013-02-06 Created: 2013-02-06 Last updated: 2017-12-06Bibliographically approved
    2. The International Physical Activity Questionnaire modified for the elderly: aspects of validity and feasibility
    Open this publication in new window or tab >>The International Physical Activity Questionnaire modified for the elderly: aspects of validity and feasibility
    2010 (English)In: Public Health Nutrition, ISSN 1368-9800, E-ISSN 1475-2727, Vol. 13, no 11, p. 1847-1854Article in journal (Refereed) Published
    Abstract [en]

    OBJECTIVE: To modify the self-administered, short version of the International Physical Activity Questionnaire (IPAQ) for adults to be used in the elderly (aged 65 years and above), and to validate this modified IPAQ for the elderly (IPAQ-E).

    DESIGN: A direct validity study using accelerometer-measured physical activity (PA) as the criterion measure, and an indirect criterion validity study using high-sensitivity C-reactive protein (hs-CRP) as a biological marker of activity.

    SETTING: Organisations for retired persons in Sweden.

    SUBJECTS: The direct validity study consisted of fifty-four participants and the indirect criterion validity study consisted of 359 participants. All participants were retired persons (66-91 years) living independently.

    RESULTS: All self-reported activity domains (sitting, walking, moderate and vigorous) were positively correlated with the corresponding variable objectively assessed by an accelerometer (rho = 0.277-0.471), but a systematic error was observed. The specificity of IPAQ-E to identify low-active participants was 85 %, and the sensitivity to identify the more active participants was 81 %. A main effect of IPAQ-E category (Low, Moderate or High) was observed for hs-CRP (P = 0.041).

    CONCLUSIONS: We found this modified version of IPAQ, the IPAQ-E, to be well accepted by our sample of socially active elderly. It provided acceptable estimates of PA, well in line with other questionnaires, even though it had a systematic error. The IPAQ-E was able to identify an expected response of a biomarker (hs-CRP) to PA. We recommend the use of the IPAQ-E to classify participants aged 65 years and above into PA categories, to rank individuals or to identify individuals meeting certain PA criteria.

    Place, publisher, year, edition, pages
    Cambridge: Cambridge University Press, 2010
    National Category
    Geriatrics
    Research subject
    Biomedicine
    Identifiers
    urn:nbn:se:oru:diva-10730 (URN)10.1017/S1368980010000157 (DOI)000284046900013 ()20196910 (PubMedID)2-s2.0-79451476316 (Scopus ID)
    Available from: 2010-05-19 Created: 2010-05-18 Last updated: 2017-12-12Bibliographically approved
    3. Subjective well-being in Swedish active seniors and its relationship with physical activity and commonly available biomarkers
    Open this publication in new window or tab >>Subjective well-being in Swedish active seniors and its relationship with physical activity and commonly available biomarkers
    2014 (English)In: Clinical Interventions in Aging, ISSN 1176-9092, E-ISSN 1178-1998, Vol. 9, p. 233-239Article in journal (Refereed) Published
    Abstract [en]

    Background: Physical activity is claimed to be related to well-being and to a lower risk of cardiovascular disease. Therefore, the possible associations of well-being with physical activity and biomarkers of somatic health were studied in a sample of Swedish active seniors to determine the strength of these associations.

    Methods: Three hundred and eighty-nine community-dwelling senior citizens (127 men and 262 women) of mean age 74 +/- 5 years were recruited for this cross-sectional population study. Serum samples were analyzed for lipoproteins and markers of inflammation. The Psychological General Well-Being (PGWB) index was used to measure subjective well-being. Physical activity was assessed by the International Physical Activity Questionnaire modified for the elderly.

    Results: More than 50% of men and women rated their physical activity as high; in the women, there was a significant difference between the age groups (younger and older than the median age [median =74.1 years], respectively). The mean PGWB index indicates a high degree of subjective well-being in this group of Swedish seniors. Of the PGWB subdimensions, general health had the strongest positive relationship with physical activity (r(2)=5.4%). for the subdimensions of depressed mood, positive well-being, vitality, and PGWB index, physical activity had an r(2)<= 4%, while the contributions of sex, age, and biomarkers were minor.

    Conclusion: We have estimated the contribution of physical activity to the variance of subjective well-being in active seniors. Physical activity appears to play a greater role as a determinant of subjective well-being than do biomarkers of somatic health, especially in females, but most of the variance remained unaccounted for by the studied variables.

    Place, publisher, year, edition, pages
    Dove Medical Press, 2014
    Keywords
    subjective well-being, physical activity, biomarkers
    National Category
    Geriatrics
    Research subject
    Geriatrics
    Identifiers
    urn:nbn:se:oru:diva-36184 (URN)10.2147/CIA.S63198 (DOI)000339920600001 ()2-s2.0-84905227461 (Scopus ID)
    Note

    Funding Agency:

    Research Committee of Örebro County Council and Nyckelfonden, Örebro, Sweden

    Available from: 2014-09-02 Created: 2014-08-28 Last updated: 2018-06-09Bibliographically approved
    4. Renal function is a determinant of subjective well-being in active seniors but not in patients with subjective memory complaints
    Open this publication in new window or tab >>Renal function is a determinant of subjective well-being in active seniors but not in patients with subjective memory complaints
    2014 (English)In: BMC Research Notes, ISSN 1756-0500, E-ISSN 1756-0500, Vol. 7, no 1, article id 647Article in journal (Refereed) Published
    Abstract [en]

    Results: There were no significant differences in cystatin C and eGFR values between the two cohorts: cystatin C medians 0.88 vs 0.86 mg/L and eGFR 73 vs 80 mL/min/1.73 m2(AS vs DGM). In the AS cohort cystatin C was negatively related to PGWB index in women (P &lt; 0.001, R 2≈ 5%), and the covariates age and BMI did not improve the models. The renal biomarkers were unrelated to the PGWB index in the DGM cohort. Cystatin C in the AS cohort was adversely related to the PGWB subdimensions anxiety, depressed mood, positive well-being, and vitality in women, but in men only to depressed mood (P &lt; 0.006; R 2≈ 6%). In the DGM cohort, depressed mood in men was also significantly related to cystatin C (P = 0.050), but not in women.

    Background: During our whole life span, factors influencing health and functioning are accumulated. In chronic kidney disease, quality of life is adversely affected. We hypothesized that biomarkers of renal function could also be determinants of subjective well-being (SWB) in Swedish elderly subjects. SWB was assessed by the Psychological General Well-Being index (PGWB index) in two study groups: Active seniors (AS) consisted of community-dwelling elderly Swedes leading an active life (n = 389), and the DGM cohort (n = 300) consisted of subjects referred to the Memory Unit at the Department of Geriatrics for memory problems, Serum creatinine, cystatin C, and eGFR (CKD-EPI) were used as biomarkers of renal function.

    Conclusions: Renal function even within the normal range, measured by serum cystatin C concentration, has significant and sex specific associations with subjective well-being and its subdimensions in healthy elderly subjects. Maintenance of good renal function in aging may be of importance in maintaining a high subjective well-being.

    Place, publisher, year, edition, pages
    BioMed Central, 2014
    Keywords
    Biomarkers; Creatinine; Cystatin C; Elderly; Renal function; Subjective well-being
    National Category
    Biomedical Laboratory Science/Technology
    Identifiers
    urn:nbn:se:oru:diva-43262 (URN)10.1186/1756-0500-7-647 (DOI)25219531 (PubMedID)2-s2.0-84907579308 (Scopus ID)
    Available from: 2015-03-03 Created: 2015-03-03 Last updated: 2018-06-18Bibliographically approved
    5. The triangulation of COMT polymorphism rs4680, physical activity, and subjective well-being in retired community-dwelling elderly subjects
    Open this publication in new window or tab >>The triangulation of COMT polymorphism rs4680, physical activity, and subjective well-being in retired community-dwelling elderly subjects
    (English)Manuscript (preprint) (Other academic)
    Abstract [en]

    Background: During normal aging dopaminergic neuromodulation declines and this has been associated with impaired cognitive function and negative and positive affects. A common polymorphism (rs4680; Val/Met) in the enzyme catechol-O6-methyltransferase (COMT) gene is a determinant of the rate of elimination of dopamine and noradrenaline in the prefrontal cortex, and is therefore thought to modulate dopaminergic signaling.

    The aim of the present study was to test whether subjective well-being (SWB) was influenced by interactions between COMT rs4680 genotype, sex, physical activity (PA), and serum biomarkers of somatic health.

    Methods: We studied 389 community dwelling, socially active seniors, mean age 74 years and M/F 127/262 (AS cohort). COMT was genotyped by pyrosequencing, PA was assessed by the IPAQ-E, and SWB by the PGWB index.

    Results: Male carriers of the rs4680 Met-allele had significantly better SWB than subjects with the ancestral wildtype Val/Val (p=0.009), also when adjusting for age, homocysteine, HbA1c, cystatin C, and IPAQ-E score (p=3.8×10 -5). There was a strong interaction between PA and the rs4680 polymorphism (p=0.001). In women on the other hand the COMT genotype was unrelated to PGWB sum and its subdimensions,

    Conclusion: In socially active, elderly retired men, COMT genotype has a major influence on SWB, partly mediated by an interaction with physical activity. This finding should help implementing better public health intervention strategies by tailoring the interventions at appropriately selected subgroups.

    National Category
    Geriatrics
    Identifiers
    urn:nbn:se:oru:diva-43289 (URN)
    Available from: 2015-03-04 Created: 2015-03-04 Last updated: 2017-10-17Bibliographically approved
  • 5.
    Olsson, Lovisa A.
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Department of Laboratory Medicine/Clinical Chemistry, Örebro University Hospital, Örebro, Sweden.
    Hagnelius, Nils-Olof
    Örebro University Hospital. Department of Geriatrics, Örebro University Hospital, Örebro, Sweden.
    Nilsson, Torbjörn K.
    Department of Medical Biosciences, Clinical Chemistry, Umeå University, Umeå, Sweden.
    Renal function is a determinant of subjective well-being in active seniors but not in patients with subjective memory complaints2014In: BMC Research Notes, ISSN 1756-0500, E-ISSN 1756-0500, Vol. 7, no 1, article id 647Article in journal (Refereed)
    Abstract [en]

    Results: There were no significant differences in cystatin C and eGFR values between the two cohorts: cystatin C medians 0.88 vs 0.86 mg/L and eGFR 73 vs 80 mL/min/1.73 m2(AS vs DGM). In the AS cohort cystatin C was negatively related to PGWB index in women (P &lt; 0.001, R 2≈ 5%), and the covariates age and BMI did not improve the models. The renal biomarkers were unrelated to the PGWB index in the DGM cohort. Cystatin C in the AS cohort was adversely related to the PGWB subdimensions anxiety, depressed mood, positive well-being, and vitality in women, but in men only to depressed mood (P &lt; 0.006; R 2≈ 6%). In the DGM cohort, depressed mood in men was also significantly related to cystatin C (P = 0.050), but not in women.

    Background: During our whole life span, factors influencing health and functioning are accumulated. In chronic kidney disease, quality of life is adversely affected. We hypothesized that biomarkers of renal function could also be determinants of subjective well-being (SWB) in Swedish elderly subjects. SWB was assessed by the Psychological General Well-Being index (PGWB index) in two study groups: Active seniors (AS) consisted of community-dwelling elderly Swedes leading an active life (n = 389), and the DGM cohort (n = 300) consisted of subjects referred to the Memory Unit at the Department of Geriatrics for memory problems, Serum creatinine, cystatin C, and eGFR (CKD-EPI) were used as biomarkers of renal function.

    Conclusions: Renal function even within the normal range, measured by serum cystatin C concentration, has significant and sex specific associations with subjective well-being and its subdimensions in healthy elderly subjects. Maintenance of good renal function in aging may be of importance in maintaining a high subjective well-being.

  • 6.
    Olsson, Lovisa A.
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital.
    Hagnelius, Nils-Olof
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Olsson, Henny
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Nilsson, Torbjörn K
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Subjective well-being in Swedish active seniors or seniors with cognitive complaints and its relation to commonly available biomarkers2013In: Archives of gerontology and geriatrics (Print), ISSN 0167-4943, E-ISSN 1872-6976, Vol. 56, no 2, p. 303-308Article in journal (Refereed)
    Abstract [en]

    Well-being (WB) is a complex variable in its relation to physical health and other personal and social characteristics. The aim was to study subjective well-being (SWB) and its possible associations with traditional biomarkers of cardiovascular risk or dementia, in Swedish seniors. SWB was estimated by the Psychological General Well-Being (PGWB) index in two study groups. The active seniors (AS) group consisted of community-dwelling elderly Swedes leading an active life (n=389). The DGM cohort (n=300) consisted of subjects referred to the Memory Unit at the Department of Geriatrics, the cognitive problems had to be subjective, mild or moderate (MMSE≥10). There were differences in all six subdimensions of SWB or distress, and in the sum of PGWB scores, between the two study groups (p<0.001 for all), and adjustment for differences in biomarkers of somatic health (age, sex, blood pressure, BMI, HDL cholesterol, ApoB/ApoA1 ratio, creatinine, and homocysteine) did not attenuate these differences. In addition, cognition as assessed by the Clock-Drawing Test (CDT) showed independent associations with four of the PGWB subdimensions and with the PGWB sum. Among the subjects in the DGM cohort, SWB was equally low among subjects with an MCI (minor cognitive impairment) diagnosis or without a dementia diagnosis as among subjects diagnosed with dementia disorder. We conclude that the nosological grouping variable (AS vs. DGM cohort) and a cognitive factor were the main independent predictors of SWB in this sample of elderly Swedes, whereas biomarkers of somatic health played a subordinated role.

  • 7.
    Olsson, Lovisa A.
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden. Örebro University Hospital. Department of Laboratory Medicine/Clinical Chemistry, Örebro University Hospital, Örebro, Sweden.
    Hurtig-Wennlöf, Anita
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Nilsson, Torbjörn K.
    Department of Medical Biosciences/Clinical Chemistry, Umeå University, Umeå, Sweden.
    Subjective well-being in Swedish active seniors and its relationship with physical activity and commonly available biomarkers2014In: Clinical Interventions in Aging, ISSN 1176-9092, E-ISSN 1178-1998, Vol. 9, p. 233-239Article in journal (Refereed)
    Abstract [en]

    Background: Physical activity is claimed to be related to well-being and to a lower risk of cardiovascular disease. Therefore, the possible associations of well-being with physical activity and biomarkers of somatic health were studied in a sample of Swedish active seniors to determine the strength of these associations.

    Methods: Three hundred and eighty-nine community-dwelling senior citizens (127 men and 262 women) of mean age 74 +/- 5 years were recruited for this cross-sectional population study. Serum samples were analyzed for lipoproteins and markers of inflammation. The Psychological General Well-Being (PGWB) index was used to measure subjective well-being. Physical activity was assessed by the International Physical Activity Questionnaire modified for the elderly.

    Results: More than 50% of men and women rated their physical activity as high; in the women, there was a significant difference between the age groups (younger and older than the median age [median =74.1 years], respectively). The mean PGWB index indicates a high degree of subjective well-being in this group of Swedish seniors. Of the PGWB subdimensions, general health had the strongest positive relationship with physical activity (r(2)=5.4%). for the subdimensions of depressed mood, positive well-being, vitality, and PGWB index, physical activity had an r(2)<= 4%, while the contributions of sex, age, and biomarkers were minor.

    Conclusion: We have estimated the contribution of physical activity to the variance of subjective well-being in active seniors. Physical activity appears to play a greater role as a determinant of subjective well-being than do biomarkers of somatic health, especially in females, but most of the variance remained unaccounted for by the studied variables.

  • 8.
    Olsson, Lovisa A.
    et al.
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    Karlsson, Jan
    Nilsson, Torbjörn K
    Örebro University, School of Health and Medical Sciences, Örebro University, Sweden.
    The triangulation of COMT polymorphism rs4680, physical activity, and subjective well-being in retired community-dwelling elderly subjectsManuscript (preprint) (Other academic)
    Abstract [en]

    Background: During normal aging dopaminergic neuromodulation declines and this has been associated with impaired cognitive function and negative and positive affects. A common polymorphism (rs4680; Val/Met) in the enzyme catechol-O6-methyltransferase (COMT) gene is a determinant of the rate of elimination of dopamine and noradrenaline in the prefrontal cortex, and is therefore thought to modulate dopaminergic signaling.

    The aim of the present study was to test whether subjective well-being (SWB) was influenced by interactions between COMT rs4680 genotype, sex, physical activity (PA), and serum biomarkers of somatic health.

    Methods: We studied 389 community dwelling, socially active seniors, mean age 74 years and M/F 127/262 (AS cohort). COMT was genotyped by pyrosequencing, PA was assessed by the IPAQ-E, and SWB by the PGWB index.

    Results: Male carriers of the rs4680 Met-allele had significantly better SWB than subjects with the ancestral wildtype Val/Val (p=0.009), also when adjusting for age, homocysteine, HbA1c, cystatin C, and IPAQ-E score (p=3.8×10 -5). There was a strong interaction between PA and the rs4680 polymorphism (p=0.001). In women on the other hand the COMT genotype was unrelated to PGWB sum and its subdimensions,

    Conclusion: In socially active, elderly retired men, COMT genotype has a major influence on SWB, partly mediated by an interaction with physical activity. This finding should help implementing better public health intervention strategies by tailoring the interventions at appropriately selected subgroups.

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